CN113633751A

CN113633751A - Medicament for treating livestock foot-and-mouth disease

Info

Publication number: CN113633751A
Application number: CN202111119527.2A
Authority: CN
Inventors: 王楠
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-17
Filing date: 2021-09-17
Publication date: 2021-11-12

Abstract

The invention discloses a medicament for treating livestock foot-and-mouth disease, which is characterized by being prepared from the following components in parts by weight: indigo naturalis 1 ~ 4, 1 ~ 4 of borneol, 8 ~ 12 of realgar, 2 ~ 5 of phellodendron, 4 ~ 8 of Zingiberis rhizoma, 4 ~ 8 of saponin, 4 ~ 8 of radix Dipsaci, 8 ~ 12 of alum, 4 ~ 8 of trogopterus dung, 0.2 ~ 0.6 of radix Aconiti. The invention can increase coronary blood flow and improve microcirculation, and has the functions of resisting stress injury and enhancing immunity. Has strong analgesic effect, and has effects in dilating blood vessel and lowering blood pressure. Has better effects on relieving swelling and pain and resisting virus, and has stable and rapid drug action. Clinical use results show that the curative ratio of the foot-and-mouth disease curing medicine for livestock pigs, cattle and sheep reaches 100%, the treatment course is short, the medicine effect is quick, the medicine effect is stable, the pain is small, the cost is low, no side effect exists, no sequela exists after the disease is cured, the loss of livestock breeding can be effectively reduced, and the medicine is easy to accept by farmers.

Description

Medicament for treating livestock foot-and-mouth disease

Technical Field

The invention relates to a medicament for treating foot-and-mouth disease of livestock.

Background

Foot-and-mouth disease is an acute, febrile and highly contact infectious disease which is commonly suffered by main domestic animals such as pigs, cattle, sheep and the like and other domestic and wild artiodactyls, and more than 70 kinds of susceptible animals are easily suffered. Clinically, it is characterized by the development of vesicular eruptions in the oral mucosa, hooves and breast skin. The disease has multiple transmission ways and high speed, and has been epidemic in the world for many times, which causes huge loss. Foot-and-mouth disease has epidemiological characteristics of fast epidemic, wide spread, acute disease, great harm and the like, the disease incidence in an epidemic area can reach 50-100%, the calf mortality is higher, and the others are lower. Sick animals and latent animals are the most dangerous sources of infection. The vesicular fluid, milk, urine, saliva, tears and feces of the sick livestock contain viruses. The invasion route of the disease is mainly the digestive tract, and the disease can also be transmitted through the respiratory tract. Although the disease is spread without obvious seasonality, the disease is more in winter. Wind and birds are also one of the factors that spread over long distances.

Symptoms of foot-and-mouth disease in cattle: the incubation period is 1-7 days, the sick cattle are depressed in spirit, close the mouth and drool in 2-4 days on average, the sucking sound is generated when the cattle are opened, and the body temperature can be raised to 40-41 ℃. After 1-2 days of disease attack, large blisters from broad beans to walnuts can be seen on the gum, tongue surface and inner lip surface of the sick cattle, saliva is increased and hung at the mouth in a white foam shape, and ingestion and rumination are stopped. The blister breaks about a day and night and then forms an ulcer, at which time the body temperature gradually drops to normal. At the same time or later as blisters occur in the mouth, blisters also occur between the toes and on the soft skin of the hoof crown, which also break open quickly and then heal gradually. Blisters are also sometimes seen on the teat skin. The disease usually presents a benign course, and can be self-healed after about one week; if the hoof is diseased, the disease can be prolonged to 2-3 weeks or more, the death rate is 1% -2%, and the disease type is benign foot-and-mouth disease. In the process of blister healing, some sick cattle have sudden deterioration, general weakness, trembling muscles, accelerated heartbeat, irregular rhythm, abominable appetite, stopping rumination, swinging walking and unstable standing and are often killed suddenly due to cardioplegia, and the death rate of the sick cattle is up to 25-50 percent. Characteristic blisters are often not seen in the onset of calves, mainly manifested by hemorrhagic gastroenteritis and myocarditis, with extremely high mortality.

Pig suffering from hoof symptoms: the sick pigs have poor spirit, high body temperature and reduced or abolished appetite, and are red, swollen, slightly hot and sensitive locally at the hoof crown, the hoof fork, the heel and the skin of the osculating end, the tongue surface, the oral mucosa and the like, and blister with different sizes appears to be broken quickly. When the sick pig lims, some hoof shells deform or fall off, and the sick pig is difficult to stand in a lying state. Sometimes, blisters also appear in the nipples, breasts, etc. of sows. The mortality rate of the hoof inflammation to the adult pigs is not more than 3 percent generally, but acute death cases also exist in the early period of the outbreak of the hoof inflammation of the pigs in recent years, and pregnant sows can have abortion. The blister symptoms of the infected piglets are not obvious, particularly the piglets in the lactation period, but the piglets can be quickly killed in a short period due to myocarditis and gastroenteritis, and the mortality rate is up to more than 80%.

Symptoms of foot and mouth disease in sheep: initial stage of foot and mouth disease of sheep, increased body temperature, decreased appetite, depressed spirit, choking mouth and salivation. Sheep water pustules are mostly seen in four limbs and can have slight claudication; goat blisters are found in the mouth. The blister is automatically ruptured after 1-2 days to form a plaque, and then gradually heals. If the foot-and-mouth disease of sheep is inadequately nursed and infected with suppurative bacteria, ulcer and necrosis are formed. If other complications do not occur, the disease generally goes well and the death rate is low. Lamb sometimes has hemorrhagic gastroenteritis and myocarditis with high mortality rate. The incubation period is 3-4 days on average. The symptom of the foot-and-mouth disease of sheep goats is characterized in that: body temperature is above 40 ℃, depression, food waste, oral mucosa blister, tongue rare (goat is more than sheep and is on hard palate and tongue surface), hoof blister is small, lameness, abortion. The symptoms of the foot-and-mouth disease of the dairy goats are characterized in that: the nipple is diseased and the milk amount is reduced. The foot-and-mouth disease symptom characteristics of the nursing lambs are as follows: it is especially easy to cause hemorrhagic gastroenteritis. Malignant foot and mouth disease, cardioplegia and death may also occur. The fatality rate is 20-50%.

The current main prevention and treatment means for the livestock with the foot-and-mouth disease are as follows: hoof treatment: after being mixed with vinegar, the medicine becomes thin and atherous, and can be easily and evenly coated on the diseased part. Treatment of breast: the preparation is applied to affected parts of breast uniformly. Oral treatment: spraying the prepared medicine into oral cavity of sick livestock. Although the treatment method is simple and the treatment process is short, the method has defects that the medicine can only be externally applied and can not be orally taken, the medicine can only be used for the symptomatic livestock after diseases, can not be used for the livestock which are not directly died after diseases, and the myocarditis and the hemorrhagic enteritis are easy to occur after young livestock are infected with the foot-and-mouth disease virus, the death rate is very high because the myocardium is usually dead due to the paralysis of the myocardium, and the dissected examination can show that the myocardium has faint yellow or gray-white, strip-shaped or dot-shaped stripes, which are similar to the tiger skin, so the medicine is called as the tiger-spot heart. In the case of conditions such as these, the existing preventive agents and methods are not effective for the treatment of foot-and-mouth disease in livestock, and only gradually recover or die depending on the livestock themselves.

Disclosure of Invention

The invention provides a medicament for treating livestock foot-and-mouth disease, which aims to solve the problems in the prior art.

In order to realize the purpose of the invention, the medicament for treating the foot-and-mouth disease of the livestock is characterized by being prepared from the following components in parts by weight: indigo naturalis 1 ~ 4, 1 ~ 4 of borneol, 8 ~ 12 of realgar, 2 ~ 5 of phellodendron, 4 ~ 8 of Zingiberis rhizoma, 4 ~ 8 of saponin, 4 ~ 8 of radix Dipsaci, 8 ~ 12 of alum, 4 ~ 8 of trogopterus dung, 0.2 ~ 0.6 of radix Aconiti.

