CN102884035B - 厚朴酚及其类似化合物的合成 - Google Patents

厚朴酚及其类似化合物的合成 Download PDF

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Publication number
CN102884035B
CN102884035B CN201080064851.2A CN201080064851A CN102884035B CN 102884035 B CN102884035 B CN 102884035B CN 201080064851 A CN201080064851 A CN 201080064851A CN 102884035 B CN102884035 B CN 102884035B
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CN
China
Prior art keywords
formula
compound
organic solvent
magnolol
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201080064851.2A
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English (en)
Chinese (zh)
Other versions
CN102884035A (zh
Inventor
B.V.S.雷迪
J.S.亚达夫
R.苏布拉曼亚姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indian Institute of Chemical Technology
Colgate Palmolive Co
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Indian Institute of Chemical Technology
Colgate Palmolive Co
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Publication of CN102884035A publication Critical patent/CN102884035A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/52—Preparation of compounds having groups by reactions producing groups by substitution of halogen only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080064851.2A 2010-02-25 2010-02-25 厚朴酚及其类似化合物的合成 Expired - Fee Related CN102884035B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/025378 WO2011106003A1 (en) 2010-02-25 2010-02-25 Synthesis of magnolol and its analogue compounds

Publications (2)

Publication Number Publication Date
CN102884035A CN102884035A (zh) 2013-01-16
CN102884035B true CN102884035B (zh) 2016-01-20

Family

ID=42028117

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CN201080064851.2A Expired - Fee Related CN102884035B (zh) 2010-02-25 2010-02-25 厚朴酚及其类似化合物的合成

Country Status (19)

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US (1) US8519197B2 (enExample)
EP (1) EP2539310B1 (enExample)
JP (1) JP2013520495A (enExample)
CN (1) CN102884035B (enExample)
AR (1) AR080656A1 (enExample)
AU (1) AU2010346597B2 (enExample)
BR (1) BR112012020603A2 (enExample)
CA (1) CA2789140C (enExample)
DK (1) DK2539310T3 (enExample)
ES (1) ES2507615T3 (enExample)
MX (1) MX2012009817A (enExample)
MY (1) MY162466A (enExample)
PH (1) PH12012501619A1 (enExample)
PL (1) PL2539310T3 (enExample)
RU (1) RU2510938C1 (enExample)
SG (1) SG183120A1 (enExample)
TW (1) TWI438185B (enExample)
WO (1) WO2011106003A1 (enExample)
ZA (1) ZA201206020B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG190880A1 (en) 2010-12-21 2013-07-31 Colgate Palmolive Co Halogenated biphenols as antibacterial agents
US9155693B2 (en) 2011-12-15 2015-10-13 Colgate-Palmolive Company Solubilized magnolol analogs
EP2790645B1 (en) 2011-12-15 2016-10-05 Colgate-Palmolive Company Solubilized magnolol analogs
US9000231B2 (en) 2011-12-20 2015-04-07 Colgate-Palmolive Company Processes for making magnolol and derivatives thereof
RU2014129908A (ru) 2011-12-20 2016-02-10 Колгейт-Палмолив Компани Способы получения аналогов магнолола
EP2948220B1 (en) 2013-01-23 2018-07-04 Colgate-Palmolive Company Processes for making magnolol derivatives
JP2015007054A (ja) * 2014-07-24 2015-01-15 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ マグノロールおよびその類似体化合物の合成
EP3364957B1 (en) * 2015-10-23 2020-12-09 Colgate-Palmolive Company Improved synthesis of honokiol
CN109053387B (zh) * 2018-09-19 2021-07-09 九江学院 一种厚朴酚的合成方法
MX2021007084A (es) 2018-12-18 2021-08-11 Unilever Ip Holdings B V Una composicion antimicrobiana.
CN115581690A (zh) * 2021-07-05 2023-01-10 北京红惠新医药科技有限公司 厚朴酚或和厚朴酚的芳环氨基取代衍生物在用于制备抗心肌缺血药物中的应用、药物组合物
CN116139115A (zh) * 2021-11-19 2023-05-23 北京红惠新医药科技有限公司 厚朴酚和/或和厚朴酚芳环氨基取代类衍生物的抗低氧/缺氧损伤用途及药物组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331968A (zh) * 2001-07-18 2002-01-23 广州美晨股份有限公司 一种中药牙膏
WO2002092726A2 (en) * 2001-05-16 2002-11-21 Petroleo Brasileiro S.A. - Petrobras Process for the catalytic oxidation of sulfur, nitrogen and unsaturated compounds from hydrocarbon streams
CN1723011A (zh) * 2002-06-25 2006-01-18 Wm·雷格利Jr·公司 含有厚朴提取物的口气清新和口腔清洁产品

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103847A (en) * 1991-11-25 2000-06-01 Lilly Co Eli 4,5-disubstituted 2-phenylphenol leukotriene antagonists and pharmaceutical compositions containing them
US20060140885A1 (en) 2004-12-29 2006-06-29 Abdul Gaffar Method of reducing oral tissue inflammation using magnolia extract
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092726A2 (en) * 2001-05-16 2002-11-21 Petroleo Brasileiro S.A. - Petrobras Process for the catalytic oxidation of sulfur, nitrogen and unsaturated compounds from hydrocarbon streams
CN1331968A (zh) * 2001-07-18 2002-01-23 广州美晨股份有限公司 一种中药牙膏
CN1723011A (zh) * 2002-06-25 2006-01-18 Wm·雷格利Jr·公司 含有厚朴提取物的口气清新和口腔清洁产品

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Phenol Dehydrogenations Ⅷ Synthesis of Magnolol;J.RUNEBERG;《Acta Chem. Scand. 》;19581231;第12卷;第190页第14-25行 *
Synthesis of (-)-Monoterpenylmagnolol and Magnolol;Mohamad R. Agharahimi等;《J. Org. Chem.》;19951231;第60卷;第1857页右栏倒数第6-9行、1858页方程式、第1858页右栏倒数第18-22行、第1858页右栏倒数第10-17行、图3 *

Also Published As

Publication number Publication date
ES2507615T3 (es) 2014-10-15
PL2539310T3 (pl) 2015-01-30
EP2539310A1 (en) 2013-01-02
AR080656A1 (es) 2012-04-25
HK1180297A1 (en) 2013-10-18
TW201141823A (en) 2011-12-01
CA2789140C (en) 2015-01-27
RU2012140748A (ru) 2014-03-27
MX2012009817A (es) 2012-09-12
WO2011106003A1 (en) 2011-09-01
EP2539310B1 (en) 2014-07-16
CN102884035A (zh) 2013-01-16
US8519197B2 (en) 2013-08-27
JP2013520495A (ja) 2013-06-06
DK2539310T3 (da) 2014-10-20
SG183120A1 (en) 2012-09-27
BR112012020603A2 (pt) 2017-07-11
AU2010346597B2 (en) 2013-09-19
PH12012501619A1 (en) 2014-09-24
US20120302647A1 (en) 2012-11-29
MY162466A (en) 2017-06-15
AU2010346597A1 (en) 2012-08-23
ZA201206020B (en) 2014-01-29
TWI438185B (zh) 2014-05-21
RU2510938C1 (ru) 2014-04-10
CA2789140A1 (en) 2011-09-01

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Granted publication date: 20160120