SE446940B - MEASURES FOR FIGHTING DISEASE CONDITIONS IN THE FOOD MELTER CONTAINING SHALL OR OUTSIDE OF BEERS OR FRUITS - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Pathogenic bacteria emit exotoxins that cause nausea, vomiting, diarrhea and dizziness. The invention is based on the insight that the exotoxins are proteins with both anionic and cationic character and can therefore be absorbed by ion exchange of macromolecular material, such as cellulose, which contains anionic carboxyl groups, and polymeric anthocyanins, which are cationic by oxonium ion or carbonium ion in resonance with each other. Because the inventive agent intended for oral administration contains cellulose, the exotoxins will be absorbed on the cellulose and, when the agent also contains anthocyanins, on the polymeric anthocyanins and thereby prevent the exotoxins from entering the organism and causing disease states therein.

Instead, the exotoxins accompany the feces from the body. Due to the organic acids preferably contained in the agent, an inhibition of the activity of the pathogenic bacteria is achieved. Organic acids have a toxic effect on mainly pathogenic bacteria. Low pH tends to act selectively bacteriostatic as bacteria beneficial to the organism of families such as Lactobacillus and Escherichia benefit from low pH while pathogens such as Salmonella and Vibrio are inhibited. Some studies also suggest that anthocyanins may also have some bactericidal activity; however, this is not currently unambiguously established.

Anthocyanins have more physiological effects that are important in counteracting diseases and harmful effects on the organism of, for example, exotoxins. Thus, Lietti et al [Arzneím.- Forsch., 26 (5), 829-832 (1976)] state vascular protective and anti-inflammatory effect thereof, Crippa et al (German Publication No. 3,027,933) improving the healing of wounds. , Pourrat et al [Medicinal Plants. 11, no special, 143-151 (1977)] significant improvements in the patients' condition in arteriosclerosis, coronary sclerosis, cirrhosis, in the veins during bleeding and in the use of anticoagulants, and Seeger [Ärtzliche Forschung 21 (2), 68-78 (1967) ] carcinostatic effect. The anthocyanins act as vitamin P with twice as strong an effect as 'routine' and strengthen the walls of the blood vessels and reduce blood flow. The acute toxicity is extremely low. Pourrat 446 940 states that the acute oral toxicity could not be determined as LD 0 2 25 g / kg for mouse and 2 20 g / kg for rat, Chim.

Thérap., 2, 33-38 (1967).

Thus, since the agent according to the invention contains cellulose and both organic acids and anthocyanins, an agent with bacteriostatic, healing, anti-inflammatory, bacterial florenormalizing and ammoxin-absorbing action is obtained. It is significant that the agent is substantially free of or contains a relatively small amount of constituents that constitute nutrients for microorganisms, as will be discussed in more detail below. Cellulose is virtually inert to microorganisms.

In addition to being an absorbent of the exotoxins, the cellulose acts as a carrier for the anthocyanins and the organic acids through the stomach and intestinal tract in such a way that action is obtained throughout the digestive system. The anthocyanins and the organic acids are thus absorbed into the cellulose and are therefore continuously released during transport through the apparatus. In the duodenum, the environment is weakly alkaline 'and therefore favorable for the growth of a number of pathogenic microorganisms such as salmonella and vibrio, some of which individuals may have passed the strongly acidic environment in the stomach without being killed. The organic acids in the product here counteract the growth of pathogenic microorganisms. In the small intestine and large intestine, the environment is acidic again.

According to the invention, the preparation is carried out in such a way that the main part of the pulp and preferably also any kernels are removed from berries or fruits which naturally contain cellulose, organic acids and anthocyanins, after which the residue is used as or for preparation of the preparation. The invention is based on the insight that in berries and 44e 940. 4 fruits, such as Ribes nigrum L (black currants), Vaccinium myrtíllus L (blueberries), Vaccinium Vitis-idaéa L (lingonberries), Sambucus nigra (elderberries), Vitis vínifera ( grapes), etc., which contain varying amounts of, among other things, organic acids, pectins, tannins, sugar, anthocyanins and cellulose, the nutrients for the microorganisms, namely sugar, are predominantly present in the pulp. By separating the main part of the fruit flesh and using the remainder for the agent in accordance with the invention, so that the agent will thus contain a relatively small amount of constituents which constitute nutrients for the microorganisms, a surprisingly large increase in the effect is obtained compared with that achieved. when allowing the patient to consume the pulp as well. The residue utilized for the agent which has been substantially freed from the pulp will thus have a substantially bacteriostatic effect. Pectins and tannins may also contribute to the beneficial effect of the product on the organism.

By thus starting from naturally occurring berries and fruits, the possibility of economical production of the agent is opened up. The removal of the pulp is preferably carried out by pressing the berries or fruits through a sieve with such a mesh size that the peel or outer parts of the berries or fruits are retained while the main part of the pulp and body passes through the openings of the sieve. The pressing thus gives a residue consisting of the skins and outer parts of the berries or fruits, in which are contained what is referred to according to the invention, namely cellulose, organic acids and anthocyanins. The remainder generally amounts to about 40% by weight but can vary between 10 and 70% by weight.

The resulting press cake is then dried. Anthocyanins are close to other easily oxidizable compounds such as ascorbic acid and d-CX tocopherol acetate (Efvitamin) on the redox scale and, like other phenolic compounds, tend to polymerize at elevated temperature. The material resulting from the pressing to be used for the composition should thus be dried at moderate temperatures, namely at a temperature not exceeding 110 ° C.

The drying temperature is preferably between 40 and 110 ° C at atmospheric pressure. The drying should preferably be carried out at a temperature below 90 ° C in vacuo; the temperature range can be, for example, 35 ~ 90 ° C.

The content of anthocyanins varies between different berries and fruits.

Concentrations above 3 g / kg fresh here are considered high and are found in blueberries and blackcurrants, among other things. In blueberries, the anthocyanins are approximately evenly distributed between the skin and the flesh.

In blackcurrants, most of it is concentrated in the skin, which is an advantage when the pulp is separated.

The material resulting after drying can then be comminuted by grating or grinding. The grated material can be used for the preparation of soups, while the ground material can be pressed into tablets, which can either be used for the preparation of soups or ingested whole.

It is also possible to freeze the berries or fruits to ~ 5 to -50 ° C, usually -20 ° C, after which the berries are passed through a sieve, for example a slotted sieve, net sieve or hole sieve, where tears and other plant parts such as mainly does not belong to the berry or the fruit is separated. The berries or fruits are then thawed and pressed into a sieve with such a mesh size that the flesh and seeds pass through. The press cake is torn and dried, after which the procedure is as described above.

A dose of the finished agent can amount to 2-10 g but can be both larger and smaller.

In the preparation of the agent starting from berries or fruits by removing the pulp, the content of anthocyanins is at least 10 mg / g agent and generally about 25 mg / g agent, ie 2.5%. The aforementioned publication by Crippa et al states for an ointment for external use 1% anthocyanins.

The effect of the agent prepared by removing the pulp from berries or fruits can be enhanced by increasing the content of organic acids or anthocyanins or both by adding to the finished agent. Anthocyanins can be extracted from berries, for example black currants, or fruits according to known methods such as ion exchange according to French patent specification 2,299,385. 446 940 6 Due to their high content of anthocyanins, the inventive agent should be able to be used in addition to acute gastric diseases and diarrhea in other diseases of the stomach, such as irritable bowel syndrome, enteritis, colitis, enterocolitis and ulcers.

It is preferred that sodium sulfite be added to the agent which counteracts the degradation of the anthocyanins. The sodium sulphite additive preferably amounts to a maximum of 5% by weight of the dry matter of the agent.

EXAMPLE OF THE INVENTION Example 1 The berries of Ribes nigrum L are pressed into a 2.5 mm mesh sieve with pulp and seeds passing through the sieve. This gives 410 g of press cake, which contains both the skins of the berries and a thin layer of pulp closest to the skin with a total dry matter content of 19%. The press cake is dried at 90 ° C to 94% dry matter, whereby 83 g of dried material are obtained. The dried material is then ground and sieved on a 2 mm mesh. 600 mg tablets are made from the sold material. 1 g of the ground product, when slurried in 100 ml of distilled water, gives a pH of 3.2 at 37 ° C. Electrometric titration of the slurry with a 0,1 M sodium hydroxide solution charantitre curve with the appearance according to the attached diagram, the acid content when titrated to a few different pH giving the corresponding mmol HCl according to the following table. pH HCl, mmol / g 4.0 0.5 5.0 '- 1.1 6.0 1.6 7.0 1.9 The content of organic acids in the product corresponds to about 20% citric acid.

Example 2 1 kg berry vaccine Vitis-ideaa L is frozen at -20 ° C. The frozen berries pass through a mesh sole with a 3 mm mesh width where smaller particles are separated. The berries are thawed and then pressed in a sieve with a 2 mm mesh width, whereby seeds and pulp are separated. 416,940 l of 450 g of press cake with 24% dry content are obtained. It is dried at 95 ° C to 93% dry matter to give 116 g of dried material. This is treated as in the previous example.

Example 3 '3% by weight of sodium sulphite is mixed into the press cake according to Example 1.

The press cake is dried at 90 ° C to 94% dry content as in Example 1, after which the procedure is also carried out according to said example. A Example 4 The press cake according to Example 1 mixes 5% by weight of citric acid and 5% by weight of lactic acid and 1% by weight of anthocyanins. The press cake is dried at 90 ° C to 94% dry content as in Example 1, after which the process is otherwise carried out according to the said example.

Claims (10)

446,940 Patent claims 1. Berries or fruit-based agents for controlling disease in the digestive tract and containing cellulose, organic acids and anthocyanins, characterized in that the agent is prepared by removing from the berries or fruits the bulk of the constituents which constitute nutrients for microorganisms, namely the pulp and preferably also any kernels and utilize the residue consisting of the peel or outer parts of the berries or fruits as or for the preparation of the agent. 2. An agent according to claim 1, characterized in that sodium sulphite is added thereto. 3. An agent according to claim 2, characterized in that it contains sodium sulphite to a content of not more than 5% by weight of the dry matter of the agent. 4. An agent according to claim 1, characterized in that it has an anthocyanin content of at least 10 mg / g agent, preferably about 25 mg / g. Agent according to claim 1, characterized in that the removal of the pulp is carried out by pressing the berries or fruits against a sieve with such a hole dimensioning that the peel or outer parts of the berries or fruits are retained while the main part of the pulp and possibly kernels pass through the sieve holes. Composition according to Claim 1 or 5, characterized in that the removal of the pulp is carried out so that the residue constitutes 10-70% by weight of the whole berry or fruit. Agent according to any one of claims 4-6, characterized in that the residue is dried at a temperature not exceeding 11 ° C. 8. A composition according to claim 7, characterized in that the residue is dried at a temperature not exceeding 90 ° C. 446 940 Agent according to any one of claims 1-8, characterized in that the residue, preferably after drying, is comminuted. Agent according to any one of claims 1-9, characterized in that one or more edible organic acids such as citric acid, succinic acid and lactic acid and / or anthocyanins are added to the residue.