CN108524494A - Application and potassium dehydroandrographolide succinate animal medicament of the potassium dehydroandrographolide succinate in preparing veterinary drug - Google Patents
Application and potassium dehydroandrographolide succinate animal medicament of the potassium dehydroandrographolide succinate in preparing veterinary drug Download PDFInfo
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- CN108524494A CN108524494A CN201810495862.4A CN201810495862A CN108524494A CN 108524494 A CN108524494 A CN 108524494A CN 201810495862 A CN201810495862 A CN 201810495862A CN 108524494 A CN108524494 A CN 108524494A
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- potassium dehydroandrographolide
- dehydroandrographolide succinate
- succinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Abstract
The application and potassium dehydroandrographolide succinate animal medicament of a kind of potassium dehydroandrographolide succinate in preparing veterinary drug, are related to new medicine use field.Application of the potassium dehydroandrographolide succinate of the embodiment of the present invention in preparing veterinary drug is the drug that potassium dehydroandrographolide succinate is used to prepare treatment domestic animal and fowl's enteritis or mastitis for milk cows, to the cure rate of domestic animal and fowl's enteritis up to 95% or more, drug residue free in the milk of milk cow production, without abandoning milk, significant effect has no drug resistance.The potassium dehydroandrographolide succinate animal medicament that the embodiment of the present invention treats domestic animal and fowl's enteritis is that potassium dehydroandrographolide succinate is added pharmaceutic adjuvant appropriate, and injection or enema is made in preparation process routinely；The potassium dehydroandrographolide succinate animal medicament that the embodiment of the present invention treats mastitis for milk cows is that potassium dehydroandrographolide succinate is added pharmaceutic adjuvant appropriate, preparation process routinely, is made injection or ointment, and preparation process is simple, production cost is low, is conducive to economic benefit and the comprehensive of social benefit is improved.
Description
Technical field
The present invention relates to new medicine use fields, and application of more particularly to a kind of potassium dehydroandrographolide succinate in preparing veterinary drug and
Potassium dehydroandrographolide succinate animal medicament.
Background technology
In livestock and poultry breeding industry, livestock and poultry will produce various body inflammatory phenomenons, such as domestic animal and fowl's enteritis, mastitis for milk cows, no
Can only there be very big harm to the health of livestock and poultry, and the quality of animal products can be seriously affected.Enteritis, that is, intestinal mucosa is inflamed,
Clinically characterized by digestive function obstacle, diarrhea.There are many pathogenic factors of domestic animal and fowl's enteritis, such as feeding management is improper, raises
Feed not timing, quantitative, the full unevenness of famine；Feed arrangement is improper, hypotrophy, is deficient in vitamin, minerals and sand grains；Green forage
Excessively or feed is mouldy, rancid rotten, and drinking-water is unclean, or feeding is difficult to the feed digested；Weather cataclysm, supercooling, overheat, ring
Border sanitary condition is poor, eats noxious material poisoning, and with certain parasitic diseases and infectious disease etc..Treatment domestic animal and fowl's enteritis at present
Drug include aminosalicyclic acid supplement, glucocorticoid, immunosuppressor, biological agent, antibiotic etc., although there is a constant current modulation
Effect, but treatment cycle is long, toxic side effect is big, curative effect is undesirable, Relapse rate, and delay is refractory.Therefore, controlling for enteritis is also needed
It treats drug further to study, improve its curative effect and reduces its side effect.
Mastitis for milk cows (Bovine Mastitis) is since (such as milking vacuum pressure is excessive or breast exists for mechanical damage
Colony house scratch etc.) and the caused serial breast inflammation of cause of disease invasion, gently then cause milk quality comparison, severe one to cause breast red and swollen
Hot pain, and the proliferation of mammary gland or even papillary necrosis may be developed into etc..The scheme for the treatment of mastitis for milk cows mainly passes through at present
Muscle or intravenous injection antibacterials, although more can quickly treat mastitis for milk cows using sulfamido, furans, this
The drawback that a little drugs are grown there are residual life, milk cannot be drunk, also be brought while causing largely to waste prodigious in a short time
Economic loss.Further, since treatment mastitis for milk cows is mostly systemic administration, administration route is unfavorable for drug and suffers from area's richness in breast
Collection, it is difficult to efficiently suffer from area into cow breast and play a role, drug effect cannot be played more preferably.
In addition, potassium dehydroandrographolide succinate, that is, POTASSIUM DEHYDRO-OGRAPHOLIDE SUCCINATE, is with the Herba Andrographitis in Chinese medicine Herba Andrographitis
Lactone is raw material, and a kind of synthetic drug obtained is reacted with succinic anhydride etc., and structural formula is：Molecular formula：C28H35KO10.Potassium dehydroandrographolide succinate is as antiviral, anti-
The effect of bacterium, anti-inflammatory drugs, the application in people's medication has more than 20 years applicating history, big using the radix of crowd, product,
Safety has always relatively good reputation in medical matters circle, but the application in for animals has not been reported.
Invention content
The purpose of the present invention is to provide a kind of application of potassium dehydroandrographolide succinate in preparing veterinary drug, the healing to domestic animal and fowl's enteritis
Rate is up to 95% or more, and drug residue free in the milk of milk cow production, without abandoning milk, significant effect has no drug resistance.
