CN102596967B - 制备青蒿素的光化学法 - Google Patents
制备青蒿素的光化学法 Download PDFInfo
- Publication number
- CN102596967B CN102596967B CN201080049390.1A CN201080049390A CN102596967B CN 102596967 B CN102596967 B CN 102596967B CN 201080049390 A CN201080049390 A CN 201080049390A CN 102596967 B CN102596967 B CN 102596967B
- Authority
- CN
- China
- Prior art keywords
- artemisinin
- formula
- mixture
- alkyl group
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- WFWSJKWRBXIYHU-VTVRSZQSSA-N CC(OC(OC(/C(/C)=C1\[C@H]2C=C(C)CC[C@H]2[C@H](C)CC1)=O)=O)Cl Chemical compound CC(OC(OC(/C(/C)=C1\[C@H]2C=C(C)CC[C@H]2[C@H](C)CC1)=O)=O)Cl WFWSJKWRBXIYHU-VTVRSZQSSA-N 0.000 description 1
- VOINTJFMKKNFTD-OEAJRASXSA-N CCOC(OC(C([C@H]1[C@H]2C=C(C)CC[C@H]2[C@H](C)CC1)=C)=O)=O Chemical compound CCOC(OC(C([C@H]1[C@H]2C=C(C)CC[C@H]2[C@H](C)CC1)=C)=O)=O VOINTJFMKKNFTD-OEAJRASXSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
- B01J19/127—Sunlight; Visible light
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305805A EP2289897A1 (en) | 2009-09-01 | 2009-09-01 | Photochemical process for producing artemisinin |
| EP09305805.5 | 2009-09-01 | ||
| PCT/EP2010/062811 WO2011026865A1 (en) | 2009-09-01 | 2010-09-01 | Photochemical process for producing artemisinin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102596967A CN102596967A (zh) | 2012-07-18 |
| CN102596967B true CN102596967B (zh) | 2015-08-26 |
Family
ID=41557558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080049390.1A Active CN102596967B (zh) | 2009-09-01 | 2010-09-01 | 制备青蒿素的光化学法 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8507697B2 (https=) |
| EP (2) | EP2289897A1 (https=) |
| JP (1) | JP5719366B2 (https=) |
| KR (1) | KR101787777B1 (https=) |
| CN (1) | CN102596967B (https=) |
| AP (1) | AP2988A (https=) |
| AU (2) | AU2010291253B2 (https=) |
| BR (1) | BR112012004702B1 (https=) |
| CA (1) | CA2772264C (https=) |
| CL (1) | CL2012000554A1 (https=) |
| CO (1) | CO6511258A2 (https=) |
| CY (1) | CY1121969T1 (https=) |
| EA (1) | EA021181B1 (https=) |
| ES (1) | ES2561080T3 (https=) |
| HU (1) | HUE027477T2 (https=) |
| IL (1) | IL218346A0 (https=) |
| MA (1) | MA33596B1 (https=) |
| MX (1) | MX358030B (https=) |
| MY (1) | MY155962A (https=) |
| NZ (1) | NZ598878A (https=) |
| PL (1) | PL2473512T3 (https=) |
| SG (1) | SG178600A1 (https=) |
| SI (1) | SI2473512T1 (https=) |
| WO (1) | WO2011026865A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289897A1 (en) * | 2009-09-01 | 2011-03-02 | Sanofi-Aventis | Photochemical process for producing artemisinin |
| EP2751113B1 (en) * | 2011-08-29 | 2017-07-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and device for the synthesis of artemisinin |
| CN103788110B (zh) * | 2013-11-28 | 2015-10-28 | 湖南科源生物制品有限公司 | 一种以青蒿酸为原料制备青蒿素的方法 |
| CN110327984B (zh) * | 2019-07-12 | 2022-04-22 | 西北工业大学 | 一种用于双氢青蒿酸制备青蒿素的Pt@PCN-224光催化剂及其制备方法 |
| CN110590802B (zh) * | 2019-09-18 | 2021-02-02 | 浙江海正药业股份有限公司 | 一种青蒿素的化学半合成方法 |
| CN116606303A (zh) * | 2023-05-10 | 2023-08-18 | 中科苏州药物研究院 | 青蒿素的制备新工艺及其所使用的光反应器 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053237A (zh) * | 1990-01-12 | 1991-07-24 | 中国科学院上海有机化学研究所 | 青蒿酸合成青蒿素的方法 |
| CN1077455A (zh) * | 1993-03-25 | 1993-10-20 | 中国科学院上海有机化学研究所 | 4位取代青蒿素类似物 |
| WO2006128126A1 (en) * | 2005-05-27 | 2006-11-30 | Amyris Biotechnologies, Inc. | Conversion of amorpha-4,11- diene to artemisinin and artemisinin precursors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| US4992561A (en) * | 1990-05-11 | 1991-02-12 | The United States Of America As Represented By The Secretary Of The Army | Simple conversion of artemisinic acid into artemisinin |
