CN102008490B - Compound florfenicol injection for animal - Google Patents
Compound florfenicol injection for animal Download PDFInfo
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- CN102008490B CN102008490B CN2010105770705A CN201010577070A CN102008490B CN 102008490 B CN102008490 B CN 102008490B CN 2010105770705 A CN2010105770705 A CN 2010105770705A CN 201010577070 A CN201010577070 A CN 201010577070A CN 102008490 B CN102008490 B CN 102008490B
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Abstract
The invention discloses compound florfenicol injection for an animal. Every 1,000ml of the compound florfenicol injection contains 50 to 300g of florfenicol, 50 to 300g of doxycycline hydrochloride, 150 to 800g of organic solvent, 5 to 90g of complexing agent and 0.2 to 1g of antioxidant. The compound florfenicol injection has the advantages that: (1) the preparation is high in complexation degree and stable in quality, and the doxycycline hydrochloride injection is instable in property; (2) the injection is low in dosage and convenient to use, and the injection twice can be finished at one time; (3) the injection greatly saves the labor cost for veterinary medicine under an intensive feeding condition; and (4) the production of the preparation is controllable in terms of technical conditions, the injection is suitable for industrial production, various raw and auxiliary materials are needed to be accurately weighed in the production process, only the reaction temperature and the reaction time are needed to be controlled without any special technical requirement, and the production technology is easy to master and control.
Description
Technical field
The present invention relates to a kind of injection, relate in particular to a kind of veterinary compound florfenicol injection.
Background technology
Florfenicol is the plain type semi-synthetic antimicrobial drug of the chloropharin amine of latest generation; It is because of good anti-bacterial effect, the little control that is widely used for livestock and poultry of toxic and side effects; Become at present one of maximum a kind of special-purpose antimicrobial drug for animals of global sales, florfenicol injection is mainly used in the gastrointestinal infection that control poultry poultry colibacillosis, salmonellosis, Bacillus pasteurii disease etc. cause.Doxycycline hydrochloride is the semi-synthetic antimicrobial drug of the latest generation of Tetracyclines; It is as the important control medication of poultry, its antibiotic and protozoacide effect be oxytetracycline 4-8 doubly, be added usually in feedstuff or process injection; Since its remarkable effect, its global dosage seniority among brothers and sisters for animals prostatitis.Doxycycline hydrochloride injection is mainly used in respiratory tract, the urogenital infections that the various positive sensitive organism, mycoplasma, chlamydia, Eperythrozoon etc. of control poultry cause; This injection has manufacturer production at present; But quality is all unstable, perishable inefficacy in the shelf-life.Extracorporeal bacteria inhibitor test shows; Doxycycline hydrochloride and florfenicol are processed the antimicrobial spectrum that compound injection not only can increase product; And having potentiation, clinical trial shows that also the prevention effect of this compound preparation is superior to single preparations of ephedrine, can not only prevent and treat respiratory tract and urogenital infections that various positive sensitive organisms, mycoplasma, chlamydia, Eperythrozoon cause well; But also can prevent and treat well by escherichia coli and salmonellal gastroenteropathy; Preparation also has long-lasting, presses the therapeutic dose single administration, and drug effect can be kept more than 48 hours.Data is looked into newly and is also shown, said preparation does not also have the research data report at present, does not appear on the market in market yet.
Summary of the invention
The object of the present invention is to provide a kind of veterinary compound florfenicol injection, it is superior to the doxycycline hydrochloride injection and the florfenicol injection of folk prescription on quality and performance.
The present invention realizes like this, it is characterized in that containing florfenicol 50-300g, doxycycline hydrochloride 50-300g (by doxycycline), organic solvent 150-800g, chelating agent 5-90g and antioxidant 0.2-1g in the compound florfenicol injection of every 1000ml.
The weight of said doxycycline hydrochloride is by doxycycline.