Another object of the present invention is to provide a kind of potassium dehydroandrographolide succinate animal medicaments, and preparation process is simple, and production cost is low, has
It is improved conducive to economic benefit and the comprehensive of social benefit.
The present invention solves its technical problem using following technical scheme to realize.
The present invention proposes that a kind of application of potassium dehydroandrographolide succinate in preparing veterinary drug, potassium dehydroandrographolide succinate are used to prepare treatment domestic animal and fowl's enteritis
Or the drug of mastitis for milk cows.
Further, in a preferred embodiment of the present invention, potassium dehydroandrographolide succinate is used to prepare the drug for the treatment of domestic animal and fowl's enteritis, specifically
Potassium dehydroandrographolide succinate is added into pharmaceutic adjuvant appropriate, injection or enema is made in preparation process routinely.
Further, in a preferred embodiment of the present invention, potassium dehydroandrographolide succinate is used to prepare the drug for the treatment of mastitis for milk cows, specifically
It is that potassium dehydroandrographolide succinate is added into pharmaceutic adjuvant appropriate, injection or ointment is made in preparation process routinely.
The present invention proposes a kind of potassium dehydroandrographolide succinate animal medicament of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug,
Potassium dehydroandrographolide succinate animal medicament is potasium dehydroandrographolisuccinate succinate injection, is made of mainly by following raw material per 1000mL potasium dehydroandrographolisuccinate succinate injections：
The present invention proposes a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament comprising following steps：
Each raw material is weighed by recipe quantity, water is added in moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent
Middle stirring and dissolving, obtains mixed solution；
Potassium dehydroandrographolide succinate is added in mixed solution and is dissolved, then adjusts pH value to 6.5 ± 0.1, injects water to 1000mL, essence
Filter, sterilize to get.
The present invention proposes a kind of potassium dehydroandrographolide succinate animal medicament of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug,
Potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate enema, is mainly made of following raw material per 1000mL potassium dehydroandrographolide succinate enemas：
The present invention proposes a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament comprising following steps：
Each raw material is weighed by recipe quantity, by moisturizer, cosolvent, surfactant, metal chelating agent, preservative, stabilization
Agent is added to the water stirring and dissolving, obtains mixed solution；
Will potassium dehydroandrographolide succinate be added mixed solution in dissolve, add water to 1000ml to get.
The present invention proposes a kind of potassium dehydroandrographolide succinate animal medicament of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug,
Potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate breast injection, per 1000mL potassium dehydroandrographolide succinate breast injections mainly by following raw material system
At：
The present invention proposes a kind of potassium dehydroandrographolide succinate animal medicament of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug,
Potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate ointment, is mainly made of following raw material per 1000g potassium dehydroandrographolide succinate ointment：
The present invention proposes a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament comprising following steps：
Each raw material is weighed by recipe quantity, by moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent, anti-corrosion
Agent is added to the water stirring and dissolving, obtains mixed solution；
Will potassium dehydroandrographolide succinate be added mixed solution in dissolve, then add stabilizer to 1000g to get.
The advantageous effect of application and potassium dehydroandrographolide succinate animal medicament of the potassium dehydroandrographolide succinate of the embodiment of the present invention in preparing veterinary drug
It is：Application of the potassium dehydroandrographolide succinate of the embodiment of the present invention in preparing veterinary drug is that potassium dehydroandrographolide succinate is used to prepare treatment domestic animal and fowl's enteritis or milk
The drug of garget, to the cure rate of domestic animal and fowl's enteritis up to 95% or more, drug residue free in the milk of milk cow production, without abandoning
Milk, significant effect have no drug resistance.The potassium dehydroandrographolide succinate animal medicament for the treatment of domestic animal and fowl's enteritis of the embodiment of the present invention is that potassium dehydroandrographolide succinate addition is suitable
When pharmaceutic adjuvant, injection or enema is made in preparation process routinely；The embodiment of the present invention treats mastitis for milk cows
Potassium dehydroandrographolide succinate animal medicament is that potassium dehydroandrographolide succinate is added pharmaceutic adjuvant appropriate, and injection or ointment is made in preparation process routinely,
Preparation process is simple, and production cost is low, is conducive to economic benefit and the comprehensive of social benefit is improved.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Application to the potassium dehydroandrographolide succinate of the embodiment of the present invention in preparing veterinary drug below and potassium dehydroandrographolide succinate animal medicament carry out
It illustrates.
The embodiment of the present invention provides a kind of application of potassium dehydroandrographolide succinate in preparing veterinary drug, and potassium dehydroandrographolide succinate is used to prepare treatment poultry
The drug of fowl enteritis or mastitis for milk cows.Wherein, potassium dehydroandrographolide succinate is used to prepare the drug for the treatment of domestic animal and fowl's enteritis, specifically by potassium dehydroandrographolide succinate
Pharmaceutic adjuvant appropriate is added, injection or enema is made in preparation process routinely, in order to potassium dehydroandrographolide succinate active ingredient
It absorbs, and quickly reaches at body inflammatory.Potassium dehydroandrographolide succinate is used to prepare the drug for the treatment of mastitis for milk cows, specifically adds potassium dehydroandrographolide succinate
Add pharmaceutic adjuvant appropriate, injection or ointment is made in preparation process routinely, in order to the suction of potassium dehydroandrographolide succinate active ingredient
It receives, and quickly reaches at body inflammatory.
