WO1996003150B1 - Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders - Google Patents
Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disordersInfo
- Publication number
- WO1996003150B1 WO1996003150B1 PCT/US1995/009230 US9509230W WO9603150B1 WO 1996003150 B1 WO1996003150 B1 WO 1996003150B1 US 9509230 W US9509230 W US 9509230W WO 9603150 B1 WO9603150 B1 WO 9603150B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- dietary fiber
- food
- polyphenol
- group
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 32
- 150000008442 polyphenolic compounds Chemical class 0.000 title claims abstract 14
- 235000013824 polyphenols Nutrition 0.000 title claims abstract 14
- 229920002488 Hemicellulose Polymers 0.000 title claims abstract 12
- 208000008665 Gastrointestinal Disease Diseases 0.000 title claims abstract 3
- 241000894006 Bacteria Species 0.000 claims abstract 6
- 239000000969 carrier Substances 0.000 claims abstract 6
- 102000004190 Enzymes Human genes 0.000 claims abstract 4
- 108090000790 Enzymes Proteins 0.000 claims abstract 4
- 241001465754 Metazoa Species 0.000 claims abstract 3
- 230000001717 pathogenic Effects 0.000 claims abstract 3
- 230000003247 decreasing Effects 0.000 claims abstract 2
- 235000013325 dietary fiber Nutrition 0.000 claims 15
- 235000013305 food Nutrition 0.000 claims 13
- 229920000189 Arabinogalactan Polymers 0.000 claims 7
- 239000001904 Arabinogalactan Substances 0.000 claims 7
- 235000019312 arabinogalactan Nutrition 0.000 claims 7
- BJHIKXHVCXFQLS-UYFOZJQFSA-N Fructose Natural products OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 claims 6
- 235000021285 flavonoid Nutrition 0.000 claims 6
- 150000002215 flavonoids Chemical class 0.000 claims 6
- 229930003935 flavonoids Natural products 0.000 claims 6
- 229920001542 oligosaccharide Polymers 0.000 claims 6
- 150000002482 oligosaccharides Polymers 0.000 claims 6
- CXQWRCVTCMQVQX-LSDHHAIUSA-N taxifolin Natural products C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-LSDHHAIUSA-N 0.000 claims 6
- 239000000419 plant extract Substances 0.000 claims 5
- OMDQUFIYNPYJFM-XKDAHURESA-N (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 3
- 239000005715 Fructose Substances 0.000 claims 3
- 229920000926 Galactomannan Polymers 0.000 claims 3
- 229920001202 Inulin Polymers 0.000 claims 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N Inulin Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 3
- 229940029339 Inulin Drugs 0.000 claims 3
- UGXQOOQUZRUVSS-ZZXKWVIFSA-N [5-[3,5-dihydroxy-2-(1,3,4-trihydroxy-5-oxopentan-2-yl)oxyoxan-4-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound OC1C(OC(CO)C(O)C(O)C=O)OCC(O)C1OC1C(O)C(O)C(COC(=O)\C=C\C=2C=CC(O)=CC=2)O1 UGXQOOQUZRUVSS-ZZXKWVIFSA-N 0.000 claims 3
- 235000010208 anthocyanin Nutrition 0.000 claims 3
- 239000004410 anthocyanin Substances 0.000 claims 3
- 150000004636 anthocyanins Chemical class 0.000 claims 3
- 229930002877 anthocyanins Natural products 0.000 claims 3
- 229920000617 arabinoxylan Polymers 0.000 claims 3
- -1 catecholines Substances 0.000 claims 3
- 230000029087 digestion Effects 0.000 claims 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 3
- 239000001648 tannin Substances 0.000 claims 3
- 235000018553 tannin Nutrition 0.000 claims 3
- 229920001864 tannin Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 235000015099 wheat brans Nutrition 0.000 claims 3
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 241001112696 Clostridia Species 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000218652 Larix Species 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 150000001765 catechin Chemical class 0.000 claims 2
- 229930016253 catechin Natural products 0.000 claims 2
- 235000005487 catechin Nutrition 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 abstract 3
- 241000186000 Bifidobacterium Species 0.000 abstract 1
- 201000002146 gastrointestinal system disease Diseases 0.000 abstract 1
Abstract
Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The hemicelluloses preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, in the gastrointestinal tract, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.
Claims
1. A composition comprising a dietary fiber which is water soluble, resists digestion by alimentary enzymes and is selectively digested by Bifidobactena and a polyphenol in an amount effective to alleviate gastrointestinal diseases caused by putrefactive or pathogenic bacteria in a human or other animal.
2. The composition of claim 1 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
3. The composition of claim 2 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
4. The composition of claim 1 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides, and transglycosylated oligosaccharides.
5. The composition of claim 1 wherein the polyphenol is a flavonoid.
6. The composition of claim 5 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins, and catechins.
7. The composition of claim 1 further comprising a pharmaceutically acceptable carrier for oral consumption.
8. The composition of claim 7 wherein the carrier is food.
9. A method for treating diseases in animals caused by putrefactive or pathogenic bacteria, the method comprising administering an effective amount of a composition comprising a dietary fiber which is water soluble, resists digestion by alimentary enzymes and is selectively digested by Bifidobactena, and a polyphenol to alleviate the disease in a human or other animal in need of treatment thereof.
10. The method of claim 9 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
11. The method of claim 10 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
12. The method of claim 9 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides and transglycosylated oligosaccharides.
13. The method of claim 9 wherein the polyphenol is a flavonoid.
14. The method of claim 13 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins and catechii-s.
15. The method of claim 9 wherein the composition is administered in a dosage of between 10 and 300 mg/kg body weight.
16. The method of claim 9 further comprising adding a carrier to the composition.
17. The method of claim 16 wherein the carrier is food.
18. The method of claim 17 wherein the composition is added to food in a concentration effective to increase the relative ratio of Bifidobactena to Clostridia.
19. The method of claim 17 wherein the composition is added to food in a concentration of between 0.1 and 5% by weight of the food.
20. The method of claim 17 wherein the composition is added to food in a concentration of between 0.1 and 2% by weight of the food.
21. The method of claim 9 wherein the animal is human.
22. The method of claim 21 wherein the animal is selected from the group consisting of poultry, swine, horses, calves, dogs and cats.
23. A method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal, the method comprising administering an effective amount of a composition comprising a dietary fiber, which is water soluble, resists digestion by animal alimentary enzymes, and is selectively digested by Bifidobactena, and a polyphenol to the animal.
24. The method of claim 23 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
25. The method of claim 24 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
26. The method of claim 23 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides and transglycosy lated oligosaccharides .
27. The method of claim 23 wherein the polyphenol is a flavonoid.
28. The method of claim 27 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins and catechins.
29. The method of claim 23 wherein the composition is administered in a dosage of between 10 and 300 mg/kg body weight.
30. The method of claim 23 further comprising adding a carrier to the composition.
31. The method of claim 30 wherein the carrier is food.
32. The method of claim 31 wherein the composition is added to food in a concentration effective to increase the relative ratio of bifidobactena to Clostridia.
33. The method of claim 32 wherein the composition is added to food in a concentration of between 0.1 and 5% by weight of the food.
34. The method of claim 32 wherein the composition is added to food in a concentration of between 0.1 and 2% by weight of the food.
35. The method of claim 35 wherein the animal is selected from the group consisting of poultry, swine, horses, calves, dogs and cats.
36. The composition of claim 3 wherein the dietary fiber is arabinogalactan.
37. The composition of claim 1 wherein the composition comprises a plant extract comprising the dietary fiber and the polyphenol.
38. The composition of claim 37 wherein the plant extract is derived from a tree of the genus Larix.
39. The composition of claim 38 wherein the dietary fiber is arabinogalactan.
40. The method of claim 9 or 23 wherein the dietary fiber is arabinogalactan.
41. The method of claim 9 or 23 wherein the method comprises administering to the animal a plant extract, wherein the plant extract comprises the dietary fiber and the polyphenol.
42. The method of claim 41 wherein the plant extract is derived from a tree of the genus Larix.
43. The method of claim 42 wherein the dietary fiber is arabinogalactan.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95927341A EP0797451B1 (en) | 1994-07-21 | 1995-07-21 | Compositions containing arabinogalactan and polyphenols from larix for treating gastrointestinal disorders |
| DE69533593T DE69533593T2 (en) | 1994-07-21 | 1995-07-21 | PREPARATIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDER CONTAINING ARABINOGALACTAN AND POLYPHENOLS OF LARIX. |
| AT95927341T ATE277638T1 (en) | 1994-07-21 | 1995-07-21 | PREPARATIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS CONTAINING ARABINOGALACTAN AND POLYPHENOLS FROM LARIX. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27841494A | 1994-07-21 | 1994-07-21 | |
| US278,414 | 1994-07-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996003150A1 WO1996003150A1 (en) | 1996-02-08 |
| WO1996003150B1 true WO1996003150B1 (en) | 1996-05-02 |
Family
ID=23064883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/009230 WO1996003150A1 (en) | 1994-07-21 | 1995-07-21 | Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5614501A (en) |
| EP (1) | EP0797451B1 (en) |
| AT (1) | ATE277638T1 (en) |
| DE (1) | DE69533593T2 (en) |
| WO (1) | WO1996003150A1 (en) |
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| US3337526A (en) * | 1965-10-15 | 1967-08-22 | St Regis Paper Co | Process for preparing arabinogalactan |
| SE446940B (en) * | 1983-02-16 | 1986-10-20 | Carl Axel Virdalm | MEASURES FOR FIGHTING DISEASE CONDITIONS IN THE FOOD MELTER CONTAINING SHALL OR OUTSIDE OF BEERS OR FRUITS |
| SE8304821L (en) * | 1983-09-08 | 1985-03-09 | Bio Carb Ab | ARABINOGALACTANTS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM |
| DK454683D0 (en) * | 1983-10-03 | 1983-10-03 | Mogens Gjerloev | GAS ADMINISTRATIVE FOR TREATMENT OF ANIMALS AND USE OF ANIMALS |
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| GB8923890D0 (en) * | 1989-10-24 | 1989-12-13 | Rowett Research Services Limit | Dietary material |
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| US5614501A (en) * | 1994-07-21 | 1997-03-25 | The University Of Montana | Compositions and methods for animal husbandry and for treating gastrointestinal disorders |
| US5882520A (en) * | 1995-10-26 | 1999-03-16 | The University Of Montana | Use of arabinogalactan in aqueous two phase extractions |
-
1995
- 1995-05-04 US US08/434,492 patent/US5614501A/en not_active Expired - Lifetime
- 1995-07-21 AT AT95927341T patent/ATE277638T1/en not_active IP Right Cessation
- 1995-07-21 EP EP95927341A patent/EP0797451B1/en not_active Expired - Lifetime
- 1995-07-21 DE DE69533593T patent/DE69533593T2/en not_active Expired - Lifetime
- 1995-07-21 WO PCT/US1995/009230 patent/WO1996003150A1/en active IP Right Grant
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1999
- 1999-07-19 US US09/356,759 patent/US6087092A/en not_active Expired - Lifetime
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