CN104042619B - A kind of Ceftiofur Hydrochloride cream and preparation method thereof - Google Patents
A kind of Ceftiofur Hydrochloride cream and preparation method thereof Download PDFInfo
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- CN104042619B CN104042619B CN201410034363.7A CN201410034363A CN104042619B CN 104042619 B CN104042619 B CN 104042619B CN 201410034363 A CN201410034363 A CN 201410034363A CN 104042619 B CN104042619 B CN 104042619B
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Abstract
The present invention relates to a kind of Ceftiofur Hydrochloride cream and preparation method thereof, described Ceftiofur Hydrochloride cream, Buddhist nun, vitamin E, glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, polyoxyethylene sorbitan monoleate, ethylparaben and purified water are sprinkled by Ceftiofur Hydrochloride, acetic acid hydrogenation to constitute, oil phase, water phase are first prepared during preparation, add Ceftiofur Hydrochloride, the bold and vigorous Buddhist nun of acetic acid hydrogenation to be well mixed, the cream is used to treat mastitis for milk cows.
Description
Technical field
The present invention relates to a kind of Ceftiofur Hydrochloride cream and preparation method thereof.
Background technology
Mastitis for milk cows is a kind of disease of the breast tissue and nipple inflammation caused by many factors such as pathogenic microorganisms.
At present, the whole world there are about 2.3 hundred million cow heads, wherein the milk cow that there are about 1/3 suffers from various types of mammitises, every year because of mammitis
The loss for causing is up to 300,000,000,000 yuans.In China, mastitis for milk cows positive rate is up to 50%~70%, and economic loss is about
1.35 hundred million yuans.Therefore, mammitis turns into most common on veterinary clinic, while being also maximum to Cow product harmfulness
Disease.At present, injection of antibiotic method is still domestic treatment mastitis for milk cows most common method, there is antibiotic usage agent
Amount is larger, and bacterial drug resistance is serious, the problems such as clinical therapeutic efficacy is poor.
Ceftiofur Hydrochloride is the third generation cephalosporin of animal specific.Medication effect is excellent, to gram-positive bacteria and
Gram-negative bacteria is respectively provided with super broad spectrum high-effect antibacterial action, compared with other antibiotic, content of the medicine in infected tissue
It is higher than non-infected tissue 2~4 times, play medicine in the integrated distribution for having target and act on, with lasting medicine, toxic and side effect is small,
Drug resistance is not likely to produce, is had a extensive future in veterinary clinic.China introduces Ceftiofur Hydrochloride and its preparation is studied
Relatively later, what currently acquired Ministry of Agriculture's approval production and selling was permitted is only limitted to Ceftiofur Hydrochloride bulk drug and its injection
Agent.Cream has the advantages that easy to use, stable in properties, effect is fast, good effect.Therefore, Ceftiofur Hydrochloride is made breast
Paste has significant application value and wide market prospects to safely and effectively treatment mastitis for milk cows.
, the content of the invention
It is an object of the invention to provide a kind of Ceftiofur Hydrochloride cream；
Another object of the present invention is to provide a kind of preparation method of Ceftiofur Hydrochloride cream.
Technical scheme is as follows：
A kind of Ceftiofur Hydrochloride cream, by following weight percent match into being grouped into：
Ceftiofur Hydrochloride 1.5-3
Hydroprednisone acetate 0.04-0.1
Vitamin E 0.05-0.2
Glycerin monostearate 7-15
Albolene 2-10
Lanolin 3-8
Atoleine 10-55
Sorbester p17 1.5-5
Polyoxyethylene sorbitan monoleate 0.8-2.5
Ethylparaben 0.05-0.1
Purified water 15-60.
The preparation method of described Ceftiofur Hydrochloride cream, preparation process is：
A be micronized for Ceftiofur Hydrochloride by (), cross 100-400 mesh sieves；
B () takes recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in burning
In cup, 65-85 DEG C of heating water bath melts it, and magnetic agitation is uniform, is oil phase；
C () separately takes recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water in beaker, 65-85 DEG C of heating water bath, magnetic
Power stirs, and is water phase；
Water is mutually added slowly to oil phase under (d) stirring, acetic acid hydrogenation is then respectively adding and is sprinkled Buddhist nun, step (a) gained salt
Sour Ceftiofur, is well mixed, and filling, Co 60 ray sterilizing is obtained final product.
The preparation method of the Ceftiofur Hydrochloride cream, oil phase in preparation process, water phase water-bath heating-up temperature it is excellent
Elect 80 DEG C as.