The embodiment of the present invention also provides a kind of potassium dehydroandrographolide succinate of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug
Animal medicament, potassium dehydroandrographolide succinate animal medicament is potasium dehydroandrographolisuccinate succinate injection, for treating domestic animal and fowl's enteritis, is per 1000mL potasium dehydroandrographolisuccinate succinate injections
Mainly it is made of following raw material：Potassium dehydroandrographolide succinate 15-25g；Moisturizer 200-300g；Cosolvent 3-8g；Antioxidant 0.7-1.4g；Surface
Activating agent 80-120g；Metal chelating agent 0.8-1.3g, remaining is water for injection.Wherein, moisturizer is that injection often uses moisturizing
Agent, such as propylene glycol, glycerine；Cosolvent is that injection often uses cosolvent, such as sodium salicylate, sodium bicarbonate, sodium carbonate；It is anti-
Oxygen agent is that injection often uses antioxidant, such as L-cysteine salt；Surfactant is injection conventional surfactant, such as
Lauryl sodium sulfate, glycerin monostearate；Metal chelating agent is injection common metal complexing agent, such as ethylenediamine tetrem
Acid, Ethylenediaminetetraacetic Acid Calcium Salt.
The embodiment of the present invention also provides a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament (i.e. potasium dehydroandrographolisuccinate succinate injection),
It includes the following steps：
Each raw material is weighed by recipe quantity, water is added in moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent
Middle stirring and dissolving, obtains mixed solution；
Potassium dehydroandrographolide succinate is added in mixed solution and is dissolved, pH adjusting agent (such as disodium hydrogen phosphate, sodium dihydrogen phosphate) is reused
PH value is adjusted to 6.5 ± 0.1, injects water to 1000mL, refined filtration, filling, sealing, 100-110 DEG C of sterilizing 30-60min, i.e.,
.
The embodiment of the present invention also provides a kind of potassium dehydroandrographolide succinate of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug
Animal medicament, potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate enema, for treating domestic animal and fowl's enteritis, per 1000mL potassium dehydroandrographolide succinate enema masters
If being made of following raw material：Potassium dehydroandrographolide succinate 15-25g；Moisturizer 400-600g；Cosolvent 120-180g；Surfactant 40-
60g；Metal chelating agent 4-6g；Preservative 4-6g；Stabilizer 80-120ml, remaining is water.Wherein, moisturizer is common for enema
Moisturizer, such as propylene glycol, glycerine；Cosolvent is that enema often uses cosolvent, such as sodium bicarbonate, sodium salicylate, carbonic acid
Sodium；Surfactant is enema conventional surfactant, such as lauryl sodium sulfate, glycerin monostearate；Metal network
Mixture is enema common metal complexing agent, such as Ethylenediaminetetraacetic Acid Calcium Salt, ethylenediamine tetra-acetic acid；Preservative is bowel lavage
Agent Common Preservatives, such as ethyl-para-hydroxybenzoate, benzyl alcohol；Stabilizer is that enema often uses stabilizer, such as 75% second
Alcohol.
The embodiment of the present invention also provides a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament (i.e. potassium dehydroandrographolide succinate enema),
It includes the following steps：
Each raw material is weighed by recipe quantity, by moisturizer, cosolvent, surfactant, metal chelating agent, preservative, stabilization
Agent is added to the water stirring and dissolving, obtains mixed solution；
Will potassium dehydroandrographolide succinate be added mixed solution in dissolve, add water to 1000ml to get.
The embodiment of the present invention also provides a kind of potassium dehydroandrographolide succinate of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug
Animal medicament, potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate breast injection, for treating mastitis for milk cows, per 1000mL potassium dehydroandrographolide succinate breasts
Room injectant is mainly made of following raw material：Potassium dehydroandrographolide succinate 15-25g；Moisturizer 400-600g；Cosolvent 8-12g；Antioxidant
1.5-2.5g；Surfactant 40-60g；Metal chelating agent 0.8-1.3g；Remaining is water for injection.Wherein, moisturizer is injection
Liquid often uses moisturizer, such as propylene glycol, glycerine；Cosolvent is that injection often uses cosolvent, such as sodium salicylate, bicarbonate
Sodium, sodium carbonate；Antioxidant is that injection often uses antioxidant, such as L-cysteine salt；Surfactant is injection common watch
Face activating agent, such as lauryl sodium sulfate, glycerin monostearate；Metal chelating agent is injection common metal complexing agent,
Such as ethylenediamine tetra-acetic acid, Ethylenediaminetetraacetic Acid Calcium Salt.
The embodiment of the present invention also provides a kind of preparation of above-mentioned potassium dehydroandrographolide succinate animal medicament (i.e. potassium dehydroandrographolide succinate breast injection)
Method comprising following steps：
Each raw material is weighed by recipe quantity, water is added in moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent
Middle stirring and dissolving, obtains mixed solution；
Potassium dehydroandrographolide succinate is added in mixed solution and is dissolved, pH adjusting agent (such as citric acid, sodium citrate) is reused and adjusts pH
Value injects water to 1000ml to 6.5 ± 0.1, refined filtration, filling, sealing, 100-110 DEG C of sterilizing 30-60min to get.
The embodiment of the present invention also provides a kind of potassium dehydroandrographolide succinate of the application based on above-mentioned potassium dehydroandrographolide succinate in preparing veterinary drug
Animal medicament, potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate ointment, main per 1000g potassium dehydroandrographolide succinate ointment for treating mastitis for milk cows
It is made of following raw material：Potassium dehydroandrographolide succinate 15-25g；Moisturizer 400-600g；Cosolvent 50-80g；Antioxidant 1.5-2.5g；Surface
Activating agent 220-350g；Metal chelating agent 1.5-2.5g；Preservative 40-60m1；Remaining is stabilizer.Wherein, moisturizer is soft
Cream often uses moisturizer, such as glycerine, propylene glycol；Cosolvent is that ointment often uses cosolvent, such as sodium carbonate, sodium bicarbonate, water
Poplar acid sodium；Antioxidant is that ointment often uses antioxidant, such as L-cysteine salt；Surfactant is that ointment often uses surface-active
Agent, such as glycerin monostearate, lauryl sodium sulfate；Metal chelating agent is ointment common metal complexing agent, such as second two
Amine tetraacethyl calcium disodium salt, ethylenediamine tetra-acetic acid；Preservative is ointment Common Preservatives, such as benzyl alcohol, P-hydroxybenzoic acid
Ethyl ester；Stabilizer is that ointment often uses stabilizer, such as 75% ethyl alcohol.
The embodiment of the present invention also provides a kind of preparation method of above-mentioned potassium dehydroandrographolide succinate animal medicament (i.e. potassium dehydroandrographolide succinate ointment),
Include the following steps：
Each raw material is weighed by recipe quantity, by moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent, anti-corrosion
Agent is added to the water stirring and dissolving, obtains mixed solution；
Will potassium dehydroandrographolide succinate be added mixed solution in dissolve, then add stabilizer to 1000g to get.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of potasium dehydroandrographolisuccinate succinate injection, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 250g；
Cosolvent：Sodium salicylate 5g；
Antioxidant：L-cysteine salt 1g；
Surfactant：Lauryl sodium sulfate 100g；
Metal chelating agent：Ethylenediamine tetra-acetic acid 1g；
PH adjusting agent：Disodium hydrogen phosphate 0.5g, sodium dihydrogen phosphate 2g；
Add water for injection that 1000ml is made.
The preparation method of potasium dehydroandrographolisuccinate succinate injection is：Each ingredient is weighed by above-mentioned recipe quantity, by propylene glycol 250g, sodium salicylate
5g, L-cysteine salt 1g, lauryl sodium sulfate 100g, ethylenediamine tetra-acetic acid 1g are added to the water stirring and dissolving, then will wear amber
It is rather added in this solution and dissolves, then pH value is adjusted to 6.5 ± 0.1 with disodium hydrogen phosphate 0.5g, sodium dihydrogen phosphate 2g, add injection
For water to 1000ml, refined filtration is filling, sealing, 100 DEG C sterilizing 30min to get.
Embodiment 2
The present embodiment provides a kind of potasium dehydroandrographolisuccinate succinate injection, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 220g；
Cosolvent：Sodium salicylate 4g；
Antioxidant：L-cysteine salt 1.2g；
Surfactant：Lauryl sodium sulfate 85g；
Metal chelating agent：Ethylenediamine tetra-acetic acid 1.2g；
PH adjusting agent：Disodium hydrogen phosphate 1g, sodium dihydrogen phosphate 2g；
Add water for injection that 1000ml is made.
The preparation method of potasium dehydroandrographolisuccinate succinate injection is：Each ingredient is weighed by above-mentioned recipe quantity, by propylene glycol 220g, sodium salicylate
4g, L-cysteine salt 1.2g, lauryl sodium sulfate 85g, ethylenediamine tetra-acetic acid 1.2g are added to the water stirring and dissolving, then will wear
Amber, which is rather added in this solution, to be dissolved, then adjusts pH value to 6.5 ± 0.1 with disodium hydrogen phosphate 1g, sodium dihydrogen phosphate 2g, adds injection
For water to 1000ml, refined filtration is filling, sealing, 100 DEG C sterilizing 30min to get.
Embodiment 3
The present embodiment provides a kind of potassium dehydroandrographolide succinate enema, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 500g；
Cosolvent：Sodium bicarbonate 150g；
Surfactant：Lauryl sodium sulfate 50g；
Metal chelating agent：Disodium EDTA 5g；
Preservative：Ethyl-para-hydroxybenzoate 50g；
Stabilizer：75% ethyl alcohol 100ml；
Add water that 1000ml is made.
The preparation method of potassium dehydroandrographolide succinate enema is：Each ingredient is weighed by recipe quantity, by propylene glycol 500g, sodium bicarbonate
150g, lauryl sodium sulfate 50g, Ethylenediaminetetraacetic Acid Calcium Salt 5g, ethyl-para-hydroxybenzoate 50g, 75% ethyl alcohol
100ml is added to the water stirring and dissolving, then potassium dehydroandrographolide succinate is added in this solution and is dissolved, add water to 1000ml to get.
Embodiment 4
The present embodiment provides a kind of potassium dehydroandrographolide succinate enema, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 450g；
Cosolvent：Sodium bicarbonate 170g；
Surfactant：Lauryl sodium sulfate 60g；
Metal chelating agent：Disodium EDTA 4g；
Preservative：Ethyl-para-hydroxybenzoate 40g；
Stabilizer：75% ethyl alcohol 100ml；
Add water that 1000ml is made.
The preparation method of potassium dehydroandrographolide succinate enema is：Each ingredient is weighed by recipe quantity, by propylene glycol 450g, sodium bicarbonate
170g, lauryl sodium sulfate 60g, Ethylenediaminetetraacetic Acid Calcium Salt 4g, ethyl-para-hydroxybenzoate 40g, 75% ethyl alcohol
100ml is added to the water stirring and dissolving, then potassium dehydroandrographolide succinate is added in this solution and is dissolved, add water to 1000ml to get.
Embodiment 5
The present embodiment provides a kind of potassium dehydroandrographolide succinate breast injection, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 500g；
Cosolvent：Sodium salicylate 10g；
Antioxidant：L-cysteine salt 2g；
Surfactant：Lauryl sodium sulfate 50g；
Metal chelating agent：Ethylenediamine tetra-acetic acid 1g；
PH adjusting agent：Citric acid 10g, sodium citrate 15g；
Add water for injection that 1000ml is made.
The preparation method of potassium dehydroandrographolide succinate breast injection is：Each ingredient is weighed by recipe quantity, by propylene glycol 500g, sodium salicylate
10g, L-cysteine salt 2g, lauryl sodium sulfate 50g, ethylenediamine tetra-acetic acid 1g are added to the water stirring and dissolving, then will wear amber
It is rather added in this solution and dissolves, then pH value is adjusted to 6.5 ± 0.1 with citric acid 10g, sodium citrate 15g, inject water to
1000ml, refined filtration is filling, sealing, 100 DEG C sterilizing 30min to get.
Embodiment 6
The present embodiment provides a kind of potassium dehydroandrographolide succinate breast injection, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Propylene glycol 450g；
Cosolvent：Sodium salicylate 11g；
Antioxidant：L-cysteine salt 1.5g；
Surfactant：Lauryl sodium sulfate 45g；
Metal chelating agent：Ethylenediamine tetra-acetic acid 1.2g；
PH adjusting agent：Citric acid 12g, sodium citrate 15g；
Add water for injection that 1000ml is made.
The preparation method of potassium dehydroandrographolide succinate breast injection is：Each ingredient is weighed by recipe quantity, by propylene glycol 450g, sodium salicylate
11g, L-cysteine salt 1.5g, lauryl sodium sulfate 45g, ethylenediamine tetra-acetic acid 1.2g are added to the water stirring and dissolving, then will
Potassium dehydroandrographolide succinate, which is added in this solution, to be dissolved, then adjusts pH value to 6.5 ± 0.1 with citric acid 12g, sodium citrate 15g, adds water for injection
To 1000ml, refined filtration is filling, sealing, 100 DEG C sterilizing 30min to get.
Embodiment 7
The present embodiment provides a kind of potassium dehydroandrographolide succinate ointment, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Glycerine 500g；
Cosolvent：Sodium carbonate 65g；
Antioxidant：L-cysteine salt 2g；
Surfactant：Glycerin monostearate 300g；
Metal chelating agent：Ethylenediaminetetraacetic Acid Calcium Salt 2g；
Preservative：Benzyl alcohol 50m1；
Add stabilizer：1000g is made in 75% ethyl alcohol.
The preparation method of potassium dehydroandrographolide succinate ointment is：Each ingredient is weighed by recipe quantity, by glycerine 500g, sodium carbonate 65g, L- half
It is molten that cystine salt 2g, glycerin monostearate 300g, Ethylenediaminetetraacetic Acid Calcium Salt 2g, benzyl alcohol 50m1 are added to the water stirring
Solution, then potassium dehydroandrographolide succinate is added in this solution and is dissolved, then add 75% ethyl alcohol to 1000g to get.
Embodiment 8
The present embodiment provides a kind of potassium dehydroandrographolide succinate ointment, prescription is as follows：
Potassium dehydroandrographolide succinate 20g；
Moisturizer：Glycerine 450g；
Cosolvent：Sodium carbonate 70g；
Antioxidant：L-cysteine salt 1.7g；
Surfactant：Glycerin monostearate 250g；
Metal chelating agent：Ethylenediaminetetraacetic Acid Calcium Salt 2.5g；
Preservative：Benzyl alcohol 60m1；
Add stabilizer：1000g is made in 75% ethyl alcohol.
The preparation method of potassium dehydroandrographolide succinate ointment is：Each ingredient is weighed by recipe quantity, by glycerine 450g, sodium carbonate 70g, L- half
Cystine salt 1.7g, glycerin monostearate 250g, Ethylenediaminetetraacetic Acid Calcium Salt 2.5g, benzyl alcohol 60m1, which are added to the water, to be stirred
Mix dissolving, then potassium dehydroandrographolide succinate be added in this solution and is dissolved, then add 75% ethyl alcohol to 1000g to get.
Drug effect and clinical trial are carried out to present invention treatment domestic animal and fowl's enteritis and mastitis for milk cows below.
One, to the Clinical Treatment Test of swine enteritis
In order to verify clinical therapeutic efficacy of the potassium dehydroandrographolide succinate animal medicament to swine enteritis of the embodiment of the present invention, in Sichuan Suining
Cultivation base has carried out swine enteritis therapeutic test.In this experiment, with the potasium dehydroandrographolisuccinate succinate injection of the embodiment of the present invention, potassium dehydroandrographolide succinate bowel lavage
Agent is grouped administration to animal, and carries out curative effect comparison with the routine medication of swine enteritis, to evaluate implementation of the present invention
The potassium dehydroandrographolide succinate animal medicament of example is to swine enteritis therapeutic effect.
1, material and method
Experimental animal selects enteritis morbid pig 80, every group 20, is raised according to normal feeding management program.
2, trial drug
The potassium dehydroandrographolide succinate enema of potasium dehydroandrographolisuccinate succinate injection, the offer of the embodiment of the present invention 3 that the embodiment of the present invention 1 provides；
Compound sulfonamide amidine piece：0.5g × 1000 piece/bag, the production of Jilin Lu Wang Pharmacy stock Co., Ltd.
3, experimental animal grouping and processing
The case of swine enteritis is mainly made a definite diagnosis by incidence and clinical symptoms, then by experimenter by morbid pig with
Machine grouping is treated, and each case is included into control group respectively at random, and trial drug group of the present invention (is divided into following 2 by dosage form difference
Group) and compound sulfonamide amidine piece control group, specifically it is grouped as follows：
It is control group to test 1 group, is not processed；It is trial drug group of the present invention to test 2 groups, using the embodiment of the present invention 1
Potasium dehydroandrographolisuccinate succinate injection drug treatment, clinical recommended dose (per kilogram of body weight 10mg), injection, successive administration 5 days；Test 3 groups
For trial drug group of the present invention, using the potassium dehydroandrographolide succinate enema drug treatment of the embodiment of the present invention 3, clinical recommended dose is (per public
Jin weight 20mg) administration, bowel lavage, successive administration 5 days；It is compound sulfonamide amidine piece group to test 4 groups, is used to specifications：Spice,
It is administered by per kilogram of body weight 0.5g, successive administration 5 days.
4, therapeutic effect determination method
Clinical symptoms disappear, and dissect is without apparent pathological change.
It cures：Clinical symptoms disappear, and defecation restores normal.
Effectively：Clinical symptom relief, excrement water sample mitigate.
In vain：Each clinical symptoms in criterion do not mitigate or aggravate.
Statistical analysis is through X2It examines.
5, test result and analysis
To the pig with enteritis, after giving potasium dehydroandrographolisuccinate succinate injection, potassium dehydroandrographolide succinate enema respectively, by being compared with control group
Compared with the clinical symptoms of sick pig are substantially reduced, food ration, weight recovery；Compound sulfonamide amidine piece control group has certain therapeutic effect, but
Food ration, weight recovery are not so good as the therapeutic effect of trial drug group of the present invention, and concrete outcome is shown in Table 1.
1 observation of curative effect situation of table
| Test group | 1 | 2 | 3 | 4 |
| Quantity (head) | 20 | 20 | 20 | 20 |
| Morbidity history | Enteritis | Enteritis | Enteritis | Enteritis |
| Treatment history | Nothing | Potasium dehydroandrographolisuccinate succinate injection | Potassium dehydroandrographolide succinate enema | Compound sulfonamide amidine piece |
| Therapeutic effect | In vain | Cure rate 98% | Cure rate 95% | Cure rate 90% |
6, conclusion
Potasium dehydroandrographolisuccinate succinate injection, the potassium dehydroandrographolide succinate enema of the present invention, to due to feeding management it is improper, eaten mouldy, rotten
Feed, drinking-water is unclean, or feeding is difficult to the feed digested；Weather cataclysm, supercooling, overheat, environmental sanitation condition is poor, and suffers from
The therapeutic effect of the pig of enteritis is notable caused by certain viruses or bacterium infection etc..
Two, to the Clinical Treatment Test of cat, dog enteritis
1, trial drug
The potassium dehydroandrographolide succinate enema that the embodiment of the present invention 4 provides；
Usage and dosage is：Bowel lavage；Two times a day, it is used in conjunction 5 days, recommended dose 20mg/kg weight.
2, clinical application is tested
1. symptom before experiment：In one pet clinic of Chengdu, Persian cat is female, 5 months within 2016.Weight 1.5kg is satiated with food roasting
It falls ill after fish, starts to vomit, have loose bowels, spirit is still.2nd day, vomit color of soy sauce liquid, diarrhea aggravation, excrement stench.Body temperature
39.7 DEG C, lassitude, after diagnosing for：Enteritis caused by indigestion.
Symptom after the potassium dehydroandrographolide succinate enema treatment provided using the embodiment of the present invention 4：After medication 3 days, spirit takes a turn for the better, vomiting
Number is reduced；After medication 4 days, spirit is good, and vomiting, diarrhea disappear, and 38.2 DEG C of continuous three days of body temperature, diet, defecation are just
Often, observation two days later, makes a definite diagnosis healing, approval discharge.
2. in August, 2016,10 dogs morbidity of dog smallholder operating, clinical symptoms are supported in Chengdu：Vomit, is malnutritive,
It becomes thin.It is diagnosed as dog gastroenteritis.Then drug therapy of the present invention is used, after medication 3 hours, the state of an illness is controlled.
3, conclusion
The potassium dehydroandrographolide succinate enema of the present invention, has preferable therapeutic effect to the enteritis caused by many reasons such as cat, dog.
Three, to the Clinical Treatment Test of chicken intestinal diorder
" Bai Yu " broiler chicken 20 that selects that 2 week old, weight are close, upgrowth situation is good, is divided into 2 groups, every group 10,
The drug therapy and contrast groups for the potasium dehydroandrographolisuccinate succinate injection that test group is provided with the embodiment of the present invention 2 are bad with commercially available common prevention broiler chicken
The drug therapy of dead property enteritis, daily medication 2 times (injection, per kilogram of body weight 10mg), other conditions all same were cultivated to 6 weeks
Age, statistics broiler chicken necrotic enteritis incidence, the death rate and average daily gain the results are shown in Table 2.
The experimental result of table 2 test group and contrast groups
| Group | Test group | Contrast groups |
| Necrotic enteritis incidence (%) | 0.5 | 5.5 |
| The death rate (%) | 0 | 2.5 |
| Average daily gain (g) | 80.2 | 74.5 |
| Body weight increase rate (%) | 3.9 | -- |
As known from Table 2, potasium dehydroandrographolisuccinate succinate injection of the invention can effectively reduce broiler chicken necrotic enteritis incidence and death
Rate improves average daily gain so that necrotic enteritis incidence is reduced to 0.5%, and the death rate is reduced to 0% so that average day
Weightening reaches 80.2g.
Four, to the Clinical Treatment Test of mastitis for milk cows
(1) therapeutic test of the potassium dehydroandrographolide succinate breast injection to mastitis for milk cows
1, evaluation criterion：
Mastitis for milk cows therapeutic effect detects two methods using the visual inspection and somatic cell from milk (SCC) of ox, wherein
The visual inspection of ox is effective standard, and lotion body cell (SCC) is to cure judgment criteria.1. visual inspection -- effective standard：It controls
More after, infected cattle spirit appetite restores normal, lactation amount rebound significantly；The symptom eliminates such as red, swollen, the hot, pain in medication breast area；Milk
Shape restores normal, no flocculus, grumeleuse, the trace of blood.2. lotion body cell (SCC) detects -- cure judgment criteria：Last time administration 7
In the future, acquisition milk sample measures somatic number (SCC), and SCC is between 50~1,000,000/ml.
Cure rate=(newborn area number/group innerlich anwenden breast area number is cured in group) * 100%；
Efficient=(effectively newborn area's number/group innerlich anwenden breast area number in group) * 100%.
2, test method：
Experimental animal：One cattle farm of Chengdu periphery shares 1300 livestock on hand milk cows, wherein 176 are suffered from mammitis, wherein
72 are minor mammitis, and clinical symptoms are that breast is slight red, swollen, and lactation amount is reduced, loss of appetite；56 are moderate breast
Inflammation, clinical symptoms are that breast moderate is red, swollen, and palpation breast has heat, pain reaction, lactation amount to reduce, and milk has a small amount of flocculus, coagulates
Block, look cold and detached, and feeding is seldom；48 are severe mammitis, and clinical symptoms are stupor, and appetite is useless exhausted, and breast is red, swollen serious,
Breast palpation heat, pain reaction are strong, lactation amount degradation even dry up, there is color floccule, extract, apparent different in milk
Taste.
Trial drug：The potassium dehydroandrographolide succinate breast injection that the embodiment of the present invention 5 provides；
Usage and dosage is：Injection；Two times a day, it is used in conjunction 5 days, recommends agent 0.5mg/kg weight.
3, test result
Treatment data shows：After administration 2 days, feed intake increases slight and moderate mammitis case, body temperature after administration 3 days
Restore normal, after successive administration 5 days, mammitis clinical symptoms disappear, and lactation amount restores normal.Have in severe mammitis case
48 cases, after successive administration 5 days, clinical symptoms are clearly better, and breast redness weakens, and color floccule disappears in milk,
Free from extraneous odour, after 6 to 8 days, clinical symptoms all disappear successive administration, and lactation amount restores normal.Test data shows successive administration
After 5 days, light, moderate mammitis cure rate has reached 100%, and the cure rate 80.0% of severe mammitis, comprehensive cure rate reaches
To 95.2%.
4, conclusion：
The potassium dehydroandrographolide succinate breast injection of the present invention is in the therapeutic process of mastitis for milk cows, without drug in the milk of milk cow production
Residual does not induce endotoxemia without abandoning milk during preventing mastitis for milk cows, mammitis significant effect is treated, without resistance to
Pharmacological property, cure rate are high, quick.It solves and causes milk in a short time cannot using antibiotics such as sulfamido, furans
It drinks, causes the economic loss largely wasted.
(2) therapeutic test of the potassium dehydroandrographolide succinate ointment to mastitis for milk cows
1, test method
Experiment packet：By the clinic mastitis milk cow 30 with red and swollen heat pain, 2 groups are randomly divided into, every group 15, is controlled
5 days treatment phases, potassium dehydroandrographolide succinate Ointment in Treatment group use the potassium dehydroandrographolide succinate Ointment in Treatment that the embodiment of the present invention 7 provides, prednisone acetate ointment
Treatment group uses commercially available prednisone acetate Ointment in Treatment, therapeutic effect to observe 7 days.
Application method：Every time after milking, ointment is uniformly applied to ill breast district surface.
