CN104352832A - Pharmaceutical composition for treating bovine laminitis and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating bovine laminitis and preparation method of pharmaceutical composition Download PDFInfo
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- CN104352832A CN104352832A CN201410536293.5A CN201410536293A CN104352832A CN 104352832 A CN104352832 A CN 104352832A CN 201410536293 A CN201410536293 A CN 201410536293A CN 104352832 A CN104352832 A CN 104352832A
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- 241000283690 Bos taurus Species 0.000 title claims abstract description 32
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
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- 239000000203 mixture Substances 0.000 claims abstract description 13
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- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 11
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
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- 238000000605 extraction Methods 0.000 claims description 3
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- 239000003814 drug Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 2
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
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- 239000004310 lactic acid Substances 0.000 description 1
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
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- 239000000273 veterinary drug Substances 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to pharmaceutical composition for treating bovine laminitis. The composition comprises components in parts by weight as follows: 10-40 parts of indigo naturalis, 10-40 parts of coptis chinensis, 5-20 parts of radix trichosanthis, 10-40 parts of radix rehmanniae, 5-30 parts of bamboo leaves, 5-30 parts of rhizoma alismatis, 0.5-3 parts of calcium gluconate and 0.1-2 part of vitamin C. The pharmaceutical composition has a good treatment effect, has low probability of relapse, doesn't have toxic and side effects and medicine residues and is convenient to use, the cultivation cost is saved, the operation is simplified, and the bioavailability is high.
Description
Technical field
The invention belongs to field of veterinary, especially a kind ofly treat pharmaceutical composition of cattle laminitis and preparation method thereof.
Background technology
Cattle laminitis is the important diseases of harm Cow product, is acute, the subacute and chronic dispersivity inflammation of Ungula Bovis seu Bubali corium and angle lobule.Its Clinical symptoms is hoof cutin softening, pain and limping in various degree.Once fall ill, milch cow will astasia, difficulty in walking, and sick hoof can not bear a heavy burden; Along with PD, milch cow will not rise with crouching, and feed intake obviously reduces, and milk yield also starts to decline, and even stops production; Serious in sleeping the reason such as not rise, have to eliminate.Causing huge economic loss to aquaculture, is the advanced subject of recent domestic hoof disease research.Think that the morbidity of cattle laminitis is the topical manifestations of general metabolism disorder for a long time, but tend to caused by comprehensive factor more, comprise childbirth front and back and eat too much carbohydrate concentrate to lactogenic peak time, unsuitable motion, heredity and seasonal factor all can participate in the generation of primary disease.Often hoof dermal vascular layer by the position encroached on, blood vessel injury the earliest directly acts on blood vessel wall by toxin or endotoxin to cause, or indirectly caused by allergy, observe clinically, cattle laminitis is usually caused gastrointestinal disorders owing to having eaten too much concentrate, or due to flip-flop feedstuff, a large amount of lactic acid can be produced in cud after cattle has eaten a large amount of carbohydrate concentrate, there is rumen ecology, cause laminitis, feed concentrate too much, rumen microflora can be caused to change, toxin and endotoxin is there is in blood circulation, capillary wall is under poisonous substance impact, not enough to the male character types in Chinese operas, usu. referring tov the bearded character cell plastid generation nutrition supply, cutin is synthesized obstacle occurs.At present, method many employings procaine block injection for the treatment of cattle laminitis or antihistamine drug injection, although can the quick control state of an illness and improve disease, a lot of case easily changes into chronic cases, cannot thoroughly cure.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of cattle laminitis, said composition therapeutic effect be good, not easily recur, have no side effect, drug residue free, easy to use, save aquaculture cost, simplify the operation, bioavailability is high.
Another object of the present invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of cattle laminitis.
The present invention is achieved through the following technical solutions:
Treat a pharmaceutical composition for cattle laminitis, component and the ratio of weight and number thereof of its compositions are respectively: Indigo Naturalis 10-40 part; Rhizoma Coptidis 10-40 part; Radix Trichosanthis 5-20 part; Radix Rehmanniae 10-40 part; Folium Bambusae 5-30 part; Rhizoma Alismatis 5-30 part; Calcium gluconate 0.5-3 part; Vitamin C 0.1-2 part.
And component and the optimum ratio of weight and number thereof of said composition are respectively: Indigo Naturalis 25 parts; Rhizoma Coptidis 30 parts; Radix Trichosanthis 18 parts; 20 parts, the Radix Rehmanniae; 12 parts, Folium Bambusae; Rhizoma Alismatis 16 parts; Calcium gluconate 0.7 part; Vitamin C 0.3 part.
Treat a preparation method for the pharmaceutical composition of cattle laminitis, its preparation methods steps is:
(1) take Indigo Naturalis, Rhizoma Coptidis, Radix Trichosanthis, the Radix Rehmanniae, Folium Bambusae, Rhizoma Alismatis by weight ratio respectively to add in size reduction machinery respectively and pulverize, obtain mixture A, for subsequent use;
(2) in the mixture A of step (1) gained, add the distilled water of 5-10 times amount, after soaking 1-2h, after supersound extraction 10-45min, decoct 2h, repeatedly decoct 2 times, merge decoction liquor, concentrated, obtain paste B, for subsequent use;
(3) calcium gluconate and vitamin C is taken respectively by weight ratio, get step (2) gained paste B, add the Mel of 1-2 times of weight as binding agent, abundant mixing, make moisture and be less than 15% plasticity ball bar, roll ball machine through three drum-types to process, obtain ball block, the pharmaceutical composition finished product of the cattle laminitis that namely obtains medical treatment.
Advantage of the present invention and beneficial effect are:
1, the present invention contains the 6 taste Chinese medicines such as Indigo Naturalis, Rhizoma Coptidis, Radix Trichosanthis, the Radix Rehmanniae, Folium Bambusae, Rhizoma Alismatis, pulverizes, be conducive to the raising of herbal medicine efficacy through super micron mill.By the compatibility of Chinese medicinal formulae, greatly can improve the curative effect of said composition, improve body disease-resistant power.
2, the present invention adopts multiple Chinese herbal medicine as effective Chinese medicinal ingredients.Wherein, Indigo Naturalis has heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, effect of arresting convulsion, can treat herpes simplex, dislike swollen, incised wound.Rhizoma Coptidis also can heat clearing and damp drying, eliminating fire and detoxication, soaked together with Indigo Naturalis, can treat rotten eye.Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a herb, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, and evacuation of pus is subsided a swelling.The Radix Rehmanniae has clearing away heat and cooling blood effect and to join the army blood for warm febrile disease.Folium Bambusae is the heat and toxic materials clearing away medicine that the traditional Chinese medical science is traditional simply, can treat muscular contracture (disease), malignant boil.Rhizoma Alismatis then has diuretic, eliminating dampness by diuresis, the effect expelled the heat-evil.
3, the Mel in the present invention is binding agent, can be good at the part bitterness eliminating Chinese medicine, is conducive to clinical dispensing.In addition, this pharmaceutical composition has no side effect, drug residue free, easy to use, and save aquaculture cost, simplify the operation, bioavailability is high, is a kind of pharmaceutical composition for the treatment of cattle laminitis meeting safe veterinary drug, guarantee animal-derived food safety requirements.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Treat a pharmaceutical composition for cattle laminitis, component and the weight thereof of its pharmaceutical composition are respectively: Indigo Naturalis 3kg, Rhizoma Coptidis 3kg, Radix Trichosanthis 2kg, Radix Rehmanniae 1.5kg, Folium Bambusae 1kg, Rhizoma Alismatis 1kg, calcium gluconate 0.5kg and vitamin C 0.2kg.
Treat a preparation method for the pharmaceutical composition of cattle laminitis, the step of its preparation method is as follows:
(1) take Indigo Naturalis, Rhizoma Coptidis, Radix Trichosanthis, the Radix Rehmanniae, Folium Bambusae, Rhizoma Alismatis by weight ratio respectively to add in size reduction machinery respectively and pulverize, obtain mixture A, for subsequent use;
(2) in the mixture A of step (1) gained, add the distilled water of 8 times amount, after soaking 1.5h, after supersound extraction 45min, decoct 2h, repeatedly decoct 2 times, merge decoction liquor, concentrated, obtain paste B, for subsequent use;
(3) calcium gluconate and vitamin C is taken respectively by weight ratio, get step (2) gained paste B, add the Mel of 2 times of weight as binding agent, abundant mixing, make moisture and be less than 15% plasticity ball bar, roll ball machine through three drum-types to process, obtain ball block, namely obtain the pill pharmaceutical product with treatment cattle laminitis.
Embodiment 2
Treat a pharmaceutical composition for cattle laminitis, component and the weight thereof of its pharmaceutical composition are respectively: Indigo Naturalis 2.5kg, Rhizoma Coptidis 3kg, Radix Trichosanthis 1.8kg, Radix Rehmanniae 2kg, Folium Bambusae 2kg, Rhizoma Alismatis 1.6kg, calcium gluconate 0.7kg and vitamin C 0.3kg.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat a pharmaceutical composition for cattle laminitis, component and the weight thereof of its pharmaceutical composition are respectively: Indigo Naturalis 4kg, Rhizoma Coptidis 3.5kg, Radix Trichosanthis 2.4kg, Radix Rehmanniae 1kg, Folium Bambusae 2.3kg, Rhizoma Alismatis 1.1kg, calcium gluconate 1.5kg and vitamin C 0.6kg.
