CN1843329A - Compound amikacin sulfate injection for animal and its preparation method - Google Patents
Compound amikacin sulfate injection for animal and its preparation method Download PDFInfo
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- CN1843329A CN1843329A CN 200610013736 CN200610013736A CN1843329A CN 1843329 A CN1843329 A CN 1843329A CN 200610013736 CN200610013736 CN 200610013736 CN 200610013736 A CN200610013736 A CN 200610013736A CN 1843329 A CN1843329 A CN 1843329A
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Abstract
The invention discloses a compound amikacin sulfate injection for animal and the method for preparing the same. The method comprises: (1) dissolving the lactic acid trimethoprim in water for injection, adding methyl ethylene glycol; (2) dissolving sodium sulfite into water for injection; (3) adding amikacin sulfate into water for injection, stirring until dissolution; (4) mixing solution got in step (1)(2) and (3), stirring evenly, regulating pH to 4.0-5.0, filtering initially and filtering with micro porous membrane, embedding and sterilizing, and getting said amikacin sulfate injection for animal. The amikacin sulfate acts mainly on process of bacterial protein synthesis to cause irregular protein synthesis, and increases permeability of cell membrane to block up bacterial breeding; the trimethoprim is used as potentiating agent for antibiotic.
Description
Technical field
The present invention relates to a kind of injection and preparation method thereof, particularly relate to a kind of compound amikacin sulfate injection for animal and preparation method.
Background technology
Bacterial disease is modal disease in animal produces, and has a strong impact on Developing of Animal Industry, and along with the continuous appearance of Resistant strain, bacterial disease also presents the trend of a rising.Amikacin is semi-synthetic aminoglycosides antibiotics, and antimicrobial spectrum is similar to gentamycin, and is all effective to golden Portugal bacterium, bacillus pyocyaneus, escherichia coli and Bacillus proteus etc.To other aminoglycosides antibiotics Resistant strain, also effective in cure, but single amikacin sulfate of using, to some bacterial infection curative effect still a little less than.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of compound amikacin sulfate injection for animal is provided.
Second purpose of the present invention provides a kind of preparation method of compound amikacin sulfate injection for animal.
Technical scheme of the present invention is summarized as follows:
A kind of compound amikacin sulfate injection for animal is to make with following method: (1) is got 1～6 weight portion Trimethoprim lactate and is dissolved in 45～60 weight portion waters for injection, adds the propylene glycol of 45～60 weight portions; (2) 1～3 weight portion sodium metabisulfite is dissolved in 45～60 weight portion waters for injection; (3) get 500～700 weight portion waters for injection, add 6～10 weight portion amikacin sulfates, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 150～200 weight portion waters for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.0～5.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
A kind of preparation method of compound amikacin sulfate injection for animal comprises the steps: that (1) get 1～6 weight portion Trimethoprim lactate and be dissolved in 45～60 weight portion waters for injection, adds the propylene glycol of 45～60 weight portions; (2) 1～3 weight portion sodium metabisulfite is dissolved in 45～60 weight portion waters for injection; (3) get 500～700 weight portion waters for injection, add 6～10 weight portion amikacin sulfates, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 150～200 weight portion waters for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.0～5.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
Advantage of the present invention:
Amikacin sulfate in a kind of compound amikacin sulfate injection for animal of the present invention, mainly act on the building-up process of bacterioprotein, make antibacterial resulting anomaly albumen, the release of impede protein matter increases and the blocking-up bacterial reproduction bacterial cell membrane permeability.Trimethoprim is a Trimethoprim, and it and amikacin sulfate synergism make antibacterial effect strengthen several times.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of preparation method of compound amikacin sulfate injection for animal comprises the steps: that (1) get the 3g Trimethoprim lactate and be dissolved in the 5g water for injection, adds the propylene glycol of 50g; (2) the 2g sodium metabisulfite is dissolved in the 50g water for injection; (3) get 600g water for injection, add the 8g amikacin sulfate, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 180g water for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.5, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
Embodiment 2
A kind of preparation method of compound amikacin sulfate injection for animal comprises the steps: that (1) get the 1g Trimethoprim lactate and be dissolved in the 45g water for injection, adds the propylene glycol of 45g; (2) the 1g sodium metabisulfite is dissolved in the 45g water for injection; (3) get 500g water for injection, add the 6g amikacin sulfate, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 150g water for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
Embodiment 3
A kind of preparation method of compound amikacin sulfate injection for animal comprises the steps: that (1) get the 6g Trimethoprim lactate and be dissolved in the 60g water for injection, adds the propylene glycol of 60g; (2) the 3g sodium metabisulfite is dissolved in the 60g water for injection; (3) get 70g water for injection, add the 10g amikacin sulfate, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 200g water for injection, add lactic acid or sodium hydroxide and transfer pH value to 5.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
Embodiment 4
Clinical trial:
90 of picked at random are breathed, are coughed, spiritual depressed pig, and according to body condition, term, close situation was divided into three groups.Medication three days, every day secondary.
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | Symptom pig's head number is arranged during end |
| A | Do not treat (matched group) | 3 | - | - | - | - |
| B | Amikacin sulfate injection treatment (0.8mg/kg) | 1 | 6.7 | 93.3 | 90.0 | 3 |
| C | Sulfated compound amikacin injection for treating (0.5mg/kg) | 0 | 3.3 | 96.7 | 96.7 | 1 |
This result of the test is analyzed by statistics, amikacin sulfate injection treatment group, sulfated compound amikacin injection for treating group and matched group difference is (P＜0.01) extremely significantly, amikacin sulfate injection treatment group and sulfated compound amikacin injection for treating group significant difference (P＜0.05).
Claims (4)
1. compound amikacin sulfate injection for animal, it is characterized in that making with following method: (1) is got 1～6 weight portion Trimethoprim lactate and is dissolved in 45～60 weight portion waters for injection, adds the propylene glycol of 45～60 weight portions; (2) 1～3 weight portion sodium metabisulfite is dissolved in 45～60 weight portion waters for injection; (3) get 500～700 weight portion waters for injection, add 6～10 weight portion amikacin sulfates, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 150～200 weight portion waters for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.0～5.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
2. a kind of compound amikacin sulfate injection for animal according to claim 1, the parts by weight that it is characterized in that described Trimethoprim lactate are 3, and the parts by weight of described sodium metabisulfite are 2, and the weight portion of described amikacin sulfate is 8.
3. the preparation method of a compound amikacin sulfate injection for animal is characterized in that comprising the steps: that (1) get 1～6 weight portion Trimethoprim lactate and be dissolved in 45～60 weight portion waters for injection, adds the propylene glycol of 45～60 weight portions; (2) 1～3 weight portion sodium metabisulfite is dissolved in 45～60 weight portion waters for injection; (3) get 500～700 weight portion waters for injection, add 6～10 weight portion amikacin sulfates, be stirred to dissolving; (4) solution that step (1), step (2), step (3) is made merges, stirring and evenly mixing, add 150～200 weight portion waters for injection, add lactic acid or sodium hydroxide and transfer pH value to 4.0～5.0, through filter just and with 0.45 micron filtering with microporous membrane, a kind of compound amikacin sulfate injection for animal is promptly made in the embedding sterilization.
4. the preparation method of a kind of compound amikacin sulfate injection for animal according to claim 3, the parts by weight that it is characterized in that described Trimethoprim lactate are 3, the parts by weight of described sodium metabisulfite are 2, and the weight portion of described amikacin sulfate is 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610013736 CN1843329A (en) | 2006-05-17 | 2006-05-17 | Compound amikacin sulfate injection for animal and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610013736 CN1843329A (en) | 2006-05-17 | 2006-05-17 | Compound amikacin sulfate injection for animal and its preparation method |
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| CN1843329A true CN1843329A (en) | 2006-10-11 |
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| CN 200610013736 Pending CN1843329A (en) | 2006-05-17 | 2006-05-17 | Compound amikacin sulfate injection for animal and its preparation method |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259135B (en) * | 2008-04-16 | 2010-06-09 | 韩耀云 | Antidiarrheal pharmaceutical composition for animals and preparation method thereof |
| CN101244137B (en) * | 2008-02-28 | 2011-05-04 | 郑明刚 | Medicament for treating pulmonitis, and high fever, lower fever, and preparation method |
| CN102784158A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Preparation method of compound synergy tylosin tartrate for veterinary injection |
| CN102784159A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Compound synergistic tartaric acid tylosin for injection of livestock |
| CN103405465A (en) * | 2012-08-06 | 2013-11-27 | 四川德润通生物科技有限公司 | Preparation method of medicine for treating respiratory system infection of livestock and poultry |
| CN103405464A (en) * | 2012-08-06 | 2013-11-27 | 四川德润通生物科技有限公司 | Medicine for treating respiratory system infection of livestock and poultry |
| CN103405466A (en) * | 2012-08-06 | 2013-11-27 | 重庆金邦动物药业有限公司 | Compound synergistic tylosin tartrate |
| CN103405463A (en) * | 2012-08-06 | 2013-11-27 | 四川联美生物药业有限公司 | Preparation method of synergistic tylosin tartrate soluble powder compound medicine |
| CN103432151A (en) * | 2012-08-06 | 2013-12-11 | 重庆金邦动物药业有限公司 | Preparation method for compound synergistic tylosin tartrate |
-
2006
- 2006-05-17 CN CN 200610013736 patent/CN1843329A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244137B (en) * | 2008-02-28 | 2011-05-04 | 郑明刚 | Medicament for treating pulmonitis, and high fever, lower fever, and preparation method |
| CN101259135B (en) * | 2008-04-16 | 2010-06-09 | 韩耀云 | Antidiarrheal pharmaceutical composition for animals and preparation method thereof |
| CN102784158A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Preparation method of compound synergy tylosin tartrate for veterinary injection |
| CN102784159A (en) * | 2012-08-06 | 2012-11-21 | 四川德润通生物科技有限公司 | Compound synergistic tartaric acid tylosin for injection of livestock |
| CN103405465A (en) * | 2012-08-06 | 2013-11-27 | 四川德润通生物科技有限公司 | Preparation method of medicine for treating respiratory system infection of livestock and poultry |
| CN103405464A (en) * | 2012-08-06 | 2013-11-27 | 四川德润通生物科技有限公司 | Medicine for treating respiratory system infection of livestock and poultry |
| CN103405466A (en) * | 2012-08-06 | 2013-11-27 | 重庆金邦动物药业有限公司 | Compound synergistic tylosin tartrate |
| CN103405463A (en) * | 2012-08-06 | 2013-11-27 | 四川联美生物药业有限公司 | Preparation method of synergistic tylosin tartrate soluble powder compound medicine |
| CN103432150A (en) * | 2012-08-06 | 2013-12-11 | 四川联美生物药业有限公司 | Compound medicine of synergistic tartaric acid tylosin soluble powder |
| CN103432151A (en) * | 2012-08-06 | 2013-12-11 | 重庆金邦动物药业有限公司 | Preparation method for compound synergistic tylosin tartrate |
| CN103405464B (en) * | 2012-08-06 | 2015-04-22 | 四川德润通生物科技有限公司 | Medicine for treating respiratory system infection of livestock and poultry |
| CN103432150B (en) * | 2012-08-06 | 2015-12-09 | 四川联美生物药业有限公司 | The compound medicine of potentiation tylosin tartrate soluble powder |
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