CN102845685A - 含雌马酚的大豆发酵物 - Google Patents
含雌马酚的大豆发酵物 Download PDFInfo
- Publication number
- CN102845685A CN102845685A CN2012102391975A CN201210239197A CN102845685A CN 102845685 A CN102845685 A CN 102845685A CN 2012102391975 A CN2012102391975 A CN 2012102391975A CN 201210239197 A CN201210239197 A CN 201210239197A CN 102845685 A CN102845685 A CN 102845685A
- Authority
- CN
- China
- Prior art keywords
- plumular axis
- equol
- soybean plumular
- fermentate
- soybean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000010469 Glycine max Nutrition 0.000 title claims abstract description 212
- 244000068988 Glycine max Species 0.000 title claims abstract description 212
- 235000019126 equol Nutrition 0.000 title claims abstract description 100
- ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 title claims abstract description 100
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 title claims abstract description 100
- 239000000463 material Substances 0.000 title abstract description 8
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N Daidzein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 claims abstract description 48
- 235000007240 daidzein Nutrition 0.000 claims abstract description 24
- 235000013305 food Nutrition 0.000 claims abstract description 23
- 239000002537 cosmetic Substances 0.000 claims abstract description 20
- -1 daidzein compound Chemical class 0.000 claims abstract description 11
- 229930182470 glycoside Natural products 0.000 claims abstract description 5
- 150000002338 glycosides Chemical class 0.000 claims abstract description 4
- 241000894006 Bacteria Species 0.000 claims description 36
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 35
- 235000008696 isoflavones Nutrition 0.000 claims description 35
- 239000002994 raw material Substances 0.000 claims description 25
- 150000001949 daidzein Chemical class 0.000 claims description 13
- DXYUAIFZCFRPTH-UHFFFAOYSA-N glycitein Chemical class C1=C(O)C(OC)=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 DXYUAIFZCFRPTH-UHFFFAOYSA-N 0.000 claims description 11
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- GMTUGPYJRUMVTC-UHFFFAOYSA-N Daidzin Natural products OC(COc1ccc2C(=O)C(=COc2c1)c3ccc(O)cc3)C(O)C(O)C(O)C=O GMTUGPYJRUMVTC-UHFFFAOYSA-N 0.000 claims description 7
- KYQZWONCHDNPDP-UHFFFAOYSA-N Daidzoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-UHFFFAOYSA-N 0.000 claims description 7
- 150000002272 genistein Chemical class 0.000 claims description 7
- OZBAVEKZGSOMOJ-MIUGBVLSSA-N glycitin Chemical compound COC1=CC(C(C(C=2C=CC(O)=CC=2)=CO2)=O)=C2C=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OZBAVEKZGSOMOJ-MIUGBVLSSA-N 0.000 claims description 7
- KYQZWONCHDNPDP-QNDFHXLGSA-N daidzein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-QNDFHXLGSA-N 0.000 claims description 5
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims description 5
- 235000006539 genistein Nutrition 0.000 claims description 5
- 229940045109 genistein Drugs 0.000 claims description 5
- NNUVCMKMNCKPKN-UHFFFAOYSA-N glycitein Natural products COc1c(O)ccc2OC=C(C(=O)c12)c3ccc(O)cc3 NNUVCMKMNCKPKN-UHFFFAOYSA-N 0.000 claims description 5
- 235000008466 glycitein Nutrition 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- ZCOLJUOHXJRHDI-FZHKGVQDSA-N Genistein 7-O-glucoside Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)c1cc(O)c2C(=O)C(c3ccc(O)cc3)=COc2c1 ZCOLJUOHXJRHDI-FZHKGVQDSA-N 0.000 claims description 3
- CJPNHKPXZYYCME-UHFFFAOYSA-N Genistin Natural products OCC1OC(Oc2ccc(O)c3OC(=CC(=O)c23)c4ccc(O)cc4)C(O)C(O)C1O CJPNHKPXZYYCME-UHFFFAOYSA-N 0.000 claims description 3
- XJTZHGNBKZYODI-UHFFFAOYSA-N Glycitin Natural products OCC1OC(Oc2ccc3OC=C(C(=O)c3c2CO)c4ccc(O)cc4)C(O)C(O)C1O XJTZHGNBKZYODI-UHFFFAOYSA-N 0.000 claims description 3
- YCUNGEJJOMKCGZ-UHFFFAOYSA-N Pallidiflorin Natural products C1=CC(OC)=CC=C1C1=COC2=CC=CC(O)=C2C1=O YCUNGEJJOMKCGZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000000968 intestinal effect Effects 0.000 claims description 3
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims description 3
- MTXMHWSVSZKYBT-UHFFFAOYSA-N malonyl daidzin Natural products OC1C(O)C(O)C(COC(=O)CC(O)=O)OC1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 MTXMHWSVSZKYBT-UHFFFAOYSA-N 0.000 claims description 3
- MTXMHWSVSZKYBT-ASDZUOGYSA-N malonyldaidzin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O[C@H]1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 MTXMHWSVSZKYBT-ASDZUOGYSA-N 0.000 claims description 3
- FRAUJUKWSKMNJY-UHFFFAOYSA-N 5-hydroxy-3-(4-hydroxyphenyl)-7-(6-malonyl-beta-D-glucopyranosyloxy)-4H-1-benzopyran-4-one Natural products OC1C(O)C(O)C(COC(=O)CC(O)=O)OC1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 FRAUJUKWSKMNJY-UHFFFAOYSA-N 0.000 claims description 2
- HEZSALBPROZVOO-UHFFFAOYSA-N Dihydroglycitein Chemical compound C1OC=2C=C(O)C(OC)=CC=2C(=O)C1C1=CC=C(O)C=C1 HEZSALBPROZVOO-UHFFFAOYSA-N 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- UQGVUYNHDKMLSE-UHFFFAOYSA-N dihydrogenistein Chemical compound C1=CC(O)=CC=C1C1C(=O)C2=C(O)C=C(O)C=C2OC1 UQGVUYNHDKMLSE-UHFFFAOYSA-N 0.000 claims description 2
- HEZSALBPROZVOO-GFCCVEGCSA-N dihydroglycitein Natural products COc1cc2C(=O)[C@H](COc2cc1O)c3ccc(O)cc3 HEZSALBPROZVOO-GFCCVEGCSA-N 0.000 claims description 2
- DUBPGEJGGVZKDD-PFKOEMKTSA-N glycitein 7-(6-O-acetyl-beta-D-glucoside) Chemical compound COC1=CC(C(C(C=2C=CC(O)=CC=2)=CO2)=O)=C2C=C1O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O DUBPGEJGGVZKDD-PFKOEMKTSA-N 0.000 claims description 2
- OWMHCYFEIJPHFB-UHFFFAOYSA-N malonyl glycitin Natural products COc1cc2c(cc1OC1OC(COC(=O)CC(O)=O)C(O)C(O)C1O)occ(-c1ccc(O)cc1)c2=O OWMHCYFEIJPHFB-UHFFFAOYSA-N 0.000 claims description 2
- FRAUJUKWSKMNJY-RSEYPYQYSA-N malonylgenistin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 FRAUJUKWSKMNJY-RSEYPYQYSA-N 0.000 claims description 2
- OWMHCYFEIJPHFB-GOZZSVHWSA-N malonylglycitin Chemical compound COC1=CC(C(C(C=2C=CC(O)=CC=2)=CO2)=O)=C2C=C1O[C@@H]1O[C@H](COC(=O)CC(O)=O)[C@@H](O)[C@H](O)[C@H]1O OWMHCYFEIJPHFB-GOZZSVHWSA-N 0.000 claims description 2
- 239000002023 wood Substances 0.000 claims description 2
- 244000005700 microbiome Species 0.000 abstract description 14
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 8
- JHYXBPPMXZIHKG-CYBMUJFWSA-N Dihydrodaidzein Natural products C1=CC(O)=CC=C1[C@@H]1C(=O)C2=CC=C(O)C=C2OC1 JHYXBPPMXZIHKG-CYBMUJFWSA-N 0.000 abstract 1
- JHYXBPPMXZIHKG-UHFFFAOYSA-N dihydrodaidzein Chemical compound C1=CC(O)=CC=C1C1C(=O)C2=CC=C(O)C=C2OC1 JHYXBPPMXZIHKG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 description 37
- 230000004151 fermentation Effects 0.000 description 37
- 150000002515 isoflavone derivatives Chemical class 0.000 description 33
- 239000000203 mixture Substances 0.000 description 17
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 16
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 16
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 16
- 229960003104 ornithine Drugs 0.000 description 16
- 230000000694 effects Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 11
- 239000004475 Arginine Substances 0.000 description 8
- 241000194017 Streptococcus Species 0.000 description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 8
- 235000009697 arginine Nutrition 0.000 description 8
- 208000001132 Osteoporosis Diseases 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 7
- 229930182490 saponin Natural products 0.000 description 7
- 150000007949 saponins Chemical class 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000194040 Lactococcus garvieae Species 0.000 description 5
- 101710089395 Oleosin Proteins 0.000 description 5
- 239000013566 allergen Substances 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 229930182478 glucoside Natural products 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 241000606125 Bacteroides Species 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 4
- 241000194036 Lactococcus Species 0.000 description 4
- 208000001145 Metabolic Syndrome Diseases 0.000 description 4
- 101710162629 Trypsin inhibitor Proteins 0.000 description 4
- 229940122618 Trypsin inhibitor Drugs 0.000 description 4
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 4
- 235000015872 dietary supplement Nutrition 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000001076 estrogenic effect Effects 0.000 description 4
- 210000002307 prostate Anatomy 0.000 description 4
- 239000002753 trypsin inhibitor Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 235000009754 Vitis X bourquina Nutrition 0.000 description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 description 3
- 240000006365 Vitis vinifera Species 0.000 description 3
- 235000014787 Vitis vinifera Nutrition 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 241001295925 Gegenes Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 241000219793 Trifolium Species 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000009928 pasteurization Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000021067 refined food Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical group OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 241001135228 Bacteroides ovatus Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102100029951 Estrogen receptor beta Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 101001010910 Homo sapiens Estrogen receptor beta Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241001547082 Pseudobacillus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
- 241000194008 Streptococcus anginosus Species 0.000 description 1
- 241001291896 Streptococcus constellatus Species 0.000 description 1
- 241000194046 Streptococcus intermedius Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000003544 deproteinization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000013597 soy food Nutrition 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/50—Fermented pulses or legumes; Fermentation of pulses or legumes based on the addition of microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
- A23L11/07—Soya beans, e.g. oil-extracted soya bean flakes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0636—Ornithine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2116—Flavonoids, isoflavones
- A23V2250/21172—Soy Isoflavones, daidzein, genistein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Hematology (AREA)
- Birds (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Agronomy & Crop Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Alternative & Traditional Medicine (AREA)
- Urology & Nephrology (AREA)
- Medical Informatics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005352337 | 2005-12-06 | ||
| JP2005-352337 | 2005-12-06 | ||
| JP2006-277934 | 2006-10-11 | ||
| JP2006277934 | 2006-10-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800458564A Division CN101325881A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆胚轴发酵物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102845685A true CN102845685A (zh) | 2013-01-02 |
Family
ID=38122801
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102391975A Pending CN102845685A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆发酵物 |
| CN201210239156.6A Active CN102726683B (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆胚轴发酵物 |
| CN201310591449.5A Pending CN103947960A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆胚轴发酵物及其制备方法 |
| CN201310591447.6A Pending CN103947959A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆发酵物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210239156.6A Active CN102726683B (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆胚轴发酵物 |
| CN201310591449.5A Pending CN103947960A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆胚轴发酵物及其制备方法 |
| CN201310591447.6A Pending CN103947959A (zh) | 2005-12-06 | 2006-12-05 | 含雌马酚的大豆发酵物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20090311353A1 (enExample) |
| EP (3) | EP1961309A4 (enExample) |
| JP (5) | JP5030790B2 (enExample) |
| KR (4) | KR101306362B1 (enExample) |
| CN (4) | CN102845685A (enExample) |
| AR (2) | AR057220A1 (enExample) |
| AU (1) | AU2006323754B2 (enExample) |
| BR (2) | BRPI0619484A8 (enExample) |
| CA (1) | CA2631850C (enExample) |
| ES (2) | ES2858674T3 (enExample) |
| MY (1) | MY169554A (enExample) |
| PH (1) | PH12014500480A1 (enExample) |
| TR (1) | TR201807884T4 (enExample) |
| TW (2) | TWI491732B (enExample) |
| WO (1) | WO2007066655A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8668914B2 (en) * | 2002-07-24 | 2014-03-11 | Brigham Young University | Use of equol for treating skin diseases |
| EP1569636B1 (en) | 2002-10-29 | 2017-12-13 | Colorado State University Research Foundation | Use of equol for treating androgen mediated diseases |
| US8580846B2 (en) | 2002-10-29 | 2013-11-12 | Brigham Young University | Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders |
| WO2007066655A1 (ja) | 2005-12-06 | 2007-06-14 | Otsuka Pharmaceutical Co., Ltd. | エクオール含有大豆胚軸発酵物、及びその製造方法 |
| TW201444815A (zh) * | 2007-06-13 | 2014-12-01 | 大塚製藥股份有限公司 | 含雌馬酚（ｅｑｕｏｌ）之萃取物、其製造方法、雌馬酚萃取方法及含雌馬酚之食品（二） |
| KR20130133894A (ko) * | 2007-12-27 | 2013-12-09 | 오츠카 세이야쿠 가부시키가이샤 | 에쿠올 합성에 관여하는 효소 |
| EP2313082B1 (en) * | 2008-07-31 | 2017-08-23 | Coreana Cosmetics Co., Ltd. | Cosmetic composition for anti-aging of the skin comprising phaseolus radiatus seed extracts by fermentation and enzyme treatment |
| AU2014240200B2 (en) * | 2008-09-19 | 2015-08-13 | Otsuka Pharmaceutical Co., Ltd. | Fermentation product containing equol-producing microorganism having maintained equol-producing ability, and method for producing same |
| MY158628A (en) * | 2008-09-19 | 2016-10-31 | Otsuka Pharma Co Ltd | Fermentation product containing equol-producing microorganism having maintained equol-producing ability, and method for producing same |
| JP5777287B2 (ja) * | 2009-09-18 | 2015-09-09 | 大塚製薬株式会社 | エクオール産生能が維持されたエクオール産生微生物を含む発酵製品、及びその製造方法 |
| WO2011034126A1 (ja) * | 2009-09-18 | 2011-03-24 | 不二製油株式会社 | エクオールの不斉合成法 |
| JP5851685B2 (ja) * | 2010-12-24 | 2016-02-03 | 株式会社ダイセル | エクオールの製造方法、エクオール産生組成物、食品、食品添加物及び医薬品 |
| JP5851687B2 (ja) * | 2010-12-24 | 2016-02-03 | 株式会社ダイセル | エクオールの製造方法、エクオール産生組成物、食品、食品添加物及び医薬品 |
| JP5851686B2 (ja) * | 2010-12-24 | 2016-02-03 | 株式会社ダイセル | エクオールの製造法、エクオール産生組成物、食品、食品添加物及び医薬品 |
| JP6005453B2 (ja) * | 2012-09-14 | 2016-10-12 | 株式会社ダイセル | オルニチンとエクオールを含む組成物 |
| JP6371055B2 (ja) * | 2013-12-20 | 2018-08-08 | 株式会社ダイセル | イソフラバノン類の製造方法 |
| JP2015139424A (ja) * | 2014-01-30 | 2015-08-03 | 株式会社ダイセル | エクオール含有組成物の製造方法 |
| JP2015168668A (ja) * | 2014-03-10 | 2015-09-28 | 株式会社ダイセル | エクオールを含有する抗糖化剤 |
| JP6512548B2 (ja) * | 2015-04-03 | 2019-05-15 | 株式会社ダイセル | エクオール、酸化防止剤、及び油類を含有する外用組成物 |
| US20190045819A1 (en) * | 2015-09-29 | 2019-02-14 | Kaneka Corporation | Fermented food composition production method |
| TWI774660B (zh) * | 2016-03-08 | 2022-08-21 | 日商大塚製藥股份有限公司 | 女性特有之身體及/或精神不快症狀之改善劑 |
| JP7068816B2 (ja) * | 2017-12-15 | 2022-05-17 | 大塚製薬株式会社 | エクオールおよびコラーゲンペプチドを含有する経口組成物 |
| KR102064055B1 (ko) | 2018-02-08 | 2020-01-08 | 신선옥 | 에쿠올이 생성된 발효커피생두, 그 제조방법 및 그 추출물 |
| JP6486529B1 (ja) * | 2018-03-19 | 2019-03-20 | 室戸海洋深層水株式会社 | 腸内フローラ改善健康食品 |
| JP2022022349A (ja) * | 2018-10-24 | 2022-02-03 | 株式会社ダイセル | エクオール含有組成物の製造方法 |
| JP2019011370A (ja) * | 2018-10-24 | 2019-01-24 | 株式会社ダイセル | エクオール含有組成物の製造方法 |
| KR20200070502A (ko) | 2018-12-07 | 2020-06-18 | 전북대학교산학협력단 | 에쿠올함유 발효커피음료 및 그 제조방법 |
| US20220257676A1 (en) | 2019-07-24 | 2022-08-18 | Asahi Group Holdings, Ltd. | Agent for regulating female hormone secretion and agent for alleviating unpleasant symptoms |
| KR102124400B1 (ko) * | 2019-12-17 | 2020-06-18 | 주식회사 비앤비코리아 | 담자균류균사의 액상배양공정에 의한 천문동 및 대두배아의 생물전환산물을 포함하는 미세먼지 세정용 화장료 조성물 |
| JP7479832B2 (ja) * | 2019-12-18 | 2024-05-09 | 小林製薬株式会社 | 経口組成物 |
| JP7479833B2 (ja) * | 2019-12-18 | 2024-05-09 | 小林製薬株式会社 | エストロゲン様活性剤組成物 |
| WO2021235278A1 (ja) * | 2020-05-21 | 2021-11-25 | 株式会社ダイセル | 閉経後で更年期障害を有しない満４０歳以上の女性のためのｑｏｌ改善用組成物 |
| WO2022138909A1 (ja) * | 2020-12-24 | 2022-06-30 | 株式会社ダイセル | シクロデキストリンにエクオールが包接された包接体、該包接体を含有するエクオール吸収性組成物、及びこれらの製造方法 |
