CN104042619A - Ceftiofur hydrochloride cream and preparation method thereof - Google Patents
Ceftiofur hydrochloride cream and preparation method thereof Download PDFInfo
- Publication number
- CN104042619A CN104042619A CN201410034363.7A CN201410034363A CN104042619A CN 104042619 A CN104042619 A CN 104042619A CN 201410034363 A CN201410034363 A CN 201410034363A CN 104042619 A CN104042619 A CN 104042619A
- Authority
- CN
- China
- Prior art keywords
- ceftiofur hydrochloride
- water
- preparation
- ointment
- oil phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to ceftiofur hydrochloride cream and a preparation method thereof. The ceftiofur hydrochloride cream comprises ceftiofur hydrochloride, prednisolone acetate, vitamin E, monoglyceride stearate, albolene, lanolin, liquid paraffin, span 80, polysorbate 80, ethylparaben and purified water. The preparation method comprises the following steps of preparing an oil phase and a water phase, adding ceftiofur hydrochloride and prednisolone acetate into the oil phase and the water phase, and carrying out mixing to obtain a uniform mixture. The ceftiofur hydrochloride cream can be used for treating cow mastitis.
Description
technical field
The present invention relates to a kind of Ceftiofur Hydrochloride ointment and preparation method thereof.
Background technology
Mammitis of cow is the breast tissue that caused by many factors such as pathogenic microorganisms and a kind of disease of nipple inflammation.At present, approximately there are 2.3 hundred million cow heads in the whole world, wherein approximately has 1/3 milch cow to suffer from various types of mastitiss, and the loss causing because of mastitis is every year up to 3,000 hundred million yuans.In China, mammitis of cow positive rate is up to 50%～70%, approximately 1.35 hundred million yuans of economic losses.Therefore, mastitis becomes on veterinary clinic the most common, is also the disease to milch cow disserve to produce maximum simultaneously.The problems such as at present, injection of antibiotic method remains the most frequently used method of state's internal therapy mammitis of cow, exists antibiotic using dosage larger, and bacterial drug resistance is serious, and clinical therapeutic efficacy is poor.
Ceftiofur Hydrochloride is the third generation cephalosporin of animal specific.This medication effect is excellent, gram positive bacteria and gram negative bacteria are all had to super broad spectrum high-effect antibacterial action, compared with other antibiotic, the content of this medicine in infected tissue is higher 2～4 times than non-infected tissue, be the concentrated distribution performance drug effect that has target, have lasting medicine, toxic and side effects is little, be difficult for producing drug resistance, have a extensive future at veterinary clinic.China introduces Ceftiofur Hydrochloride and also its preparation is studied to relatively evening, and what obtain at present Ministry of Agriculture's approval production and selling license only limits to Ceftiofur Hydrochloride crude drug and injection thereof.The advantages such as that ointment has is easy to use, stable in properties, effect are fast, good effect.Therefore, Ceftiofur Hydrochloride is made to ointment safe and effective treatment mammitis of cow is had to significant application value and wide market prospect.
summary of the invention
The object of the present invention is to provide a kind of Ceftiofur Hydrochloride ointment;
Another object of the present invention is to provide a kind of preparation method of Ceftiofur Hydrochloride ointment.
Technical scheme of the present invention is as follows:
A kind of Ceftiofur Hydrochloride ointment, is grouped into by the one-tenth of following weight percent proportioning:
Ceftiofur Hydrochloride 1.5-3
Hydroprednisone acetate (prednisolone) 0.04-0.1
Vitamin E 0.05-0.2
Glyceryl monostearate 7-15
White vaseline 2-10
Lanoline 3-8
Liquid paraffin 10-55
Sorbester p17 1.5-5
Polyoxyethylene sorbitan monoleate 0.8-2.5
Ethyl hydroxybenzoate 0.05-0.1
Purified water 15-60.
The preparation method of described Ceftiofur Hydrochloride ointment, preparation process is:
(a), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(b) get recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath 65-85 DEG C, makes its fusing, and magnetic agitation is even, is oil phase;
(c) separately get recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath 65-85 DEG C, magnetic agitation is even, is water;
(d) under stirring, water is slowly joined to oil phase, then add respectively acetic acid hydrogenation to sprinkle Buddhist nun, step (a) gained Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, to obtain final product.
The preparation method of described Ceftiofur Hydrochloride ointment, in preparation process, the heating-up temperature of oil phase, water water-bath is preferably 80 DEG C.
The preparation method of described Ceftiofur Hydrochloride ointment, in preparation process, the speed of magnetic agitation is 500-1000r/min.
technical scheme of the present invention has following advantages:
(1) in the present invention, Ceftiofur Hydrochloride all has super broad spectrum high-effect antibacterial action to gram positive bacteria and gram negative bacteria, vitamin E has the immune function of enhancing, be equipped with hydroprednisone acetate (prednisolone) antiinflammatory advantage, mammitis of cow is had to obvious therapeutical effect, can be used for preventing and treating the mammitis of cow that gram positive bacteria and gram negative bacteria cause.
(2) preparation technology of the present invention is simple, and production cost is low, is easy to realize industrialization, easy to use.
specific embodiment
form is by the following examples described in further detail foregoing of the present invention again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
the preparation example 1 of embodiment 1 Ceftiofur Hydrochloride ointment
The formula of Ceftiofur Hydrochloride ointment is as follows:
Every 100g Ceftiofur Hydrochloride ointment is made up of the raw material of following weight ratio:
Ceftiofur Hydrochloride 2.5 g
Hydroprednisone acetate (prednisolone) 0.1 g
Vitamin E 0.1g
Glyceryl monostearate 13g
White vaseline 5g
Lanoline 7g
Liquid paraffin 50g
Sorbester p17 3g
Polyoxyethylene sorbitan monoleate 2.2g
Ethyl hydroxybenzoate 0.1g
Purified water 22g
The preparation method of Ceftiofur Hydrochloride ointment of the present invention is as follows:
(1), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(2) take recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath to 80 DEG C, makes its fusing, and magnetic agitation is even, and rotating speed is 900r/min,, be oil phase;
(3) take recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath to 80 DEG C, magnetic agitation is even, and rotating speed is 700r/min, is water;
(4) under the magnetic agitation condition that rotating speed is 500r/min, water is slowly joined to oil phase, then add respectively hydroprednisone acetate (prednisolone), Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, obtains product.
the preparation example 2 of embodiment 2 Ceftiofur Hydrochloride ointments
The formula of Ceftiofur Hydrochloride ointment is as follows:
Every 100g Ceftiofur Hydrochloride ointment is made up of the raw material of following weight ratio:
Ceftiofur Hydrochloride 2g
Hydroprednisone acetate (prednisolone) 0.08g
Vitamin E 0.15g
Glyceryl monostearate 15g
White vaseline 2g
Lanoline 5g
Liquid paraffin 11.72g
Sorbester p17 1.5 g
Polyoxyethylene sorbitan monoleate 2.5 g
Ethyl hydroxybenzoate 0.05g
Purified water 60g
The preparation method of Ceftiofur Hydrochloride ointment of the present invention is as follows:
(1), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(2) take recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath to 80 DEG C, makes its fusing, and magnetic agitation is even, and rotating speed is 1000r/min, is oil phase;
(3) take recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath to 80 DEG C, magnetic agitation is even, and rotating speed is 500r/min, is water;
(4) under the magnetic agitation condition that rotating speed is 800r/min, water is slowly joined to oil phase, then add respectively hydroprednisone acetate (prednisolone), Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, obtains product.
the preparation example 3 of embodiment 3 Ceftiofur Hydrochloride ointments
The formula of Ceftiofur Hydrochloride ointment is as follows:
Every 100g Ceftiofur Hydrochloride ointment is made up of the raw material of following weight ratio:
Ceftiofur Hydrochloride 3g
Hydroprednisone acetate (prednisolone) 0.04g
Vitamin E 0.05g
Glyceryl monostearate 10g
White vaseline 10g
Lanoline 3g
Liquid paraffin 53.01g
Sorbester p17 5g
Polyoxyethylene sorbitan monoleate 0.8g
Ethyl hydroxybenzoate 0.1g
Purified water 15g
The preparation method of Ceftiofur Hydrochloride ointment of the present invention is as follows:
(1), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(2) take recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath to 80 DEG C, makes its fusing, and magnetic agitation is even, and rotating speed is 500r/min, is oil phase;
(3) take recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath to 80 DEG C, magnetic agitation is even, and rotating speed is 700r/min, is water;
(4) under the magnetic agitation condition that rotating speed is 600r/min, water is slowly joined to oil phase, then add respectively hydroprednisone acetate (prednisolone), Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, obtains product.
the preparation example 4 of embodiment 4 Ceftiofur Hydrochloride ointments
The formula of Ceftiofur Hydrochloride ointment is as follows:
Every 100g Ceftiofur Hydrochloride ointment is made up of the raw material of following weight ratio:
Ceftiofur Hydrochloride 1.5g
Hydroprednisone acetate (prednisolone) 0.1g
Vitamin E 0.2g
Glyceryl monostearate 12g
White vaseline 8g
Lanoline 8g
Liquid paraffin 10g
Sorbester p17 3g
Polyoxyethylene sorbitan monoleate 2g
Ethyl hydroxybenzoate 0.08g
Purified water 55.12g
The preparation method of Ceftiofur Hydrochloride ointment of the present invention is as follows:
(1), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(2) take recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath to 80 DEG C, makes its fusing, and magnetic agitation is even, and rotating speed is 800r/min, is oil phase;
(3) take recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath to 80 DEG C, magnetic agitation is even, and rotating speed is 600r/min, is water;
(4) under the magnetic agitation condition that rotating speed is 500r/min, water is slowly joined to oil phase, then add respectively hydroprednisone acetate (prednisolone), Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, obtains product.
the preparation example 5 of embodiment 5 Ceftiofur Hydrochloride ointments
The formula of Ceftiofur Hydrochloride ointment is as follows:
Every 100g Ceftiofur Hydrochloride ointment is made up of the raw material of following weight ratio:
Ceftiofur Hydrochloride 2g
Hydroprednisone acetate (prednisolone) 0.05g
Vitamin E 0.12g
Glyceryl monostearate 7g
White vaseline 5g
Lanoline 6g
Liquid paraffin 55g
Sorbester p17 2g
Polyoxyethylene sorbitan monoleate 1g
Ethyl hydroxybenzoate 0.05g
Purified water 21.78g
The preparation method of Ceftiofur Hydrochloride ointment of the present invention is as follows:
(1), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(2) take recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath to 80 DEG C, makes its fusing, and magnetic agitation is even, and rotating speed is 1000r/min, is oil phase;
(3) take recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath to 80 DEG C, magnetic agitation is even, and rotating speed is 800r/min, is water;
(4) under the magnetic agitation condition that rotating speed is 600r/min, water is slowly joined to oil phase, then add respectively hydroprednisone acetate (prednisolone), Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, obtains product.
embodiment 6 Ceftiofur Hydrochloride ointment stability tests
Materials and methods
Test drug
Prepare gained Ceftiofur Hydrochloride ointment by method described in embodiment 1.
Test method
Ceftiofur Hydrochloride ointment is put respectively in room temperature (25 DEG C), calorstat (39 ± 1 DEG C) and refrigerator (5 ± 2 DEG C) and investigated 3 months, investigate Ceftiofur Hydrochloride ointment stability.
Result of the test
The results are shown in Table 1.
Result of the test shows, salt Ceftiofur Hydrochloride ointment of the present invention is under room temperature (25 DEG C), calorstat (39 ± 1 DEG C) and three temperature environments of refrigerator (5 ± 2 DEG C), appearance character, relative amount all change not quite, show higher stability.
the therapeutic effect of embodiment 7 Ceftiofur Hydrochloride ointments to mammitis of cow
Materials and methods
Test drug
Prepare gained Ceftiofur Hydrochloride ointment by method described in embodiment 1.
Experimental animal
Experimental animal selects 26 to determine after diagnosing the lactating cow that infects mammitis of cow.
Test method
By after mastitis milk cow milking, every newborn chamber perfusion 10g Ceftiofur Hydrochloride ointment, every day 2 times, is used in conjunction 3 times.
Curative effect judging standard
(1) be completely recovered: breast red and swollen heat pain disappears, and milk perusal is normal, milk yield is gone up, and pathogen is turned out cloudy.
(2) clinical recovery: breast red and swollen heat pain disappears, and milk transfers to normally completely, milk yield is recovered, but pathogen fails to turn out cloudy.
(3) effective: breast red and swollen heat pain obviously alleviates, milk milk, extract substantially disappear or significantly reduce, and milk yield is gone up gradually.
(4) invalid: after a course of therapy, mastitis is without taking a turn for the better or even more serious, and that milk is thrown away is rare clearly, turn to be yellow or have flocculus, extract to exist.
2 result of the tests
The results are shown in Table 2.
Result of the test shows, medicine Ceftiofur Hydrochloride ointment of the present invention is remarkable to mammitis of cow therapeutic effect.
Claims (4)
1. a Ceftiofur Hydrochloride ointment, is characterized in that, is grouped into by the one-tenth of following weight percent proportioning:
Ceftiofur Hydrochloride 1.5-3
Hydroprednisone acetate (prednisolone) 0.04-0.1
Vitamin E 0.05-0.2
Glyceryl monostearate 7-15
White vaseline 2-10
Lanoline 3-8
Liquid paraffin 10-55
Sorbester p17 1.5-5
Polyoxyethylene sorbitan monoleate 0.8-2.5
Ethyl hydroxybenzoate 0.05-0.1
Purified water 15-60.
2. a preparation method for Ceftiofur Hydrochloride ointment as claimed in claim 1, is characterized in that, preparation process is:
(a), by Ceftiofur Hydrochloride micronization, cross 100-400 mesh sieve;
(b) get recipe quantity glyceryl monostearate, white vaseline, lanoline, liquid paraffin, sorbester p17, vitamin E in beaker, heating in water bath 65-85 DEG C, makes its fusing, and magnetic agitation is even, is oil phase;
(c) separately get recipe quantity polyoxyethylene sorbitan monoleate, ethyl hydroxybenzoate and purified water in beaker, heating in water bath 65-85 DEG C, magnetic agitation is even, is water;
(d) under stirring, water is slowly joined to oil phase, then add respectively acetic acid hydrogenation to sprinkle Buddhist nun, step (a) gained Ceftiofur Hydrochloride, mix homogeneously, fill, Co 60 ray sterilizing, to obtain final product.
3. a preparation method for the Ceftiofur Hydrochloride ointment of stating as claim 2, is characterized in that, in described preparation process, the heating-up temperature of oil phase, water water-bath is 80 DEG C.
4. a preparation method for the Ceftiofur Hydrochloride ointment of stating as claim 2, is characterized in that, in described preparation process, the speed of magnetic agitation is 500-1000r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410034363.7A CN104042619B (en) | 2014-01-24 | 2014-01-24 | A kind of Ceftiofur Hydrochloride cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410034363.7A CN104042619B (en) | 2014-01-24 | 2014-01-24 | A kind of Ceftiofur Hydrochloride cream and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104042619A true CN104042619A (en) | 2014-09-17 |
| CN104042619B CN104042619B (en) | 2017-07-11 |
Family
ID=51496344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410034363.7A Active CN104042619B (en) | 2014-01-24 | 2014-01-24 | A kind of Ceftiofur Hydrochloride cream and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104042619B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622875A (en) * | 2015-02-12 | 2015-05-20 | 江西博莱大药厂有限公司 | Breast injection medicament for resisting cow mastitis and preparation method thereof |
| CN105106215A (en) * | 2015-07-31 | 2015-12-02 | 河南牧业经济学院 | Ointment for treating cow acute mastitis and preparation method thereof |
| RU2570396C1 (en) * | 2014-12-29 | 2015-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Орловский государственный аграрный университет" | Preparation "dioksomast" for treatment subclinical mastitis in cows |
| CN105726461A (en) * | 2014-12-10 | 2016-07-06 | 瑞普（天津）生物药业有限公司 | Ceftiofur hydrochloride breast injectant during dry period |
| RU2600881C1 (en) * | 2015-11-24 | 2016-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Орловский государственный аграрный университет" | Preparation "suhostin" for treating mastitis in non-lactating cows |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488694A (en) * | 2011-12-21 | 2012-06-13 | 齐鲁动物保健品有限公司 | Perfusion medicament for treating milk cow mastitis and preparation method thereof |
| CN103006672A (en) * | 2012-12-26 | 2013-04-03 | 齐鲁动物保健品有限公司 | Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent |
-
2014
- 2014-01-24 CN CN201410034363.7A patent/CN104042619B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488694A (en) * | 2011-12-21 | 2012-06-13 | 齐鲁动物保健品有限公司 | Perfusion medicament for treating milk cow mastitis and preparation method thereof |
| CN103006672A (en) * | 2012-12-26 | 2013-04-03 | 齐鲁动物保健品有限公司 | Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent |
Non-Patent Citations (3)
| Title |
|---|
| 张响英 等: "维生素E在养牛业上应用的研究进展", 《饲料博览》 * |
| 陈瑞 等: "头孢噻呋及其在奶牛乳房炎治疗上的应用", 《中国奶牛》 * |
| 韩博 等: "《牛病学——疾病与管理》", 31 August 2006, 中国农业大学出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726461A (en) * | 2014-12-10 | 2016-07-06 | 瑞普（天津）生物药业有限公司 | Ceftiofur hydrochloride breast injectant during dry period |
| CN105726461B (en) * | 2014-12-10 | 2021-02-09 | 瑞普（天津）生物药业有限公司 | Ceftiofur hydrochloride breast injection in dry period |
| RU2570396C1 (en) * | 2014-12-29 | 2015-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Орловский государственный аграрный университет" | Preparation "dioksomast" for treatment subclinical mastitis in cows |
| CN104622875A (en) * | 2015-02-12 | 2015-05-20 | 江西博莱大药厂有限公司 | Breast injection medicament for resisting cow mastitis and preparation method thereof |
| CN104622875B (en) * | 2015-02-12 | 2017-05-10 | 江西博莱大药厂有限公司 | Breast injection medicament for resisting cow mastitis and preparation method thereof |
| CN105106215A (en) * | 2015-07-31 | 2015-12-02 | 河南牧业经济学院 | Ointment for treating cow acute mastitis and preparation method thereof |
| CN105106215B (en) * | 2015-07-31 | 2018-03-02 | 河南牧业经济学院 | Treat ointment of acute mammitis of cow and preparation method thereof |
| RU2600881C1 (en) * | 2015-11-24 | 2016-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Орловский государственный аграрный университет" | Preparation "suhostin" for treating mastitis in non-lactating cows |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104042619B (en) | 2017-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104042619A (en) | Ceftiofur hydrochloride cream and preparation method thereof | |
| CN102132927A (en) | Moringa oleifera leaf suspension drink | |
| CN104922073A (en) | Soluble florfenicol powder and preparation method thereof | |
| CN110934914A (en) | Composition with liver protection function and preparation method and application thereof | |
| CN104522316A (en) | Composition for preventing and treating chicken enteritis | |
| CN102488694B (en) | Perfusion medicament for treating milk cow mastitis and preparation method thereof | |
| CN112353909A (en) | Traditional Chinese medicine composition for preventing and treating gout and preparation method and application thereof | |
| CN104815138A (en) | Immature bitter orange extract, preparation and application | |
| CN105533450A (en) | Nutritional health-care rice flour and preparation method thereof | |
| CN104687048A (en) | Maca tablet and preparation method thereof | |
| CN106361750A (en) | Pharmaceutical composition containing sodium ozagrel and preparation method thereof | |
| CN102813104B (en) | Auxiliary antihypertensive jelly and preparation method thereof | |
| CN103804433A (en) | Refining method of lactose | |
| CN105169359A (en) | Chinese wampee fruit enzyme nutrient solution and preparation method thereof | |
| CN105125639A (en) | Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle | |
| CN103304600B (en) | A kind of voriconazole phosphate ester trihydrate and its preparation method and application | |
| CN110368429A (en) | Prevent and treat the Chinese medicine composition and preparation method thereof that bacillary enterogastritis draws dysentery | |
| CN107823463A (en) | A kind of Chinese Drug Gualouzi of medicine-food two-purpose, PERICARPIUM TRICHOSANTHIS preparation and processing method | |
| CN101890049B (en) | Pediatric paracetamol oral solution formula and preparation method thereof | |
| CN106619767A (en) | Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof | |
| CN105878179A (en) | Preparation method and application of florfenicol solution | |
| CN103961308B (en) | A kind of preparation method of ibuprofen inflation cotton candy | |
| CN103263523B (en) | A kind of for breast perfusion preparation preventing and treating mastitis and preparation method thereof | |
| TWI744971B (en) | Use of extraction of auricularia polytricha for preparing composition for inducing differentiation of non-polarized immune cells into anti-inflammatory immune cells | |
| CN103690964B (en) | A kind of sheep independently searches for food type pharmaceutical carrier and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |