TWI581801B - 治療血管新生相關之眼疾之組合物及方法 - Google Patents
治療血管新生相關之眼疾之組合物及方法 Download PDFInfo
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- TWI581801B TWI581801B TW099145616A TW99145616A TWI581801B TW I581801 B TWI581801 B TW I581801B TW 099145616 A TW099145616 A TW 099145616A TW 99145616 A TW99145616 A TW 99145616A TW I581801 B TWI581801 B TW I581801B
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- snake venom
- venom protein
- protein variant
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Zoology (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28962409P | 2009-12-23 | 2009-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201138801A TW201138801A (en) | 2011-11-16 |
| TWI581801B true TWI581801B (zh) | 2017-05-11 |
Family
ID=44151942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099145616A TWI581801B (zh) | 2009-12-23 | 2010-12-23 | 治療血管新生相關之眼疾之組合物及方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9044436B2 (enExample) |
| EP (1) | EP2515926A4 (enExample) |
| JP (1) | JP5739908B2 (enExample) |
| KR (1) | KR20120130752A (enExample) |
| CN (1) | CN102883738A (enExample) |
| AR (1) | AR079706A1 (enExample) |
| AU (1) | AU2010336475A1 (enExample) |
| BR (1) | BR112012015188A8 (enExample) |
| CA (1) | CA2782796A1 (enExample) |
| MX (1) | MX2012007416A (enExample) |
| NZ (1) | NZ600544A (enExample) |
| RU (1) | RU2012131251A (enExample) |
| TW (1) | TWI581801B (enExample) |
| WO (1) | WO2011079175A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| EP2456454A4 (en) * | 2009-07-20 | 2013-03-20 | Univ Nat Cheng Kung | FOR AV-3-INTEGRIN SELECTIVE POLYPEPTIDE AND PHARMACEUTICAL USES THEREOF ASSOCIATED WITH A HUMAN SERUM ALUMINUM (HSA) VARIATION |
| AU2010311332B2 (en) | 2009-10-30 | 2015-04-23 | Albumedix Ltd. | Albumin variants |
| KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
| HK1200842A1 (en) | 2011-11-18 | 2015-08-14 | Albumedix Ltd | Proteins with improved half-life and other properties |
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| WO2015147616A1 (ko) * | 2014-03-28 | 2015-10-01 | 연세대학교 산학협력단 | Rgd 모티프를 포함하는 펩타이드 또는 단백질을 포함하는 신경염증 예방, 억제 또는 치료용 조성물 |
| CA2958906C (en) * | 2014-08-22 | 2021-05-04 | National Cheng Kung University | Disintegrin variants and pharmaceutical uses thereof |
| WO2016108669A1 (ko) | 2014-12-31 | 2016-07-07 | 주식회사 휴온스 | Rgd 모티프 함유 펩티드 또는 이의 단편을 포함하는 화상 및 녹내장 치료, 피부 주름 개선 및 발모 촉진용 조성물 |
| MX382540B (es) * | 2015-06-28 | 2025-03-13 | Allgenesis Biotherapeutics Inc | Proteinas de fusion para inhibir la angiogenesis |
| BR112018003179A2 (pt) | 2015-08-20 | 2018-09-25 | Albumedix As | conjugados e variantes de albumina |
| US12304037B2 (en) | 2021-11-03 | 2025-05-20 | Aob Products Company | Torque driver |
| US11723955B1 (en) | 2022-05-13 | 2023-08-15 | Allgenesis Biotherapeutics Inc. | VEGFR fusion protein pharmaceutical composition |
| KR20250021281A (ko) | 2023-08-04 | 2025-02-12 | 주식회사 넥스세라 | 콜라겐 타입 i 및 색소 상피성 인자 펩타이드를 유효성분으로 포함하는 안구 혈관신생 질환의 예방 또는 치료용 점안제 조성물 |