The preparation method of described Ceftiofur Hydrochloride cream, the speed of magnetic agitation is 500- in preparation process
1000r/min。
Technical scheme has following advantages：
（1）Ceftiofur Hydrochloride is respectively provided with super broad spectrum high-effect to gram-positive bacteria and Gram-negative bacteria and resists in the present invention
Bacterium acts on, and vitamin E has the immune function of enhancing, is equipped with hydroprednisone acetate anti-inflammatory advantage, has to mastitis for milk cows
Obvious therapeutic action, can be used to prevent and treat the mastitis for milk cows that gram-positive bacteria and Gram-negative bacteria cause.
（2）Preparation process is simple of the present invention, low production cost, it is easy to accomplish industrialization, it is easy to use.
, specific embodiment
Form by the following examples is described in further detail again to the above of the invention, but should not be by this
The scope for being interpreted as above-mentioned theme of the invention is only limitted to following example, and all technologies realized based on the above of the present invention are equal
Belong to the scope of the present invention.
The preparation example 1 of the Ceftiofur Hydrochloride cream of embodiment 1
The formula of Ceftiofur Hydrochloride cream is as follows：
It is made up of the raw material of following weight ratio per 100g Ceftiofur Hydrochlorides cream：
The g of Ceftiofur Hydrochloride 2.5
The g of hydroprednisone acetate 0.1
Vitamin E 0.1g
Glycerin monostearate 13g
Albolene 5g
Lanolin 7g
Atoleine 50g
Sorbester p17 3g
Polyoxyethylene sorbitan monoleate 2.2g
Ethylparaben 0.1g
Purified water 22g
The preparation method of Ceftiofur Hydrochloride cream of the present invention is as follows：
（1）Ceftiofur Hydrochloride is micronized, 100-400 mesh sieves are crossed；
（2）Weigh recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in
In beaker, heating water bath melts it to 80 DEG C, and magnetic agitation is uniform, and rotating speed is 900r/min, it is oil phase；
（3）Recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, heating water bath to 80 DEG C, magnetic
Power stirs, and rotating speed is 700r/min, is water phase；
（4）Rotating speed is then respectively adding vinegar for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 500r/min
Sour prednisolone, Ceftiofur Hydrochloride, are well mixed, and filling, Co 60 ray sterilizing obtains final product product.
The preparation example 2 of the Ceftiofur Hydrochloride cream of embodiment 2
The formula of Ceftiofur Hydrochloride cream is as follows：
It is made up of the raw material of following weight ratio per 100g Ceftiofur Hydrochlorides cream：
Ceftiofur Hydrochloride 2g
Hydroprednisone acetate 0.08g
Vitamin E 0.15g
Glycerin monostearate 15g
Albolene 2g
Lanolin 5g
Atoleine 11.72g
The g of sorbester p17 1.5
The g of polyoxyethylene sorbitan monoleate 2.5
Ethylparaben 0.05g
Purified water 60g
The preparation method of Ceftiofur Hydrochloride cream of the present invention is as follows：
（1）Ceftiofur Hydrochloride is micronized, 100-400 mesh sieves are crossed；
（2）Weigh recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in
In beaker, heating water bath melts it to 80 DEG C, and magnetic agitation is uniform, and rotating speed is 1000r/min, is oil phase；
（3）Recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, heating water bath to 80 DEG C, magnetic
Power stirs, and rotating speed is 500r/min, is water phase；
（4）Rotating speed is then respectively adding vinegar for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 800r/min
Sour prednisolone, Ceftiofur Hydrochloride, are well mixed, and filling, Co 60 ray sterilizing obtains final product product.
The preparation example 3 of the Ceftiofur Hydrochloride cream of embodiment 3
The formula of Ceftiofur Hydrochloride cream is as follows：
It is made up of the raw material of following weight ratio per 100g Ceftiofur Hydrochlorides cream：
Ceftiofur Hydrochloride 3g
Hydroprednisone acetate 0.04g
Vitamin E 0.05g
Glycerin monostearate 10g
Albolene 10g
Lanolin 3g
Atoleine 53.01g
Sorbester p17 5g
Polyoxyethylene sorbitan monoleate 0.8g
Ethylparaben 0.1g
Purified water 15g
The preparation method of Ceftiofur Hydrochloride cream of the present invention is as follows：
（1）Ceftiofur Hydrochloride is micronized, 100-400 mesh sieves are crossed；
（2）Weigh recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in
In beaker, heating water bath melts it to 80 DEG C, and magnetic agitation is uniform, and rotating speed is 500r/min, is oil phase；
（3）Recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, heating water bath to 80 DEG C, magnetic
Power stirs, and rotating speed is 700r/min, is water phase；
（4）Rotating speed is then respectively adding vinegar for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 600r/min
Sour prednisolone, Ceftiofur Hydrochloride, are well mixed, and filling, Co 60 ray sterilizing obtains final product product.