The preparation method of the medicament for treating the livestock foot-and-mouth disease comprises the following steps: mixing borneol, realgar, phellodendron, dried ginger, Chinese honeylocust fruit, dipsacus root, alum, trogopterus dung and monkshood in parts by weight, crushing into powder of 40-50 meshes, then adding powdered indigo naturalis and mixing uniformly.

The invention has the following effects:

indigo naturalis: has effects of clearing away heat and toxic materials, relieving swelling and pain, cooling blood, stopping bleeding, tranquilizing mind, improving phagocytosis of mononuclear macrophage system, and treating abnormal hyperplastic granulocyte and eosinophilic granulocyte. Indigo naturalis has inhibitory effect on Bacillus anthracis, pneumococcus, Shigella shigella, Vibrio cholerae, Staphylococcus aureus, and Staphylococcus albus. Can make the wound in a dry environment and has good astringing effect on the affected part with broken blister.

Dried ginger: has effects of promoting blood circulation and removing blood stasis.

And (2) Chinese honeylocust fruit: has effects in dispelling blood stasis, relieving swelling and pain, and relieving arthralgia.

And (3) Himalayan teasel root: has effects in promoting blood circulation, removing blood stasis, relieving pain, and promoting healing of injury of bones and muscles.

Borneol: borneol can clear heat, suppuration and relieve pain, and has the functions of antibiosis and antiphlogosis. Has antibacterial and disinfectant effects on the wound surface of burn, and can reduce bacterial infection on wound, promote absorption of medicine, and accelerate wound healing.

Alum: has repercussive and analgesic effects.

Radix aconiti: has strong analgesic effect, and has effects in dilating blood vessel and lowering blood pressure.

Trogopterus dung: has effects of promoting blood circulation, relieving pain, removing blood stasis, and stopping bleeding. The trogopterus dung is a commonly used medicine for promoting blood circulation and removing blood stasis, contains a large amount of resin and vitamin A, has the effects of inhibiting platelet aggregation, increasing coronary blood flow and improving microcirculation, and has the effects of resisting stress injury and enhancing immunologic function.

Realgar: has effects in resisting pathogenic microorganism, and relieving spasm and pain of nerve after absorption.

Phellodendron bark: has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substance, removing bone steaming, clearing deficiency heat, etc., and can be used for treating pyocutaneous disease, toxic swelling, eczema, pruritus, etc.

Vinegar: astringe, sterilize, dissipate blood stasis and relieve pain, and is helpful for medicine absorption.

Indigo naturalis and cortex Phellodendri can strengthen the actions of removing toxic substance, cooling blood, clearing heat, etc.

The borneol and the phellodendron bark have the efficacies of clearing heat and purging fire, detoxifying and reducing swelling, eliminating dampness and astringing sores, relieving pain and itching, and have the functions of treating ulcer, erosion and the like more effectively.

The dipsacus root and the monkshood have the functions of dissipating blood stasis, tonifying liver and kidney, strengthening tendons and bones, promoting blood circulation and the like.

The invention contains antiviral elements, can effectively kill viruses in vivo, enhances the resistance of the body to external viruses, has certain clinical treatment effect, can supplement some vitamins in the body and enhances the immunologic function of the body.

The dried ginger of the invention has the effects of promoting blood circulation, dissipating blood stasis and the like. The Chinese honeylocust fruit has the effects of dissipating blood stasis, swelling and pain, relieving joint pain and the like. Radix Dipsaci has effects of promoting blood circulation, removing blood stasis, relieving pain, and promoting healing of injury of tendons and bones. Borneolum has heat clearing away, suppurative, analgesic, antibacterial, and anti-inflammatory effects. Can reduce the infection of bacteria to the wound, promote the absorption of the medicine and accelerate the healing of the wound. Alumen has repercussive and analgesic effects. Chuanwu has strong analgesic effect, and has effects of dilating blood vessel and lowering blood pressure. Oletum Trogopterori has effects of promoting blood circulation, relieving pain, removing blood stasis, and stopping bleeding. The trogopterus dung is a commonly used medicine for promoting blood circulation and removing blood stasis, contains a large amount of resin and vitamin A, has the effects of inhibiting platelet aggregation, increasing coronary blood flow and improving microcirculation, and has the effects of resisting stress injury and enhancing immunologic function. The realgar has the function of resisting pathogenic microorganisms, and has the functions of relieving spasm and pain after being absorbed: cortex Phellodendri has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substance, removing bone steaming, and clearing deficiency heat, and can be used for treating pyocutaneous disease, toxic swelling, eczema, and pruritus. Vinegar has effects of astringing, sterilizing, removing blood stasis and relieving pain, and can help medicine absorption.

In the invention, the compatibility of the medicines can achieve the effects of detoxifying, relieving swelling, relieving pain, promoting blood circulation, removing blood stasis and the like, and has better treatment effect on foot-and-mouth disease.

The foot-and-mouth disease of livestock is typically easy to identify, so that the preliminary diagnosis can be easily made by combining clinical pathology investigation. The diagnosis key points are as follows:

firstly, the disease is acute, popular and wide in spread, the disease rate is high, but the mortality rate is low, and the disease is more benign;

(II) a large amount of drooling is in a guide strand shape;

the aphtha is positioned clearly (oral mucosa, hoof and nipple skin) and has specific pathological changes (blisters and erosion);

fourthly, tiger's spot heart can be seen when the foot-and-mouth disease is malignant;

slightly diseased livestock: fever, limping, hoof swelling, no food intake, herpes and the like do not exist.

Moderate diseased animals: fever, limping, hoof swelling, no food intake, and herpes leaking out of the body but not yet ruptured and lying down.

Severely ill livestock: the hoof and fork ulceration, fever, no eating, limping, lying down, herpes and herpes leakage occur.

In order to show the treatment effect of the invention on the livestock foot-and-mouth disease, 60 cases of livestock with the bovine foot-and-mouth disease, the porcine foot-and-mouth disease and the ovine foot-and-mouth disease are selected as the observation objects.

Wherein, the animals with mild cattle foot and mouth disease have 20 heads, the animals with moderate cattle foot and mouth disease have 20 heads, and the animals with severe cattle foot and mouth disease have 20 heads; wherein, the animals with mild pig foot-and-mouth disease have 20 heads, the animals with moderate pig foot-and-mouth disease have 20 heads, and the animals with severe pig foot-and-mouth disease have 20 heads; wherein, the animals have 20 heads of mild sheep foot and mouth disease, 20 heads of moderate sheep foot and mouth disease and 20 heads of severe sheep foot and mouth disease. The clinical cure standard is as follows: normal body temperature, normal appetite, normal mental state, and normal leg movements.

The use method of the invention comprises the following steps: applied to affected parts of the sick livestock respectively 1 time in the morning and evening every day, and continuously applied for three days.

Through clinical treatment and observation, the relevant treatment effects are shown in the following table:

comparison table of therapeutic effect

Clinical use results show that the medicine of the invention has obvious special effect and efficacy in the following aspects:

1. in the invention, indigo naturalis: has effects of clearing away heat and toxic materials, relieving swelling and pain, cooling blood, stopping bleeding, tranquilizing mind, and promoting phagocytosis of mononuclear macrophage system, and can be used for treating abnormal hyperplastic granulocyte and eosinophilic granulocyte. Indigo naturalis has inhibitory effect on Bacillus anthracis, pneumococcus, Shigella shigella, Vibrio cholerae, Staphylococcus aureus, and Staphylococcus albus. Trogopterus dung: has effects of promoting blood circulation, relieving pain, removing blood stasis, and stopping bleeding. The trogopterus dung is a commonly used medicine for promoting blood circulation and removing blood stasis, contains a large amount of resin and vitamin A, has the effects of inhibiting platelet aggregation, increasing coronary blood flow and improving microcirculation, and has the effects of resisting stress injury and enhancing immunologic function. Chuanwu has strong analgesic effect, and has effects of dilating blood vessel and lowering blood pressure. Especially has better effects on detumescence, acesodyne and antivirus, and has stable drug effect and quick effect. 2. The clinical use results show that the traditional Chinese medicine composition has the advantages of quick effect, short treatment course, stable effect, little pain, low cost, no side effect, no sequelae after healing, wide application and easy acceptance by farmers.