| JP2022132404A (ja) * | 2021-12-07 | 2022-09-08 | 株式会社ダイセル | エクオール含有組成物の製造方法 |
| JP2023090339A (ja) * | 2021-12-17 | 2023-06-29 | 小林製薬株式会社 | 経口組成物 |
| CN119173160A (zh) * | 2022-05-19 | 2024-12-20 | 株式会社大赛璐 | 包含雌马酚的食品组合物及其制造方法 |
| JP2024000267A (ja) * | 2022-06-20 | 2024-01-05 | 株式会社ダイセル | エクオールの製造方法 |
| JP2023105251A (ja) * | 2022-07-13 | 2023-07-28 | 株式会社ダイセル | エクオール含有組成物の製造方法 |
| JP7596493B1 (ja) * | 2023-11-24 | 2024-12-09 | 株式会社ダイセル | 男性のｑｏｌの改善のための組成物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265596A (zh) * | 1997-08-08 | 2000-09-06 | 大塚制药株式会社 | 含异黄酮的组合物 |
| WO2004009035A2 (en) * | 2002-07-24 | 2004-01-29 | Children's Hospital Medical Center | Compositions and products containing enantiomeric equol, and methods for their making |
| WO2005000042A1 (ja) * | 2003-06-30 | 2005-01-06 | Otsuka Pharmaceutical Co., Ltd. | エクオール産生乳酸菌含有組成物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0761241B2 (ja) | 1989-07-07 | 1995-07-05 | マルサンアイ株式会社 | 大豆胚軸の発酵生産物並にその製造法 |
| JPH07506822A (ja) * | 1992-05-19 | 1995-07-27 | ノボゲン リサーチ ピーティーワイ リミッテッド | フィト−エストロゲン，類似体またはその代謝産物を含有する健康補助剤 |
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| EP1023435B1 (fr) * | 1997-10-17 | 2006-09-06 | Societe Des Produits Nestle S.A. | Nouvelle espece de bacterie lactique |
| ATE282032T1 (de) * | 1998-01-12 | 2004-11-15 | Nichimo Kabushiki Kaisha | Verfahren zur herstellung von isoflavonverbindungen |
| JP3497083B2 (ja) | 1998-09-21 | 2004-02-16 | 不二製油株式会社 | 乳酸発酵豆乳の製造法 |
| US20030044475A1 (en) * | 2000-03-24 | 2003-03-06 | Van De Wiel Andriaan Emanuel Hendricus Anna Maria | Cosmetic use of hop and ornithine |
| JP2002234844A (ja) | 2000-12-05 | 2002-08-23 | Toyo Seito Kk | 骨密度向上剤およびその利用 |
| JP2002330723A (ja) * | 2001-02-28 | 2002-11-19 | Samjo Celltech Ltd | 大豆胚芽を用いた麹およびその製造方法、ならびにそれを用いて製造された醤類 |
| AUPR363301A0 (en) * | 2001-03-08 | 2001-04-05 | Novogen Research Pty Ltd | Dimeric isoflavones |
| JP4212838B2 (ja) * | 2002-06-26 | 2009-01-21 | カルピス株式会社 | 抗アレルギー剤 |
| JP2004033092A (ja) | 2002-07-02 | 2004-02-05 | Aomori Prefecture | 植物性エストロゲン誘導体のえぐ味改善方法、ならびにそれを利用した納豆または納豆食品、およびその製造方法 |
| JP2003081855A (ja) | 2002-08-19 | 2003-03-19 | Yakult Honsha Co Ltd | 脂質代謝改善剤およびそれを含有する食品 |
| JP2004236523A (ja) | 2003-02-04 | 2004-08-26 | Hidehachiro Kato | 醗酵食品及びその製造方法 |
| JP4889979B2 (ja) * | 2005-08-30 | 2012-03-07 | 浜松ホトニクス株式会社 | Ｘ線源 |
| WO2007066655A1 (ja) * | 2005-12-06 | 2007-06-14 | Otsuka Pharmaceutical Co., Ltd. | エクオール含有大豆胚軸発酵物、及びその製造方法 |
| JP6005453B2 (ja) | 2012-09-14 | 2016-10-12 | 株式会社ダイセル | オルニチンとエクオールを含む組成物 |
-
2006
- 2006-12-05 WO PCT/JP2006/324255 patent/WO2007066655A1/ja not_active Ceased
- 2006-12-05 KR KR1020117028321A patent/KR101306362B1/ko active Active
- 2006-12-05 CN CN2012102391975A patent/CN102845685A/zh active Pending
- 2006-12-05 BR BRPI0619484A patent/BRPI0619484A8/pt not_active Application Discontinuation
- 2006-12-05 AU AU2006323754A patent/AU2006323754B2/en active Active
- 2006-12-05 JP JP2007549133A patent/JP5030790B2/ja active Active
- 2006-12-05 KR KR1020137005149A patent/KR101346504B1/ko active Active
- 2006-12-05 CN CN201210239156.6A patent/CN102726683B/zh active Active
- 2006-12-05 MY MYPI20081910A patent/MY169554A/en unknown