Efficacy determination：Efficiently：Breast suffers from the symptoms such as red, swollen, the hot, pain in area and disappears, and breast softens, and no pain, temperature is normal,
For milk normally without ziega, milk color restores normal；It is effective：Breast suffers from red, swollen, hot, the bitterly apparent recession in area, milk ziega
It significantly reduces, color is normal；In vain：Breast suffers from the symptoms such as red, swollen, the hot, pain in area without significant change, and milk grumeleuse does not subtract
Few, milk color is unchanged.
2, test result
Test result is shown in Table 3 Comparison of clinical effect table.
3 Comparison of clinical effect table of table
3, conclusion
The potassium dehydroandrographolide succinate ointment of the present invention directly can suffer from area's enrichment administration in cow breast, efficiently suffer from area into cow breast and send out
The effect of waving, and drug residue free in the milk produced to milk cow in the therapeutic process of mastitis for milk cows, have no drug resistance, and curative effect is better than city
Sell mastitis hormone medicine.
In conclusion cure rate of application of the potassium dehydroandrographolide succinate of the embodiment of the present invention in preparing veterinary drug to domestic animal and fowl's enteritis
Up to 95% or more, drug residue free in the milk of milk cow production, without abandoning milk, significant effect has no drug resistance；The embodiment of the present invention
The preparation process of potassium dehydroandrographolide succinate animal medicament is simple, and production cost is low, is conducive to economic benefit and the comprehensive of social benefit is improved.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of application of potassium dehydroandrographolide succinate in preparing veterinary drug, which is characterized in that the potassium dehydroandrographolide succinate is used to prepare treatment livestock and poultry
The drug of enteritis or mastitis for milk cows.
2. application of the potassium dehydroandrographolide succinate according to claim 1 in preparing veterinary drug, which is characterized in that the potassium dehydroandrographolide succinate is used
In the drug for preparing treatment domestic animal and fowl's enteritis, the potassium dehydroandrographolide succinate is specifically added into pharmaceutic adjuvant appropriate, preparation work routinely
Injection or enema is made in skill.
3. application of the potassium dehydroandrographolide succinate according to claim 1 in preparing veterinary drug, which is characterized in that the potassium dehydroandrographolide succinate is used
In the drug for preparing treatment mastitis for milk cows, the potassium dehydroandrographolide succinate is specifically added into pharmaceutic adjuvant appropriate, preparation routinely
Injection or ointment is made in technique.
4. a kind of potassium dehydroandrographolide succinate animal medicament of application based on potassium dehydroandrographolide succinate described in claim 1 in preparing veterinary drug,
Be characterized in that, the potassium dehydroandrographolide succinate animal medicament is potasium dehydroandrographolisuccinate succinate injection, be per potasium dehydroandrographolisuccinate succinate injection described in 1000mL mainly by with
Lower raw material is made：
5. a kind of preparation method of potassium dehydroandrographolide succinate animal medicament as claimed in claim 4, which is characterized in that it includes following step
Suddenly：
Each raw material is weighed by recipe quantity, moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent are added to the water and stirred
Dissolving is mixed, mixed solution is obtained；
Potassium dehydroandrographolide succinate is added in the mixed solution and is dissolved, then adjusts pH value to 6.5 ± 0.1, injects water to 1000mL, essence
Filter, sterilize to get.
6. a kind of potassium dehydroandrographolide succinate animal medicament of application based on potassium dehydroandrographolide succinate described in claim 1 in preparing veterinary drug,
Be characterized in that, the potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate enema, per potassium dehydroandrographolide succinate enema described in 1000mL mainly by with
Lower raw material is made：
7. a kind of preparation method of potassium dehydroandrographolide succinate animal medicament as claimed in claim 6, which is characterized in that it includes following step
Suddenly：
Each raw material is weighed by recipe quantity, moisturizer, cosolvent, surfactant, metal chelating agent, preservative, stabilizer are added
Enter stirring and dissolving in water, obtains mixed solution；
Potassium dehydroandrographolide succinate is added in the mixed solution and is dissolved, add water to 1000ml to get.
8. a kind of potassium dehydroandrographolide succinate animal medicament of application based on potassium dehydroandrographolide succinate described in claim 1 in preparing veterinary drug,
It is characterized in that, the potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate breast injection, potassium dehydroandrographolide succinate breast injection master described in every 1000mL
If being made of following raw material：
9. a kind of potassium dehydroandrographolide succinate animal medicament of application based on potassium dehydroandrographolide succinate described in claim 1 in preparing veterinary drug,
It is characterized in that, the potassium dehydroandrographolide succinate animal medicament is potassium dehydroandrographolide succinate ointment, and potassium dehydroandrographolide succinate ointment is mainly by following raw material described in every 1000g
It is made：
10. a kind of preparation method of potassium dehydroandrographolide succinate animal medicament as claimed in claim 9, which is characterized in that it includes following step
Suddenly：
Each raw material is weighed by recipe quantity, moisturizer, cosolvent, antioxidant, surfactant, metal chelating agent, preservative are added
Enter stirring and dissolving in water, obtains mixed solution；
Potassium dehydroandrographolide succinate is added in the mixed solution and is dissolved, then add stabilizer to 1000g to get.
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| CN202110656181.3A CN113244220A (en) | 2018-05-22 | 2018-05-22 | Application of potassium dehydroandrographolide succinate in preparation of veterinary drug for treating cow mastitis and potassium dehydroandrographolide succinate veterinary drug |
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Application publication date: 20180914 |