A kind of or some kinds of mixture of the preferred 2-Pyrrolidone of said organic solvent, propylene glycol, dimethyl acetylamide, dimethyl formamide, ethanol, glycerin methylal, glycerol.
The mixture of the preferred magnesium chloride of said chelating agent, magnesium sulfate, magnesium oxide, magnesium hydroxide, magnesium carbonate a kind of or some kinds.
The mixture of the preferred sodium formaldehyde sulphoxylate of said antioxidant, sodium pyrosulfite, thiourea, sodium sulfite, L-half light amine hydrochlorate, vitamin C, ethylenediamine a kind of or some kinds.
The method for preparing of above-mentioned animal compound doxycycline hydrochloride-florfenicol injection is to carry out according to the following steps: get suitable quantity of water, add chelating agent and make dissolving, add doxycycline hydrochloride; Be heated to 70-90 ℃, make dissolving, add florfenicol again and make mix homogeneously; Add organic solvent, heating makes the florfenicol dissolving fully, adds solvent antioxidant in advance again; Use ethanolamine to transfer pH value to be 6.0-9.5, add water to full dose; Detect doxycycline hydrochloride and florfenicol content and answer requirement up to specification, otherwise regulate with raw material or organic solvent; Filter, by loading amount requirement embedding; 100 ℃, sterilization promptly got in 30 minutes.
Above-mentioned veterinary compound florfenicol injection, its applicable object is: various domestic animals, poultry, other economic animal and house pet etc.Its route of administration can be: intramuscular injection, subcutaneous injection, intravenous drip, oral or other route of administration.Its character can be: yellow to the clear and bright thick liquid of yellowish-brown, and contain florfenicol and doxycycline hydrochloride and should be labelled amount 90.0-110.0%.
Technique effect of the present invention is: (1) preparation complexation degree is high; Steady quality: product carries out complex reaction under 70-90 ℃ of condition; Its complexation degree is high, does not have free doxycycline hydrochloride and florfenicol molecule, and preparation is not subject to the influence of photo-thermal and goes bad; In common 2 years shelf-life, the appearance property of product and active ingredient are still in the scope of regulation at veterinary drug.Through comparative analysis, high concentration florfenicol preparation is separated out under the cryopreservation condition usually easily on the market at present, and the doxycycline hydrochloride injection character is unstable.(2) preparation is the compound preparation of combination among the strong ones; Not only antimicrobial spectrum is wider, and presents synergetic antibacterial effect: show that through the external drug sensitive test and the clinical test of pesticide effectiveness antibacterial effect of said preparation significantly is superior to the florfenicol injection and the doxycycline hydrochloride injection of folk prescription; Antibacterial effect improves 4-8 doubly; Not only can be used to prevent and treat the respiratory tract infection that gram positive bacteria, mycoplasma, chlamydia, Eperythrozoon etc. cause, but also can prevent and treat the gastroenteropathy that causes by escherichia coli, Salmonella and pasteurellosis bacillus etc., and dosage is little; Easy to use, biphasic injection can merge once to be accomplished.(3) preparation long half time in vivo; Can keep more than 48 hours the action time after the administration of seance amount; The medication number of times is few: the preparation principal agent all carries out complex reaction under specific condition; Drug absorption goes into can slowly remove complex status in vivo behind the blood and discharge, and this has saved a large amount of labour cost for veterinary under the current intensive culture condition.(4) process conditions of preparation production are controlled; Be suitable for suitability for industrialized production: in process of production except that need accurately take by weighing the various supplementary materials of recipe quantity; Only need reaction temperature and response time are controlled, do not have other special skill requirement, this production technology is easier to grasp and control.
The specific embodiment
Embodiment 1: water intaking 130ml, add magnesium chloride 15g, and make dissolving, add doxycycline hydrochloride 50g (, as follows) again, be heated to 70-90 ℃ by doxycycline, make dissolving, add florfenicol 50g again, make mix homogeneously, subsequent use; In reserve liquid, add 2-Pyrrolidone 100ml, propylene glycol 100ml, heating makes the florfenicol dissolving, add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 2g, add water to full dose 1000ml; Be up to the standards, filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 2: water intaking 130ml, add magnesium chloride 20g, and make dissolving, add doxycycline hydrochloride 75g again, be heated to 70-90 ℃, make dissolving, add florfenicol 75g again, make mix homogeneously, subsequent use; In reserve liquid, add ethanol 300ml, propylene glycol 100ml; Heating makes florfenicol dissolving, add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 3g; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml; Be up to the standards, filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 3: water intaking 130ml, add magnesium sulfate 10g, magnesium oxide 5g, and make dissolving, add doxycycline hydrochloride 100g again, be heated to 70-90 ℃, make dissolving, add florfenicol 100g again, make mix homogeneously, subsequent use; In reserve liquid, add dimethyl acetylamide 200ml, ethanol 100ml, heating makes the florfenicol dissolving; Add the mixing antioxidant 4g that forms with the solvent in advance thiourea of 20ml water, sodium sulfite again; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 4: water intaking 130ml, add magnesium sulfate 10g, magnesium oxide 10g, and make dissolving, add doxycycline hydrochloride 125g, be heated to 70-90 ℃, make dissolving, add florfenicol 125g again, make mix homogeneously, subsequent use; In reserve liquid, add dimethyl acetylamide 250ml, ethanol 100ml, heating makes the florfenicol dissolving; Add the mixing antioxidant 5g that forms with the solvent in advance thiourea of 20ml water, sodium sulfite again; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 5: water intaking 130ml, add magnesium hydroxide 10g, magnesium carbonate 15g, and make dissolving, add doxycycline hydrochloride 150g again, be heated to 70-90 ℃, make dissolving, add florfenicol 150g again, make mix homogeneously, subsequent use; In reserve liquid, add dimethyl formamide 200ml, glycerin methylal 100ml; Heating; Make florfenicol dissolving, add again with the solvent in advance sodium sulfite of 20ml water and L-cysteine hydrochloride composition mix antioxidant 6 g, with ethanolamine adjusting pH value to 6.0-9.5; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 6: water intaking 130ml, and add magnesium carbonate 40g, make dissolving, add doxycycline hydrochloride 200g again, be heated to 70-90 ℃, make dissolving, add florfenicol 200g again, make mix homogeneously, subsequent use; In reserve liquid, add 2-Pyrrolidone 100ml, propylene glycol 100ml; Heating; Make florfenicol dissolving, add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and vitamin C composition mix antioxidant 8g, with ethanolamine adjusting pH value to 6.0-9.5; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 7: water intaking 130ml, add magnesium oxide 25g, and make dissolving, add doxycycline hydrochloride 250g again, be heated to 70-90 ℃, make dissolving, add florfenicol 250g again, make mix homogeneously, subsequent use; In reserve liquid, add 2-Pyrrolidone 200ml, propylene glycol 100ml; Add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 9g; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml; Be up to the standards, filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 8: water intaking 130ml, add magnesium oxide 20g, magnesium hydroxide 14g, and make dissolving, add doxycycline hydrochloride 300g, be heated to 70-90 ℃, make dissolving, add florfenicol 300g again, make mix homogeneously, subsequent use; In reserve liquid, add glycerin methylal 300ml, propylene glycol 100ml; Heating; Make florfenicol dissolving, add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 10g, with ethanolamine adjusting pH value to 6.0-9.5; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 9: water intaking 130ml, add magnesium chloride 15g, magnesium sulfate 10g, magnesium oxide 5g, and make dissolving, add doxycycline hydrochloride 50g, be heated to 70-90 ℃, make dissolving, add florfenicol 75g again, make mix homogeneously, subsequent use; In reserve liquid, add 2-Pyrrolidone 100ml, propylene glycol 100ml; Heating makes the florfenicol dissolving; Add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 3g; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 10: water intaking 130ml, add magnesium oxide 10g, magnesium hydroxide 7g, magnesium carbonate 10g, and make dissolving, add doxycycline hydrochloride 100g, heat makes dissolving to 70-90 ℃, adds florfenicol 150g again, makes mix homogeneously, and is subsequent use; In reserve liquid, add dimethyl acetylamide 100ml, ethanol 100ml, glycerin methylal 100ml; Heating; Make the florfenicol dissolving, add the mixing antioxidant 4g that forms with the solvent in advance thiourea of 20ml water, sodium sulfite again, regulate pH value to 6.0-9.5 with ethanolamine; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 11: water intaking 130ml, add magnesium chloride 90g, magnesium sulfate 10g, and make dissolving, add doxycycline hydrochloride 150g, be heated to 70-90 ℃, make dissolving, add florfenicol 225g again, make mix homogeneously, subsequent use; In reserve liquid, add dimethyl acetylamide 400ml, glycerol 50ml; Heating; Make the florfenicol dissolving, add the mixing antioxidant 6g that forms with 20ml water solvent in advance sodium sulfite, L-cysteine hydrochloride and vitamin C again, regulate pH value to 6.0-9.5 with ethanolamine; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 12: water intaking 130ml, add magnesium sulfate 60g, magnesium oxide 20g, and make dissolving, add doxycycline hydrochloride 200g, be heated to 70-90 ℃, make dissolving, add florfenicol 300g again, subsequent use; In reserve liquid, add ethanol 300ml, glycerin methylal 100ml; Heating; Make florfenicol dissolving, add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and ethylenediamine composition mix antioxidant 7g, with ethanolamine adjusting pH value to 6.0-9.5; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 13: water intaking 130ml, add magnesium oxide 30g, and make dissolving, add doxycycline hydrochloride 50g, be heated to 70-90 ℃, make dissolving, add florfenicol 100g again, make mix homogeneously, subsequent use; In reserve liquid, add dimethyl formamide 300ml, heating makes the florfenicol dissolving; Add again with 20ml water in advance solvent formaldehyde close time sodium sulfite and sodium pyrosulfite composition mix antioxidant 3 g; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 14: water intaking 130ml, add magnesium hydroxide 42g, magnesium oxide 5g, and add doxycycline hydrochloride 100g, make dissolving, be heated to 70-90 ℃, make dissolving, add florfenicol 200g again, make mix homogeneously, subsequent use; In reserve liquid, add glycerin methylal 200ml, glycerol 200ml; Heating; Make florfenicol dissolving, add again with the solvent in advance L-cysteine hydrochloride of 20ml water and sodium pyrosulfite composition mix antioxidant 6 g, with ethanolamine adjusting pH value to 6.0-9.5; Add water to full dose 1000ml, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 15: water intaking 130ml, add magnesium carbonate 60g, magnesium oxide 10g, and make dissolving, add doxycycline hydrochloride 125g, be heated to 70-90 ℃, make dissolving, add florfenicol 250g again, make mix homogeneously, subsequent use; In reserve liquid, add glycerin methylal 300ml, glycerol 100ml; Heating makes florfenicol dissolving, adds to mix antioxidant 7 g with the solvent in advance thiourea of 20ml water and sodium pyrosulfite composition again; Regulate pH value to 6.0-9.5 with ethanolamine; Add water to full dose 1000ml, be up to the standards, be up to the standards; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Embodiment 16: water intaking 130ml, add magnesium hydroxide 42g, magnesium oxide 5g, and make dissolving, add doxycycline hyclate 150g, be heated to 70-90 ℃, make dissolving, add florfenicol 300g again, make mix homogeneously, subsequent use; In reserve liquid, add 2-Pyrrolidone 500ml; Heating makes florfenicol dissolving, adds to mix antioxidant 7 g with the solvent in advance L-cysteine hydrochloride of 20ml water and sodium pyrosulfite composition again; Regulate pH value to 6.0-9.5 with ethanolamine, add water to full dose 1000ml; Filter, fill the nitrogen embedding; 100 ℃ of sterilizations promptly got in 30 minutes.
Clinical test results
1, acute toxicity: get 40 of healthy adult white mice, accurately claim to decide body weight, average body
Heavily be 19.5 g, evenly be divided into 4 groups by the body weight size, 10 every group, average weight does not have significant difference (P < 0.05) between the group.By per kilogram of body weight 0.1ml, 0.2ml, 0.4ml, these article of 0.8ml intramuscular injection (product specification: contain doxycycline 15%, florfenicol 30%, down together), the injection back was observed 7 days respectively, and none example appearance as a result is dead, also finds to have any untoward reaction.The result shows that it is safe that these article use under the normal using dosage of per kilogram of body weight 0.1ml.
2, drug metabolism test: get 6 of healthy test rabbits, it is fixed accurately to claim, average weight 2.5
Kilogram is all by these article of per kilogram of body weight intramuscular injection 0.1ml, respectively at 0.5h, 1h, 2h, 4h, 8h, 16h, 32h, 48h, 72h, 84,96h; Adopt test Cor Leporis blood, the content of florfenicol and doxycycline hydrochloride in the difference determination test rabbit blood, florfenicol and doxycycline hydrochloride all blood medicine peak occurs at 2h as a result; Its blood drug level is respectively 3.1ug/ml, 4.3ug/ml, after slowly descend; 48h is respectively 1.1 ug/ml, 1.4 ug/ml; Be effective blood drug concentration, the result shows that the drug effect of these article is more than the 48h (2 days).
3, drug residue test: get 10 of healthy test rabbits, it is fixed accurately to claim, average weight
2.7 kilogram; All by these article of per kilogram of body weight intramuscular injection 0.1ml; Respectively at 3d, 4d, 6d, 9d, 13d, 18dh, 24d, 28d, 34d, 40d, adopt test Sanguis Leporis seu oryctolagi and liver, nephridial tissue, respectively the content of its florfenicol of determination test and doxycycline hydrochloride; Florfenicol and doxycycline hydrochloride as a result, the result all can not detect doxycycline hydrochloride and florfenicol (detection is limited to 10ng/ml (g)) when 13d.The result shows that the withdrawal time of these article can be decided to be 13 days.
4, external antibacterial contrast test: get commercially available folk prescription doxycycline hydrochloride injection and florfenicol injection and compare; , two kinds of medicines are diluted with doubling dilution as test organisms with escherichia coli, Salmonella, staphylococcic pathogenic strain, the minimal inhibitory concentration of these article is the 1/4-1/8 of folk prescription injection as a result.The result shows, doxycycline hydrochloride and the potentiation of florfenicol compatibility tool, and potentiation 4-8 is doubly.
5, the clinical test of pesticide effectiveness: get and be diagnosed as 63 of the sick pigs in hyperpyrexia disease pig farm, evenly be divided into three groups, 21 every group.Contrast is not established in test; Three groups use respectively doxycycline hydrochloride injection (specification: content 15%), florfenicol injection (specification: content 30%) and compound florfenicol injection (specification: the same) treat; Consumption is the 0.1ml/kg body weight; Normally searching for food, no longer the fever bounce-back is for curing sign.Through nearly 7 days treatment and observation; The cure rate of three groups is respectively: 61.9%, 57.14% and 90.5%; There is significant difference (P < 0.05) in its cure rate, and compound florfenicol injection can enlarge antimicrobial spectrum, and the potentiation of having again strengthens the effect of antibacterial efficacy; This product is a kind of ideal hyperpyrexia disease medicine for treatment, and present hyperpyrexia disease is many to be showed with mixed infection.
6, the stability test of product: these article are stored under 40 ℃ the ambient temperature, observe under 0-4 ℃ and the room temperature; Through 6 months observations and detection, the result, product colour and content do not have obvious variation; Still in the scope of regulation, deepfreeze does not have crystallization yet and separates out phenomenon.The result shows, the shelf-life of these article should be and is not less than 2 years effect duration of regulation.
Claims (1)
1. veterinary compound florfenicol injection is characterized in that containing florfenicol 50-300g, doxycycline hydrochloride 50-300g, organic solvent 150-800g, chelating agent 5-90g and antioxidant 0.2-1g in the compound florfenicol injection of every 1000ml; The weight of said doxycycline hydrochloride is by doxycycline; Said organic solvent is selected from a kind of or some kinds of mixture of 2-Pyrrolidone, propylene glycol, dimethyl acetylamide, dimethyl formamide, ethanol, glycerin methylal, glycerol; Said chelating agent is selected from the mixture of a kind of of magnesium chloride, magnesium sulfate, magnesium oxide, magnesium hydroxide, magnesium carbonate or some kinds; Said antioxidant is selected from the mixture of a kind of of sodium formaldehyde sulphoxylate, sodium pyrosulfite, thiourea, sodium sulfite, L-Mercaptamine, vitamin C, ethylenediamine or some kinds; The method for preparing of said veterinary compound florfenicol injection is: get suitable quantity of water, add chelating agent and make dissolving, add doxycycline hydrochloride; Be heated to 70-90 ℃, make dissolving, add florfenicol again and make mix homogeneously; Add organic solvent, heating makes the florfenicol dissolving fully, adds solvent antioxidant in advance again; Use the ethanolamine adjust pH to be 6.0-9.5, add water to full dose; Detect doxycycline hydrochloride and florfenicol content and answer requirement up to specification, its character is: yellow to the clear and bright thick liquid of yellowish-brown, and contain florfenicol and doxycycline hydrochloride and should be labelled amount 90.0-110.0%, otherwise regulate with raw material or organic solvent; Filter, by loading amount requirement embedding; 100 ℃, sterilization promptly got in 30 minutes.
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| CN2010105770705A CN102008490B (en) | 2010-12-07 | 2010-12-07 | Compound florfenicol injection for animal |
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| CN2010105770705A CN102008490B (en) | 2010-12-07 | 2010-12-07 | Compound florfenicol injection for animal |
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| CN102008490B true CN102008490B (en) | 2012-06-27 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102973578A (en) * | 2011-09-06 | 2013-03-20 | 菏泽普恩药业有限公司 | Compound preparation used for controlling avian mycoplasma and Escherichia coli mixed infection, and preparation method thereof |
| CN102784136B (en) * | 2012-08-06 | 2014-04-30 | 四川德润通生物科技有限公司 | Preparation process of compound florfenicol injection for livestock |
| CN102973498A (en) * | 2012-12-13 | 2013-03-20 | 江苏恒丰强生物技术有限公司 | Florfenicol injection and preparation method thereof |
| CN103520211B (en) * | 2013-10-23 | 2015-10-07 | 天津市中升挑战生物科技有限公司 | A kind of compound florfenicol injection and preparation method thereof and application |
| CN104188901A (en) * | 2014-08-12 | 2014-12-10 | 河南迪冉生物科技有限公司 | Florfenicol injection for livestock and preparation method thereof |
| ES2846882T3 (en) * | 2015-03-23 | 2021-07-30 | Biopharmx Inc | Pharmaceutical composition of tetracycline for dermatological use |
| CN105012304B (en) * | 2015-07-08 | 2018-12-11 | 河南牧业经济学院 | A kind of compound florfenicol composition |
| CN105012320A (en) * | 2015-07-20 | 2015-11-04 | 济南亿民动物药业有限公司 | Preparation technology for compound solution of florfenicol and doxycycline |
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