Detailed Description

The present invention is further illustrated by the following specific examples.

Example 1:

mixing 2g of borneol, 9g of realgar, 4g of phellodendron, 6g of dried ginger, 6.5g of Chinese honeylocust fruit, 5g of dipsacus root, 9g of alum, 6g of trogopterus dung and 0.5g of monkshood, crushing into powder of 40-50 meshes, then adding 2g of powdered indigo naturalis, and uniformly mixing to obtain the medicament for treating the foot and mouth disease of livestock.

When the foot-and-mouth disease treatment liquid is used, the prepared foot-and-mouth disease treatment liquid and mature vinegar are uniformly mixed according to the mass ratio of 0.9-1.2: 10 to obtain brown turbid liquid medicine, the consumption of the mature vinegar is 500g, and then the liquid medicine is smeared on the disease-affected parts of foot-and-mouth disease animals for 2 times a day for three days continuously. The invention has toxicity, can not be taken orally, and can be used for early treatment of young livestock to prevent myocarditis.

Other examples differ from example 1 in the following table:

unit: g

The application effect of the invention to pigs is as follows:

subject: the method comprises the steps of randomly extracting 60 pigs confirmed to be infected by foot-and-mouth disease as experimental objects (the symptoms are similar, the body temperature is high, the pigs do not eat, the mental state is not good, the pigs cannot stand normally, and the pigs have obvious herpes on hooves), dividing the experimental objects into 6 groups, respectively smearing 1-5 groups of the experimental objects prepared in the embodiments 1-5, wherein a control group is a blank group, and isolating each experimental group to prevent mutual infection.

The test method comprises the following steps: the sick pigs of each experimental group are coated with different test medicine proportions once, the coating standards (50g of each of examples 1-5 are respectively and uniformly mixed with 500g of mature vinegar) are coated on the diseased parts of the pigs, and the conditions in 12h, 24h, 36h, 48h, 60h and 72h time periods are observed after administration.

As a result: during the observation period, the appetite of the pigs in the experimental group is increased, the original mental state is restored, the body temperature is restored to be normal, the pigs can stand normally, the hoof herpes is cracked, and scab begins. In contrast, the control group did not improve the disease condition.

The using method comprises the following steps: 1 bag (50 g/bag) of the medicament is uniformly mixed with 500g of mature vinegar to obtain mixed liquid medicine, then the liquid medicine is smeared at the disease part of pigs suffering from the foot-and-mouth disease, 1 time is respectively carried out in the morning and evening every day, and the treatment condition of each group is observed after three days of continuous use.

For mild pig foot-and-mouth disease animals: the traditional Chinese medicine composition can be continuously applied for three days, wherein the traditional Chinese medicine composition is respectively applied for 1 time in the morning and at night, the body temperature begins to drop the next day after the traditional Chinese medicine composition is used for treating, the hoof begins to reduce the swelling, and the external herpes does not leak out of the body.

For moderate disease animals of pig foot-and-mouth disease: the invention can be used for treating fever, cripple, hoof swelling, non-eating, herpes leakage, non-rupture, lying and standing, and can be used for treating fever, crippling, hoof swelling, non-eating, herpes, standing eating, herpes and herpes regression.

For the livestock with severe pig foot-and-mouth disease: after the traditional Chinese medicine is used for treating the herpes, the patients begin to eat the medicine the next day, the body temperature is reduced, the patients can stand, lie for a plurality of times and less, and the ulcer part of the hoof and the fork begins to dry on the third day, so that the hoof shell slowly falls off.

The experimental result for treating the pig foot-and-mouth disease is as follows: the results of the experiment are shown in table 1.

TABLE 1 application Effect for the treatment of foot and mouth disease in pigs

The application effect of the invention for treating the foot-and-mouth disease of cattle

Subject: the method comprises the steps of randomly extracting 60 cattle confirmed to be infected by foot-and-mouth disease as experimental objects (similar symptoms, high body temperature, no food, poor mental state, incapability of standing normally and obvious herpes on hooves), dividing the experimental objects into 6 groups, respectively smearing 1-5 groups of the experimental objects prepared in the embodiments 1-5, wherein a control group is a blank group, and isolating each experimental group to prevent mutual infection.

The test method comprises the following steps: the sick cattle of each experimental group are smeared with different test medicine proportions once, smearing standards (50g of each of examples 1-5 are respectively and uniformly mixed with 500g of mature vinegar) are smeared on the diseased positions of the cattle, and the conditions in 12h, 24h, 36h, 48h, 60h and 72h time periods are observed after administration.

As a result: during the observation period, the cattle in the experimental group had increased appetite and recovered their original mental state, and the body temperature had returned to normal, and they could stand normally, and the hoof herpes had ruptured and began to scab. In contrast, the control group did not improve the disease condition.

The using method comprises the following steps: 1 bag (50 g/bag) of the medicament is uniformly mixed with 500g of mature vinegar to obtain mixed liquid medicine, then the liquid medicine is smeared at the disease position of the foot-and-mouth disease cattle, 1 time is respectively carried out in the morning and evening every day, and the treatment condition of each group is observed after three days of continuous use.

For cattle with mild foot-and-mouth disease: the traditional Chinese medicine composition can be continuously applied for three days, wherein the traditional Chinese medicine composition is respectively applied for 1 time in the morning and at night, the body temperature begins to drop the next day after the traditional Chinese medicine composition is used for treating, the hoof begins to reduce the swelling, and the external herpes does not leak out of the body.

For cattle with moderate foot-and-mouth disease: the invention can be used for treating fever, cripple, hoof swelling, non-eating, herpes leakage, non-rupture, lying and standing, and can be used for treating fever, crippling, hoof swelling, non-eating, herpes, standing eating, herpes and herpes regression.

For cattle with severe foot-and-mouth disease: after the traditional Chinese medicine is used for treating the herpes, the patients begin to eat the medicine the next day, the body temperature is reduced, the patients can stand, lie for a plurality of times and less, and the ulcer part of the hoof and the fork begins to dry on the third day, so that the hoof shell slowly falls off.

The experimental result for treating the foot-and-mouth disease of the cattle is as follows: the results of the experiment are shown in table 2.

TABLE 2 application Effect for treating foot and mouth disease in cattle

The application effect of the invention for treating sheep foot-and-mouth disease

Subject: 60 sheep confirmed to be infected by foot-and-mouth disease are randomly selected as experimental subjects (similar symptoms, high body temperature, no food, bad mental state, unable to stand normally, and obvious herpes on hooves), and are divided into 6 groups, 1 to 5 groups are respectively smeared with the invention prepared in the embodiments 1 to 5, a control group is a blank group, and each experimental group is isolated to prevent mutual infection.

The test method comprises the following steps: different test medicine proportions are smeared on each diseased sheep of each experimental group at one time, smearing standards (50g of each of examples 1-5 is respectively and uniformly mixed with 500g of mature vinegar) are smeared on the diseased positions of the sheep, and the conditions in 12h, 24h, 36h, 48h, 60h and 72h time periods are observed after administration.

As a result: during the observation period, the appetite of the sheep in the experimental group is increased, the original mental state is restored, the body temperature is restored to be normal, the sheep can stand normally, the hoof herpes is cracked, and scab begins. In contrast, the control group did not improve the disease condition.

The using method comprises the following steps: 1 bag (50 g/bag) of the medicament is uniformly mixed with 500g of mature vinegar to obtain mixed liquid medicine, then the liquid medicine is smeared at the disease position of the foot-and-mouth disease sheep, 1 time is respectively carried out in the morning and evening every day, and the treatment condition of each group is observed after three days of continuous use.

For animals with mild foot and mouth disease: the traditional Chinese medicine composition can be continuously applied for three days, wherein the traditional Chinese medicine composition is respectively applied for 1 time in the morning and at night, the body temperature begins to drop the next day after the traditional Chinese medicine composition is used for treating, the hoof begins to reduce the swelling, and the external herpes does not leak out of the body.

For animals with moderate foot-and-mouth disease: the invention can be used for treating fever, cripple, hoof swelling, non-eating, herpes leakage, non-rupture, lying and standing, and can be used for treating fever, crippling, hoof swelling, non-eating, herpes, standing eating, herpes and herpes regression.

For animals with severe foot and mouth disease: after the traditional Chinese medicine is used for treating the herpes, the patients begin to eat the medicine the next day, the body temperature is reduced, the patients can stand, lie for a plurality of times and less, and the ulcer part of the hoof and the fork begins to dry on the third day, so that the hoof shell slowly falls off.

The experimental result for treating the foot-and-mouth disease of sheep: the results of the experiment are shown in table 3.

TABLE 3 therapeutic effect on foot and mouth disease in sheep

As can be seen from tables 1 to 3, the curative ratio of the traditional Chinese medicine composition for the foot-and-mouth disease of the livestock and the pig, the cow and the sheep is as high as 100%, the treatment course is short, the drug effect is quick, and the loss of livestock breeding can be effectively reduced.

The typical case of the invention is as follows:

foot-and-mouth disease occurs in Daxi Korean pig farmers in the fat rural areas in the north and the river in 2015 in winter, foot-and-mouth disease occurs in 13 sows and weaned piglets, and obvious herpes, no food or fever and incapability of standing occur on hoofs and breasts. The prepared invention (50g per bag) is mixed with 500ml of mature vinegar, then the mixture is uniformly smeared on the affected part, and the smearing is carried out once (2 times a day) after 12 hours, and the leg is limed and stood after the smearing is finished. The body temperature begins to drop after the first medicine application on the next day, the opening is fed, the hoofs begin to subside, the herpes already breaks, the herpes of the hoofs and the breasts already begins to scab after the second medicine application on the next day, and the herpes part can be completely scabbed after three days of medicine application. On the fifth day, the telephone returns to visit, no casualties appear in the size, and the whole course of treatment is fully cured.

Foot and mouth diseases of Handan City Han village beef cattle raising farmers in 2016 winter and 2017 summer respectively occur, 20 cattle have herpes on breast and oral cavity, and the hoofs have no obvious herpes, do not eat, have fever and do not want to stand. The prepared invention (50g per bag) is mixed with 500ml of mature vinegar, then the mixture is uniformly smeared on the affected part, and the mixture is smeared once (2 times a day) after 12 hours, and the patient can stand after the mixture is smeared for the second time. The body temperature begins to drop after the first medication on the next day, the mouth is opened for eating, the hoofs have no herpes, the breasts and the oral herpes have been cracked, the herpes in the oral cavity and the breasts begin to scab when the second medication is performed on the next day, and the scabs at the herpes parts can be seen after the herpes is smeared for three days, so that the herpes is completely cured without casualties.

40 pigs of a certain raiser in Quzhou county of Handan city in 2017 are attacked (8 sows and 32 fattening pigs respectively), the affected parts of the sows are hoofs and breasts, the affected parts of the fattening pigs are hoofs, and the affected parts have obvious herpes and are all manifested as fever, no food and incapability of standing. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the mixture can stand after being smeared for the second time. After the third application, the body temperature begins to drop, the opening is fed, the herpes begins to break, the hooves begin to subside, the herpes begins to scab after the fourth application, the herpes becomes scab after the fifth and sixth applications, and the hooves subside. On the fifth day, the telephone returns to the visit and is completely cured without casualty.

A23-pig (fattening pig) with foot and mouth disease occurs in a Handan City south West Han village certain pig-raising family in 2018, the diseased part is on the hoof, and the affected part has obvious herpes, and the patients all show fever, do not eat and cannot stand. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the mixture can stand after being smeared for the second time. After the third application, the body temperature begins to drop, the opening is opened for eating, the herpes begins to break, the hoof begins to reduce swelling, the herpes begins to scab after the fourth application, the herpes already scabs after the fifth application and the sixth application, the hoof has reduced swelling, all the herpes is cured, and no casualties exist.

