CN102784159A - Compound synergistic tartaric acid tylosin for injection of livestock - Google Patents
Compound synergistic tartaric acid tylosin for injection of livestock Download PDFInfo
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- CN102784159A CN102784159A CN2012102771673A CN201210277167A CN102784159A CN 102784159 A CN102784159 A CN 102784159A CN 2012102771673 A CN2012102771673 A CN 2012102771673A CN 201210277167 A CN201210277167 A CN 201210277167A CN 102784159 A CN102784159 A CN 102784159A
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- CN
- China
- Prior art keywords
- tylosin
- injection
- tartaric acid
- trimethoprim
- livestock
- Prior art date
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- Granted
Links
- 239000007924 injection Substances 0.000 title claims abstract description 34
- 238000002347 injection Methods 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 28
- 229930194936 Tylosin Natural products 0.000 title abstract description 11
- 239000004182 Tylosin Substances 0.000 title abstract description 11
- 229960004059 tylosin Drugs 0.000 title abstract description 11
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 title abstract description 11
- 235000019375 tylosin Nutrition 0.000 title abstract description 11
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 title abstract description 9
- 244000144972 livestock Species 0.000 title abstract description 6
- 239000011975 tartaric acid Substances 0.000 title abstract 8
- 235000002906 tartaric acid Nutrition 0.000 title abstract 8
- 230000002195 synergetic effect Effects 0.000 title abstract 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000001384 succinic acid Substances 0.000 claims abstract description 11
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical group Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960001309 procaine hydrochloride Drugs 0.000 claims abstract description 10
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims abstract description 8
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000006184 cosolvent Substances 0.000 claims abstract description 7
- ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 claims description 49
- 229960001717 tylosin tartrate Drugs 0.000 claims description 49
- 241001465754 Metazoa Species 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000002131 composite material Substances 0.000 claims description 5
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 abstract description 30
- 229960002064 kanamycin sulfate Drugs 0.000 abstract description 30
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 abstract description 30
- 229960001082 trimethoprim Drugs 0.000 abstract description 30
- 230000000694 effects Effects 0.000 abstract description 20
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- 238000001228 spectrum Methods 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 208000003322 Coinfection Diseases 0.000 abstract description 2
- 206010028470 Mycoplasma infections Diseases 0.000 abstract description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
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- 238000012360 testing method Methods 0.000 description 13
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- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 238000011835 investigation Methods 0.000 description 6
- 244000144977 poultry Species 0.000 description 6
- 239000000273 veterinary drug Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- 241000204031 Mycoplasma Species 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
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- 210000002345 respiratory system Anatomy 0.000 description 4
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- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000204003 Mycoplasmatales Species 0.000 description 2
- 241000606856 Pasteurella multocida Species 0.000 description 2
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- 239000010931 gold Substances 0.000 description 2
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention relates to a compound synergistic tartaric acid tylosin for injection of livestock and aims at providing a compound synergistic tartaric acid tylosin, which can be used for achieving a rapid and definite curative effect on the breathing system infection and complications of livestock, for injection of livestock. The medicine comprises the following components in parts by weight: 1 part of tartaric acid tylosin, 1 part of kanamycin sulfate, 0.2 parts of trimethoprim, 0.2 parts of cosolvent and 0.05-0.1 parts of pain alleviator, wherein the cosolvent is citric acid or succinic acid or a combination of the citric acid and the succinic acid; and the pain alleviator is procaine hydrochloride or lidocaine hydrochloride or a combination of procaine hydrochloride and the lidocaine hydrochloride. The compound synergistic tartaric acid tylosin for injection of livestock contains medicine components of three types, namely tartaric acid tylosin, kanamycin sulfate and trimethoprim, can be used for solving the problems that tartaric acid tylosin is narrow in antimicrobial spectrum and cannot well control secondary infection during the treatment of mycoplasma infection and the problem that trimethoprim is insoluble in water, and achieving a synergy effect on tartaric acid tylosin and kanamycin sulfate, and is accurate in dosage and convenient in use.
Description
Technical field
The present invention relates to injection use compound potentiation tylosin tartrate for animals.
Background technology
From present China Developing of Animal Industry situation, current poultry respiratory system infection is occurred frequently, complication is seriously big to poultry harm.The medicine that does not also have comparatively ideal treating both the principal and secondary aspects of a disease now on the market.Through investigation domestic, the international market is found that market presses for a kind of efficacy stability, good effect, stable high, easy to use, complication serious specific medicine occurred frequently to the poultry respiratory system infection.
In the prior art, tylosin tartrate belongs to vinegar class animal specific antibacterials in the macro ring, mainly most gram-positive bacterias, Gram-negative coccus, anaerobe level legionella, mycoplasma, chlamydia is had good action.Belong to the quick-acting antibacterial of trophophase.Under high concentration, have bactericidal action, be the macrolide apoplexy due to endogenous wind to one of the strongest medicine of mycoplasma effect, be mainly used in control pig, fowl mycoplasma, like the mycoplasma pneumonia of chronic respiratory disease of fowl (CRD) and infectiousness hole chamber inflammation and pig.
The antimicrobial spectrum of kanamycin sulfate is similar with streptomycin, but effect is strong slightly.Most of gram negative bacterias such as escherichia coli, Bacillus proteus, Salmonella and pasteurella multocida etc. there are powerful antibacterial action, also responsive to gold-coloured staphylococci and tubercule bacillus.Intramuscular injection is used for the various severe infections due to the sensitive organism, like septicemia, urogenital infection, respiratory tract infection, skin and soft tissue infection etc.
Trimethoprim is the broad-spectrum antiseptic synergist, can the antibacterial action of multiple antibiotics be increased substantially (but potentiation several times to tens times), and can reduce the appearance of drug resistance strain.
Injection means that the confession that medicine is processed injects intravital sterile solution, emulsion or suspension, and supplies to face the sterilized powder concentrated solution with preceding wiring solution-forming or suspension.The characteristics of injection, mainly show route of administration without digestive system with defence tissue (liver) and directly inject tissue or blood vessel, so drug effect is rapid, is applicable to first aid.But also the curative effect of some injection is extended, to adapt to the needs in the medical treatment.The dosage of injection is accurate, and reliable effect possibly suffer influences such as Digestive system, food, and make the dosage of taking that curative effect can not take place fully unlike the endo-medicine that kind.In addition, can make some drugs performance positioning action again.
Injectable sterile powder is claimed the powder pin again, faces with preceding and injects with sterilized water for injection dissolving back, and be a kind of injection type commonly used.Be applicable to unsettled medicine in water, particularly to damp and hot sensitive antibiotics and biological product.
Summary of the invention
The purpose of this invention is to provide a kind of injection use compound potentiation tylosin tartrate for animals, it has quick, definite curative effect to poultry respiratory system infection and complication.
For realizing the foregoing invention purpose, the technical scheme that the present invention adopted is: a kind of injection use compound potentiation tylosin tartrate for animals, it is characterized in that, and form by following components in part by weight:
Amounts of components is strict in the described prescription, and other component does not almost have the leeway of adjustment except that pain relief agents.Only can on material choice, do following replacement:
Described cosolvent is that citric acid or succinic acid or the two are composite.
Described pain relief agents is that procaine hydrochloride or lidocaine hydrochloride or the two are composite.
The method for preparing of injection of the present invention:
Take by weighing trimethoprim, the cosolvent of recipe quantity, mix, cross 120 orders or thinner sieve after fluid energy mill is pulverized;
Again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases;
Inspection of semifinished product content, dissolubility, qualified back packing, packing promptly gets.
Further, described pulverizing is to pulverize through fluid energy mill.
Further, described sieving to crossing 120 mesh sieves.
The usage of product of the present invention and consumption: earlier product of the present invention is dissolved with analog such as solvent for injection such as water for injection or ethylene glycol, ethanol, then muscle or subcutaneous injection.In tylosin tartrate: amount once, every 1kg body weight, pig, fowl 5～13mg, once a day.
The injection use compound potentiation tylosin tartrate for animals of the present invention's development includes tylosin tartrate, kanamycin sulfate, three kinds of pharmaceutical compositions of trimethoprim.Three kinds of composite indications that not only are directed against of ingredient are more extensive, and enhancing evident in efficacy.And have a following effect of having a mind to:
1, develops for veterinary clinic a kind of injection use compound potentiation tylosin tartrate for animals and preparation method thereof is provided;
2, solved because the tylosin tartrate narrow antimicrobial spectrum, can not fine control secondary infection during the treatment mycoplasma infection;
3, solve the problem that trimethoprim is insoluble in water, and paratartaric acid tylosin and kanamycin sulfate potentiation;
4, be injectable sterile powder, preparation stabilization, storage period is long;
5, rapid-action, duration of efficacy is long, and bioavailability is high;
6, safe in utilization, determined curative effect, quality controllable;
7, dosage is accurate, and is easy to use;
8, irritating property is little, reduce to poultry stress.
The specific embodiment
Embodiment one
Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, citric acid 0.2g, procaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the citric acid of recipe quantity respectively, mix, cross 120 mesh sieves after fluid energy mill is pulverized; Again with tylosin tartrate, kanamycin sulfate, procaine hydrochloride by the equivalent method mix homogeneously that progressively increases, the inspection of semifinished product, packing; Packing, product inspection promptly gets.
Embodiment two
Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, succinic acid 0.2g, procaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the succinic acid of recipe quantity respectively, mix, cross 120 mesh sieves after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment three
Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, citric acid 0.2g, lidocaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the citric acid of recipe quantity respectively, mix, cross 150 mesh sieves after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment four
Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, succinic acid 0.2g, lidocaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the succinic acid of recipe quantity respectively, mix, cross 120 mesh sieves after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment five
Tylosin tartrate 0.5g, kanamycin sulfate 0.5g, trimethoprim 0.1g, citric acid 0.1g, procaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the citric acid of recipe quantity respectively, mix, cross 120 mesh sieves after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment six
Tylosin tartrate 0.5g, kanamycin sulfate 0.5g, trimethoprim 0.1g, succinic acid 0.1g, procaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the succinic acid of recipe quantity respectively, mix, sieve after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment seven
Tylosin tartrate 0.5g, kanamycin sulfate 0.5g, trimethoprim 0.1g, citric acid 0.1g, procaine hydrochloride 0.03g, lidocaine hydrochloride 0.02g.
Method for preparing:
Take by weighing trimethoprim, the cosolvent of recipe quantity respectively, mix, cross 120 mesh sieves after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Embodiment eight
Tylosin tartrate 0.5g, kanamycin sulfate 0.5g, trimethoprim 0.1g, citric acid 0.05g, succinic acid 0.05g, lidocaine hydrochloride 0.05g.
Method for preparing:
Take by weighing trimethoprim, the cosolvent of recipe quantity respectively, mix, sieve after fluid energy mill is pulverized, again with tylosin tartrate, kanamycin sulfate, pain relief agents by the equivalent method mix homogeneously that progressively increases; The inspection of semifinished product, packing, packing; Product inspection, warehouse-in promptly gets.
Result of study
1, prescription research
The present invention writes out a prescription with crude drug tylosin tartrate, kanamycin sulfate, trimethoprim, records one one of " Chinese veterinary drug allusion quotation " version in 2010." Chinese veterinary drug allusion quotation " record, similar with the erythromycin antimicrobial spectrum.A little less than the effect to antibacterial, strong to the Mycoplasma effect, be that the macrolide apoplexy due to endogenous wind is to one of the strongest medicine of mycoplasma effect.Sensitive organism produces drug resistance to these article, and staphylococcus aureus has part crossing drug resistant phenomenon to these article and erythromycin; The antimicrobial spectrum of kanamycin sulfate is similar with streptomycin, but effect is strong slightly.Most of gram negative bacterias such as escherichia coli, Bacillus proteus, Salmonella and pasteurella multocida etc. there are powerful antibacterial action, also responsive to gold-coloured staphylococci and tubercule bacillus.Intramuscular injection is used for the various severe infections due to the sensitive organism, like septicemia, urogenital infection, respiratory tract infection, skin and soft tissue infection etc.; Trimethoprim is the broad-spectrum antiseptic synergist, can the antibacterial action of multiple antibiotics be increased substantially, and can reduce the appearance of drug resistance strain.
The present invention's prescription is with tylosin tartrate, kanamycin sulfate drug combination; Through trimethoprim potentiation; Clinical trial shows, in the effect and purposes basis of " Chinese veterinary drug allusion quotation " record, can solve the pain that produces when tylosin tartrate is injected; Control livestock and poultry respiratory and digestive tract disease effect are more remarkable, and reduce chemical sproof generation.
2, stability study
Injection use compound potentiation tylosin tartrate product stability research for animals of the present invention; System is according to " veterinary drug stability test technical specification (trying) " way of the Ministry of Agriculture's promulgation; Adopt temperature, humidity accelerated test and acceleration by light test, three lot sample article are carried out stability study.
2.1 temperature, humidity accelerated test
2.1.1 test material
Product of the present invention: injection use compound potentiation tylosin tartrate for animals
Batch number: 110701,110702,110703
Product requirement: commercially available back
2.1.2 experimental condition: adopt the medicine stability test case, temperature transfers to 40 ± 2 ℃, and relative humidity is controlled at 75 ± 5%.
2.1.3 observing time: product of the present invention was placed 6 months, and at duration of test, each month sampling secondary detects product by stable high spot reviews project.
2.1.4 investigation project: character, content, the investigation project is confirmed according to " veterinary drug stability test technical specification (the trying) " way for Ministry of Agriculture's promulgation.
2.1.5 test data
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110701
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110702
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110703
2.2 acceleration by light test
2.2.1 test material
Product of the present invention: injection use compound potentiation tylosin tartrate for animals
Batch number: 110701,110702,110703
Product requirement: commercially available back
2.2.2 experimental condition: in the proof box of test medicament strong illumination, illumination is 4500 native 500LX
2.2.3 observing time: get product of the present invention and pack in the water white transparency container, be positioned in the light durability proof box, in the condition held of illumination 4500LX ± 500LX ten days, sampling when walking in the 5th, ten day detected by stable high spot reviews project.
2.2.4 investigation project: character, pH value, clarity, content, investigation project are confirmed according to " veterinary drug stability test technical specification (the trying) " way for Ministry of Agriculture's promulgation.
2.2.5 test data
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110701
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110702
Name of product: injection use compound potentiation tylosin tartrate for animals, product batch number: 110703
2.3 result of study: product three lot sample article of the present invention are investigated through temperature, humidity accelerated test and first accelerated test; The result shows that product character, pH value, clarity, content etc. detect in each investigation time all up to specification, compares each item detection index with the O month and do not have significant degreeization.
3. the clinical trial of injection use compound potentiation tylosin tartrate for animals
Method: choose ill moving, be divided into experimental group, matched group 1 and matched group 2 at random:
(1) drug test group intramuscular injection injection use compound potentiation tylosin tartrate for animals of the present invention;
(2) medicine matched group 1 intramuscular injection injection tylosin tartrate matched group; Manufacturer: animal pharmaceutcal corporation, Ltd of Chongqing gold nation, effective ingredient: tylosin tartrate, trimethoprim.
(3) the kanamycin sulfate matched group is used in 2 intramuscular injections of medicine matched group; Manufacturer: animal pharmaceutcal corporation, Ltd of the golden nation of gold celebrating, effective ingredient: kanamycin sulfate, trimethoprim.
Therapeutic dose: test group is in tylosin, 1kg body weight 5mg; Matched group 1 is in tylosin, 1kg body weight 10mg; Matched group 2 is in kanamycin sulfate, 1kg body weight 10mg.After the treatment beginning,, write down infected animal health situation of change every day, treat and add up therapeutic outcome after 2 days with identical administering mode and corresponding disease.
The result shows that the matched group 1,2 of injection use compound potentiation tylosin tartrate for animals and folk prescription medicine is relatively treated disease effects and obviously is superior to matched group.The compound of more existing tylosin tartrate of curative effect and trimethoprim or the compound of kanamycin sulfate and trimethoprim significantly strengthen.Disease complete obiteration with animal is healing.
The clinical application effect statistics of injection use compound potentiation tylosin tartrate for animals
Claims (3)
1. an injection use compound potentiation tylosin tartrate for animals is characterized in that, is made up of following components in part by weight:
2. a kind of injection use compound potentiation tylosin tartrate for animals according to claim 1 is characterized in that: described cosolvent is that citric acid or succinic acid or the two are composite.
3. a kind of injection use compound potentiation tylosin tartrate for animals according to claim 1 and 2 is characterized in that: described pain relief agents is that procaine hydrochloride or lidocaine hydrochloride or the two are composite.
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| CN201310364033.XA CN103432150B (en) | 2012-08-06 | 2012-08-06 | The compound medicine of potentiation tylosin tartrate soluble powder |
| CN 201210277167 CN102784159B (en) | 2012-08-06 | 2012-08-06 | Compound synergistic tartaric acid tylosin for injection of livestock |
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| CN 201210277167 CN102784159B (en) | 2012-08-06 | 2012-08-06 | Compound synergistic tartaric acid tylosin for injection of livestock |
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| CN201310363449.XA Division CN103405464B (en) | 2012-08-06 | 2012-08-06 | Medicine for treating respiratory system infection of livestock and poultry |
| CN201310364326.8A Division CN103405466B (en) | 2012-08-06 | 2012-08-06 | Compound synergistic tylosin tartrate |
| CN201310364033.XA Division CN103432150B (en) | 2012-08-06 | 2012-08-06 | The compound medicine of potentiation tylosin tartrate soluble powder |
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| CN102784159B CN102784159B (en) | 2013-08-21 |
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| CN201310364033.XA Expired - Fee Related CN103432150B (en) | 2012-08-06 | 2012-08-06 | The compound medicine of potentiation tylosin tartrate soluble powder |
| CN 201210277167 Expired - Fee Related CN102784159B (en) | 2012-08-06 | 2012-08-06 | Compound synergistic tartaric acid tylosin for injection of livestock |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308176A (en) * | 2017-07-05 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of injection Tylosin Tartrate and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104892705A (en) * | 2015-05-11 | 2015-09-09 | 成都中牧生物药业有限公司 | Preparation technology of tylosin tartrate for injection |
| CN104926899A (en) * | 2015-05-11 | 2015-09-23 | 成都中牧生物药业有限公司 | Preparation process avoiding the reduction of tylosin tartrate original drug potency |
| CN115068420A (en) * | 2022-07-27 | 2022-09-20 | 石家庄石牧药业有限公司 | Tylosin tartrate solution for livestock and poultry and preparation method thereof |
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| CN1843329A (en) * | 2006-05-17 | 2006-10-11 | 天津生机集团有限公司 | Compound amikacin sulfate injection for animal and its preparation method |
| CN101468032A (en) * | 2007-12-26 | 2009-07-01 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating respiratory illness of livestock and poultry |
| CN101822688A (en) * | 2010-05-19 | 2010-09-08 | 陈建波 | Compound tylosin injection for animals and preparation method thereof |
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2012
- 2012-08-06 CN CN201310364033.XA patent/CN103432150B/en not_active Expired - Fee Related
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843329A (en) * | 2006-05-17 | 2006-10-11 | 天津生机集团有限公司 | Compound amikacin sulfate injection for animal and its preparation method |
| CN101468032A (en) * | 2007-12-26 | 2009-07-01 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating respiratory illness of livestock and poultry |
| CN101822688A (en) * | 2010-05-19 | 2010-09-08 | 陈建波 | Compound tylosin injection for animals and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308176A (en) * | 2017-07-05 | 2017-11-03 | 山东中牧兽药有限公司 | A kind of injection Tylosin Tartrate and preparation method thereof |
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| CN102784159B (en) | 2013-08-21 |
| CN103432150A (en) | 2013-12-11 |
| CN103432150B (en) | 2015-12-09 |
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