CN102764242B - 含有pde 4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 - Google Patents
含有pde 4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 Download PDFInfo
- Publication number
- CN102764242B CN102764242B CN201210231798.1A CN201210231798A CN102764242B CN 102764242 B CN102764242 B CN 102764242B CN 201210231798 A CN201210231798 A CN 201210231798A CN 102764242 B CN102764242 B CN 102764242B
- Authority
- CN
- China
- Prior art keywords
- formulation
- pde
- inhibitor
- roflumilast
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (17)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10207160.8 | 2002-02-20 | ||
EP02003811 | 2002-02-20 | ||
EP02003811.3 | 2002-02-20 | ||
DE2002107160 DE10207160A1 (de) | 2002-02-20 | 2002-02-20 | Darreichungsform enthaltend PDE 4-Hemmer als Wirkstoff |
CN038042304A CN1635909B (zh) | 2002-02-20 | 2003-02-19 | 含有pde4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN038042304A Division CN1635909B (zh) | 2002-02-20 | 2003-02-19 | 含有pde4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102764242A CN102764242A (zh) | 2012-11-07 |
CN102764242B true CN102764242B (zh) | 2016-09-07 |
Family
ID=27758398
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210231798.1A Expired - Lifetime CN102764242B (zh) | 2002-02-20 | 2003-02-19 | 含有pde 4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
CN038042304A Expired - Lifetime CN1635909B (zh) | 2002-02-20 | 2003-02-19 | 含有pde4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN038042304A Expired - Lifetime CN1635909B (zh) | 2002-02-20 | 2003-02-19 | 含有pde4抑制剂作为活性成分和聚乙烯吡咯烷酮作为赋形剂的口服剂型 |
Country Status (34)
Country | Link |
---|---|
US (11) | US7951397B2 (zh) |
EP (2) | EP2258394B1 (zh) |
JP (1) | JP4163120B2 (zh) |
KR (2) | KR101253033B1 (zh) |
CN (2) | CN102764242B (zh) |
AR (1) | AR038527A1 (zh) |
AT (1) | ATE550038T1 (zh) |
AU (1) | AU2003206924B2 (zh) |
BR (1) | BR0307739A (zh) |
CA (1) | CA2475923C (zh) |
CY (2) | CY1112811T1 (zh) |
DK (2) | DK2258394T3 (zh) |
EA (1) | EA008219B1 (zh) |
EC (1) | ECSP045238A (zh) |
ES (2) | ES2384378T3 (zh) |
GE (1) | GEP20074079B (zh) |
HK (1) | HK1077752A1 (zh) |
IL (3) | IL162843A0 (zh) |
IS (1) | IS7410A (zh) |
MA (1) | MA27100A1 (zh) |
ME (1) | ME00566B (zh) |
MX (1) | MXPA04005759A (zh) |
MY (1) | MY140561A (zh) |
NO (1) | NO332844B1 (zh) |
NZ (1) | NZ535197A (zh) |
PE (1) | PE20030823A1 (zh) |
PL (1) | PL226401B1 (zh) |
PT (2) | PT2258394E (zh) |
RS (1) | RS52548B (zh) |
SI (2) | SI1478399T1 (zh) |
TN (1) | TNSN04124A1 (zh) |
TW (1) | TWI363636B (zh) |
UA (1) | UA84266C2 (zh) |
WO (1) | WO2003070279A1 (zh) |
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MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
PT1606261E (pt) | 2003-03-10 | 2010-01-11 | Nycomed Gmbh | Novo processo para a preparação de roflumilast |
CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
EA012279B1 (ru) | 2003-05-22 | 2009-08-28 | Никомед Гмбх | Композиция, включающая ингибитор pde4 и ингибитор pde5 |
DE10350528A1 (de) * | 2003-10-29 | 2005-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arzneimittelformulierung, enthaltend einen LTB4-Antagonisten, sowie Verfahren zu deren Herstellung und deren Verwendung |
ES2245891B1 (es) * | 2004-07-09 | 2006-11-16 | Clinmet S.L. | "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo". |
DE102004046235A1 (de) * | 2004-09-22 | 2006-03-30 | Altana Pharma Ag | Arzneimittelzubereitung |
EP2258350B1 (en) | 2005-03-16 | 2014-12-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
AU2006237300B2 (en) * | 2005-04-19 | 2011-10-13 | Takeda Gmbh | Roflumilast for the treatment of pulmonary hypertension |
KR101433394B1 (ko) | 2006-07-05 | 2014-08-26 | 다케다 게엠베하 | 염증성 폐질환의 치료를 위한 HMG-CoA 리덕타제 억제제와 포스포디에스터라제 4 억제제의 병용 |
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JP5390014B2 (ja) | 2010-03-19 | 2014-01-15 | 第一三共株式会社 | 抗凝固剤の溶出改善方法 |
JP5568139B2 (ja) | 2010-10-22 | 2014-08-06 | デウー シップビルディング アンド マリン エンジニアリング カンパニー リミテッド | 液化天然ガスの貯蔵容器 |
US9504663B2 (en) | 2011-02-07 | 2016-11-29 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
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CN102274222B (zh) * | 2011-08-18 | 2013-04-10 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特药物组合物及其制备方法 |
WO2013030789A1 (en) | 2011-08-30 | 2013-03-07 | Ranbaxy Laboratories Limited | Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor |
SI2797581T1 (sl) * | 2011-12-27 | 2020-08-31 | Amgen (Europe) GmbH | Formulacije (+)-2-(1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil)- 4-acetil aminoizoindolin-1,3-diona |
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