| WO2025033777A1 (ko) | 2023-08-04 | 2025-02-13 | 주식회사 넥스세라 | 콜라겐 타입 i 및 색소 상피성 인자 펩타이드를 유효성분으로 포함하는 안구 혈관신생 질환의 예방 또는 치료용 점안제 조성물 |
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| TW200848070A (en) * | 2006-12-26 | 2008-12-16 | Univ Nat Taiwan | Disintegrin variants and pharmaceutical uses thereof |
| TW201107471A (en) * | 2009-07-20 | 2011-03-01 | Univ Nat Cheng Kung | Polypeptides selective for αvβ3 integrin conjugated with a variant of human serum albumin (HSA) and pharmaceutical uses thereof |
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| JP2005529166A (ja) | 2002-06-07 | 2005-09-29 | ウィスコンシン アルムニ リサーチ ファウンデーション | ペプチドカップリングのための試薬の化学合成 |
| CA2606989A1 (en) * | 2005-04-29 | 2006-11-09 | Research Development Foundation | Vascular targeting of ocular neovascularization |
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2010
- 2010-12-22 KR KR1020127019529A patent/KR20120130752A/ko not_active Withdrawn
- 2010-12-22 WO PCT/US2010/061738 patent/WO2011079175A1/en not_active Ceased
- 2010-12-22 US US12/975,630 patent/US9044436B2/en not_active Expired - Fee Related
- 2010-12-22 CN CN2010800594090A patent/CN102883738A/zh active Pending
- 2010-12-22 CA CA2782796A patent/CA2782796A1/en not_active Abandoned
- 2010-12-22 JP JP2012546185A patent/JP5739908B2/ja not_active Expired - Fee Related
- 2010-12-22 AR ARP100104891A patent/AR079706A1/es unknown
- 2010-12-22 MX MX2012007416A patent/MX2012007416A/es not_active Application Discontinuation
- 2010-12-22 BR BR112012015188A patent/BR112012015188A8/pt not_active IP Right Cessation
- 2010-12-22 AU AU2010336475A patent/AU2010336475A1/en not_active Abandoned
- 2010-12-22 NZ NZ600544A patent/NZ600544A/en not_active IP Right Cessation
- 2010-12-22 RU RU2012131251/15A patent/RU2012131251A/ru not_active Application Discontinuation
- 2010-12-22 EP EP20100840104 patent/EP2515926A4/en not_active Withdrawn
- 2010-12-23 TW TW099145616A patent/TWI581801B/zh active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200848070A (en) * | 2006-12-26 | 2008-12-16 | Univ Nat Taiwan | Disintegrin variants and pharmaceutical uses thereof |
| TW201107471A (en) * | 2009-07-20 | 2011-03-01 | Univ Nat Cheng Kung | Polypeptides selective for αvβ3 integrin conjugated with a variant of human serum albumin (HSA) and pharmaceutical uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110152192A1 (en) | 2011-06-23 |
| RU2012131251A (ru) | 2014-01-27 |
| JP2013515739A (ja) | 2013-05-09 |
| EP2515926A4 (en) | 2013-10-09 |
| BR112012015188A8 (pt) | 2016-08-09 |
| TW201138801A (en) | 2011-11-16 |
| CN102883738A (zh) | 2013-01-16 |
| BR112012015188A2 (pt) | 2016-04-05 |
| WO2011079175A1 (en) | 2011-06-30 |
| US9044436B2 (en) | 2015-06-02 |
| KR20120130752A (ko) | 2012-12-03 |
| MX2012007416A (es) | 2012-07-23 |
| AU2010336475A1 (en) | 2012-06-14 |
| NZ600544A (en) | 2014-06-27 |
| CA2782796A1 (en) | 2011-06-30 |
| AR079706A1 (es) | 2012-02-15 |
| JP5739908B2 (ja) | 2015-06-24 |
| EP2515926A1 (en) | 2012-10-31 |
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