CN102549424B - 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法 - Google Patents

合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法 Download PDF

Info

Publication number
CN102549424B
CN102549424B CN201080043818.1A CN201080043818A CN102549424B CN 102549424 B CN102549424 B CN 102549424B CN 201080043818 A CN201080043818 A CN 201080043818A CN 102549424 B CN102549424 B CN 102549424B
Authority
CN
China
Prior art keywords
mycotoxin
mip
methods
template
molecularly imprinted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080043818.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN102549424A (zh
Inventor
亚历克桑德斯·伊安尼克里斯
斯蒂凡·奎特阔斯基
麻奴吉·宝佳帕·库杜鲍捷
克莱顿·马特尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alltech Corp
Original Assignee
Alltech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alltech Corp filed Critical Alltech Corp
Priority to CN201410359900.5A priority Critical patent/CN104190378B/zh
Priority to CN201510468506.XA priority patent/CN105218393B/zh
Publication of CN102549424A publication Critical patent/CN102549424A/zh
Application granted granted Critical
Publication of CN102549424B publication Critical patent/CN102549424B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A23L5/273Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption using adsorption or absorption agents, resins, synthetic polymers, or ion exchangers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26Synthetic macromolecular compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26Synthetic macromolecular compounds
    • B01J20/268Polymers created by use of a template, e.g. molecularly imprinted polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10Esters
    • C08F222/1006Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12HPASTEURISATION, STERILISATION, PRESERVATION, PURIFICATION, CLARIFICATION OR AGEING OF ALCOHOLIC BEVERAGES; METHODS FOR ALTERING THE ALCOHOL CONTENT OF FERMENTED SOLUTIONS OR ALCOHOLIC BEVERAGES
    • C12H1/00Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages
    • C12H1/02Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material
    • C12H1/04Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material with the aid of ion-exchange material or inert clarification material, e.g. adsorption material
    • C12H1/0416Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material with the aid of ion-exchange material or inert clarification material, e.g. adsorption material with the aid of organic added material
    • C12H1/0424Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material with the aid of ion-exchange material or inert clarification material, e.g. adsorption material with the aid of organic added material with the aid of a polymer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3852Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography using imprinted phases or molecular recognition
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/20Esters of polyhydric alcohols or phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
CN201080043818.1A 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法 Active CN102549424B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201410359900.5A CN104190378B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
CN201510468506.XA CN105218393B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23754909P 2009-08-27 2009-08-27
US61/237,549 2009-08-27
PCT/US2010/047032 WO2011031562A1 (en) 2009-08-27 2010-08-27 Synthetic mycotoxin adsorbents and methods of making and utilizing the same

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201410359900.5A Division CN104190378B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
CN201510468506.XA Division CN105218393B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法

Publications (2)

Publication Number Publication Date
CN102549424A CN102549424A (zh) 2012-07-04
CN102549424B true CN102549424B (zh) 2016-01-13

Family

ID=43625814

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201080043818.1A Active CN102549424B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
CN201510468506.XA Active CN105218393B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
CN201410359900.5A Active CN104190378B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201510468506.XA Active CN105218393B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
CN201410359900.5A Active CN104190378B (zh) 2009-08-27 2010-08-27 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法

Country Status (20)

Country Link
US (3) US8153737B2 (enExample)
EP (1) EP2470894B1 (enExample)
JP (1) JP5650223B2 (enExample)
KR (2) KR101556591B1 (enExample)
CN (3) CN102549424B (enExample)
AU (1) AU2010292495B2 (enExample)
BR (1) BR112012004316B1 (enExample)
CA (1) CA2770343C (enExample)
CL (1) CL2012000494A1 (enExample)
CO (1) CO6440520A2 (enExample)
EA (2) EA024530B9 (enExample)
IN (1) IN2012DN01219A (enExample)
MA (1) MA33597B1 (enExample)
MX (1) MX2012002494A (enExample)
MY (2) MY153040A (enExample)
NZ (2) NZ598160A (enExample)
PE (2) PE20161381A1 (enExample)
UA (1) UA105228C2 (enExample)
WO (1) WO2011031562A1 (enExample)
ZA (1) ZA201200973B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9182398B2 (en) 2006-04-01 2015-11-10 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
GB201200878D0 (en) 2012-01-19 2012-02-29 British American Tobacco Co Polymer compositions
TWI421037B (zh) 2006-12-07 2014-01-01 British American Tobacco Co 選作為煙草特異性亞硝胺類之分子拓印的聚合物及使用其之方法
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
WO2013056226A1 (en) 2011-10-13 2013-04-18 The Trustees Of Dartmouth College Molecularly imprinted polymer for wine extraction
ES2427689B2 (es) * 2012-03-30 2014-04-07 Universidad Complutense De Madrid Materiales para el reconocimiento selectivo de micotoxinas de Alternaria (alternariol y alternariol monometil éter)
CN102744048B (zh) * 2012-07-25 2015-07-15 长安大学 酵母菌微球体磁性复合材料表面印迹吸附剂的制备方法
US10000598B2 (en) * 2012-10-15 2018-06-19 The Trustees Of Dartmouth College Methods for preparation of molecularly imprinted polymers for wine extraction
US11326197B2 (en) 2012-10-29 2022-05-10 Freshair Sensor, Llc Molecularly imprinted polymer-based passive sensor
ES2732481T3 (es) * 2013-03-27 2019-11-22 Biotage Ab Uso de un sorbente para extraer micotoxinas
CN103524676B (zh) * 2013-08-26 2014-09-17 陕西师范大学 2-[(6-氧代-6H-苯并[c]色满-3-基)氧基]丙酸整体柱的制备方法及应用
FR3013057B1 (fr) 2013-11-08 2017-12-22 Univ Bourgogne Utilisation d'un polymere a empreintes moleculaires pour pieger l'iprodione en milieu aqueux
CN103604674A (zh) * 2013-11-21 2014-02-26 四川理工学院 一种大曲中赭曲霉毒素a的提取、纯化方法
WO2015130529A2 (en) 2014-02-25 2015-09-03 Freshair Sensor Corporation Molecularly imprinted polymer sensors
WO2015130664A1 (en) 2014-02-26 2015-09-03 Kemin Industries, Inc. Application of beta zeolite as multitoxin binder in animal feed
CN104034835B (zh) * 2014-05-27 2016-08-24 中华人民共和国苏州出入境检验检疫局 发酵酒中多种生物毒素的检测方法
US20160221983A1 (en) * 2015-02-04 2016-08-04 Alltech, Inc. Aflatoxin templates, molecularly imprinted polymers, and methods of making and using the same
RU2705210C2 (ru) * 2015-02-04 2019-11-06 Олтек, Инк. Шаблоны афлатоксина, полимеры с молекулярными отпечатками и способы их получения и применения
AU2016323801A1 (en) * 2015-09-17 2018-04-12 Advatect Diagnostics, Llc Methods and compositions for detecting mycotoxins
WO2017058501A1 (en) * 2015-09-29 2017-04-06 Archer-Daniels-Midland Company Process for removal of mycotoxins from insoluble plant-derived protein
AT518590A3 (de) * 2016-04-29 2022-09-15 Mosbach Klaus Speicherung von binärkodes in molekular geprägten polymeren
CN106362654B (zh) * 2016-10-08 2019-04-02 江苏大学 一种磁性蛋壳粉稳定的Pickering乳液聚合技术制备印迹微球的方法
JP7276315B2 (ja) * 2018-03-15 2023-05-18 東亞合成株式会社 重合体微粒子の製造方法
CN109342626A (zh) * 2018-11-28 2019-02-15 福州大学 特异性识别赭曲霉毒素a的poss有机-无机杂化分子印迹整体柱及其制备方法
CN109627381B (zh) * 2018-12-20 2020-09-25 成都医学院 一种虚拟模板在制备腾毒素分子印迹聚合物中的应用及腾毒素分子印迹聚合物的制备方法
CN109734929B (zh) * 2019-01-07 2021-07-13 安徽中烟工业有限责任公司 一种核壳微球结构的麦芽酚磁性分子印迹固相萃取材料的制备方法及其应用
CN109601822B (zh) * 2019-01-22 2022-11-08 北京三强核力辐射工程技术有限公司 一种生物碱协同辐照降解动物源性食品中抗生素的方法
CN110646557A (zh) * 2019-10-12 2020-01-03 北京航空航天大学 携带idh基因突变的胶质母细胞瘤患者的尿液代谢标志物及其用途
EP4267187A1 (en) * 2020-12-22 2023-11-01 Intervet International B.V. Conjugated zearalenone to protect against mycotoxicosis
CN114685607B (zh) * 2020-12-28 2025-02-28 深圳翰宇药业股份有限公司 一种依替巴肽杂质i的制备方法
WO2022183300A1 (en) * 2021-03-04 2022-09-09 Memorial University Of Newfoundland Porous sorptive solid phase microextraction devices and preparation thereof
CN113234188B (zh) * 2021-04-02 2022-02-15 华南理工大学 一种分子印迹光子晶体及其制备方法和应用
WO2022243683A1 (en) 2021-05-21 2022-11-24 Anpario Plc Composition for use in the treatment and/or prevention of mycotoxic disease
CN113929842B (zh) * 2021-11-17 2024-02-09 浙江省农业科学院 一种白僵菌素的磁性分子印迹材料及其应用
CN115901413B (zh) * 2022-12-23 2023-07-11 吉林省农业科学院 一种土壤颗粒有机碳测试前处理装置
CN116284960B (zh) * 2023-03-08 2024-12-24 北京市农林科学院 一种伏马菌素分子印迹聚合物的制备方法和应用
CN116870884B (zh) * 2023-07-26 2025-06-17 宁夏大学 一种l-赖氨酸衍生的凝胶因子混合模式色谱固定相及其制备方法和应用
CN120059297A (zh) * 2025-04-28 2025-05-30 广西产研院新型功能材料研究所有限公司 一种橡胶用交联剂及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030007982A1 (en) * 2001-04-27 2003-01-09 Peter Surai Novel method for improving antioxidant status of animals consuming feeds contaminated with mycotoxins
JP2003304812A (ja) * 2002-04-12 2003-10-28 Mitsubishi Rayon Co Ltd 脱プリンアルカロイド機能付き飲料供給器
WO2003101580A1 (en) * 2002-05-31 2003-12-11 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Solid mycoctoxin carriers
WO2007096135A1 (de) * 2006-02-20 2007-08-30 Kist-Europe Forschungsgesellschaft Mbh Molekular geprägtes polymer, verfahren zu seiner herstellung und verfahren zur selektiven behandlung von schwer abbaubaren und/oder toxischen verbindungen in flüssigkeiten
CN101308066A (zh) * 2008-06-12 2008-11-19 济南大学 痕量真菌毒素分子印迹柱制备方法及应用
CN201184874Y (zh) * 2008-05-07 2009-01-21 济南大学 用于真菌毒素检测的分子印迹膜电极

