CN102781900A - 从含有琥珀酸铵的发酵液纯化琥珀酸 - Google Patents
从含有琥珀酸铵的发酵液纯化琥珀酸 Download PDFInfo
- Publication number
- CN102781900A CN102781900A CN201080059513XA CN201080059513A CN102781900A CN 102781900 A CN102781900 A CN 102781900A CN 201080059513X A CN201080059513X A CN 201080059513XA CN 201080059513 A CN201080059513 A CN 201080059513A CN 102781900 A CN102781900 A CN 102781900A
- Authority
- CN
- China
- Prior art keywords
- acid
- ion exchange
- succinic acid
- exchange resin
- ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/14—Adipic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33518909P | 2009-12-31 | 2009-12-31 | |
| US61/335,189 | 2009-12-31 | ||
| PCT/US2010/062635 WO2011082378A2 (en) | 2009-12-31 | 2010-12-31 | Purification of succinic acid from the fermentation broth containing ammonium succinate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102781900A true CN102781900A (zh) | 2012-11-14 |
Family
ID=44227170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080059513XA Pending CN102781900A (zh) | 2009-12-31 | 2010-12-31 | 从含有琥珀酸铵的发酵液纯化琥珀酸 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9233906B2 (enExample) |
| EP (2) | EP2918574A1 (enExample) |
| JP (1) | JP2013516180A (enExample) |
| KR (1) | KR20120099154A (enExample) |
| CN (1) | CN102781900A (enExample) |
| WO (1) | WO2011082378A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105073703A (zh) * | 2013-01-03 | 2015-11-18 | 蒂森克虏伯工业解决方案股份公司 | 从发酵液中纯化羧酸的方法 |
| CN109612978A (zh) * | 2018-10-30 | 2019-04-12 | 欣旺达电子股份有限公司 | 锂离子电池电极膜片补锂量检测方法 |
| CN111164215A (zh) * | 2017-10-02 | 2020-05-15 | 代谢探索者公司 | 用于从发酵液产生有机酸盐的方法 |
| CN111732502A (zh) * | 2019-07-02 | 2020-10-02 | 安徽丰原发酵技术工程研究有限公司 | 一种分离苹果酸与丁二酸的方法 |
| CN111732507A (zh) * | 2019-07-02 | 2020-10-02 | 安徽丰原发酵技术工程研究有限公司 | 一种生产l-苹果酸联产丁二酸的方法 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010025167A1 (de) * | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure |
| DE102011120632A1 (de) * | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| JP6628604B2 (ja) * | 2012-05-07 | 2020-01-08 | アーチャー−ダニエルズ−ミッドランド カンパニー | コハク酸の精製 |
| EP2666763B1 (en) | 2012-05-24 | 2014-12-31 | Purac Biochem B.V. | Carboxylic acid recovery from magnesium carboxylate mixture |
| KR101540520B1 (ko) * | 2012-11-29 | 2015-07-30 | 롯데케미칼 주식회사 | 역삼투막을 이용한 숙신산 정제 방법 |
| EP2745905A1 (en) | 2012-12-21 | 2014-06-25 | ThyssenKrupp Uhde GmbH | Process for the purification of carboxylic acids by subcritical or supercritical fluid chromatography |
| US20160207797A1 (en) * | 2013-08-27 | 2016-07-21 | Purolite Corporation | Ion exchange resin regeneration method |
| KR102266181B1 (ko) | 2013-09-03 | 2021-06-17 | 피티티 글로벌 케미컬 퍼블릭 컴퍼니 리미티드 | 1,3-프로판디올로부터 아크릴산, 아크릴로니트릴 및 1,4-부탄디올의 제조방법 |
| KR102304838B1 (ko) | 2014-02-07 | 2021-09-28 | 바스프 에스이 | 개선된 바이오매스 분리 거동을 갖는 변형된 미생물 |
| KR102304834B1 (ko) | 2014-02-07 | 2021-09-27 | 바스프 에스이 | 숙신산 생산을 위한 개선된 미생물 |
| FR3028864B1 (fr) | 2014-11-26 | 2018-05-18 | Roquette Freres | Procede de recuperation de cristaux d'acide succinique avec mise en œuvre de tensioactifs au cours de la cristallisation, cristaux obtenus et leurs utilisations |
| WO2016164748A1 (en) | 2015-04-08 | 2016-10-13 | Invista North America S.A.R.L. | Materials and methods for the selective recovery of monovalent products from aqueous solutions using continuous ion exchange |
| WO2016164798A1 (en) * | 2015-04-08 | 2016-10-13 | Invista North America S.A.R.L. | Materials and methods for the selective recovery of multivalent products |
| ES2870324T3 (es) | 2017-05-19 | 2021-10-26 | Basf Se | Procedimiento de producción de un compuesto orgánico |
| CN109206313B (zh) * | 2017-07-05 | 2021-06-11 | 中国石化扬子石油化工有限公司 | 丁二酸盐厌氧发酵液制备丁二酸的方法 |
| PL236607B1 (pl) * | 2017-11-09 | 2021-02-08 | Politechnika Poznanska | Sposób wydzielania kwasu bursztynowego z brzeczki fermentacyjnej |
| EP3502241A1 (en) | 2017-12-21 | 2019-06-26 | Basf Se | Modified microorganism for improved production of succinate |
| US12090420B2 (en) | 2018-09-18 | 2024-09-17 | Inv Nylon Chemicals Americas, Llc | Systems and methods for recovering amines and their derivatives from aqueous mixtures |
| US12402782B2 (en) | 2020-04-30 | 2025-09-02 | Ambu A/S | Endoscope control system |
| WO2021248164A1 (en) * | 2020-06-04 | 2021-12-09 | Florida State University Research Foundation, Inc. | Large scale purification of castanospermine |
| IT202000017368A1 (it) | 2020-07-16 | 2022-01-16 | Radici Chimica S P A | Purificazione di acidi dicarbossilici alifatici prodotti mediante processi biotecnologici |
| WO2022061230A2 (en) * | 2020-09-21 | 2022-03-24 | Lygos, Inc. | Continuous ion exchange and esterification of fermented malonic acid |
| US11952609B2 (en) | 2021-03-01 | 2024-04-09 | Battelle Energy Alliance, Llc | Methods of producing succinic acid from a biomass |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132456A (en) * | 1991-05-07 | 1992-07-21 | The Regents Of The University Of California | Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine |
| US5958744A (en) * | 1997-08-18 | 1999-09-28 | Applied Carbochemicals | Succinic acid production and purification |
| US6284904B1 (en) * | 1998-03-02 | 2001-09-04 | Michigan Biotechnology Institute | Purification of organic acids using anion exchange chromatography |
| CN1860237A (zh) * | 2003-09-30 | 2006-11-08 | 味之素株式会社 | 从发酵液中纯化琥珀酸的方法 |
Family Cites Families (44)
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|---|---|---|---|---|
| US2664441A (en) * | 1951-07-19 | 1953-12-29 | Harry S Owens | Separation of organic acids |
| JPS58164541A (ja) * | 1982-03-25 | 1983-09-29 | Mitsubishi Chem Ind Ltd | 多価カルボン酸の精製方法 |
| ES2036188T3 (es) | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5068419A (en) * | 1986-12-18 | 1991-11-26 | Uop | Separation of an organic acid from a fermentation broth with an anionic polymeric adsorbent |
| JPH03503119A (ja) | 1987-12-22 | 1991-07-18 | カムペン,ウイレム ヘムモ | エタノール、グリセロール、こはく酸及び自由流動性デイステイラーズ乾燥穀粒及び可溶物の製造法及び装置 |
| US5068418A (en) | 1989-05-08 | 1991-11-26 | Uop | Separation of lactic acid from fermentation broth with an anionic polymeric absorbent |
| US5034105A (en) | 1989-07-27 | 1991-07-23 | Michigan Biotechnology Institute | Carboxylic acid purification and crystallization process |
| US5104492A (en) | 1990-07-11 | 1992-04-14 | The Regents Of The University Of California | Recovery of carboxylic acids from water by precipitation from organic solutions |
| US5412126A (en) | 1991-04-17 | 1995-05-02 | The Regents Of The University Of California | Carboxylic acid sorption regeneration process |
| US5786185A (en) | 1991-09-13 | 1998-07-28 | Reilly Industries, Inc. | Process for producing and recovering lactic acid |
| AT398982B (de) | 1993-02-18 | 1995-02-27 | Vogelbusch Gmbh | Verfahren zur abtrennung und reinigung von milchsäure |
| IL108340A (en) | 1993-03-04 | 1996-10-16 | Innova Sa | Citric acid extraction |
| JP3750026B2 (ja) * | 1994-03-24 | 2006-03-01 | 日本コーンスターチ株式会社 | 水素化澱粉水解組成物 |
| JPH08176133A (ja) | 1994-12-26 | 1996-07-09 | Takeda Chem Ind Ltd | L−アスコルビン酸の精製法 |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| US6160173A (en) | 1996-10-09 | 2000-12-12 | Cargill Incorporated | Process for the recovery of lactic acid esters and amides from aqueous solutions of lactic acid and/or salts thereof |
| IL119389A (en) | 1996-10-09 | 2001-10-31 | Cargill Inc | Process for the recovery of lactic acid by liquid-liquid extraction using a cation exchanger |
| US6319382B1 (en) | 1996-12-23 | 2001-11-20 | Lactascan Aps | Fermentative production and isolation of lactic acid |
| IL119986A (en) | 1997-01-09 | 2000-10-31 | Amylum Nv | Process for the production of crystalline aspartic acid |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| FR2799754A1 (fr) | 1999-10-18 | 2001-04-20 | Roquette Freres | Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation |
| MY137537A (en) | 2002-05-10 | 2009-02-27 | Mitsubishi Chem Corp | Method for producing organic acid |
| US7241918B1 (en) | 2003-03-18 | 2007-07-10 | Uop Llc | Separation of citric acid from gluconic acid in fermentation broth using a weakly or strongly basic anionic exchange resin adsorbent |
| JP4469568B2 (ja) | 2003-07-09 | 2010-05-26 | 三菱化学株式会社 | 有機酸の製造方法 |
| BRPI0413403A (pt) | 2003-08-28 | 2006-10-17 | Mitsubishi Chem Corp | método para produzir ácido succìnico |
| WO2005026349A1 (ja) | 2003-09-17 | 2005-03-24 | Mitsubishi Chemical Corporation | 非アミノ有機酸の製造方法 |
| CN101044245B (zh) | 2004-08-27 | 2012-05-02 | 莱斯大学 | 具有增加的琥珀酸产量的突变大肠杆菌菌株 |
| EA201100177A1 (ru) * | 2005-06-17 | 2011-06-30 | Элан Фарма Интернэшнл Лимитед | СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ |
| JP4193820B2 (ja) | 2005-07-05 | 2008-12-10 | ブラザー工業株式会社 | 管理装置、およびプログラム |
| CA2662871C (en) | 2005-10-06 | 2014-03-25 | Hyflux Ip Resources Pte Ltd | Process for recovery and purification of lactic acid |
| CN101297043B (zh) | 2005-10-18 | 2013-01-16 | 味之素株式会社 | 用于产生琥珀酸的方法 |
| JP5365824B2 (ja) * | 2006-03-23 | 2013-12-11 | 独立行政法人産業技術総合研究所 | コハク酸ジアルキルの製造方法および1,4−ブタンジオールの製造方法 |
| EP1842843A1 (de) | 2006-04-04 | 2007-10-10 | Basf Aktiengesellschaft | Verfahren zur Herstellung eines Carbonsäurealkylesters |
| EP2121915B1 (en) | 2007-03-20 | 2012-08-08 | University of Florida Research Foundation, Inc. | Materials and methods for efficient succinate and malate production |
| JP3135606U (ja) | 2007-07-12 | 2007-09-20 | 株式会社ノルコーポレーション | 収納フレーム |
| CN104818224A (zh) | 2007-11-20 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| FR2925068B1 (fr) | 2007-12-13 | 2010-01-08 | Roquette Freres | Procedes de production d'acide succinique |
| KR20090066958A (ko) | 2007-12-20 | 2009-06-24 | 한국과학기술원 | 배양액의 결정화에 의한 숙신산 정제방법 |
| CN101215583B (zh) * | 2008-01-18 | 2010-11-10 | 南京工业大学 | 一种发酵与膜分离单元耦合制备丁二酸的方法 |
| KR20120025450A (ko) | 2009-04-02 | 2012-03-15 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 석시네이트 생성을 위한 경로의 엔지니어링 |
| WO2011064151A1 (en) * | 2009-11-24 | 2011-06-03 | Dsm Ip Assets B.V. | Process for the crystallization of succinic acid |
-
2010
- 2010-12-31 KR KR1020127020082A patent/KR20120099154A/ko not_active Ceased
- 2010-12-31 EP EP15000821.7A patent/EP2918574A1/en not_active Withdrawn
- 2010-12-31 EP EP10841777.5A patent/EP2519491A4/en not_active Withdrawn
- 2010-12-31 JP JP2012547320A patent/JP2013516180A/ja active Pending
- 2010-12-31 US US13/519,491 patent/US9233906B2/en not_active Expired - Fee Related
- 2010-12-31 WO PCT/US2010/062635 patent/WO2011082378A2/en not_active Ceased
- 2010-12-31 CN CN201080059513XA patent/CN102781900A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132456A (en) * | 1991-05-07 | 1992-07-21 | The Regents Of The University Of California | Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine |
| US5958744A (en) * | 1997-08-18 | 1999-09-28 | Applied Carbochemicals | Succinic acid production and purification |
| US6284904B1 (en) * | 1998-03-02 | 2001-09-04 | Michigan Biotechnology Institute | Purification of organic acids using anion exchange chromatography |
| CN1860237A (zh) * | 2003-09-30 | 2006-11-08 | 味之素株式会社 | 从发酵液中纯化琥珀酸的方法 |
Non-Patent Citations (1)
| Title |
|---|
| HYOHAK SONG ET AL: "Recovery of succinic acid produced by fermentation of a metabolically engineered Mannheimia succiniciproducens strain", 《JOURNAL OF BIOTECHNOLOGY》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105073703A (zh) * | 2013-01-03 | 2015-11-18 | 蒂森克虏伯工业解决方案股份公司 | 从发酵液中纯化羧酸的方法 |
| CN111164215A (zh) * | 2017-10-02 | 2020-05-15 | 代谢探索者公司 | 用于从发酵液产生有机酸盐的方法 |
| CN109612978A (zh) * | 2018-10-30 | 2019-04-12 | 欣旺达电子股份有限公司 | 锂离子电池电极膜片补锂量检测方法 |
| CN111732502A (zh) * | 2019-07-02 | 2020-10-02 | 安徽丰原发酵技术工程研究有限公司 | 一种分离苹果酸与丁二酸的方法 |
| CN111732507A (zh) * | 2019-07-02 | 2020-10-02 | 安徽丰原发酵技术工程研究有限公司 | 一种生产l-苹果酸联产丁二酸的方法 |
| CN111732507B (zh) * | 2019-07-02 | 2022-07-15 | 安徽丰原发酵技术工程研究有限公司 | 一种生产l-苹果酸联产丁二酸的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013516180A (ja) | 2013-05-13 |
| US20120289742A1 (en) | 2012-11-15 |
| WO2011082378A3 (en) | 2011-11-03 |
| US9233906B2 (en) | 2016-01-12 |
| KR20120099154A (ko) | 2012-09-06 |
| EP2918574A1 (en) | 2015-09-16 |
| WO2011082378A2 (en) | 2011-07-07 |
| EP2519491A4 (en) | 2014-10-08 |
| EP2519491A2 (en) | 2012-11-07 |
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Application publication date: 20121114 |