CN102858365A - 15价肺炎球菌多糖蛋白质缀合物疫苗组合物 - Google Patents

15价肺炎球菌多糖蛋白质缀合物疫苗组合物 Download PDF

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Publication number
CN102858365A
CN102858365A CN2011800087423A CN201180008742A CN102858365A CN 102858365 A CN102858365 A CN 102858365A CN 2011800087423 A CN2011800087423 A CN 2011800087423A CN 201180008742 A CN201180008742 A CN 201180008742A CN 102858365 A CN102858365 A CN 102858365A
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adjuvant
serotype
polysaccharide
pcv
streptococcus pneumoniae
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CN2011800087423A
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Chinese (zh)
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M.J.考尔菲尔德
P.L.阿尔
J.T.布卢
J.L.肯农
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Merck Sharp and Dohme LLC
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Schering Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800087423A 2010-02-09 2011-02-03 15价肺炎球菌多糖蛋白质缀合物疫苗组合物 Pending CN102858365A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30272610P 2010-02-09 2010-02-09
US61/302,726 2010-02-09
PCT/US2011/023526 WO2011100151A1 (en) 2010-02-09 2011-02-03 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition

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CN102858365A true CN102858365A (zh) 2013-01-02

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US (2) US8192746B2 (de)
EP (1) EP2533805A4 (de)
JP (2) JP2013518891A (de)
KR (1) KR101538535B1 (de)
CN (1) CN102858365A (de)
AR (2) AR080122A1 (de)
AU (1) AU2011216095B2 (de)
BR (1) BR112012019757B8 (de)
CA (1) CA2788680C (de)
CL (1) CL2012002195A1 (de)
EC (1) ECSP12012100A (de)
IL (1) IL221283A0 (de)
MA (1) MA34051B1 (de)
MX (1) MX2012009206A (de)
MY (1) MY159984A (de)
NZ (1) NZ601711A (de)
PE (1) PE20121698A1 (de)
RU (1) RU2012138368A (de)
SG (2) SG10201500350PA (de)
TN (1) TN2012000377A1 (de)
TW (1) TW201136603A (de)
UA (1) UA106115C2 (de)
WO (1) WO2011100151A1 (de)
ZA (1) ZA201205737B (de)

Cited By (21)

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CN103495161A (zh) * 2013-10-08 2014-01-08 江苏康泰生物医学技术有限公司 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
CN106102770A (zh) * 2014-01-21 2016-11-09 辉瑞公司 包含缀合荚膜糖抗原的免疫原性组合物及其用途
TWI586363B (zh) * 2013-10-30 2017-06-11 Sk化學公司 多價肺炎球菌多醣－蛋白質共軛物組成物
CN107810010A (zh) * 2015-06-23 2018-03-16 生物E有限公司 多价肺炎球菌结合疫苗
CN108289938A (zh) * 2015-09-10 2018-07-17 创赏有限公司 多价vlp缀合物
CN108367063A (zh) * 2015-07-21 2018-08-03 辉瑞公司 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途
CN109789198A (zh) * 2016-09-30 2019-05-21 生物E有限公司 包含多糖-蛋白缀合物的多价肺炎球菌疫苗组合物
CN109862908A (zh) * 2016-08-05 2019-06-07 圣诺菲·帕斯图尔公司 多价肺炎球菌多糖-蛋白质缀合物组合物
CN110225764A (zh) * 2017-01-31 2019-09-10 默沙东公司 制备多糖-蛋白缀合物的方法
CN110392690A (zh) * 2017-02-24 2019-10-29 默沙东公司 肺炎球菌缀合物疫苗制剂
CN110996992A (zh) * 2017-08-16 2020-04-10 默沙东公司 肺炎球菌缀合物疫苗制剂
CN111050794A (zh) * 2017-09-07 2020-04-21 默沙东公司 将肺炎球菌多糖与载体蛋白缀合的配制方法
CN111065387A (zh) * 2017-09-07 2020-04-24 默沙东公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
CN111093650A (zh) * 2017-09-07 2020-05-01 默沙东公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
CN111093649A (zh) * 2017-09-07 2020-05-01 默沙东公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
CN111757753A (zh) * 2018-02-05 2020-10-09 赛诺菲巴斯德有限公司 多价肺炎球菌多糖-蛋白质缀合物组合物
CN112969474A (zh) * 2018-09-12 2021-06-15 艾芬尼维克斯公司 多价肺炎球菌疫苗
CN114025784A (zh) * 2019-06-05 2022-02-08 默沙东公司 用针对肺炎链球菌血清型29进行保护的免疫原性组合物治疗患者的方法
CN114025790A (zh) * 2019-06-05 2022-02-08 默沙东公司 免疫原性血清型35b肺炎球菌多糖-蛋白缀合物和用于制备其的缀合方法
CN114364397A (zh) * 2019-07-18 2022-04-15 赛特瑞恩股份有限公司 含多价肺炎链球菌多糖-蛋白偶联物的免疫原性组合物
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KR20140075196A (ko) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
CN105934251A (zh) * 2014-01-21 2016-09-07 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
US11160855B2 (en) * 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
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CN103893751B (zh) * 2014-03-26 2016-04-20 天津康希诺生物技术有限公司 一种肺炎球菌多糖蛋白缀合疫苗及其制备方法
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JP2020514326A (ja) 2017-02-24 2020-05-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強
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US11219680B2 (en) * 2017-02-24 2022-01-11 Merck Sharp & Dohme Corp. Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier
KR20240018697A (ko) * 2017-06-10 2024-02-13 인벤트프라이즈 인크. 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신
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JP7489324B2 (ja) * 2018-04-30 2024-05-23 メルク・シャープ・アンド・ドーム・エルエルシー リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法
KR20210002641A (ko) 2018-04-30 2021-01-08 머크 샤프 앤드 돔 코포레이션 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법
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Cited By (32)

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Publication number Priority date Publication date Assignee Title
CN103495161A (zh) * 2013-10-08 2014-01-08 江苏康泰生物医学技术有限公司 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
CN103495161B (zh) * 2013-10-08 2019-06-18 江苏康泰生物医学技术有限公司 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
TWI586363B (zh) * 2013-10-30 2017-06-11 Sk化學公司 多價肺炎球菌多醣－蛋白質共軛物組成物
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