MX382540B - Proteinas de fusion para inhibir la angiogenesis - Google Patents

Proteinas de fusion para inhibir la angiogenesis

Info

Publication number
MX382540B
MX382540B MX2017016345A MX2017016345A MX382540B MX 382540 B MX382540 B MX 382540B MX 2017016345 A MX2017016345 A MX 2017016345A MX 2017016345 A MX2017016345 A MX 2017016345A MX 382540 B MX382540 B MX 382540B
Authority
MX
Mexico
Prior art keywords
fusion proteins
inhibiting angiogenesis
relates
present
activated pathway
Prior art date
Application number
MX2017016345A
Other languages
English (en)
Other versions
MX2017016345A (es
Inventor
Jia-Hau Shiu
Kevin Zen
Madhu Cherukury
Pei-Tzu Wu
Tan Nguyen
Original Assignee
Allgenesis Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allgenesis Biotherapeutics Inc filed Critical Allgenesis Biotherapeutics Inc
Publication of MX2017016345A publication Critical patent/MX2017016345A/es
Publication of MX382540B publication Critical patent/MX382540B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con un agente biológico que inhibe la angiogénesis. En particular, la presente invención se relaciona con proteínas de fusión que inhiben la trayectoria activada por la integrina y otra trayectoria activada por el factor angiogénico, las composiciones de estas proteínas de fusión, así como los métodos para producir y utilizar las mismas.
MX2017016345A 2015-06-28 2016-06-24 Proteinas de fusion para inhibir la angiogenesis MX382540B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562185716P 2015-06-28 2015-06-28
PCT/IB2016/053794 WO2017001990A1 (en) 2015-06-28 2016-06-24 Fusion proteins for inhibiting angiogenesis

Publications (2)

Publication Number Publication Date
MX2017016345A MX2017016345A (es) 2018-08-15
MX382540B true MX382540B (es) 2025-03-13

Family

ID=57608130

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016345A MX382540B (es) 2015-06-28 2016-06-24 Proteinas de fusion para inhibir la angiogenesis

Country Status (11)

Country Link
US (4) US20180170979A1 (es)
EP (1) EP3313426B1 (es)
JP (1) JP6655718B2 (es)
KR (2) KR20180012832A (es)
CN (1) CN108430489B (es)
AU (1) AU2016286432B2 (es)
CA (1) CA2987884C (es)
ES (1) ES2797901T3 (es)
MX (1) MX382540B (es)
TW (1) TWI698447B (es)
WO (1) WO2017001990A1 (es)

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US10508137B2 (en) 2014-08-22 2019-12-17 National Cheng Kung Univeristy Disintegrin variants and pharmaceutical uses thereof
ES2873379T3 (es) * 2015-03-11 2021-11-03 Allgenesis Biotherapeutics Inc Proteína de fusión que comprende un dominio de unión a ligando de VEGF y PDGF
CA2987884C (en) 2015-06-28 2023-01-03 Allgenesis Biotherapeutics Inc. Fusion peptides comprising disintegrin binding to integrin .alpha.v.beta.x or .alpha.5.beta.1 and their use in treating an angiogenic disease
US20200148757A1 (en) * 2017-06-30 2020-05-14 Korea Advanced Institute Of Science And Technology Conjugate of vegf-grab protein and drug, and use thereof
US11202854B2 (en) * 2017-08-09 2021-12-21 National Taiwan University Disintegrin variants and uses thereof
CN111372950B (zh) 2017-10-12 2024-11-05 免疫苏醒公司 Vegfr-抗体轻链融合蛋白
WO2019079494A1 (en) * 2017-10-18 2019-04-25 Regenxbio, Inc. TREATMENT OF OCULAR DISEASES AND METASTATIC COLON CANCER WITH A VEGF TRAP WITH HUMAN POST-TRANSLATIONAL MODIFICATION
SG11202007130RA (en) 2018-01-26 2020-08-28 Univ California Methods and compositions for treatment of angiogenic disorders using anti-vegf agents
JP7249060B2 (ja) 2018-08-17 2023-03-30 トリカン・バイオテクノロジー・カンパニー・リミテッド 抗血管新生融合タンパク質およびその使用
EP3868781A4 (en) 2018-10-05 2022-07-06 Seoul National University R & DB Foundation PDGF RECEPTOR ANTIBODIES AND ITS USE
EP3891182A4 (en) * 2018-12-03 2022-08-17 Immuneonco Biopharmaceuticals (Shanghai) Co., Ltd RECOMBINANT PROTEIN AGAINST PD-L1 AND VEGF
CN112342228B (zh) * 2019-08-09 2023-07-21 上海朗昇生物科技有限公司 表达抗vegf融合蛋白的aav病毒载体及其应用
CN112552410A (zh) * 2019-09-26 2021-03-26 三生国健药业（上海）股份有限公司 一种抗体融合蛋白及其制法和在抗肿瘤中的应用
CA3168512A1 (en) 2019-11-25 2021-06-03 Napoleone Ferrara Long-acting vegf inhibitors for intraocular neovascularization
CN111084879A (zh) * 2020-02-14 2020-05-01 中国人民解放军第四军医大学 白介素18在抑制创面血管新生中的应用
CN115040695B (zh) * 2021-03-09 2023-10-13 南开大学 一种基于VE-cad-Fc/N-cad-Fc的融合蛋白活性界面的应用
US11723955B1 (en) * 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition
JP2025532642A (ja) * 2022-09-23 2025-10-01 偉哲 荘 インテグリンαＩＩｂβ３を標的とする組織プラスミノーゲン活性化因子またはその変異体を含む融合タンパク質とその使用
CN116239704B (zh) * 2023-05-09 2023-07-14 北京青云智创科技有限公司 一种治疗新生血管性眼病的多肽及其制剂