In 2018, Handan City of south West Korean village sheep raising family has foot and mouth disease, 15 diseased sheep, and ewe is breast and hoof with obvious herpes. The lamb is the hoof and has no obvious herpes. All are fever, no food, unable to stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then smeared for 2 times a day, and the ewe can stand after being smeared for the second time. The body temperature of the lamb decreases. After the ewe is smeared for the third time, the body temperature of the ewe begins to decrease, the ewe is fed with food, herpes begins to break, and the hoof begins to reduce swelling. The lamb is normal in body temperature and can stand normally. After the fourth application, the ewe had developed scabs due to the ruptured herpes. The lamb is already normal. After the fifth and sixth application, the herpes forms scabs, and the hoofs have detumescence, and are completely cured without casualty.

A certain pig-raising family in Pianzhongbao village of Handan in 2018 generates pig foot-and-mouth disease, has 30 diseased pigs with obvious herpes on hoofs, is fever-free, does not eat and cannot stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the mixture can stand after being smeared for the second time. After the third application, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. The ruptured herpes started to scab after the fourth application. After the fifth and sixth application, the herpes forms a scab and the hoof has subsided swelling. On the fifth day, the telephone returns to the visit and is completely cured without casualty.

A farmer in peak mine area of Handan city in 2019 winter has foot and mouth disease, 12 sick pigs and 12 pigs with obvious herpes on hoof, all suffer from fever, do not eat and cannot stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the people can stand after smearing for the second time. After the third time of smearing, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. After the fourth application, the ruptured herpes began to scab. After the fifth and sixth application, the herpes had scabbed and the legs had detumescence. On the fifth day, the telephone returns to the visit and is completely healed without casualty.

In 2019, foot and mouth disease occurs in a farmer in a certain village in the adult zone of Handan market in winter, 20 sick pigs have obvious herpes on the hoof, are all fever, do not eat and cannot stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the people can stand after smearing for the second time. After the third time of smearing, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. After the fourth application, the ruptured herpes began to scab. After the fifth and sixth application, the herpes had scabbed and the legs had detumescence. On the fifth day, the telephone returns to the visit and is completely healed without casualty.

In 2019, foot and mouth disease occurs in a farmer in a certain village in Handan market in winter, 10 sick pigs have obvious herpes on hoofs, all have fever, are not eaten, and cannot stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the people can stand after smearing for the second time. After the third time of smearing, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. After the fourth application, the ruptured herpes began to scab. After the fifth and sixth application, the herpes had scabbed and the legs had detumescence. On the fifth day, the telephone returns to the visit and is completely healed without casualty.

A25-head cattle of Handan City Han village Reping cattle-breeding family in rural area in the 2020 in winter generates foot-and-mouth disease, and both hoof and breast have obvious herpes, fever, no food and can not stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the people can stand after smearing for the second time. After the third time of smearing, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. After the fourth application, the ruptured herpes began to scab. After the fifth and sixth application, the herpes had scabbed and the legs had detumescence. The return visit of the fifth day shows that the wound is completely healed without casualty.

30 pigs of Handan City fat village region south west Korean village king flat-fed pig households are treated in 2020 in winter, and the breasts, the hoofs and the hoofs of the sows have obvious herpes, are fever-prone, do not eat and cannot stand normally. The invention (50g per bag) is mixed with 500ml of mature vinegar and then is smeared for 2 times a day, and the people can stand after smearing for the second time. After the third time of smearing, the body temperature begins to drop, the mouth is opened for eating, herpes begins to break, and hooves begin to subside swelling. After the fourth application, the ruptured herpes began to scab. After the fifth and sixth application, the herpes had scabbed and the legs had detumescence. The return visit of the fifth day shows that the wound is completely healed without casualty.

Claims

1. The medicament for treating the foot-and-mouth disease of the livestock is characterized by being prepared from the following components in parts by weight: indigo naturalis 1 ~ 4, 1 ~ 4 of borneol, 8 ~ 12 of realgar, 2 ~ 5 of phellodendron, 4 ~ 8 of Zingiberis rhizoma, 4 ~ 8 of saponin, 4 ~ 8 of radix Dipsaci, 8 ~ 12 of alum, 4 ~ 8 of trogopterus dung, 0.2 ~ 0.6 of radix Aconiti.