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5413496B2 (enExample) 1972-10-17 1979-05-31
US4015018A (en) 1975-11-06 1977-03-29 Food Technology Products Silage process and product
US4055667A (en) 1975-12-03 1977-10-25 Ogilvie Mills Ltd. Animal feeds
FR2380986A1 (fr) 1977-02-16 1978-09-15 Rhone Poulenc Ind Nouveau procede de stabilisation du metasilicate de sodium anhydre et produit ainsi obtenu
US4251519A (en) 1979-07-30 1981-02-17 Anheuser-Busch, Incorporated Process for the prevention and reduction of elevated blood cholesterol and triglycerides levels
FR2530647A1 (fr) 1982-07-20 1984-01-27 Rhone Poulenc Spec Chim Procede de preparation de flocons de polymeres acryliques hydrosolubles
US4765992A (en) 1984-06-01 1988-08-23 Universite De Bordeaux Ii Stimulation of alcoholic fermentation by adsorption of toxic substances with cell walls
CA1320718C (en) 1987-06-08 1993-07-27 Richard Frederick Hammen Chromatographic material
US4880632A (en) 1987-09-08 1989-11-14 The United States Of America Prevention of fescue toxicosis
US4929452A (en) 1987-09-30 1990-05-29 University Of Georgia Research Foundation, Inc. Method for rapidly fermenting alcoholic beverages
US4847243A (en) 1987-10-08 1989-07-11 Merck & Co., Inc. Treatment for fescue toxicosis in grazing animals
JPH02129169A (ja) * 1988-11-08 1990-05-17 Ube Ind Ltd キノリン化合物およびその医薬用途
US5165946A (en) 1990-03-07 1992-11-24 Engelhard Corporation Animal feed additive and method for inactivating mycotoxins present in animal feeds
US5192547A (en) 1990-10-01 1993-03-09 Engelhard Corporation Animal feed containing selected montmorillonite clay as additive and method for selecting the clay
US5149549A (en) 1990-11-21 1992-09-22 American Colloid Company Method and composition for achieving animal weight gain with mycotoxin-contaminated animal food
DE4130475A1 (de) 1991-09-13 1993-03-18 Merck Patent Gmbh Modifizierte chromatographische traegermaterialien
BR9405664A (pt) 1993-01-21 1996-04-30 Univ Georgia Composto imunogenio processos para evitar a toxicose por festuca em um herbivoro para tratar a toxicose por festuca em um herbivoro anticorpo purificado lingagem de célula de hidridoma e anticorpo
US5372818A (en) 1993-02-01 1994-12-13 Clemson University Method of treating fescue toxicosis with domperidone
JPH07274947A (ja) 1994-04-08 1995-10-24 Ebara Res Co Ltd 飼料化酵母の製造方法
US5639492A (en) 1995-01-13 1997-06-17 Amcol International Corporation Method and composition for achieving animal weight gain with mycotoxin-contaminated animal food
US5922373A (en) 1997-05-05 1999-07-13 The Ohio State University Process for preparing a soy protein feed with enhanced nutritional value
US5935623A (en) 1998-01-15 1999-08-10 Milwhite, Inc. Use of thermally treated clays in animal feeds
ATE355751T1 (de) 1998-04-17 2007-03-15 Alltech Inc Zusammensetzungen zur entfernung von mykotoxinen aus futtermitteln
MXPA01000016A (es) 1999-05-03 2002-10-17 Alltech Inc Composiciones novedosas y metodos para la reduccion de los efectos de forrajes infectados con endofitos.
US6660176B2 (en) * 2001-01-24 2003-12-09 Virginia Commonwealth University Molecular imprinting of small particles, and production of small particles from solid state reactants
JP2004250329A (ja) * 2002-12-26 2004-09-09 Dainippon Pharmaceut Co Ltd イサチン誘導体
US7041762B2 (en) * 2003-03-31 2006-05-09 Council Of Scientific And Industrial Research Polyvalent imprinted polymer and process of preparation thereof
RU2356621C2 (ru) * 2006-06-28 2009-05-27 Оао "Мапо-Фонд" Способ получения настраиваемых сорбентов на основе полимеров с молекулярными отпечатками
JP5007905B2 (ja) * 2007-08-29 2012-08-22 公立大学法人大阪府立大学 分子鋳型を有するポリマーを備えたセンサー
CN101216464B (zh) * 2007-12-29 2010-10-20 中国农业大学 一种检测孔雀石绿的分子印迹聚合物微球
CN101507916B (zh) * 2009-02-16 2011-01-19 西北工业大学 大环内酯类抗生素分子印迹聚合物微球的制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030007982A1 (en) * 2001-04-27 2003-01-09 Peter Surai Novel method for improving antioxidant status of animals consuming feeds contaminated with mycotoxins
JP2003304812A (ja) * 2002-04-12 2003-10-28 Mitsubishi Rayon Co Ltd 脱プリンアルカロイド機能付き飲料供給器
WO2003101580A1 (en) * 2002-05-31 2003-12-11 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Solid mycoctoxin carriers
WO2007096135A1 (de) * 2006-02-20 2007-08-30 Kist-Europe Forschungsgesellschaft Mbh Molekular geprägtes polymer, verfahren zu seiner herstellung und verfahren zur selektiven behandlung von schwer abbaubaren und/oder toxischen verbindungen in flüssigkeiten
CN201184874Y (zh) * 2008-05-07 2009-01-21 济南大学 用于真菌毒素检测的分子印迹膜电极
CN101308066A (zh) * 2008-06-12 2008-11-19 济南大学 痕量真菌毒素分子印迹柱制备方法及应用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Journal of Chromatography B;Karsten Haupt;《Analyst》;20010525;第126卷;第747-756页 *
Molecular imprinted polymers as synthetic receptors for the analysis of myco- and phyco-toxins;Claudio Baggiani等;《Analyst》;20080220;第133卷;第719-730页 *
Molecularly imprinted polymer-assisted sample clean-up ofochratoxin A from red wine: merits and limitations;Norbert M. Maier等;《Journal of Chromatography B》;20040505;第804卷(第1期);第103-111页 *
Solid phase extraction of food contaminants using molecular imprinted polymers;Claudio Baggiani等;《Analytica Chimica Acta》;20070515;第591卷(第1期);第29-399页 *
Synthesis of some new 5-chloro- and 3,5-dichlorosalicylamino acid,ester amide, hydrazide and tripeptide derivatives with expected biological activities;Ragab A El-Sayed等;《Proc.Indian natn.Sci. Acad.》;19971231;第63卷(第3期);第259-268页 *
Towards ochratoxin A selective molecularly imprinted polymers for solid-phase extraction;Justus Jodlbauer等;《Journal of Chromatography A》;20020201;第945卷(第1-2期);第45-63页 *
分子印迹固相萃取技术在食品有害物质分析中的应用;吕瑞鹤等;《四川化工》;20100228;第13卷(第1期);第22-25页 *

