CN102818865A - 低聚原花青素(opc)的分析方法 - Google Patents
低聚原花青素(opc)的分析方法 Download PDFInfo
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- CN102818865A CN102818865A CN2012102496110A CN201210249611A CN102818865A CN 102818865 A CN102818865 A CN 102818865A CN 2012102496110 A CN2012102496110 A CN 2012102496110A CN 201210249611 A CN201210249611 A CN 201210249611A CN 102818865 A CN102818865 A CN 102818865A
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- 238000004458 analytical method Methods 0.000 description 10
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 8
- 235000005487 catechin Nutrition 0.000 description 8
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 description 8
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- 235000007242 delphinidin Nutrition 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 description 4
- YPVZJXMTXCOTJN-UHFFFAOYSA-N pelargonidin chloride Chemical compound [Cl-].C1=CC(O)=CC=C1C(C(=C1)O)=[O+]C2=C1C(O)=CC(O)=C2 YPVZJXMTXCOTJN-UHFFFAOYSA-N 0.000 description 4
- 229930013915 (+)-catechin Natural products 0.000 description 3
- 235000007219 (+)-catechin Nutrition 0.000 description 3
- 241000219095 Vitis Species 0.000 description 3
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- FFNDMZIBVDSQFI-UHFFFAOYSA-N delphinidin chloride Chemical compound [Cl-].[O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 FFNDMZIBVDSQFI-UHFFFAOYSA-N 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- HKUHOPQRJKPJCJ-UHFFFAOYSA-N pelargonidin Natural products OC1=Cc2c(O)cc(O)cc2OC1c1ccc(O)cc1 HKUHOPQRJKPJCJ-UHFFFAOYSA-N 0.000 description 3
- 235000006251 pelargonidin Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 2
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- XFZJEEAOWLFHDH-NFJBMHMQSA-N procyanidin B2 Chemical compound C1([C@@H]2[C@H](O)[C@H](C3=C(O)C=C(O)C=C3O2)C=2C(O)=CC(O)=C3C[C@H]([C@H](OC3=2)C=2C=C(O)C(O)=CC=2)O)=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-NFJBMHMQSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000004007 reversed phase HPLC Methods 0.000 description 2
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 1
- COAWNPJQKJEHPG-UHFFFAOYSA-N 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-1lambda^{4}-chromen-1-ylium chloride Chemical compound [Cl-].[O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 COAWNPJQKJEHPG-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920002350 Procyanidin B2 Polymers 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
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- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- JKHRCGUTYDNCLE-UHFFFAOYSA-O delphinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 JKHRCGUTYDNCLE-UHFFFAOYSA-O 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
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- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004-222255 | 2004-07-29 | ||
| JP2004222255A JP4659407B2 (ja) | 2004-07-29 | 2004-07-29 | オリゴメリックプロアントシアニジン（ｏｐｃ）の分析方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200580025187XA Division CN1989407A (zh) | 2004-07-29 | 2005-07-27 | 低聚原花青素(opc)的分析方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102818865A true CN102818865A (zh) | 2012-12-12 |
Family
ID=35448015
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102496110A Pending CN102818865A (zh) | 2004-07-29 | 2005-07-27 | 低聚原花青素(opc)的分析方法 |
| CNA200580025187XA Pending CN1989407A (zh) | 2004-07-29 | 2005-07-27 | 低聚原花青素(opc)的分析方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200580025187XA Pending CN1989407A (zh) | 2004-07-29 | 2005-07-27 | 低聚原花青素(opc)的分析方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8383413B2 (enExample) |
| EP (1) | EP1774319B1 (enExample) |
| JP (1) | JP4659407B2 (enExample) |
| KR (1) | KR101166393B1 (enExample) |
| CN (2) | CN102818865A (enExample) |
| CA (1) | CA2575135C (enExample) |
| SG (1) | SG145718A1 (enExample) |
| TW (1) | TWI355490B (enExample) |
| WO (1) | WO2006011640A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114910578A (zh) * | 2022-04-11 | 2022-08-16 | 汤臣倍健股份有限公司 | 一种葡萄籽提取物中原花青素c1的测定方法 |
| CN117285498A (zh) * | 2023-09-26 | 2023-12-26 | 汤臣倍健股份有限公司 | 一种原花青素c1的制备方法 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4942953B2 (ja) * | 2005-06-30 | 2012-05-30 | サントリーホールディングス株式会社 | プロシアニジンの分析方法 |
| JP2007306872A (ja) | 2006-05-19 | 2007-11-29 | Suntory Ltd | プロアントシアニジン含有茶飲料 |
