CN102488694B - Perfusion medicament for treating milk cow mastitis and preparation method thereof - Google Patents
Perfusion medicament for treating milk cow mastitis and preparation method thereof Download PDFInfo
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- CN102488694B CN102488694B CN 201110432684 CN201110432684A CN102488694B CN 102488694 B CN102488694 B CN 102488694B CN 201110432684 CN201110432684 CN 201110432684 CN 201110432684 A CN201110432684 A CN 201110432684A CN 102488694 B CN102488694 B CN 102488694B
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Abstract
The invention discloses a perfusion medicament for treating milk cow mastitis and a preparation method thereof. The perfusion medicament is prepared from the following raw materials by weight: 0.9-4.3g of cefquinome sulphate, 0.15-0.25g of prednisolone, 0.5-1.3g of flunixin meglumine, 1-1.5g of glycerin monostearate, 3-8g of Vaseline, 0.05g of ethylparaben and 65-70g of whiteruss. The preparation method comprises the following specific steps of: (1) putting one tenth of the liquid paraffin into a burdening tank in a certain weight ratio; (2) adding one third of the liquid paraffin into a heating tank; and (3) putting the rest of the liquid paraffin left after the steps (1) and (2) and auxiliary materials in the step (2) into an emulsifying tank, adding 0.9-4.3g of cefquinome sulfate in a certain weight ratio, and stirring till uniform distribution to obtain the perfusion medicament for treating milk cow mastitis. The perfusion medicament has the advantages of no induction of endotoxemia in a milk cow mastitis treating process, remarkable curative effect on mastitis and freeness from medicament tolerance.
Description
Technical field
The present invention relates to veterinary drug, is a kind of dabbling drug of treating mammitis of cow and preparation method thereof.
Background technology
The inflammation of cow breast is a kind of common and multiple disease; This area is generally used single anti-inflammation drugs treatment for many years, but because the single anti-inflammation drugs treatment of long-term employing does not have the effect of treating both the principal and secondary aspects of a disease, and be prone to produce drug resistance; Influence therapeutic effect; Therefore, those skilled in the art provide the medicine of compound filling, though this compound medicine has some advantage; But; It still can't be treated cow breast and in inflammatory process, use the endotoxemia that produces behind the antibiotic therapy, and this endotoxemia is since in the blood antibacterial or intralesional antibacterial discharge a large amount of endotoxins to blood, cause milch cow in the process of treating mastitis, to be prone to bring out this disease and acute death.This endotoxemia does not still have medicine can avoid taking place at present.
Summary of the invention
The objective of the invention is; A kind of dabbling drug of treating mammitis of cow and preparation method thereof is provided, and it does not bring out endotoxemia in treatment mammitis of cow process, and treatment mastitis effect is remarkable; Have no drug resistance, and the symptom of suffering from endotoxemia is had therapeutical effect preferably.
The present invention is for realizing above-mentioned purpose; Realize through following technical scheme: a kind of dabbling drug of treating mammitis of cow, process by the raw material of following weight ratio: Cefquinome sulfate 0.9-4.3g, prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 65-70g.
A kind of dabbling drug of treating mammitis of cow of the present invention is processed by the raw material of following weight ratio: Cefquinome sulfate 2.6g, prednisolone 0. 2g, flunixin meglumine 0.9g, glyceryl monostearate 1.25g, vaseline 5.5g, ethyl hydroxybenzoate 0.05g, liquid paraffin 67.50g.
A kind of dabbling drug of treating mammitis of cow of the present invention is processed by the raw material of following weight ratio: Cefquinome sulfate 4.3g, prednisolone 0.25g, flunixin meglumine 1.3g, glyceryl monostearate 1.5g, vaseline 8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 70g.
A kind of method for preparing of treating the dabbling drug of mammitis of cow of the present invention, concrete steps are following:
1. insert in the material-compound tank by weight 1/10 amount of getting liquid paraffin 65-70g, by weight adding prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, with ultrasonic echography 38-42 minute to even particle distribution;
2. 1/3 amount with liquid paraffin 65-70g adds in the heating tank, be warming up to 80 ℃ after, successively by weight adding glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g, be stirred to dissolving fully;
3. surplus and the step adjuvant 2. of the liquid paraffin 65-70g after 1. step being used in 2. with step are inserted in the emulsion tank; Abundant mixing; Be cooled to after 30 ℃ and again step mixed material 1. inserted in the emulsion tank, be stirred to be uniformly dispersed after, by weight adding Cefquinome sulfate 0.9-4.3g; Be stirred to then and be evenly distributed the dabbling drug of the mammitis of cow that obtains medical treatment.
The dabbling drug of treatment mammitis of cow of the present invention, has a broad antifungal spectrum is to high, high, the instant effect of cure rate of effective percentage of pathogenic bacterium.The deficiency that has been prone to bring out the milch cow endotoxemia when having solved independent use quinoline oxime; When having solved independent use prednisolone or flunixin meglumine, only play amelioration of inflammation, heating, pain, but mastitis is not had the deficiency of obvious therapeutic effect; Medicine of the present invention is killing pathogenic bacteria directly, and is difficult for bringing out endotoxemia, and flunixin meglumine also can strengthen the antibacterial activity of quinoline oxime, makes it can kill pathogenic bacterium faster.Medicine of the present invention can also play the effect of treating both the principal and secondary aspects of a disease, can fundamentally treat mastitis, and treatment more rate reaches about 90%.
The dabbling drug of treatment mammitis of cow of the present invention, remarkable through the statistics display effect after on probation:
Criterion of cure:
The mammitis of cow therapeutic effect adopts the outward appearance of cattle to observe and two kinds of methods of milk somatic cell (SCC) detection are carried out simultaneously, and wherein the outward appearance of cattle is viewed as the produce effects standard, and emulsion somatic cell (SCC) is for curing judgment criteria:
1, outward appearance is observed---the produce effects standard:
After the healing, sick cattle spirit appetite recovers normal, the lactation amount rebound significantly; Symptoms such as medication breast district is red, swollen, hot, pain are eliminated; It is normal that the milk character is recovered, no flocculus, grumeleuse, the blood streak.
2, emulsion somatic cell (SCC) detects---cure judgment criteria:
The treatment standard: last administration was gathered milk appearance and is measured somatic number (SCC) after 7 days.According to somatic number what, judge whether to cure.
Detection method: squeeze out first three milk during sampling earlier, squeeze subsequently and get about 30ml as detecting milk kind (50ml sterilize cuvette cartridge).SCC detects and adopts integrated milk analysis appearance (MSC5000) to carry out.Comprehensive coherence check result, press following standard determination curative effect of medication:
Cure: sick cattle spirit appetite recovers normal, the lactation amount rebound significantly; Symptoms such as medication breast district is red, swollen, hot, pain are eliminated; It is normal that the milk character is recovered, milk SCC (somatic number)＜500,000/ml; Main pathogen is eliminated.
Cure rate=(curing breast district number/group innerlich anwenden breast district number in the group) * 100%
Effectively: sick cattle spirit appetite recovers normal, and lactation amount has rise; Symptoms such as medication breast district red and swollen heat pain are clearly better; The unusual character of milk has recovery, and milk SCC is between 50 ~ 1,000,000/ml; Main pathogen is eliminated.
Effective percentage=(effectively newborn district number in the group/group innerlich anwenden breast district number) * 100%.
Periphery one cattle farm, Huhehaote City, the Inner Mongol has 1349 livestock on hand milch cows, wherein suffers from mastitis for 187, and wherein 78 is slight mastitis, and clinical symptoms is that breast is slightly red, swollen, and lactation amount reduces, and appetite descends; 55 is the moderate mastitis, and clinical symptoms is that the breast moderate is red, swollen, and the palpation breast has heat, pain reaction, and lactation amount reduces, and milk has a small amount of flocculus, grumeleuse, and look cold and detached, searches for food seldom; 54 is the severe mastitis, and clinical symptoms is stupor, and appetite is useless cuts off, and breast is red, swollen serious, breast palpation heat, pain strong reaction, and lactation amount seriously descends even the dry up, and color floccule, extract, obvious abnormal flavour are arranged in the milk.
In addition, 30 healthy milk cow in lactation period of picked at random after morning, 7:00 milked for the first time, are chosen any side breast district, and perfusion contains the normal saline 15ml of 100 μ g escherichia coli endotoxins; The inoculation endotoxin is after 3 hours, and wherein 15 cow head body temperature begin obvious rising, and other 5 cow head fervescence are not obvious.Inoculate back 8 hours; Tangible inflammatory reaction all appears in the endotoxic breast of all milch cow inoculations district, shows clinical acute mastitis symptom, and judge according to clinical symptoms: wherein 7 is slight clinical mastitis; 13 is the clinical mastitis of moderate, and 10 is the clinical mastitis of severe.
To sum up have 85 slight mastitis case (78 spontaneous cases; 7 endotoxin mastitis cases), 68 moderate mastitis cases (55 spontaneous cases, 13 endotoxin mastitis cases); 64 nose heaviness mastitis cases (54 spontaneous cases, 10 endotoxin mastitis cases).
All ill milch cows were administered once in per 12 hours, and the treatment data show: slight and moderate mastitis case after administration 1 time, the feed intake rising; The administration of endotoxin mastitis case after 4 hours temperature recovery normal; Behind successive administration 2 times, the mastitis clinical symptom disappearance, it is normal that lactation amount recovers.53 cases are arranged in the severe mastitis case, and behind successive administration 3 times, clinical symptom disappearance, fertility performance recover normal; Remain 11 nose heaviness cases, clinical symptoms is clearly better after administration 3 times, and the breast redness weakens, and the color floccule disappears in the milk, and behind the free from extraneous odour, successive administration 5 to 6 times, clinical symptoms all disappears, and it is normal that lactation amount recovers; Wherein said 10 nose heaviness endotoxin mastitiss are after continuous the 2nd administration, and temperature recovery is normal, and the mental status is clearly better.Test data shows; Behind the sulfated compound cefquinome breast injection successive administration 3 times; Gently, the cure rate of moderate mastitis reached 100%, the cure rate 75.0% of severe mastitis, comprehensive cure rate has reached 92.6%; Three kinds of ingredient couplings not only have better curative effect to the mastitis that common clinical pathogenic bacteria causes, and the mastitis that endotoxin causes is also had good curative effect.
The consumption of Cefquinome sulfate of the present invention is in cefquinome.
The specific embodiment
A kind of dabbling drug of treating mammitis of cow of the present invention and preparation method thereof is processed by the raw material of following weight ratio: Cefquinome sulfate 0.9-4.3g, prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 65-70g.
A kind of dabbling drug of treating mammitis of cow of the present invention, its raw material can have multiple compound mode:
1, Cefquinome sulfate 2.6g, prednisolone 0. 2g, flunixin meglumine 0.9g, glyceryl monostearate 1.25g, vaseline 5.5g, ethyl hydroxybenzoate 0.05g, liquid paraffin 67.5g.
2, Cefquinome sulfate 4.3g, prednisolone 0.25g, flunixin meglumine 1.3g, glyceryl monostearate 1.5g, vaseline 8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 70g.
3, Cefquinome sulfate 0.9g, prednisolone 0. 22g, flunixin meglumine 1.2g, glyceryl monostearate 1g, vaseline 4g, ethyl hydroxybenzoate 0.05g, liquid paraffin 66g.
4, Cefquinome sulfate 3.5g, prednisolone 0.15g, flunixin meglumine 0.5g, glyceryl monostearate 1.1g, vaseline 3.5g, ethyl hydroxybenzoate 0.05g, liquid paraffin 65g.
5, Cefquinome sulfate 2.9g, prednisolone 0.19g, flunixin meglumine 1g, glyceryl monostearate 1.2g, vaseline 3g, ethyl hydroxybenzoate 0.05g, liquid paraffin 67g.
The various embodiment of the dabbling drug of the above-mentioned treatment mammitis of cow of the present invention all make as follows, and concrete steps are following:
1. insert in the material-compound tank by weight 1/10 amount of getting liquid paraffin 65-70g, by weight adding prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, with ultrasonic echography 38-42 minute to even particle distribution;
2. 1/3 amount with liquid paraffin 65-70g adds in the heating tank, be warming up to 80 ℃ after, successively by weight adding glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g, be stirred to dissolving fully;
3. surplus and the step adjuvant 2. of the liquid paraffin 65-70g after 1. step being used in 2. with step are inserted in the emulsion tank; Abundant mixing; Be cooled to after 30 ℃ and again step mixed material 1. inserted in the emulsion tank, be stirred to be uniformly dispersed after, by weight adding Cefquinome sulfate 0.9-4.3g; Be stirred to then and be evenly distributed the dabbling drug of the mammitis of cow that obtains medical treatment.
Be example with embodiment 1 for example, concrete method for preparing is following:
1. get 1/10 amount of liquid paraffin 67.5g and insert in the material-compound tank, add prednisolone 0.2g, flunixin meglumine 0.9g, with ultrasonic echography 40 minutes to even particle distribution;
2. 1/3 amount with liquid paraffin 67.5g adds in the heating tank, be warming up to 80 ℃ after, add glyceryl monostearate 1.25g, vaseline 5.5g, ethyl hydroxybenzoate 0.05g successively, be stirred to dissolving fully;
3. surplus and the step adjuvant 2. of the liquid paraffin 67.5g after 1. step being used in 2. with step are inserted in the emulsion tank; Abundant mixing; Be cooled to after 30 ℃ and again step mixed material 2. inserted in the emulsion tank, be stirred to be uniformly dispersed after, add Cefquinome sulfate 2.6g; Be stirred to then and be evenly distributed the dabbling drug of the mammitis of cow that obtains medical treatment.
Claims (4)
1. a dabbling drug of treating mammitis of cow is characterized in that: processed by following raw materials according: Cefquinome sulfate 0.9-4.3g, prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 65-70g.
2. a kind of dabbling drug of treating mammitis of cow according to claim 1 is characterized in that: processed by following raw materials according: Cefquinome sulfate 2.6g, prednisolone 0. 2g, flunixin meglumine 0.9g, glyceryl monostearate 1.25g, vaseline 5.5g, ethyl hydroxybenzoate 0.05g, liquid paraffin 67.50g.
3. a kind of dabbling drug of treating mammitis of cow according to claim 1 is characterized in that: processed by following raw materials according: Cefquinome sulfate 4.3g, prednisolone 0.25g, flunixin meglumine 1.3g, glyceryl monostearate 1.5g, vaseline 8g, ethyl hydroxybenzoate 0.05g, liquid paraffin 70g.
4. a kind of method for preparing of treating the dabbling drug of mammitis of cow according to claim 1, it is characterized in that: concrete steps are following:
1. get 1/10 amount of liquid paraffin 65-70g and insert in the material-compound tank, add prednisolone 0.15-0.25g, flunixin meglumine 0.5-1.3g, with ultrasonic echography 38-42 minute to even particle distribution;
2. 1/3 amount with liquid paraffin 65-70g adds in the heating tank, be warming up to 80 ℃ after, add glyceryl monostearate 1-1.5g, vaseline 3-8g, ethyl hydroxybenzoate 0.05g successively, be stirred to dissolving fully;
3. surplus and the step adjuvant 2. of the liquid paraffin 65-70g after 1. step being used in 2. with step are inserted in the emulsion tank; Abundant mixing; Be cooled to after 30 ℃ and again step mixed material 1. inserted in the emulsion tank, be stirred to be uniformly dispersed after, add Cefquinome sulfate 0.9-4.3g; Be stirred to then and be evenly distributed the dabbling drug of the mammitis of cow that obtains medical treatment.
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| CN 201110432684 CN102488694B (en) | 2011-12-21 | 2011-12-21 | Perfusion medicament for treating milk cow mastitis and preparation method thereof |
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| CN 201110432684 CN102488694B (en) | 2011-12-21 | 2011-12-21 | Perfusion medicament for treating milk cow mastitis and preparation method thereof |
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| CN104546704B (en) * | 2013-12-10 | 2017-04-05 | 中国农业科学院饲料研究所 | A kind of milk cow dry breast phase Ceftiofur Hydrochloride breast injection and preparation method thereof |
| CN104546703B (en) * | 2013-12-10 | 2017-06-23 | 中国农业科学院饲料研究所 | A kind of Lactation of Dairy Cow phase is with Cefquinome sulfate breast injection and preparation method thereof |
| CN104721206A (en) * | 2013-12-19 | 2015-06-24 | 金华施比龙生物科技有限公司 | Preparation method for Chinese and western composite veterinary drug for treating swine endotoxemia |
| CN104042619B (en) * | 2014-01-24 | 2017-07-11 | 临沂大学 | A kind of Ceftiofur Hydrochloride cream and preparation method thereof |
| CN104873462B (en) * | 2014-11-18 | 2017-04-05 | 中国农业科学院饲料研究所 | A kind of milch cow dry breast phase Cefquinome sulfate breast injection and preparation method thereof |
| CN104840420B (en) * | 2014-11-18 | 2017-04-05 | 中国农业科学院饲料研究所 | It is a kind of to be used for Lactation of Dairy Cow phase metritic Cefquinome sulfate uterus injectant and preparation method thereof |
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| CN101579347A (en) * | 2009-06-25 | 2009-11-18 | 中国农业大学 | Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101579347A (en) * | 2009-06-25 | 2009-11-18 | 中国农业大学 | Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof |
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