The step of its preparation method is with embodiment 1.
Clinical practice is tested
In order to verify that the present invention has the pharmaceutical composition for the treatment of cattle laminitis to the therapeutic effect of cattle laminitis natural cases, we carry out therapeutic test in vaccary, Xiqing District, Tianjin.By various dose drug administration, and adopt conventional chemical medicine to carry out suiting the medicine to the illness, thus evaluate this pill at cattle laminitis therapeutic effect and optimum amount.
Materials and methods
1, experimental animal
Select the milch cow 20 of laminitis morbidity, raise according to normal feeding and management program.
2, trial drug
Pharmaceutical composition of the present invention, contrast chemical medicine is the hydrocortisone injection that market is bought.
3, test method
Each case distinguishes 4 groups at random, often organizes 5.The present invention is divided into high, medium and low three groups by dosage, and hydrocortisone matched group, specific as follows:
High dose group of the present invention: each 600g, every day 2 times.
Dosage group in the present invention: each 400g, every day 2 times.
Low dose group of the present invention: each 200g, every day 2 times.
Chemical medicine matched group: hydrocortisone injection, 0.5g/d, intravenous injection.4 days courses for the treatment of.
4, result of the test
Table 1 Experimental Comparison result of the present invention
| Group | Sample number | Dosage | Administration natural law | Cure rate |
| High dose group of the present invention | 5 | 600g*2/d | 6d | 100％ |
| Dosage group in the present invention | 5 | 400g*2/d | 6d | 100％ |
| Low dose group of the present invention | 5 | 200g*2/d | 6d | 60％ |
| Chemical medicine matched group | 5 | 0.5g/d.iv | 6d | 100％ |
5, result and conclusion
Visible by result of the test, the middle and high dosage of the present invention is suitable with hydrocortisone matched group drug effect, all reach the cure rate of 100%, but low dose group of the present invention cannot reach clinical efficacy.By clinical observation, although high dose group and chemical medicine matched group can both control milch cow laminitis, onset time is variant.Hydrocortisone is at about 4d and control PD, and the Chinese medicine preparation of high dose group is in the 6th genius onset, and visible high dose group of the present invention will be slower than chemical medicine matched group on onset time.But followed the trail of by later stage test, find that treatment group of the present invention is thoroughly worth higher, and chemical medicine treatment group relapse rate is high.Consider economic benefit, final advisory the present invention, by each 500g, every day 2 times, carries out therapeutic effect the best to laminitis in continuous 5 days.
Claims (3)
1. treat a pharmaceutical composition for cattle laminitis, it is characterized in that: component and the ratio of weight and number thereof of said composition are respectively: Indigo Naturalis 10-40 part; Rhizoma Coptidis 10-40 part; Radix Trichosanthis 5-20 part; Radix Rehmanniae 10-40 part; Folium Bambusae 5-30 part; Rhizoma Alismatis 5-30 part; Calcium gluconate 0.5-3 part; Vitamin C 0.1-2 part.
2. the pharmaceutical composition for the treatment of cattle laminitis according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of said composition are respectively: Indigo Naturalis 25 parts; Rhizoma Coptidis 30 parts; Radix Trichosanthis 18 parts; 20 parts, the Radix Rehmanniae; 12 parts, Folium Bambusae; Rhizoma Alismatis 16 parts; Calcium gluconate 0.7 part; Vitamin C 0.3 part.
3. a preparation method for the pharmaceutical composition for the treatment of cattle laminitis as claimed in claim 1, is characterized in that: this preparation method step is:
(1) take Indigo Naturalis, Rhizoma Coptidis, Radix Trichosanthis, the Radix Rehmanniae, Folium Bambusae, Rhizoma Alismatis by weight ratio respectively to add in size reduction machinery respectively and pulverize, obtain mixture A, for subsequent use;
(2) in the mixture A of step (1) gained, add the distilled water of 5-10 times amount, after soaking 1-2h, after supersound extraction 10-45min, decoct 2h, repeatedly decoct 2 times, merge decoction liquor, concentrated, obtain paste B, for subsequent use;
(3) calcium gluconate and vitamin C is taken respectively by weight ratio, get step (2) gained paste B, add the Mel of 1-2 times of weight as binding agent, abundant mixing, make moisture and be less than 15% plasticity ball bar, roll ball machine through three drum-types to process, obtain ball block, the pharmaceutical composition finished product of the cattle laminitis that namely obtains medical treatment.
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