CN102875441A - Ppar活性化合物 - Google Patents
Ppar活性化合物 Download PDFInfo
- Publication number
- CN102875441A CN102875441A CN2012103274659A CN201210327465A CN102875441A CN 102875441 A CN102875441 A CN 102875441A CN 2012103274659 A CN2012103274659 A CN 2012103274659A CN 201210327465 A CN201210327465 A CN 201210327465A CN 102875441 A CN102875441 A CN 102875441A
- Authority
- CN
- China
- Prior art keywords
- indol
- propionic acid
- benzenesulfonyl
- methoxyl group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CN(C)C(*)(*)* Chemical compound CN(C)C(*)(*)* 0.000 description 11
- VHLFRBQIBFLCCV-UHFFFAOYSA-N CC(C)Oc(cc1)ccc1S([n](cc(CCC(O)=O)c1c2)c1ccc2OC)(=O)=O Chemical compound CC(C)Oc(cc1)ccc1S([n](cc(CCC(O)=O)c1c2)c1ccc2OC)(=O)=O VHLFRBQIBFLCCV-UHFFFAOYSA-N 0.000 description 1
- YSYIBFYCKDWHMP-UHFFFAOYSA-N CC(CC1C)C(C)CC1OC1=CC([S+2](ON(CC2(C)CCC(O)=O)C(CC3C)=C2C=C3OC)=O)=CCC1 Chemical compound CC(CC1C)C(C)CC1OC1=CC([S+2](ON(CC2(C)CCC(O)=O)C(CC3C)=C2C=C3OC)=O)=CCC1 YSYIBFYCKDWHMP-UHFFFAOYSA-N 0.000 description 1
- BALYUXIDGBUWEV-UHFFFAOYSA-N CC1C(C)CC(CN2C(C=CC(C)(C3)OC)=C3C(C)(CCC(OC)=O)C2)=CC1 Chemical compound CC1C(C)CC(CN2C(C=CC(C)(C3)OC)=C3C(C)(CCC(OC)=O)C2)=CC1 BALYUXIDGBUWEV-UHFFFAOYSA-N 0.000 description 1
- CLOINCSLSZBQDE-UHFFFAOYSA-N COC(CCc(c1cc(C2C=CSC2)ccc11)c[n]1S(c1ccccc1)(=O)=O)=O Chemical compound COC(CCc(c1cc(C2C=CSC2)ccc11)c[n]1S(c1ccccc1)(=O)=O)=O CLOINCSLSZBQDE-UHFFFAOYSA-N 0.000 description 1
- QXILRKSEIWJQPA-UHFFFAOYSA-N COC(CCc(c1cc(OC)ccc11)c[n]1[S+](c(cc1)ccc1F)O)=O Chemical compound COC(CCc(c1cc(OC)ccc11)c[n]1[S+](c(cc1)ccc1F)O)=O QXILRKSEIWJQPA-UHFFFAOYSA-N 0.000 description 1
- YERVDUPPRCYKRQ-UHFFFAOYSA-O COC(CCc(c1cc(OC)ccc11)c[n]1[S+](c1cc(F)ccc1)(O)=O)=O Chemical compound COC(CCc(c1cc(OC)ccc11)c[n]1[S+](c1cc(F)ccc1)(O)=O)=O YERVDUPPRCYKRQ-UHFFFAOYSA-O 0.000 description 1
- OLLUHQDOSMKXFB-UHFFFAOYSA-N COc(cc1)cc(c(CCC(O)=O)c2)c1[n]2S(c1ccc(C[n]2c3ncccc3cc2)cc1)(=O)=O Chemical compound COc(cc1)cc(c(CCC(O)=O)c2)c1[n]2S(c1ccc(C[n]2c3ncccc3cc2)cc1)(=O)=O OLLUHQDOSMKXFB-UHFFFAOYSA-N 0.000 description 1
- ZLSZCJIWILJKMR-UHFFFAOYSA-N COc1ccc2[nH]cc(CCC(O)=O)c2c1 Chemical compound COc1ccc2[nH]cc(CCC(O)=O)c2c1 ZLSZCJIWILJKMR-UHFFFAOYSA-N 0.000 description 1
- OLHBKXYPKCHVNW-UHFFFAOYSA-N Cc(cc1)cc2c1OCC2 Chemical compound Cc(cc1)cc2c1OCC2 OLHBKXYPKCHVNW-UHFFFAOYSA-N 0.000 description 1
- AKIUYHHBFACIEZ-UHFFFAOYSA-N Cc1ccc2[nH]cc(CCC(O)=O)c2c1 Chemical compound Cc1ccc2[nH]cc(CCC(O)=O)c2c1 AKIUYHHBFACIEZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48852303P | 2003-07-17 | 2003-07-17 | |
US60/488,523 | 2003-07-17 | ||
US55299404P | 2004-03-12 | 2004-03-12 | |
US60/552,994 | 2004-03-12 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200480025050XA Division CN1845898A (zh) | 2003-07-17 | 2004-07-16 | Ppar活性化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102875441A true CN102875441A (zh) | 2013-01-16 |
Family
ID=34107772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2012103274659A Pending CN102875441A (zh) | 2003-07-17 | 2004-07-16 | Ppar活性化合物 |
Country Status (18)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115504925A (zh) * | 2021-06-22 | 2022-12-23 | 广东药科大学 | 一类新型ppar激动剂、其制备方法及其作为药物的用途 |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8603949B2 (en) * | 2003-06-17 | 2013-12-10 | California Institute Of Technology | Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes |
NZ545326A (en) | 2003-07-17 | 2009-12-24 | Plexxikon Inc | PPAR active compounds |
US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
WO2005026193A2 (en) * | 2003-09-08 | 2005-03-24 | United States Army Medical Research And Materiel Command | Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof |
PE20060303A1 (es) | 2004-06-23 | 2006-05-19 | Wyeth Corp | Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6 |
WO2006060535A2 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as ppar active compounds |
EP1819673A2 (en) * | 2004-11-30 | 2007-08-22 | Plexxikon, Inc. | Indole derivatives for use as ppar active compounds |
WO2007010965A1 (ja) * | 2005-07-22 | 2007-01-25 | Shionogi & Co., Ltd. | Pgd2受容体アンタゴニスト活性を有するアザインドール酸誘導体 |
FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
FR2890072A1 (fr) * | 2005-09-01 | 2007-03-02 | Fournier S A Sa Lab | Nouveaux composesde pyrrolopyridine |
RU2419618C2 (ru) * | 2005-09-07 | 2011-05-27 | Плекссикон, Инк. | Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом) |
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