CN102574860A - 吡咯并[2,3-d]嘧啶化合物 - Google Patents

吡咯并[2,3-d]嘧啶化合物 Download PDF

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Publication number
CN102574860A
CN102574860A CN2010800461239A CN201080046123A CN102574860A CN 102574860 A CN102574860 A CN 102574860A CN 2010800461239 A CN2010800461239 A CN 2010800461239A CN 201080046123 A CN201080046123 A CN 201080046123A CN 102574860 A CN102574860 A CN 102574860A
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methyl
alkyl
hydrogen
pyrrolo
cyclohexyl
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CN2010800461239A
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Chinese (zh)
Inventor
B·A·阿克
S·J·哈特曼
黄鸿志
E·J·雅各布森
M·A·普罗莫
S·G·沃尔夫森
谢进
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
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  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010800461239A 2009-10-15 2010-10-01 吡咯并[2,3-d]嘧啶化合物 Pending CN102574860A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25203909P 2009-10-15 2009-10-15
US61/252,039 2009-10-15
PCT/IB2010/054447 WO2011045702A1 (en) 2009-10-15 2010-10-01 Pyrrolo[2,3-d] pyrimidine compounds

Publications (1)

Publication Number Publication Date
CN102574860A true CN102574860A (zh) 2012-07-11

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US (1) US8633206B2 (https=)
EP (1) EP2488524B1 (https=)
JP (1) JP5629324B2 (https=)
KR (1) KR20120083452A (https=)
CN (1) CN102574860A (https=)
AP (1) AP2012006192A0 (https=)
AR (1) AR078635A1 (https=)
AU (1) AU2010308028A1 (https=)
CA (1) CA2776028C (https=)
CL (1) CL2012000795A1 (https=)
CO (1) CO6531451A2 (https=)
CR (1) CR20120164A (https=)
CU (1) CU20120059A7 (https=)
DO (1) DOP2012000080A (https=)
EA (1) EA201290147A1 (https=)
EC (1) ECSP12011855A (https=)
ES (1) ES2426407T3 (https=)
IL (1) IL218802A0 (https=)
IN (1) IN2012DN02577A (https=)
MA (1) MA33670B1 (https=)
MX (1) MX2012004379A (https=)
NI (1) NI201200053A (https=)
PE (1) PE20121077A1 (https=)
PH (1) PH12012500583A1 (https=)
TN (1) TN2012000146A1 (https=)
TW (1) TWI398444B (https=)
UY (1) UY32947A (https=)
WO (1) WO2011045702A1 (https=)
ZA (1) ZA201202718B (https=)

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Publication number Priority date Publication date Assignee Title
CN103896946A (zh) * 2012-12-28 2014-07-02 浙江导明医药科技有限公司 用于预防及治疗多种自身免疫疾病的新化合物
CN105164133A (zh) * 2013-05-02 2015-12-16 豪夫迈·罗氏有限公司 作为CB2受体激动剂的吡咯并[2，3-d]嘧啶衍生物
CN105008362B (zh) * 2013-02-22 2017-06-06 辉瑞大药厂 作为詹纳斯相关激酶(jak)抑制剂的吡咯并[2,3‑d]嘧啶衍生物
CN111499641A (zh) * 2019-01-30 2020-08-07 格格巫（珠海）生物科技有限公司 一种jak抑制剂及其制备方法
CN114025758A (zh) * 2019-07-01 2022-02-08 钱立刚 P2x7r拮抗剂
CN114761011A (zh) * 2019-08-26 2022-07-15 肯沃斯公司 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物
CN115246833A (zh) * 2021-04-27 2022-10-28 洛阳惠中兽药有限公司 一种奥拉替尼化合物及其中间体化合物的制备方法

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DK2875013T3 (en) * 2012-07-17 2018-01-22 Glaxosmithkline Intellectual Property (No 2) Ltd INDOLECAR CARBON NITRILS AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
US20160123982A1 (en) 2013-02-04 2016-05-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for assaying jak2 activity in red blood cells and uses thereof
JP6248948B2 (ja) 2013-02-08 2017-12-20 日産化学工業株式会社 ３環性ピロロピリジン化合物及びｊａｋ阻害剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
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JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
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BR112016023299A8 (pt) 2014-05-14 2021-06-29 Nissan Chemical Ind Ltd composto tricíclico e inibidor de jak, agente preventivo, terapêutico ou de melhoria para doenças contra as quais inibição de jak é eficaz e para artrite reumatoide, medicamento e utilização desses compostos
WO2016024185A1 (en) 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
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CN107098908B (zh) * 2016-02-23 2021-01-08 欣凯医药科技(上海)有限公司 一种吡咯并嘧啶类化合物的制备方法和应用
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
EP3610264A1 (en) 2017-04-13 2020-02-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
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