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AU4721901A (en) * 2000-02-25 2001-09-03 Immunex Corp Integrin antagonists
US20030027751A1 (en) * 2001-04-10 2003-02-06 Genvec, Inc. VEGF fusion proteins
US20030064053A1 (en) * 2001-08-31 2003-04-03 Shengjiang Liu Multivalent protein conjugate with multiple ligand-binding domains of receptors
JP4680997B2 (ja) 2004-06-08 2011-05-11 ツェンドゥー カンホン バイオテクノロジーズ カンパニー リミテッド 血管新生を阻害するキメラタンパク質およびその利用
CA2577370A1 (en) 2004-08-16 2006-03-02 Medimmune, Inc. Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity
US20080207502A1 (en) * 2004-10-14 2008-08-28 Sopherion Therapeutics, Inc. Anti-Angiogenic Peptides and Methods of Use Thereof
ES2325344B1 (es) * 2004-11-02 2010-06-09 Univ Madrid Autonoma Inhibidores de angiogenesis multifuncionales y multivalentes.
US20060234347A1 (en) * 2005-04-13 2006-10-19 Harding Thomas C Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors
AU2006279658A1 (en) * 2005-08-12 2007-02-22 Regeneron Pharmaceuticals, Inc. Treatment of diseases by subcutaneous administration of a VEGF antagonist
EP2032605A2 (en) 2006-05-24 2009-03-11 Bayer Schering Pharma Aktiengesellschaft HIGH AFFINITY HUMAN AND HUMANIZED ANTI-alpha5ß1 INTEGRIN FUNCTION BLOCKING ANTIBODIES WITH REDUCED IMMUNOGENICITY
US7943728B2 (en) * 2006-12-26 2011-05-17 National Cheng Kung University Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases
US8454960B2 (en) * 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
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AR079706A1 (es) * 2009-12-23 2012-02-15 Univ Nat Cheng Kung Composiciones, metodos para el tratamiento de enfermedades oculares relacionadas con la angiogenesis y uso
KR101397088B1 (ko) 2011-06-10 2014-05-19 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
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SG10201912956YA (en) * 2013-03-13 2020-02-27 Genzyme Corp Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof
US20150266945A1 (en) 2014-03-21 2015-09-24 Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Fusion protein, a method of making the same, and a method of delivering antigenic peptide into the endoplasmic reticulum by the fusion protein
EP3122783B1 (en) 2014-03-24 2019-09-04 Immuneonco Biopharmaceuticals (Shanghai) Co., Ltd. Novel recombinant bi-functional fusion proteins, preparation and use thereof
US10508137B2 (en) 2014-08-22 2019-12-17 National Cheng Kung Univeristy Disintegrin variants and pharmaceutical uses thereof
ES2873379T3 (es) 2015-03-11 2021-11-03 Allgenesis Biotherapeutics Inc Proteína de fusión que comprende un dominio de unión a ligando de VEGF y PDGF
CA2987884C (en) 2015-06-28 2023-01-03 Allgenesis Biotherapeutics Inc. Fusion peptides comprising disintegrin binding to integrin .alpha.v.beta.x or .alpha.5.beta.1 and their use in treating an angiogenic disease

Also Published As

Publication number Publication date
TW201712037A (zh) 2017-04-01
US20200181214A1 (en) 2020-06-11
TWI698447B (zh) 2020-07-11
JP2018522583A (ja) 2018-08-16
US20250051404A1 (en) 2025-02-13
EP3313426B1 (en) 2020-04-29
ES2797901T3 (es) 2020-12-04
CN108430489B (zh) 2022-03-25
AU2016286432B2 (en) 2019-02-14
KR20200013101A (ko) 2020-02-05
JP6655718B2 (ja) 2020-02-26
AU2016286432A1 (en) 2018-01-04
US12152057B2 (en) 2024-11-26
US20190194271A1 (en) 2019-06-27
KR102155875B1 (ko) 2020-09-16
MX2017016345A (es) 2018-08-15
WO2017001990A1 (en) 2017-01-05
US11192927B2 (en) 2021-12-07
EP3313426A1 (en) 2018-05-02
BR112017027567A2 (pt) 2018-09-04
EP3313426A4 (en) 2019-02-20
US20180170979A1 (en) 2018-06-21
CA2987884C (en) 2023-01-03
KR20180012832A (ko) 2018-02-06
CA2987884A1 (en) 2017-01-05
CN108430489A (zh) 2018-08-21

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