The preparation example 4 of the Ceftiofur Hydrochloride cream of embodiment 4
The formula of Ceftiofur Hydrochloride cream is as follows：
It is made up of the raw material of following weight ratio per 100g Ceftiofur Hydrochlorides cream：
Ceftiofur Hydrochloride 1.5g
Hydroprednisone acetate 0.1g
Vitamin E 0.2g
Glycerin monostearate 12g
Albolene 8g
Lanolin 8g
Atoleine 10g
Sorbester p17 3g
Polyoxyethylene sorbitan monoleate 2g
Ethylparaben 0.08g
Purified water 55.12g
The preparation method of Ceftiofur Hydrochloride cream of the present invention is as follows：
（1）Ceftiofur Hydrochloride is micronized, 100-400 mesh sieves are crossed；
（2）Weigh recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in
In beaker, heating water bath melts it to 80 DEG C, and magnetic agitation is uniform, and rotating speed is 800r/min, is oil phase；
（3）Recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, heating water bath to 80 DEG C, magnetic
Power stirs, and rotating speed is 600r/min, is water phase；
（4）Rotating speed is then respectively adding vinegar for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 500r/min
Sour prednisolone, Ceftiofur Hydrochloride, are well mixed, and filling, Co 60 ray sterilizing obtains final product product.
The preparation example 5 of the Ceftiofur Hydrochloride cream of embodiment 5
The formula of Ceftiofur Hydrochloride cream is as follows：
It is made up of the raw material of following weight ratio per 100g Ceftiofur Hydrochlorides cream：
Ceftiofur Hydrochloride 2g
Hydroprednisone acetate 0.05g
Vitamin E 0.12g
Glycerin monostearate 7g
Albolene 5g
Lanolin 6g
Atoleine 55g
Sorbester p17 2g
Polyoxyethylene sorbitan monoleate 1g
Ethylparaben 0.05g
Purified water 21.78g
The preparation method of Ceftiofur Hydrochloride cream of the present invention is as follows：
（1）Ceftiofur Hydrochloride is micronized, 100-400 mesh sieves are crossed；
（2）Weigh recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E in
In beaker, heating water bath melts it to 80 DEG C, and magnetic agitation is uniform, and rotating speed is 1000r/min, is oil phase；
（3）Recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, heating water bath to 80 DEG C, magnetic
Power stirs, and rotating speed is 800r/min, is water phase；
（4）Rotating speed is then respectively adding vinegar for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 600r/min
Sour prednisolone, Ceftiofur Hydrochloride, are well mixed, and filling, Co 60 ray sterilizing obtains final product product.
The Ceftiofur Hydrochloride cream stability test of embodiment 6
Materials and methods
Test drug
Gained Ceftiofur Hydrochloride cream is prepared by the methods described of embodiment 1.
Test method
Ceftiofur Hydrochloride cream is put into room temperature respectively（25℃）, in insulating box (39 ± 1 DEG C) and refrigerator (5 ± 2 DEG C)
Investigate 3 months, investigate Ceftiofur Hydrochloride cream stability.
Result of the test
The results are shown in Table 1.
Result of the test shows that salt Ceftiofur Hydrochloride cream of the present invention is in room temperature（25℃）, insulating box (39 ± 1 DEG C) and
Under three temperature environments of refrigerator (5 ± 2 DEG C), appearance character, relative amount change less, show stability higher.
Therapeutic effect of the Ceftiofur Hydrochloride cream of embodiment 7 to mastitis for milk cows
Materials and methods
Test drug
Gained Ceftiofur Hydrochloride cream is prepared by the methods described of embodiment 1.
Experimental animal
Experimental animal selects 26 lactating cows for determining infection mastitis for milk cows after diagnosing.
Test method
After by mammitis milk cow milking, per breast room perfusion 10g Ceftiofur Hydrochloride creams, 2 times a day, is used in conjunction 3 times.
Curative effect judging standard
（1）It is completely recovered：Breast red and swollen heat pain is disappeared, and milk is visually observed normally, and the output of milk is gone up, and pathogen is turned out cloudy.
（2）Clinical recovery：Breast red and swollen heat pain disappears, and milk switchs to normally completely, and the output of milk is recovered, but pathogen fails
Turn out cloudy.
（3）Effectively：Breast red and swollen heat pain substantially mitigates, and milk milk, extract disappear or substantially reduce substantially, the output of milk
Gradually go up.
（4）It is invalid：By after a course of therapy, mammitis without taking a turn for the better or even more serious, milk throw away it is thin, turn to be yellow or have
Flocculus, extract are present.
2 result of the tests
The results are shown in Table 2.
Result of the test shows that medicine Ceftiofur Hydrochloride cream of the present invention is notable to mastitis for milk cows therapeutic effect.
Claims (2)
1. a kind of Ceftiofur Hydrochloride cream, it is characterised in that per 100g Ceftiofur Hydrochloride creams by following weight ratio
Raw material composition：
Ceftiofur Hydrochloride 1.5g
Hydroprednisone acetate 0.1g
Vitamin E 0.2g
Glycerin monostearate 12g
Albolene 8g
Lanolin 8g
Atoleine 10g
Sorbester p17 3g
Polyoxyethylene sorbitan monoleate 2g
Ethylparaben 0.08g
Purified water 55.12g；
The preparation method of described Ceftiofur Hydrochloride cream is as follows：
(1) Ceftiofur Hydrochloride is micronized, crosses 100-400 mesh sieves；
(2) recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E are weighed in beaker
In, 80 DEG C of heating water bath melts it, and magnetic agitation is uniform, and rotating speed is 800r/min, is oil phase；
(3) recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, 80 DEG C of heating water bath, magnetic agitation
Uniformly, rotating speed is 600r/min, is water phase；
(4) rotating speed is then respectively adding cellulose acetate hydrogen for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 500r/min
Change metacortandracin, step (1) gained Ceftiofur Hydrochloride, be well mixed, filling, Co 60 ray sterilizing is obtained final product.
2. a kind of preparation method of Ceftiofur Hydrochloride cream as claimed in claim 1, it is characterised in that described hydrochloric acid
The preparation method of Ceftiofur cream is as follows：
(1) Ceftiofur Hydrochloride is micronized, crosses 100-400 mesh sieves；
(2) recipe quantity glycerin monostearate, albolene, lanolin, atoleine, sorbester p17, vitamin E are weighed in beaker
In, 80 DEG C of heating water bath melts it, and magnetic agitation is uniform, and rotating speed is 800r/min, is oil phase；
(3) recipe quantity polyoxyethylene sorbitan monoleate, ethylparaben and purified water are weighed in beaker, 80 DEG C of heating water bath, magnetic agitation
Uniformly, rotating speed is 600r/min, is water phase；
(4) rotating speed is then respectively adding cellulose acetate hydrogen for water is mutually added slowly into oil phase under the conditions of the magnetic agitation of 500r/min
Change metacortandracin, step (1) gained Ceftiofur Hydrochloride, be well mixed, filling, Co 60 ray sterilizing is obtained final product.
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Families Citing this family (5)
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| CN105726461B (en) * | 2014-12-10 | 2021-02-09 | 瑞普（天津）生物药业有限公司 | Ceftiofur hydrochloride breast injection in dry period |
| RU2570396C1 (en) * | 2014-12-29 | 2015-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Орловский государственный аграрный университет" | Preparation "dioksomast" for treatment subclinical mastitis in cows |
| CN104622875B (en) * | 2015-02-12 | 2017-05-10 | 江西博莱大药厂有限公司 | Breast injection medicament for resisting cow mastitis and preparation method thereof |
| CN105106215B (en) * | 2015-07-31 | 2018-03-02 | 河南牧业经济学院 | Treat ointment of acute mammitis of cow and preparation method thereof |
| RU2600881C1 (en) * | 2015-11-24 | 2016-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Орловский государственный аграрный университет" | Preparation "suhostin" for treating mastitis in non-lactating cows |
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| CN102488694B (en) * | 2011-12-21 | 2012-12-19 | 齐鲁动物保健品有限公司 | Perfusion medicament for treating milk cow mastitis and preparation method thereof |
| CN103006672A (en) * | 2012-12-26 | 2013-04-03 | 齐鲁动物保健品有限公司 | Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent |
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