PE20121698A1 - Composicion de vacuna conjugada de polisacarido-proteina neumococica 15-valente - Google Patents

Composicion de vacuna conjugada de polisacarido-proteina neumococica 15-valente

Info

Publication number
PE20121698A1
PE20121698A1 PE2012001178A PE2012001178A PE20121698A1 PE 20121698 A1 PE20121698 A1 PE 20121698A1 PE 2012001178 A PE2012001178 A PE 2012001178A PE 2012001178 A PE2012001178 A PE 2012001178A PE 20121698 A1 PE20121698 A1 PE 20121698A1
Authority
PE
Peru
Prior art keywords
composition
polysaccharide
valent
aluminum
pneumococcal protein
Prior art date
Application number
PE2012001178A
Other languages
English (en)
Inventor
Michael J Caulfield
Patrick L Ahl
Jeffrey T Blue
Jayme L Cannon
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20121698A1 publication Critical patent/PE20121698A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UNA COMPOSICION INMUNOGENICA QUE COMPRENDE UNA MEZCLA DE CONJUGADOS POLISACARIDO-PROTEICOS MULTIVALENTES TAL COMO POLISACARIDOS CAPSULARES A PARTIR DE SEROTIPOS 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F,23F Y 33F DE STREPTOCOCCUS PNEUMONIAE CONJUGADO CON UNA PROTEINA TRANSPORTADORA TAL COMO CRM197. TAMBIEN COMPRENDE UN COADYUVANTE CON BASE DE ALUMINIO TAL COMO FOSFATO DE ALUMINIO, SULFATO DE ALUMINIO O HIDROXIDO DE ALUMINIO. DICHA COMPOSICION ES UTIL CONTRA LA ENFERMEDAD NEUMOCOCICA
PE2012001178A 2010-02-09 2011-02-03 Composicion de vacuna conjugada de polisacarido-proteina neumococica 15-valente PE20121698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30272610P 2010-02-09 2010-02-09

Publications (1)

Publication Number Publication Date
PE20121698A1 true PE20121698A1 (es) 2012-12-11

Family

ID=44353903

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012001178A PE20121698A1 (es) 2010-02-09 2011-02-03 Composicion de vacuna conjugada de polisacarido-proteina neumococica 15-valente

Country Status (24)

Country Link
US (2) US8192746B2 (es)
EP (1) EP2533805A4 (es)
JP (2) JP2013518891A (es)
KR (1) KR101538535B1 (es)
CN (1) CN102858365A (es)
AR (2) AR080122A1 (es)
AU (1) AU2011216095B2 (es)
BR (1) BR112012019757B8 (es)
CA (1) CA2788680C (es)
CL (1) CL2012002195A1 (es)
EC (1) ECSP12012100A (es)
IL (1) IL221283A0 (es)
MA (1) MA34051B1 (es)
MX (1) MX2012009206A (es)
MY (1) MY159984A (es)
NZ (1) NZ601711A (es)
PE (1) PE20121698A1 (es)
RU (1) RU2012138368A (es)
SG (2) SG10201500350PA (es)
TN (1) TN2012000377A1 (es)
TW (1) TW201136603A (es)
UA (1) UA106115C2 (es)
WO (1) WO2011100151A1 (es)
ZA (1) ZA201205737B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815327A (zh) 2005-04-08 2015-08-05 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
HUE031380T2 (en) 2005-06-27 2017-07-28 Glaxosmithkline Biologicals Sa A method for producing vaccines
PT2066344E (pt) * 2006-09-07 2011-07-05 Glaxosmithkline Biolog Sa Vacina de combinação de poliovírus inactivado
PE20141029A1 (es) 2011-04-22 2014-09-04 Wyeth Llc Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
IN2014CN03391A (es) * 2011-11-23 2015-07-03 Merck Sharp & Dohme
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
US20140193451A1 (en) * 2012-10-17 2014-07-10 Glaxosmithkline Biologicals Sa Immunogenic composition
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
KR20140075201A (ko) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075196A (ko) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
CN103495161B (zh) * 2013-10-08 2019-06-18 江苏康泰生物医学技术有限公司 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
TWI586363B (zh) * 2013-10-30 2017-06-11 Sk化學公司 多價肺炎球菌多醣－蛋白質共軛物組成物
AU2015208821B2 (en) * 2014-01-21 2017-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CN105934251A (zh) * 2014-01-21 2016-09-07 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
US11160855B2 (en) * 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
MX371453B (es) 2014-01-21 2020-01-29 Pfizer Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
ES2930318T3 (es) * 2014-02-14 2022-12-09 Pfizer Conjugados glucoproteicos inmunogénicos
CN103893751B (zh) * 2014-03-26 2016-04-20 天津康希诺生物技术有限公司 一种肺炎球菌多糖蛋白缀合疫苗及其制备方法
MY187461A (en) 2015-06-08 2021-09-23 Serum Inst Of India Private Ltd Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof
LT3313436T (lt) * 2015-06-23 2021-06-10 Biological E Limited Daugiavalentė pneumokokinė konjuguota vakcina
TWI756893B (zh) * 2015-07-21 2022-03-01 美商輝瑞股份有限公司 包含經共軛之莢膜糖抗原的致免疫性組成物、包含該致免疫性組成物之套組及彼等之用途
KR20200038339A (ko) * 2015-09-10 2020-04-10 인벤트프라이즈 엘엘씨 다가 vlp 접합체
EP3436061A4 (en) * 2016-03-31 2019-12-04 Liffey Biotech Limited Saccharide-polypeptide-conjugate compositions and methods of use thereof
EP3481407A4 (en) * 2016-07-08 2020-04-01 Hawaii Biotech, Inc. VACCINE AGAINST WEST NILE VIRUS AND METHOD OF USE
EP3493840B1 (en) 2016-08-05 2022-08-24 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2019001342A (es) * 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de proteina-polisacarido de neumococo multivalente.
EP3518965A1 (en) * 2016-09-30 2019-08-07 Biological E Limited Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates
KR102083973B1 (ko) * 2016-10-28 2020-04-23 주식회사 엘지화학 향상된 IgG 역가를 갖는 다가면역원성 조성물 및 이의 용도
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
EP3576784A4 (en) * 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. PROCESS FOR THE PRODUCTION OF POLYSACCHARIDE PROTEIN CONJUGATES
EP3576759A4 (en) 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. PROCESS FOR THE PREPARATION OF CAPSULE POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F
CA3052621A1 (en) 2017-02-03 2018-08-09 Schadeck, Eva Barbara Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof
BR112019017390A2 (pt) * 2017-02-24 2020-03-31 Merck Sharp & Dohme Corp. Formulações de vacina pneumocócica conjugada e uso das mesmas
JP2020514326A (ja) 2017-02-24 2020-05-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強
US11400162B2 (en) 2017-02-24 2022-08-02 Merck Sharp & Dohme Llc Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein
US11219680B2 (en) * 2017-02-24 2022-01-11 Merck Sharp & Dohme Corp. Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier
KR20240018697A (ko) * 2017-06-10 2024-02-13 인벤트프라이즈 인크. 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
US20200360500A1 (en) * 2017-08-16 2020-11-19 Merck Sharp & Dohme Corp. Pneumococcal conjugate vaccine formulations
JP2020533299A (ja) * 2017-09-07 2020-11-19 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． キャリアタンパク質へのコンジュゲーションのための肺炎球菌多糖の製剤方法
AU2018328035B2 (en) 2017-09-07 2024-03-07 Chitrananda Abeygunawardana Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
CA3074708A1 (en) * 2017-09-07 2019-03-14 Merck Sharp & Dohme Corp. Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
KR20200051005A (ko) * 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
US11524076B2 (en) 2017-09-07 2022-12-13 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
KR20200051003A (ko) * 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
EP3720483A2 (en) 2017-12-06 2020-10-14 Merck Sharp&Dohme Corp. Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
EP3749358A4 (en) 2018-02-05 2022-04-20 Sanofi Pasteur, Inc. MULTIVALENT POLYSACCHARIDE-PNEUMOCOCCAL PROTEIN CONJUGATE COMPOSITION
IL304977A (en) 2018-02-05 2023-10-01 Sanofi Pasteur Inc A multivalent pneumococcal protein-polysaccharide conjugate preparation
BR112020021296A2 (pt) 2018-04-18 2021-01-26 Sk Bioscience Co., Ltd. polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo
JP7489324B2 (ja) * 2018-04-30 2024-05-23 メルク・シャープ・アンド・ドーム・エルエルシー リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法
KR20210002641A (ko) 2018-04-30 2021-01-08 머크 샤프 앤드 돔 코포레이션 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법
WO2019212846A1 (en) * 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
WO2019220304A1 (en) * 2018-05-14 2019-11-21 Tergene Biotech Pvt. Ltd. 15 valent pneumococcal polysaccharide conjugate vaccine
WO2020009462A1 (ko) * 2018-07-06 2020-01-09 주식회사 유바이오로직스 다가 폐렴구균 다당체-단백질 접합체를 포함하는 면역원성 조성물, 및 이를 포함하는 폐렴구균에 의한 질환 예방 백신
WO2020016322A1 (en) * 2018-07-19 2020-01-23 Glaxosmithkline Biologicals Sa Processes for preparing dried polysaccharides
SG11202102007UA (en) * 2018-09-12 2021-03-30 Affinivax Inc Multivalent pneumococcal vaccines
CR20210333A (es) 2018-12-19 2021-08-18 Merck Sharp & Dohme Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso
KR20220017996A (ko) * 2019-06-05 2022-02-14 머크 샤프 앤드 돔 코포레이션 면역원성 혈청형 35b 폐렴구균 폴리사카라이드-단백질 접합체 및 그를 제조하기 위한 접합 방법
AU2020289048A1 (en) * 2019-06-05 2021-12-09 Merck Sharp & Dohme Llc Methods of treating patients with an immunogenic composition that protects against
AU2020315673A1 (en) * 2019-07-18 2022-02-10 Celltrion, Inc. Immunogenic composition comprising multivalent Streptococcus pneumoniae polysaccharide-protein conjugates
EP4003410A1 (en) 2019-07-31 2022-06-01 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
KR20220102871A (ko) * 2021-01-14 2022-07-21 (주)셀트리온 다가 폐렴구균 다당류-단백질 접합체를 포함하는 면역원성 조성물
TW202245835A (zh) 2021-02-04 2022-12-01 美商默沙東有限責任公司 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
MXPA03000198A (es) * 2000-06-29 2004-09-13 Glaxosmithkline Biolog Sa Composicion de vacuna multivalente.
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
BRPI0510659A (pt) * 2004-06-04 2007-12-04 Pharmexa Inc indução de uma resposta imunológica contra polissacarìdeos de streptococcus pneumoniae
CN1660881A (zh) * 2005-01-12 2005-08-31 北京万赛生物医药技术发展有限公司 新型的免疫刺激分子及其制备方法
CN104815327A (zh) * 2005-04-08 2015-08-05 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
HUE031380T2 (en) * 2005-06-27 2017-07-28 Glaxosmithkline Biologicals Sa A method for producing vaccines
EP1945249A2 (en) * 2005-11-01 2008-07-23 Novartis AG Compositions with antigens adsorbed to calcium phosphate
CA2808919C (en) * 2005-12-22 2016-04-19 Glaxosmithkline Biologicals S.A. Streptococcus pneumoniae capsular saccharide vaccine
KR20080079697A (ko) * 2005-12-23 2008-09-01 글락소스미스클라인 바이오로지칼즈 에스.에이. 컨쥬게이트 백신
WO2007127668A2 (en) * 2006-04-26 2007-11-08 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
SI2436700T1 (sl) * 2007-03-23 2018-09-28 Wyeth Llc Skrajšan postopek čiščenja za proizvodnjo kapsularnih polisaharidov streptococcusa pneumoniae
DK2167121T3 (en) * 2007-06-26 2015-11-23 Glaxosmithkline Biolog Sa A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
CN101590224A (zh) 2009-06-30 2009-12-02 广州精达医学科技有限公司 高效14价肺炎球菌结合疫苗

Also Published As

Publication number Publication date
SG10201500350PA (en) 2015-03-30
SG183199A1 (en) 2012-09-27
CL2012002195A1 (es) 2012-11-30
KR101538535B1 (ko) 2015-07-22
MA34051B1 (fr) 2013-03-05
KR20120114345A (ko) 2012-10-16
AR080122A1 (es) 2012-03-14
IL221283A0 (en) 2012-10-31
BR112012019757B8 (pt) 2023-04-25
US8192746B2 (en) 2012-06-05
BR112012019757A2 (pt) 2016-05-10
RU2012138368A (ru) 2014-03-20
ECSP12012100A (es) 2013-03-28
CA2788680A1 (en) 2011-08-18
EP2533805A4 (en) 2013-08-28
MY159984A (en) 2017-02-15
CA2788680C (en) 2014-12-16
US20120301502A1 (en) 2012-11-29
AR116043A2 (es) 2021-03-25
BR112012019757B1 (pt) 2020-11-17
NZ601711A (en) 2014-03-28
EP2533805A1 (en) 2012-12-19
AU2011216095A1 (en) 2012-08-09
JP2014012720A (ja) 2014-01-23
TN2012000377A1 (en) 2014-01-30
UA106115C2 (uk) 2014-07-25
JP2013518891A (ja) 2013-05-23
AU2011216095B2 (en) 2013-07-18
ZA201205737B (en) 2013-04-24
MX2012009206A (es) 2012-08-23
CN102858365A (zh) 2013-01-02
US20110195086A1 (en) 2011-08-11
WO2011100151A1 (en) 2011-08-18
TW201136603A (en) 2011-11-01

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