Also Published As

Publication number Publication date
EA024530B9 (ru) 2017-02-28
MX2012002494A (es) 2012-03-26
MY153040A (en) 2014-12-31
CL2012000494A1 (es) 2012-09-07
EP2470894A1 (en) 2012-07-04
EP2470894A4 (en) 2013-02-13
WO2011031562A1 (en) 2011-03-17
EA201490727A1 (ru) 2014-08-29
NZ598160A (en) 2014-04-30
ZA201200973B (en) 2013-05-29
KR20140019486A (ko) 2014-02-14
USRE45274E1 (en) 2014-12-02
MY171129A (en) 2019-09-26
IN2012DN01219A (enExample) 2015-04-10
BR112012004316A2 (pt) 2016-03-15
UA105228C2 (ru) 2014-04-25
CN102549424A (zh) 2012-07-04
BR112012004316B1 (pt) 2022-05-03
CN105218393A (zh) 2016-01-06
AU2010292495A1 (en) 2012-03-08
JP2013503251A (ja) 2013-01-31
JP5650223B2 (ja) 2015-01-07
CN104190378B (zh) 2017-06-09
KR101406960B1 (ko) 2014-06-13
EA028279B1 (ru) 2017-10-31
PE20120862A1 (es) 2012-07-23
CN104190378A (zh) 2014-12-10
CA2770343A1 (en) 2011-03-17
EA201290061A1 (ru) 2012-11-30
US20120214897A1 (en) 2012-08-23
MA33597B1 (fr) 2012-09-01
NZ620131A (en) 2015-01-30
CA2770343C (en) 2015-03-31
KR20120041763A (ko) 2012-05-02
AU2010292495B2 (en) 2013-11-21
KR101556591B1 (ko) 2015-10-01
PE20161381A1 (es) 2016-12-28
CO6440520A2 (es) 2012-05-15
EA024530B1 (ru) 2016-09-30
US8153737B2 (en) 2012-04-10
US8426541B2 (en) 2013-04-23
US20110054132A1 (en) 2011-03-03
CN105218393B (zh) 2017-10-24
EP2470894B1 (en) 2021-12-29

Similar Documents

Publication Publication Date Title
CN102549424B (zh) 合成真菌毒素吸附剂以及制备和使用所述合成真菌毒素吸附剂的方法
Wang et al. Metal–organic frameworks for food safety
US10472484B2 (en) Aflatoxin templates, molecularly imprinted polymers, and methods of making and using the same
Quesada et al. Caffeine removal by chitosan/activated carbon composite beads: Adsorption in tap water and synthetic hospital wastewater
CN105148558B (zh) 一种净化真菌毒素的固相萃取柱及其应用
Lin et al. Recent advances in porous organic frameworks for sample pretreatment of pesticide and veterinary drug residues: a review
Feng et al. Facile pathway to construct mesoporous silica nanoparticles loaded with pyraclostrobin: Physicochemical properties, antifungal activity, and biosafety
Thirugnanasambandan et al. Nanomaterials in food industry for the protection from mycotoxins: an update
AU2014200349B2 (en) Synthetic mycotoxin adsorbents and methods of making and utilizing the same
JP2016141665A (ja) アフラトキシン鋳型、分子インプリントポリマー、ならびにその作製法および使用法
RU2705210C2 (ru) Шаблоны афлатоксина, полимеры с молекулярными отпечатками и способы их получения и применения
CA2880969C (en) Aflatoxin templates, molecularly imprinted polymers, and methods of making and using the same
Barabas et al. Crospovidone
CN101822331A (zh) 去除伏马菌素的方法
CN101139411A (zh) 可去除鲜奶中青霉素类抗生素的分子印记聚合物的制备方法
Díaz Bao Design and application of molecularly imprinted polymers (MIPs) for detection of veterinary residues and contaminants in food safety
CN109354649A (zh) 一种醚菌酯类分子印迹聚合物的制备方法及其应用
CN113713025A (zh) 一种预防阿尔茨海默症的颗粒冲剂及其制备

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant