RU2600881C1 - Preparation "suhostin" for treating mastitis in non-lactating cows - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention relates to veterinary science and aims at treating mastitis in non-lactating cows. Declared preparation comprises apramycin, xanthan gum, prednisolone, liquid paraffin and distilled water in the following component ratio, wt%: apramycin - 7.0; xanthane gum - 0.3; prednisolone - 10; liquid paraffin - 4.5; distilled water - 78.2. Invention allows reducing time of recuperation of cows suffering from mastitis, and improving milk quality in the next lactation.

EFFECT: preparation provides better upgrading glandular udder tissue and improving milk quality in the next lactation.

1 cl, 1 tbl, 1 ex

Description

The invention relates to veterinary medicine, in particular for the treatment of mastitis in cows in the dry period.

A known drug for the treatment of mastitis in cows in the dry period, which includes: apramycin - 5.0-10.0%; xanthan gum - 0.25-1.0%; distilled water - the rest is up to 100% (RF patent No. 2491921, publ. 09/10/2013) [1].

The disadvantage of the drug is that it takes a long time to carry out treatment, disrupting the restoration processes in the glandular tissue of the udder of cows, which subsequently leads to a decrease in the quality of milk in subsequent lactation.

The objective of the invention is to remedy the above drawback.

The problem is achieved due to the fact that the well-known drug for the treatment of mastitis in cows in the dry period, containing apramycin, xanthan gum, distilled water, according to the invention additionally contains prednisolone and liquid paraffin in the following ratio, wt. %: apramycin - 7.0; xanthan gum - 0.3; prednisone - 10; liquid paraffin - 4.5; distilled water - 78.2.

Apramycin is an antibacterial drug of the broad-spectrum aminoglycoside group. The drug has a bactericidal effect against gram-negative, some gram-positive bacteria and some types of mycoplasmas. The mechanism of antibacterial action of apramycin is due to the suppression of protein synthesis of microorganisms. A unique feature of apramycin is the lack of risk of microflora resistance formation to this antibiotic, while ensuring high efficiency even in the case of multiple drug resistance of microflora.

Xanthan gum is a biopolymer capable of stabilizing solutions, having good emulsifying properties, forming a protective film on the surface, moisturizing the skin and not having a harmful effect on the body.

Prednisolone is a synthetic medium-strength glucocorticoid drug. It is the strongest anti-inflammatory drug that reduces the inflammatory reaction in a matter of hours and at the same time does not have a negative effect on the activity of phagocytes in the focus of inflammation. It affects the alternative and exudative phases of inflammation and prevents the spread of the inflammatory process. Prednisolone reduces the number of lymphocytes (somatic cells) in the milk of cows with mastitis and, thus, improves the quality of milk [2] (http://kuc-apk.ru/index.php?option=com_content&view=article&id=225&Itemid=550&lang = ru) and contributes to the recovery of the animal as soon as possible [3] (http://dki.h12.ru/vp/provet/multimast.htm).

Liquid paraffin is a mixture of liquid hydrocarbons of petroleum distillate, which is obtained in the process of purification and bleaching. In pharmacology, liquid paraffin is used as one of the main components of most moisturizers. Liquid paraffin will create a protective barrier and maintain the necessary moisture level. This tool has high emollient and regenerative properties.

A complex combination of these substances allowed to reduce the recovery time of cows with mastitis, and to improve the quality of milk obtained.

The inventive drug was used to treat mastitis in cows in the dry period at milk production farms located in the Oryol region.

The identification of patients with mastitis in cows was carried out in accordance with the instruction “Instructions for the diagnosis, therapy and prevention of mastitis in cows” (2000). Subclinical mastitis was detected using a rapid mastitis test (BMT). Clinical mastitis was diagnosed visually by the nature of the secretion of the mammary gland.

For research, four groups of cows were selected. In the first two groups (the 1st with subclinical and the 2nd with clinical mastitis), a well-known drug was used for treatment. In the second two groups of cows (3rd with subclinical and 4th with clinical mastitis), the proposed drug was used.

Immediately upon completion of the lactation period, in every quarter of the udder, irrespective of their defeat, the drug was administered itcisterially in the amount of 10 ml 3 times with an interval of 3-4 days.

Before using the drug, the secret from the diseased quarters of the udder was extruded and disposed of, the nipple was treated with a disinfectant solution, then an injector cannula was inserted into the nipple canal and the contents were carefully squeezed into the affected quarter of the udder. In the cold season, the drug was heated to 37 ° C before use, and shaken thoroughly until a uniform suspension was obtained. After the administration of the drug, a light massage of the nipple of the affected udder lobe was performed from the bottom up for better distribution of the drug.

The treatment results for cow troups are shown in the table.

Based on the studies, it was found that the use of the proposed drug for the treatment of mastitis in cows in the dry period allows to obtain high therapeutic efficacy, and also prevents the spread of the inflammatory process and contributes to the recovery of animals in a short time. The drug promotes better renewal of the glandular tissue of the udder and improves the quality of milk in subsequent lactation.

Claims (1)

The drug for the treatment of mastitis in cows in the dry period, containing apramycin, xanthan gum, prednisone, liquid paraffin and distilled water in the following ratio, wt. %:
apramycin - 7.0;
xanthan gum - 0.3;
prednisone - 10;
liquid paraffin - 4.5;
distilled water - 78.2.