CN102883738A - 治疗血管发生相关的眼部疾病的组合物和方法 - Google Patents

治疗血管发生相关的眼部疾病的组合物和方法 Download PDF

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Publication number
CN102883738A
CN102883738A CN2010800594090A CN201080059409A CN102883738A CN 102883738 A CN102883738 A CN 102883738A CN 2010800594090 A CN2010800594090 A CN 2010800594090A CN 201080059409 A CN201080059409 A CN 201080059409A CN 102883738 A CN102883738 A CN 102883738A
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CN
China
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malaysia
protein variant
compositions
seq
variant
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Pending
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CN2010800594090A
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English (en)
Chinese (zh)
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庄韦杰
傅文美
黄彦伦
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National Taiwan University NTU
National Cheng Kung University NCKU
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National Taiwan University NTU
National Cheng Kung University NCKU
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Publication of CN102883738A publication Critical patent/CN102883738A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN2010800594090A 2009-12-23 2010-12-22 治疗血管发生相关的眼部疾病的组合物和方法 Pending CN102883738A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28962409P 2009-12-23 2009-12-23
US61/289,624 2009-12-23
PCT/US2010/061738 WO2011079175A1 (en) 2009-12-23 2010-12-22 Compositions and methods for the treatment of angiogenesis-related eye diseases

Publications (1)

Publication Number Publication Date
CN102883738A true CN102883738A (zh) 2013-01-16

Family

ID=44151942

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800594090A Pending CN102883738A (zh) 2009-12-23 2010-12-22 治疗血管发生相关的眼部疾病的组合物和方法

Country Status (14)

Country Link
US (1) US9044436B2 (enExample)
EP (1) EP2515926A4 (enExample)
JP (1) JP5739908B2 (enExample)
KR (1) KR20120130752A (enExample)
CN (1) CN102883738A (enExample)
AR (1) AR079706A1 (enExample)
AU (1) AU2010336475A1 (enExample)
BR (1) BR112012015188A8 (enExample)
CA (1) CA2782796A1 (enExample)
MX (1) MX2012007416A (enExample)
NZ (1) NZ600544A (enExample)
RU (1) RU2012131251A (enExample)
TW (1) TWI581801B (enExample)
WO (1) WO2011079175A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430489A (zh) * 2015-06-28 2018-08-21 新源生物科技股份有限公司 用于抑制血管新生的融合蛋白
US12304037B2 (en) 2021-11-03 2025-05-20 Aob Products Company Torque driver

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* Cited by examiner, † Cited by third party
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KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
MX2012000895A (es) * 2009-07-20 2012-06-01 Univ Nat Cheng Kung Polipeptidos selectivos para integrina alfavbeta3 conjugada con una variante de albumina de suero humana (hsa) y usos farmaceuticos de los mismos.
MX2012004793A (es) 2009-10-30 2012-07-20 Novozymes Biopharma Dk As Variantes de albumina.
JP5969458B2 (ja) 2010-04-09 2016-08-17 アルブミディクス アクティーゼルスカブ アルブミン誘導体及び変異体
US20140315817A1 (en) 2011-11-18 2014-10-23 Eleven Biotherapeutics, Inc. Variant serum albumin with improved half-life and other properties
DK2825556T3 (en) 2012-03-16 2018-04-16 Albumedix As albumin Variants
KR20150082422A (ko) 2012-11-08 2015-07-15 노보자임스 바이오파마 디케이 에이/에스 알부민 변이체
KR101724129B1 (ko) * 2014-03-28 2017-04-10 연세대학교 산학협력단 Rgd 모티프를 포함하는 펩타이드 또는 단백질을 포함하는 신경염증 예방, 억제 또는 치료용 조성물
CN106714818B (zh) 2014-08-22 2020-04-21 成功大学 去整合蛋白变异体及其医药用途
ES2836426T3 (es) 2014-12-31 2021-06-25 Huons Co Ltd Composición, que contiene péptido que contiene motivo RGD o fragmento de éste, para aliviar las arrugas de la piel
EP3337816B1 (en) 2015-08-20 2024-02-14 Albumedix Ltd Albumin variants and conjugates
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition
KR20250021281A (ko) 2023-08-04 2025-02-12 주식회사 넥스세라 콜라겐 타입 i 및 색소 상피성 인자 펩타이드를 유효성분으로 포함하는 안구 혈관신생 질환의 예방 또는 치료용 점안제 조성물

Citations (3)

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US5659018A (en) * 1995-08-01 1997-08-19 Genetics Institute, Inc. Mocarhagin, a cobra venom protease, and therapeutic uses thereof
WO2008088548A2 (en) * 2006-12-26 2008-07-24 National Taiwan University Disintegrin variants and pharmaceutical uses thereof
CN102470156A (zh) * 2009-07-20 2012-05-23 成功大学 选择性作用于αvβ3整合素并缀合人血清白蛋白(HSA)变体的多肽及其药学用途

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US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US6710030B1 (en) 1993-10-22 2004-03-23 University Of Southern California Contortrostain (CN) and methods for its use in preventing metastasis and other conditions
US20030228298A1 (en) * 2001-09-04 2003-12-11 Mark Nesbit Abrogen polypeptides, nucleic acids encoding them and methods for using them to inhibit angiogenesis
US6974884B2 (en) 2002-06-07 2005-12-13 Wisconsin Alumni Research Foundation Chemical synthesis of reagents for peptide coupling
CA2606989A1 (en) * 2005-04-29 2006-11-09 Research Development Foundation Vascular targeting of ocular neovascularization

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5659018A (en) * 1995-08-01 1997-08-19 Genetics Institute, Inc. Mocarhagin, a cobra venom protease, and therapeutic uses thereof
WO2008088548A2 (en) * 2006-12-26 2008-07-24 National Taiwan University Disintegrin variants and pharmaceutical uses thereof
CN102470156A (zh) * 2009-07-20 2012-05-23 成功大学 选择性作用于αvβ3整合素并缀合人血清白蛋白(HSA)变体的多肽及其药学用途

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430489A (zh) * 2015-06-28 2018-08-21 新源生物科技股份有限公司 用于抑制血管新生的融合蛋白
CN108430489B (zh) * 2015-06-28 2022-03-25 新源生物科技股份有限公司 用于抑制血管新生的融合蛋白
US12304037B2 (en) 2021-11-03 2025-05-20 Aob Products Company Torque driver
US12447591B1 (en) 2021-11-03 2025-10-21 Aob Products Company Torque driver

Also Published As

Publication number Publication date
JP5739908B2 (ja) 2015-06-24
AU2010336475A1 (en) 2012-06-14
AR079706A1 (es) 2012-02-15
BR112012015188A2 (pt) 2016-04-05
EP2515926A1 (en) 2012-10-31
US20110152192A1 (en) 2011-06-23
TWI581801B (zh) 2017-05-11
KR20120130752A (ko) 2012-12-03
MX2012007416A (es) 2012-07-23
EP2515926A4 (en) 2013-10-09
BR112012015188A8 (pt) 2016-08-09
JP2013515739A (ja) 2013-05-09
WO2011079175A1 (en) 2011-06-30
TW201138801A (en) 2011-11-16
NZ600544A (en) 2014-06-27
RU2012131251A (ru) 2014-01-27
CA2782796A1 (en) 2011-06-30
US9044436B2 (en) 2015-06-02

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Application publication date: 20130116