CN103110794B - Traditional Chinese medicine composition for treating laminitis in dairy cows and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating laminitis in dairy cows and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention relates to a traditional Chinese medicine composition for treating laminitis in dairy cows and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 20-25 parts of rhizoma coptidis, 15-20 parts of rhizoma dioscoeae bulbiferae, 15-25 parts of herba andrographitis, 10-18 parts of fosythia fruits, 10-15 parts of red flowers, 10-15 parts of platycodon grandiflorus, 15-20 parts of garlic and 15-25 parts of hawthorns. The traditional Chinese medicine composition disclosed by the invention is mainly used for treating laminitis in dairy cows; and the traditional Chinese medicine composition has no drug residues, and is easy to use.
Description
Technical field
The invention belongs to field of veterinary, especially a kind ofly treat Chinese medicine composition of milch cow laminitis and preparation method thereof.
Background technology
In the feeding process of milch cow, feed Hi CHO feedstuff and Long-term Feeding high-protein feed owing to changing, cause digestibility disorderly, cause causing laminitis.The harm of milch cow laminitis is very large, can cause declines of loss of appetite, lactation amount, tremble in perspirations, muscular tremor, coronet portion, pain when playing wall percussion, does not even rise sleepingly, finally cause milch cow death, bring economic loss to raiser time serious.
Nowadays most of raiser uses the method for for oral administration or injection such as antibiotic, hormone, chemical drugs to treat milch cow laminitis, although instant effect, but the above-mentioned medicine of a large amount of use, can produce the harm such as toxic and side effects, anaphylaxis, superinfection, drug resistance.Cause a large amount of antibacterial to produce drug resistance after a large amount of use antibiotic, become Resistant strain.Use the milch cow of antibiotic etc, its side-product milk drug residue is comparatively serious, affects milk quality, threatens human health.
Part raiser adopts external used medicine to clean hoof leaf, although directly and focal contact, can use complicated, can not effect a radical cure, and due to problems such as technology are not smart in cleaning process, causes focus to expand, reduction cure rate.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of milch cow laminitis, the medicine in this Chinese medicine composition has the effect of heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation and stopping pain, invigorating the stomach and promoting digestion, and drug residue can not occur, easy to use.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of milch cow laminitis.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for milch cow laminitis, component and the ratio of weight and number thereof of its Chinese medicine composition are respectively:
Rhizoma Coptidis 20-25 part;
Rhizoma Dioscoreae Bulbiferae 15-20 part;
Herba Andrographis 15-25 part;
Fructus Forsythiae 10-18 part;
Flos Carthami 10-15 part;
Radix Platycodonis 10-15 part;
Bulbus Allii 15-20 part;
Fructus Crataegi 15-25 part.
And component and the optimum ratio of weight and number thereof of this Chinese medicine composition are respectively:
Rhizoma Coptidis 23 parts;
Rhizoma Dioscoreae Bulbiferae 18 parts;
Herba Andrographis 20 parts;
Fructus Forsythiae 15 parts;
13 parts, Flos Carthami;
Radix Platycodonis 12 parts;
18 parts, Bulbus Allii;
Fructus Crataegi 20 parts.
Treat a preparation method for the Chinese medicine composition of milch cow laminitis, its step is as follows:
(1) take Rhizoma Coptidis by weight ratio respectively, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi pulverize, and all by 80 mesh sieves;
(2) Rhizoma Coptidis after sieving, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi are put into abundant mix homogeneously in three-dimensional hybrid tank, the Chinese medicine composition finished product of the milch cow laminitis that namely obtains medical treatment.
Advantage of the present invention and beneficial effect are:
Rhizoma Coptidis in the Chinese medicine composition of 1, this treatment milch cow laminitis, the equal property of Fructus Forsythiae are bitter, cold, and having the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, pathogenic fire purging dampness, is the principal agent of we.Rhizoma Dioscoreae Bulbiferae, Herba Andrographis have effect of heat-clearing and toxic substances removing, removing heat from blood, reducing swelling and alleviating pain, are the accessory drugss of Rhizoma Coptidis, Fructus Forsythiae, can strengthen effect of principal agent.Flos Carthami, Radix Platycodonis have the effect such as blood circulation promoting and blood stasis dispelling, pain relieving evacuation of pus, and all pungent temperature of property, mutually restrict and the effect of potentiation with playing the property of medicine with above-mentioned principal agent, accessory drugs.Bulbus Allii can be regulated the flow of vital energy appetizing, detoxicating, killing bacteria, increases milch cow self-resistance, can increase appetite by the sense of taste, increases feed intake.Fructus Crataegi can promoting digestion and removing stagnation, increase appetite, milk production of cow is increased.
2, the present invention has the effect of heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation and stopping pain, invigorating the stomach and promoting digestion, and drug residue can not occur, easy to use.
3, broad-spectrum high efficacy of the present invention, to gastric acid quite stable, absorption for oral administration is good, can reach blood peak concentration of drug, reach therapeutic effect after oral within the extremely low short time.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
What Rhizoma Coptidis involved in the present invention, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi commercially all can be bought arrives.
Embodiment 1
Treat a Chinese medicine composition for milch cow laminitis, component and the weight thereof of its Chinese medicine composition are respectively: Rhizoma Coptidis 20g, Rhizoma Dioscoreae Bulbiferae 15g, Herba Andrographis 15g, Fructus Forsythiae 10g, Flos Carthami 10g, Radix Platycodonis 10g, Bulbus Allii 15g, Fructus Crataegi 15g.
Treat a preparation method for the Chinese medicine composition of milch cow laminitis, the step of preparation method is as follows:
(1) take Rhizoma Coptidis by weight ratio respectively, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi pulverize, and all by 80 mesh sieves;
(2) Rhizoma Coptidis after sieving, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi are put into abundant mix homogeneously in three-dimensional hybrid tank, the Chinese medicine composition finished product of the milch cow laminitis that namely obtains medical treatment.
Embodiment 2
Treat a Chinese medicine composition for milch cow laminitis, component and the weight thereof of its Chinese medicine composition are respectively: Rhizoma Coptidis 23, Rhizoma Dioscoreae Bulbiferae 18g, Herba Andrographis 20g, Fructus Forsythiae 15g, Flos Carthami 13g, Radix Platycodonis 12g, Bulbus Allii 18g, Fructus Crataegi 20g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat a Chinese medicine composition for milch cow laminitis, component and the weight thereof of its Chinese medicine composition are respectively: Rhizoma Coptidis 25g, Rhizoma Dioscoreae Bulbiferae 20g, Herba Andrographis 25g, Fructus Forsythiae 18g, Flos Carthami 15g, Radix Platycodonis 15g, Bulbus Allii 20g, Fructus Crataegi 25g.
The step of its preparation method is with embodiment 1.
The using method of Chinese medicine composition of the present invention: each 10g of milk cow in lactation period, every day three times, used in combination with feedstuff; The each 15g of non-milk cow in lactation period, every day three times, used in combination with feedstuff.
Clinical practice is tested
In order to verify the therapeutic effect of the present invention to milch cow laminitis natural cases, in August, 2012, we carried out the therapeutic test of milch cow laminitis in milk cattle cultivating base, Beichen District, Tianjin.Have 62 cow heads to occur in cultivation base gait is stiff, be reluctant to stand, lie prone can not crouch, appetite and milk production declines, hoof wall temperature raises, plays the symptoms such as footing toe is hemorrhage, be diagnosed as milch cow laminitis.In test, Chinese medicine composition of the present invention will contrast its therapeutic effect with other treatment medicine, thus judge that Chinese medicine composition of the present invention is best to the therapeutic effect of milch cow laminitis.
1 materials and methods
1.1 experimental animal
Select above-mentionedly to make a definite diagnosis ill milch cow 62, often organize 31, be designated as test group of the present invention and amoxicillin test group respectively.Milch cow is raised according to normal feeding and management program.
1.2 trial drug
The present invention is provided by our company, uses according to using method.
Amoxicillin soluble powder: specification; 10%, Wan Kang bio tech ltd, Jiangxi, product batch number 140661199
1.3 test method
Situation is treated at the bottom of the average daily milk yield of milch cow and milk Ungula Bovis seu Bubali during viewing test.Gather fresh blood by the method for tail vein blood, and make marks, will instill after hemodilution on special calculating dial, then under being placed in microscope, calculate quantity of leucocyte, detect the situation of change of quantity of leucocyte in cow blood.
The diagnostic criteria of 1.4 milch cow laminitis
Milch cow laminitis can not be walked by normal stand with milch cow, and the symptoms such as gait is stiff, lies prone and can not crouch, and feed intake and milk production all decrease, and hoof wall temperature raises, redness at the bottom of hoof are standard, can be diagnosed as milch cow laminitis.Carry out routine blood test test to ill milch cow, observing blood middle leukocytes quantity obviously increases.
1.5 grouping medications
Test group of the present invention uses according to operation instruction; Amoxicillin matched group uses amoxicillin soluble powder to carry out mixed feeding.Observe quantity of leucocyte, milk yield, situation of searching for food in 15d two groups of milch cow routine blood tests, play end situation, every 3d does once detailed record.
The judgement of 1.6 therapeutic effect
In cow blood, normal white cell quantity is 12 × 10
9individual/L, healthy cow average milk production every day is 35 kilograms, on average searches for food 7-9 time, and each feed intake is comparatively large, and hoof basal surface is smooth, soft, and pinkiness.
2 result of the tests
2.1 measure leukocytic par in cow blood
| Time | Test group of the present invention | Amoxicillin matched group |
| 1-3d | （20-23）×10 9Individual/L | （21-23）×10 9Individual/L |
| 4-6d | （18-20）×10 9Individual/L | （19-21）×10 9Individual/L |
| 7-9d | （15-17）×10 9Individual/L | （17-19）×10 9Individual/L |
| 10-12d | （12-14）×10 9Individual/L | （16-17）×10 9Individual/L |
| 13-15d | 12×10 9Individual/L | （14-16）×10 9Individual/L |
Above-mentioned two groups of milch cows quantity of leucocyte in test initial stage blood, apparently higher than normal value, shows that all milch cow laminitis are comparatively serious.Along with two groups of continuous medications, in blood, quantity of leucocyte is close to normal value gradually.Illustrate that the effect of test group of the present invention is better than amoxicillin matched group on treatment laminitis.
Milk yield change comparing result during 2.2 medications
| Time | Test group of the present invention | Amoxicillin matched group |
| 1-3d | 20kg | 21kg |
| 4-6d | 23kg | 24kg |
| 7-9d | 25kg | 26kg |
| 10-12d | 29kg | 27kg |
| 13-15d | 35kg | 30kg |
Can obviously be found out by above-mentioned test data, test group of the present invention improves milk yield higher than amoxicillin matched group, can produce drug residue, so the milk of matched group milch cow can not eat in this process owing to using antibiotic., can not drug residue be there is in animal body in the complete pure Chinese medicine of Chinese medicine composition of the present invention.Ensure side-product safety, the green non-pollutions such as milk.Amoxicillin matched group is behind use amoxicillin, and owing to producing drug resistance, curative effect of medication reduces gradually, and milk yield increasess slowly, and Chinese medicine composition of the present invention can not produce drug resistance, and therapeutic effect increases gradually, and milch cow appetite increases, and finally improves milk yield.
2.3 play end treatment situation
Can be found out by above comparing result, the successful at the bottom of traditional Chinese medicine composition for treating hoof of the present invention is better than amoxicillin matched group.The present invention can subside a swelling fast, reduces and plays wall temperature, can effectively improve inflammation at the bottom of hoof, and pain reduces, and the milch cow mental status makes moderate progress.Cow feeding amount increases, and then improves milk yield.
3 result of the tests
After using Chinese medicine composition of the present invention, ill milch cow can walk by normal stand, and feed intake and milk production increase all to some extent, and hoof wall temperature recovers normal.Wherein have the ill milch cow recovery from illness of 27 (87.1%), other milch cow symptom takes a turn for the better to some extent.Have 20 (64.52%) to fully recover in the matched group milch cow of amoxicillin, other milch cow symptom is alleviated to some extent, but therapeutic effect is obviously weaker than test group of the present invention.In whole therapeutic process, the heart beating of all milch cows, breathing, activity intensity, the mental status are all within normal range, none is dead, without any untoward reaction, so Chinese medicine composition of the present invention has the effect for the treatment of milch cow laminitis preferably and has no side effect.
4 conclusion (of pressure testing)s
The each 10g of milk cow in lactation period, each 15g of non-milk cow in lactation period, every day three times, used in combination with feedstuff.Continuous use 15d, treatment milch cow laminitis best results.
Claims (3)
1. treat a Chinese medicine composition for milch cow laminitis, it is characterized in that: component and the ratio of weight and number thereof of this Chinese medicine composition are respectively:
Rhizoma Coptidis 20-25 part;
Rhizoma Dioscoreae Bulbiferae 15-20 part;
Herba Andrographis 15-25 part;
Fructus Forsythiae 10-18 part;
Flos Carthami 10-15 part;
Radix Platycodonis 10-15 part;
Bulbus Allii 15-20 part;
Fructus Crataegi 15-25 part.
2. the Chinese medicine composition for the treatment of milch cow laminitis according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this Chinese medicine composition are respectively:
Rhizoma Coptidis 23 parts;
Rhizoma Dioscoreae Bulbiferae 18 parts;
Herba Andrographis 20 parts;
Fructus Forsythiae 15 parts;
13 parts, Flos Carthami;
Radix Platycodonis 12 parts;
18 parts, Bulbus Allii;
Fructus Crataegi 20 parts.
3. a preparation method for the Chinese medicine composition for the treatment of milch cow laminitis as claimed in claim 1, is characterized in that: the step of this preparation method is as follows:
(1) take Rhizoma Coptidis by weight ratio respectively, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi pulverize, and all by 80 mesh sieves;
(2) Rhizoma Coptidis after sieving, Rhizoma Dioscoreae Bulbiferae, Herba Andrographis, Fructus Forsythiae, Flos Carthami, Radix Platycodonis, Bulbus Allii, Fructus Crataegi are put into abundant mix homogeneously in three-dimensional hybrid tank, the Chinese medicine composition finished product of the milch cow laminitis that namely obtains medical treatment.
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| CN201310072256.9A CN103110794B (en) | 2013-03-07 | 2013-03-07 | Traditional Chinese medicine composition for treating laminitis in dairy cows and preparation method thereof |
| PCT/CN2013/073132 WO2014134846A1 (en) | 2013-03-07 | 2013-03-25 | Traditional chinese medicine composition for treating dairy cow laminitis and preparation method for same |
| AU2013100871A AU2013100871A4 (en) | 2013-03-07 | 2013-06-21 | Traditional chinese medicine composition for treatment of dairy cow laminitis and preparation method thereof |
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| CN104352832A (en) * | 2014-10-13 | 2015-02-18 | 天津瑞贝特科技发展有限公司 | Pharmaceutical composition for treating bovine laminitis and preparation method of pharmaceutical composition |
| CN105233183A (en) * | 2015-11-20 | 2016-01-13 | 胡洪杰 | Medicine used for treating cow laminitis and preparing method thereof |
| CN106728505A (en) * | 2016-12-05 | 2017-05-31 | 张明 | A kind of Chinese medicine composition for treating pig founder |
| CN106620224A (en) * | 2016-12-12 | 2017-05-10 | 张明 | Traditional Chinese medicinal composition for treating sheep laminitis |
| CN114681527A (en) * | 2020-12-31 | 2022-07-01 | 鼎正新兴生物技术（天津）有限公司 | External application ointment for treating bovine laminitis and preparation method thereof |
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| CN1907372A (en) * | 2006-08-09 | 2007-02-07 | 张玉柱 | Medicine for treating epidemic diseases of domestic birds and animals |
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| CN1907372A (en) * | 2006-08-09 | 2007-02-07 | 张玉柱 | Medicine for treating epidemic diseases of domestic birds and animals |
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| Title |
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| 中西结合治疗家畜料伤五攒痛;何百花;《中兽医学杂志》;20110430(第2期);第23页 * |
| 红花散治疗料伤五攒痛;陈传新等;《河南畜牧兽医》;19941231;第15卷(第4期);第34-35页 * |
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| WO2014134846A1 (en) | 2014-09-12 |
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