- 2006-12-05 CN CN201310591449.5A patent/CN103947960A/zh active Pending
- 2006-12-05 EP EP06834010A patent/EP1961309A4/en not_active Withdrawn
- 2006-12-05 EP EP18160164.2A patent/EP3351258B1/en active Active
- 2006-12-05 ES ES18160164T patent/ES2858674T3/es active Active
- 2006-12-05 CA CA2631850A patent/CA2631850C/en active Active
- 2006-12-05 ES ES12160323.7T patent/ES2672871T3/es active Active
- 2006-12-05 EP EP12160323.7A patent/EP2474237B1/en active Active
- 2006-12-05 KR KR1020137021167A patent/KR101329921B1/ko active Active
- 2006-12-05 TR TR2018/07884T patent/TR201807884T4/tr unknown
- 2006-12-05 CN CN201310591447.6A patent/CN103947959A/zh active Pending
- 2006-12-05 BR BR122018067616-7A patent/BR122018067616B1/pt active IP Right Grant
- 2006-12-05 KR KR1020087016359A patent/KR101195706B1/ko active Active
- 2006-12-05 AR ARP060105357A patent/AR057220A1/es not_active Application Discontinuation
- 2006-12-05 US US12/095,828 patent/US20090311353A1/en not_active Abandoned
- 2006-12-06 TW TW095145394A patent/TWI491732B/zh active
- 2006-12-06 TW TW102115070A patent/TWI491733B/zh active
-
2012
- 2012-03-30 JP JP2012082486A patent/JP5535263B2/ja active Active
- 2012-07-03 JP JP2012149675A patent/JP5697633B2/ja active Active
- 2012-07-16 US US13/549,568 patent/US20120277302A1/en not_active Abandoned
- 2012-07-16 US US13/549,686 patent/US9386786B2/en active Active
-
2013
- 2013-10-08 AR ARP130103634A patent/AR092932A2/es not_active Application Discontinuation
-
2014
- 2014-02-20 JP JP2014030933A patent/JP5734477B2/ja active Active
- 2014-03-03 PH PH12014500480A patent/PH12014500480A1/en unknown
- 2014-04-15 JP JP2014083507A patent/JP5946489B2/ja active Active
-
2018
- 2018-04-18 US US15/956,427 patent/US20180235260A1/en not_active Abandoned
-
2022
- 2022-09-29 US US17/955,898 patent/US20230270142A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265596A (zh) * | 1997-08-08 | 2000-09-06 | 大塚制药株式会社 | 含异黄酮的组合物 |
| WO2004009035A2 (en) * | 2002-07-24 | 2004-01-29 | Children's Hospital Medical Center | Compositions and products containing enantiomeric equol, and methods for their making |
| WO2005000042A1 (ja) * | 2003-06-30 | 2005-01-06 | Otsuka Pharmaceutical Co., Ltd. | エクオール産生乳酸菌含有組成物 |
| CA2531173A1 (en) * | 2003-06-30 | 2005-01-06 | Otsuka Pharmaceutical Co., Ltd. | Equol-producing lactic acid bacteria-containing composition |
| CN1826059A (zh) * | 2003-06-30 | 2006-08-30 | 大塚制药株式会社 | 含有产生雌马酚的乳酸菌的组合物 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102726683B (zh) | 含雌马酚的大豆胚轴发酵物 | |
| HK1259202B (en) | A method for producing an equol- and ornithine-containing fermented soybean hypocotyl material | |
| HK1259202A1 (en) | A method for producing an equol- and ornithine-containing fermented soybean hypocotyl material | |
| HK1175661B (en) | Equol-containing fermentation product of soybean embryonic axis | |
| HK1121347A (en) | Equal-containing fermentation product of soybean embryonic axis, and method for production thereof | |
| HK1175958A (zh) | 含雌马酚的大豆发酵物 | |
| CN101325881A (zh) | 含雌马酚的大豆胚轴发酵物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1175958 Country of ref document: HK |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130102 |