AR080656A1 - Sintesis de magnolol y sus compuestos analogos, y composicion farmaceutica - Google Patents
Sintesis de magnolol y sus compuestos analogos, y composicion farmaceuticaInfo
- Publication number
- AR080656A1 AR080656A1 ARP110100579A ARP110100579A AR080656A1 AR 080656 A1 AR080656 A1 AR 080656A1 AR P110100579 A ARP110100579 A AR P110100579A AR P110100579 A ARP110100579 A AR P110100579A AR 080656 A1 AR080656 A1 AR 080656A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- organic solvent
- reaction
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 17
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 239000003960 organic solvent Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- XJUZRXYOEPSWMB-UHFFFAOYSA-N Chloromethyl methyl ether Chemical compound COCCl XJUZRXYOEPSWMB-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
- C07C41/52—Preparation of compounds having groups by reactions producing groups by substitution of halogen only
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/025378 WO2011106003A1 (en) | 2010-02-25 | 2010-02-25 | Synthesis of magnolol and its analogue compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR080656A1 true AR080656A1 (es) | 2012-04-25 |
Family
ID=42028117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110100579A AR080656A1 (es) | 2010-02-25 | 2011-02-24 | Sintesis de magnolol y sus compuestos analogos, y composicion farmaceutica |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8519197B2 (enExample) |
| EP (1) | EP2539310B1 (enExample) |
| JP (1) | JP2013520495A (enExample) |
| CN (1) | CN102884035B (enExample) |
| AR (1) | AR080656A1 (enExample) |
| AU (1) | AU2010346597B2 (enExample) |
| BR (1) | BR112012020603A2 (enExample) |
| CA (1) | CA2789140C (enExample) |
| DK (1) | DK2539310T3 (enExample) |
| ES (1) | ES2507615T3 (enExample) |
| MX (1) | MX2012009817A (enExample) |
| MY (1) | MY162466A (enExample) |
| PH (1) | PH12012501619A1 (enExample) |
| PL (1) | PL2539310T3 (enExample) |
| RU (1) | RU2510938C1 (enExample) |
| SG (1) | SG183120A1 (enExample) |
| TW (1) | TWI438185B (enExample) |
| WO (1) | WO2011106003A1 (enExample) |
| ZA (1) | ZA201206020B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010365812B2 (en) | 2010-12-21 | 2014-12-18 | Colgate-Palmolive Company | Halogenated biphenols as antibacterial agents |
| KR20140112481A (ko) | 2011-12-15 | 2014-09-23 | 콜게이트-파아므올리브캄파니 | 가용화된 마그놀롤 유사체 및 피피쥐-1-피이쥐-9 라우릴 글리콜 에테르를 함유하는 구강 위생 또는 클렌저 조성물 |
| AU2011383311B2 (en) | 2011-12-15 | 2014-08-21 | Colgate-Palmolive Company | Solubilized magnolol analogs |
| US9000231B2 (en) | 2011-12-20 | 2015-04-07 | Colgate-Palmolive Company | Processes for making magnolol and derivatives thereof |
| WO2013095364A1 (en) | 2011-12-20 | 2013-06-27 | Colgate-Palmolive Company | Processes for making magnolol analogs |
| AU2013374909B2 (en) | 2013-01-23 | 2015-10-15 | Colgate-Palmolive Company | Processes for making magnolol derivatives |
| JP2015007054A (ja) * | 2014-07-24 | 2015-01-15 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | マグノロールおよびその類似体化合物の合成 |
| EP3364957B1 (en) * | 2015-10-23 | 2020-12-09 | Colgate-Palmolive Company | Improved synthesis of honokiol |
| CN109053387B (zh) * | 2018-09-19 | 2021-07-09 | 九江学院 | 一种厚朴酚的合成方法 |
| CN113242751B (zh) | 2018-12-18 | 2023-09-19 | 联合利华知识产权控股有限公司 | 抗微生物组合物 |