| IN184682B (https=) | 1995-12-29 | 2000-09-23 | Council Scient Ind Res | |
| JP3148136B2 (ja) * | 1996-12-26 | 2001-03-19 | 高砂香料工業株式会社 | 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒 |
| US5995084A (en) * | 1997-01-17 | 1999-11-30 | Tritech Microelectronics, Ltd. | Touchpad pen-input and mouse controller |
| IN188174B (https=) | 1997-03-17 | 2002-08-31 | Council Scient Ind Res | |
| JP3549390B2 (ja) * | 1998-03-23 | 2004-08-04 | 高砂香料工業株式会社 | ルテニウム−ホスフィン錯体及びその製造方法 |
| WO2009088404A1 (en) | 2007-12-30 | 2009-07-16 | Amyris Biotechnologies, Inc. | Processes for the preparation of artemisinin an its precursors |
| EP2289897A1 (en) * | 2009-09-01 | 2011-03-02 | Sanofi-Aventis | Photochemical process for producing artemisinin |
-
2009
- 2009-09-01 EP EP09305805A patent/EP2289897A1/en not_active Withdrawn
-
2010
- 2010-09-01 JP JP2012526082A patent/JP5719366B2/ja active Active
- 2010-09-01 SI SI201031120A patent/SI2473512T1/sl unknown
- 2010-09-01 BR BR112012004702-7A patent/BR112012004702B1/pt active IP Right Grant
- 2010-09-01 KR KR1020127008220A patent/KR101787777B1/ko active Active
- 2010-09-01 US US12/873,925 patent/US8507697B2/en active Active
- 2010-09-01 CN CN201080049390.1A patent/CN102596967B/zh active Active
- 2010-09-01 AP AP2012006186A patent/AP2988A/xx active
- 2010-09-01 HU HUE10751915A patent/HUE027477T2/en unknown
- 2010-09-01 NZ NZ598878A patent/NZ598878A/xx not_active IP Right Cessation
- 2010-09-01 EA EA201270343A patent/EA021181B1/ru not_active IP Right Cessation
- 2010-09-01 PL PL10751915T patent/PL2473512T3/pl unknown
- 2010-09-01 ES ES10751915.9T patent/ES2561080T3/es active Active
- 2010-09-01 AU AU2010291253A patent/AU2010291253B2/en active Active
- 2010-09-01 EP EP10751915.9A patent/EP2473512B1/en active Active
- 2010-09-01 WO PCT/EP2010/062811 patent/WO2011026865A1/en not_active Ceased
- 2010-09-01 CA CA2772264A patent/CA2772264C/en active Active
- 2010-09-01 MX MX2012002652A patent/MX358030B/es active IP Right Grant
- 2010-09-01 SG SG2012014114A patent/SG178600A1/en unknown
- 2010-09-01 MY MYPI2012000913A patent/MY155962A/en unknown
-
2012
- 2012-02-27 IL IL218346A patent/IL218346A0/en active IP Right Grant
- 2012-02-29 CL CL2012000554A patent/CL2012000554A1/es unknown
- 2012-03-21 MA MA34707A patent/MA33596B1/fr unknown
- 2012-03-22 CO CO12048458A patent/CO6511258A2/es active IP Right Grant
-
2013
- 2013-07-12 US US13/940,316 patent/US20130299338A1/en not_active Abandoned
-
2016
- 2016-01-27 CY CY20161100071T patent/CY1121969T1/el unknown
- 2016-06-16 AU AU2016204057A patent/AU2016204057B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053237A (zh) * | 1990-01-12 | 1991-07-24 | 中国科学院上海有机化学研究所 | 青蒿酸合成青蒿素的方法 |
| CN1077455A (zh) * | 1993-03-25 | 1993-10-20 | 中国科学院上海有机化学研究所 | 4位取代青蒿素类似物 |
| WO2006128126A1 (en) * | 2005-05-27 | 2006-11-30 | Amyris Biotechnologies, Inc. | Conversion of amorpha-4,11- diene to artemisinin and artemisinin precursors |
Non-Patent Citations (1)
| Title |
|---|
| A Total Synthesis of the Antimakial Natural Product (+)-Qinghaosu;HSING-JANG LIU，等;《TETRAHEDRON LETTERS》;19930709;第34卷(第28期);第4435-4438页 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190325 Address after: Curio, Italy Patentee after: Howe Pharmaceutical Italian Company Address before: France Patentee before: Sai Nuofei |
|
| TR01 | Transfer of patent right |