| WO2008038726A1 (fr) * | 2006-09-29 | 2008-04-03 | Arysta Lifescience Corporation | Procédé de détermination de procyanidine oligomérique (opc) |
| KR100897519B1 (ko) * | 2007-08-31 | 2009-05-15 | (주)아모레퍼시픽 | 자외선차단 성분의 동시분석법 |
| JP2010236905A (ja) * | 2009-03-30 | 2010-10-21 | Meiji Seika Kaisha Ltd | アントシアニンの分析方法 |
| JP5337574B2 (ja) * | 2009-05-08 | 2013-11-06 | フジッコ株式会社 | プロアントシアニジンの分離精製方法 |
| CN102141519B (zh) * | 2010-12-30 | 2013-03-13 | 浙江现代中药与天然药物研究院有限公司 | 一种检测原花青素含量的方法 |
| US8877275B2 (en) | 2011-03-31 | 2014-11-04 | Suntory Holdings Limited | Proanthocyanidin-rich plant extract and method for preparing same |
| CN102323378A (zh) * | 2011-08-29 | 2012-01-18 | 湖南科技大学 | 一种快速检测植物中含原花色素的方法 |
| KR101877780B1 (ko) * | 2011-09-08 | 2018-07-13 | (주)바이오메디앙 | 유럽종 포도 추출물의 분석방법 |
| CN102924422B (zh) * | 2012-09-10 | 2015-03-11 | 华南理工大学 | 脉冲电场强化降解制备低聚原花青素的方法 |
| US20150237906A1 (en) | 2012-09-28 | 2015-08-27 | Suntory Holdings Limited | Monomeric proanthocyanidin-removed plant extract |
| JP5437537B1 (ja) * | 2012-10-05 | 2014-03-12 | フジッコ株式会社 | 低重合度プロアントシアニジンの製法 |
| WO2015020138A1 (ja) | 2013-08-09 | 2015-02-12 | サントリーホールディングス株式会社 | ヒドロキシチロソール及びその誘導体の体内吸収促進剤及びその利用 |
| CN103954700A (zh) * | 2014-04-12 | 2014-07-30 | 陕西衡道检测技术有限公司 | 一种测定原花青素含量及鉴别的方法 |
| CN105424947B (zh) * | 2015-12-28 | 2016-08-24 | 青岛古高生物科技有限公司 | 原花青素的应用及含原花青素的凝血酶时间测定试剂 |
| CN107247029B (zh) * | 2017-06-06 | 2020-01-21 | 桂林理工大学 | 一种快速检测有机半导体溴化反应产物组成的紫外可见吸收光谱分析法 |
| WO2019066031A1 (ja) | 2017-09-29 | 2019-04-04 | サントリーホールディングス株式会社 | アクアポリン３発現促進用組成物及びその使用 |
| CN109705080A (zh) * | 2018-12-20 | 2019-05-03 | 宁波天鼎生物科技有限公司 | 葡萄籽中原花青素高聚体裂解与原花青素b4的提取方法 |
| CN110988237B (zh) * | 2019-12-07 | 2022-07-01 | 四川汇宇制药股份有限公司 | 混合液中多成分检测方法 |
| FR3114814B1 (fr) | 2020-10-07 | 2023-10-27 | M&M Braun GmbH | Extrait de pépins de raisin à efficacité biologique positive accrue, son procédé de fabrication et ses utilisations |
| CN113156036B (zh) * | 2021-05-25 | 2022-08-05 | 浙江大学 | 亲水作用和反相液相色谱联用分析原花色素结构的方法 |
Family Cites Families (19)
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|---|---|---|---|---|
| US191131A (en) * | 1877-05-22 | Improvement in filtering apparatus | ||
| US402738A (en) * | 1889-05-07 | Valve mechanism for washing filter-beds | ||
| US2066479A (en) * | 1931-06-08 | 1937-01-05 | Vernon W Macisaac | Fluid straining method and apparatus |
| US3357566A (en) * | 1964-06-22 | 1967-12-12 | Zurn Ind Inc | Dual element filter assembly with backwash arms |
| US3568414A (en) * | 1969-06-05 | 1971-03-09 | Donaldson Co Inc | Cleaning apparatus for fluid filters |
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-
2004
- 2004-07-29 JP JP2004222255A patent/JP4659407B2/ja not_active Expired - Lifetime
-
2005
- 2005-07-27 EP EP05768820.2A patent/EP1774319B1/en not_active Expired - Lifetime
- 2005-07-27 CN CN2012102496110A patent/CN102818865A/zh active Pending
- 2005-07-27 CN CNA200580025187XA patent/CN1989407A/zh active Pending
- 2005-07-27 KR KR1020077002928A patent/KR101166393B1/ko not_active Expired - Fee Related
- 2005-07-27 WO PCT/JP2005/014153 patent/WO2006011640A1/en not_active Ceased
- 2005-07-27 SG SG200805839-8A patent/SG145718A1/en unknown
- 2005-07-27 CA CA2575135A patent/CA2575135C/en not_active Expired - Fee Related
- 2005-07-27 US US11/658,311 patent/US8383413B2/en not_active Expired - Fee Related
- 2005-07-28 TW TW094125641A patent/TWI355490B/zh not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114910578A (zh) * | 2022-04-11 | 2022-08-16 | 汤臣倍健股份有限公司 | 一种葡萄籽提取物中原花青素c1的测定方法 |
| CN117285498A (zh) * | 2023-09-26 | 2023-12-26 | 汤臣倍健股份有限公司 | 一种原花青素c1的制备方法 |
| CN117285498B (zh) * | 2023-09-26 | 2025-07-22 | 汤臣倍健股份有限公司 | 一种原花青素c1的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8383413B2 (en) | 2013-02-26 |
| KR20070039585A (ko) | 2007-04-12 |
| JP4659407B2 (ja) | 2011-03-30 |
| WO2006011640A1 (en) | 2006-02-02 |
| CA2575135C (en) | 2014-01-21 |
| CA2575135A1 (en) | 2006-02-02 |
| TW200617386A (en) | 2006-06-01 |
| EP1774319A1 (en) | 2007-04-18 |
| CN1989407A (zh) | 2007-06-27 |
| TWI355490B (en) | 2012-01-01 |
| WO2006011640A8 (en) | 2006-04-13 |
| US20080311662A1 (en) | 2008-12-18 |
| SG145718A1 (en) | 2008-09-29 |
| EP1774319B1 (en) | 2015-09-09 |
| JP2006038763A (ja) | 2006-02-09 |
| KR101166393B1 (ko) | 2012-07-23 |
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