CN1027891C - 5-取代鸟氨酸衍生物的制备方法 - Google Patents

5-取代鸟氨酸衍生物的制备方法 Download PDF

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Publication number
CN1027891C
CN1027891C CN89100646A CN89100646A CN1027891C CN 1027891 C CN1027891 C CN 1027891C CN 89100646 A CN89100646 A CN 89100646A CN 89100646 A CN89100646 A CN 89100646A CN 1027891 C CN1027891 C CN 1027891C
Authority
CN
China
Prior art keywords
acid
ornithine
solution
ether
grams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN89100646A
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English (en)
Chinese (zh)
Other versions
CN1037142A (zh
Inventor
格哈特·弗里茨·E
塞勒·尼古劳斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of CN1037142A publication Critical patent/CN1037142A/zh
Application granted granted Critical
Publication of CN1027891C publication Critical patent/CN1027891C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CN89100646A 1988-02-05 1989-02-04 5-取代鸟氨酸衍生物的制备方法 Expired - Fee Related CN1027891C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88400275.9 1988-02-05
EP88400275A EP0326766B1 (en) 1988-02-05 1988-02-05 5-substituted ornithine derivatives

Publications (2)

Publication Number Publication Date
CN1037142A CN1037142A (zh) 1989-11-15
CN1027891C true CN1027891C (zh) 1995-03-15

Family

ID=8200349

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89100646A Expired - Fee Related CN1027891C (zh) 1988-02-05 1989-02-04 5-取代鸟氨酸衍生物的制备方法

Country Status (22)

Country Link
US (1) US4902719A (enExample)
EP (1) EP0326766B1 (enExample)
JP (1) JP2816431B2 (enExample)
KR (1) KR0150634B1 (enExample)
CN (1) CN1027891C (enExample)
AR (1) AR244657A1 (enExample)
AT (1) ATE77367T1 (enExample)
AU (1) AU612229B2 (enExample)
CA (1) CA1311767C (enExample)
DE (1) DE3872213T2 (enExample)
DK (1) DK172113B1 (enExample)
ES (1) ES2041815T3 (enExample)
FI (1) FI90530C (enExample)
GR (1) GR3005551T3 (enExample)
HU (1) HU204770B (enExample)
IE (1) IE63162B1 (enExample)
IL (1) IL89145A (enExample)
NO (1) NO176242C (enExample)
NZ (1) NZ227783A (enExample)
PH (1) PH26422A (enExample)
PT (1) PT89637B (enExample)
ZA (1) ZA89833B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016035A1 (en) * 1990-04-26 1991-10-31 The Procter & Gamble Company Chelator compositions comprising alpha-diamine compounds
EP0609630A1 (en) * 1993-02-05 1994-08-10 Merrell Dow Pharmaceuticals Inc. Use of inhibitors of ornithine aminotransferase for the manufacture of a medicament for the treatment of Alzheimer's disease
US5677350A (en) * 1995-06-07 1997-10-14 Wisconsin Alumni Research Foundation Inhibition of cancer cell growth, proliferation, and metastasis using N,N'-dα,ω-diaminoalkanes
GB9617822D0 (en) * 1996-08-27 1996-10-09 Lilly Industries Ltd Pharmaceutical compounds
US6043218A (en) 1996-10-22 2000-03-28 Medical University Of South Carolina Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
US6566330B1 (en) 1996-10-22 2003-05-20 Medical University Of South Carolina Foundation Research Development Positively charged non-natural amino acids, methods of making and using thereof in peptides
US7166234B1 (en) * 2000-10-26 2007-01-23 Integrated Biomedical Technology, Inc. Dialdehyde assay
US6911544B2 (en) * 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
EP3062175B1 (en) 2013-10-21 2018-09-05 Fuji Electric Co., Ltd. Control system design assist device, control system design assist program, control system design assist method, operation change amount calculation device, and control device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1091661A (en) * 1977-07-11 1980-12-16 Philippe Bey .alpha.-HALOMETHYL DERIVATIVES OF .alpha.-AMINO ACIDS
US4326071A (en) * 1977-09-28 1982-04-20 Merrell Toraude Et Compagnie Halomethyl derivatives of gamma-aminobutyric acid and related compounds
AU544990B2 (en) * 1980-06-16 1985-06-27 Merrell Pharmaceuticals Inc. Antiprotozal composition containing amino compounds
US4668703A (en) * 1983-07-07 1987-05-26 Syntex (U.S.A.) Inc. γ-allenyl-γ-aminobutyric acids

Also Published As

Publication number Publication date
AR244657A1 (es) 1993-11-30
IL89145A (en) 1993-08-18
US4902719A (en) 1990-02-20
DK51589A (da) 1989-08-06
ZA89833B (en) 1989-10-25
CN1037142A (zh) 1989-11-15
EP0326766A1 (en) 1989-08-09
FI890477A0 (fi) 1989-02-01
FI890477L (fi) 1989-08-06
DK172113B1 (da) 1997-11-10
FI90530B (fi) 1993-11-15
NO176242C (no) 1995-03-01
HUT49320A (en) 1989-09-28
JP2816431B2 (ja) 1998-10-27
JPH021435A (ja) 1990-01-05
GR3005551T3 (enExample) 1993-06-07
EP0326766B1 (en) 1992-06-17
NO890455L (no) 1989-08-07
PT89637A (pt) 1989-10-04
IE63162B1 (en) 1995-03-22
ATE77367T1 (de) 1992-07-15
KR0150634B1 (ko) 1998-10-15
FI90530C (fi) 1994-02-25
NO176242B (no) 1994-11-21
KR890012942A (ko) 1989-09-20
PH26422A (en) 1992-07-15
DE3872213D1 (de) 1992-07-23
CA1311767C (en) 1992-12-22
PT89637B (pt) 1994-02-28
IE890356L (en) 1989-08-05
IL89145A0 (en) 1989-09-10
HU204770B (en) 1992-02-28
DK51589D0 (da) 1989-02-03
ES2041815T3 (es) 1993-12-01
AU2951589A (en) 1989-08-10
NZ227783A (en) 1990-12-21
DE3872213T2 (de) 1993-01-28
NO890455D0 (no) 1989-02-03
AU612229B2 (en) 1991-07-04

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee