CN102770444A - 免疫原性蛋白和组合物 - Google Patents

免疫原性蛋白和组合物 Download PDF

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Publication number
CN102770444A
CN102770444A CN2011800113184A CN201180011318A CN102770444A CN 102770444 A CN102770444 A CN 102770444A CN 2011800113184 A CN2011800113184 A CN 2011800113184A CN 201180011318 A CN201180011318 A CN 201180011318A CN 102770444 A CN102770444 A CN 102770444A
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seq
amino acid
acid sequence
polypeptide
fragment
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Pending
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CN2011800113184A
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Chinese (zh)
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D·迈文
C·D·日努多
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Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800113184A 2010-02-26 2011-02-28 免疫原性蛋白和组合物 Pending CN102770444A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1003333.0 2010-02-26
GBGB1003333.0A GB201003333D0 (en) 2010-02-26 2010-02-26 Immunogenic proteins and compositions
PCT/IB2011/000562 WO2011104632A1 (en) 2010-02-26 2011-02-28 Immunogenic proteins and compositions

Publications (1)

Publication Number Publication Date
CN102770444A true CN102770444A (zh) 2012-11-07

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Family Applications (1)

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CN2011800113184A Pending CN102770444A (zh) 2010-02-26 2011-02-28 免疫原性蛋白和组合物

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US (1) US20130216568A1 (enExample)
EP (1) EP2539360A1 (enExample)
JP (1) JP2013520487A (enExample)
CN (1) CN102770444A (enExample)
AU (1) AU2011219524B2 (enExample)
CA (1) CA2791153A1 (enExample)
GB (2) GB201003333D0 (enExample)
MX (1) MX2012009758A (enExample)
NZ (1) NZ601488A (enExample)
WO (1) WO2011104632A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715458A (zh) * 2014-07-18 2017-05-24 华盛顿大学 癌症疫苗组合物及其使用方法
CN108752480A (zh) * 2018-05-30 2018-11-06 重庆中元汇吉生物技术有限公司 一种免疫原组合物、其制备方法及其用途
CN108840914A (zh) * 2018-08-13 2018-11-20 内蒙古民族大学 一种具有免疫原性的多肽、其抗体的制备方法以及用途
CN117417419A (zh) * 2023-01-10 2024-01-19 康希诺生物股份公司 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201114923D0 (en) * 2011-08-30 2011-10-12 Novartis Ag Immunogenic proteins and compositions
BE1022792B1 (fr) * 2014-08-05 2016-09-06 Glaxosmithkline Biologicals S.A. Molecule support
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20060165716A1 (en) * 2004-07-29 2006-07-27 Telford John L Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
WO2009027768A2 (en) * 2006-07-26 2009-03-05 Novartis Ag Immunogenic compositions for gram positive bacteria
WO2009101403A1 (en) * 2008-02-11 2009-08-20 Novartis Ag Hybrid polypeptides comprising gbs-80 and spb1 proteins of streptococcus

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715458A (zh) * 2014-07-18 2017-05-24 华盛顿大学 癌症疫苗组合物及其使用方法
CN108752480A (zh) * 2018-05-30 2018-11-06 重庆中元汇吉生物技术有限公司 一种免疫原组合物、其制备方法及其用途
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
CN108840914A (zh) * 2018-08-13 2018-11-20 内蒙古民族大学 一种具有免疫原性的多肽、其抗体的制备方法以及用途
CN117417419A (zh) * 2023-01-10 2024-01-19 康希诺生物股份公司 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗
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