| CN115581690A (zh) * | 2021-07-05 | 2023-01-10 | 北京红惠新医药科技有限公司 | 厚朴酚或和厚朴酚的芳环氨基取代衍生物在用于制备抗心肌缺血药物中的应用、药物组合物 |
| CN116139115A (zh) * | 2021-11-19 | 2023-05-23 | 北京红惠新医药科技有限公司 | 厚朴酚和/或和厚朴酚芳环氨基取代类衍生物的抗低氧/缺氧损伤用途及药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL116942A (en) * | 1991-11-25 | 2000-02-29 | Lilly Co Eli | 2-phenyl-4,5-disubstituted phenol derivatives as chemical intermediates for substituted phenyl phenol leukotriene antagonists |
| US6544409B2 (en) * | 2001-05-16 | 2003-04-08 | Petroleo Brasileiro S.A. - Petrobras | Process for the catalytic oxidation of sulfur, nitrogen and unsaturated compounds from hydrocarbon streams |
| CN1147286C (zh) * | 2001-07-18 | 2004-04-28 | 广州美晨股份有限公司 | 一种中药牙膏 |
| US7347985B2 (en) * | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US20060140885A1 (en) | 2004-12-29 | 2006-06-29 | Abdul Gaffar | Method of reducing oral tissue inflammation using magnolia extract |
| WO2008098056A2 (en) * | 2007-02-06 | 2008-08-14 | Epix Pharmaceuticals, Inc. | High relaxivity chelates |
-
2010
- 2010-02-25 PH PH1/2012/501619A patent/PH12012501619A1/en unknown
- 2010-02-25 ES ES10705965.1T patent/ES2507615T3/es active Active
- 2010-02-25 SG SG2012056404A patent/SG183120A1/en unknown
- 2010-02-25 MX MX2012009817A patent/MX2012009817A/es active IP Right Grant
- 2010-02-25 CA CA2789140A patent/CA2789140C/en not_active Expired - Fee Related
- 2010-02-25 EP EP10705965.1A patent/EP2539310B1/en active Active
- 2010-02-25 BR BR112012020603A patent/BR112012020603A2/pt active Search and Examination
- 2010-02-25 CN CN201080064851.2A patent/CN102884035B/zh not_active Expired - Fee Related
- 2010-02-25 MY MYPI2012003487A patent/MY162466A/en unknown
- 2010-02-25 PL PL10705965T patent/PL2539310T3/pl unknown
- 2010-02-25 WO PCT/US2010/025378 patent/WO2011106003A1/en not_active Ceased
- 2010-02-25 DK DK10705965.1T patent/DK2539310T3/da active
- 2010-02-25 AU AU2010346597A patent/AU2010346597B2/en not_active Ceased
- 2010-02-25 RU RU2012140748/04A patent/RU2510938C1/ru not_active IP Right Cessation
- 2010-02-25 US US13/577,627 patent/US8519197B2/en active Active
- 2010-02-25 JP JP2012554971A patent/JP2013520495A/ja active Pending
-
2011
- 2011-02-24 AR ARP110100579A patent/AR080656A1/es unknown
- 2011-02-24 TW TW100106113A patent/TWI438185B/zh not_active IP Right Cessation
-
2012
- 2012-08-10 ZA ZA2012/06020A patent/ZA201206020B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2539310T3 (pl) | 2015-01-30 |
| CA2789140C (en) | 2015-01-27 |
| JP2013520495A (ja) | 2013-06-06 |
| BR112012020603A2 (pt) | 2017-07-11 |
| ZA201206020B (en) | 2014-01-29 |
| TWI438185B (zh) | 2014-05-21 |
| EP2539310B1 (en) | 2014-07-16 |
| AU2010346597A1 (en) | 2012-08-23 |
| TW201141823A (en) | 2011-12-01 |
| EP2539310A1 (en) | 2013-01-02 |
| RU2510938C1 (ru) | 2014-04-10 |
| AU2010346597B2 (en) | 2013-09-19 |
| MY162466A (en) | 2017-06-15 |
| SG183120A1 (en) | 2012-09-27 |
| MX2012009817A (es) | 2012-09-12 |
| CN102884035B (zh) | 2016-01-20 |
| US8519197B2 (en) | 2013-08-27 |
| DK2539310T3 (da) | 2014-10-20 |
| US20120302647A1 (en) | 2012-11-29 |
| CN102884035A (zh) | 2013-01-16 |
| RU2012140748A (ru) | 2014-03-27 |
| ES2507615T3 (es) | 2014-10-15 |
| PH12012501619A1 (en) | 2014-09-24 |
| HK1180297A1 (en) | 2013-10-18 |
| WO2011106003A1 (en) | 2011-09-01 |
| CA2789140A1 (en) | 2011-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |