CN102784158A - Preparation method of compound synergy tylosin tartrate for veterinary injection - Google Patents
Preparation method of compound synergy tylosin tartrate for veterinary injection Download PDFInfo
- Publication number
- CN102784158A CN102784158A CN2012102770806A CN201210277080A CN102784158A CN 102784158 A CN102784158 A CN 102784158A CN 2012102770806 A CN2012102770806 A CN 2012102770806A CN 201210277080 A CN201210277080 A CN 201210277080A CN 102784158 A CN102784158 A CN 102784158A
- Authority
- CN
- China
- Prior art keywords
- tylosin tartrate
- trimethoprim
- tylosin
- kanamycin sulfate
- tartrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 title claims abstract description 60
- 229960001717 tylosin tartrate Drugs 0.000 title claims abstract description 60
- 239000007924 injection Substances 0.000 title claims abstract description 35
- 238000002347 injection Methods 0.000 title claims abstract description 35
- 150000001875 compounds Chemical class 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 claims abstract description 32
- 229960002064 kanamycin sulfate Drugs 0.000 claims abstract description 32
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229960001082 trimethoprim Drugs 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 28
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 239000001384 succinic acid Substances 0.000 claims abstract description 11
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical group Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960001309 procaine hydrochloride Drugs 0.000 claims abstract description 10
- 239000006184 cosolvent Substances 0.000 claims abstract description 9
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims abstract description 8
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000007873 sieving Methods 0.000 claims abstract description 3
- 241001465754 Metazoa Species 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 20
- 238000007689 inspection Methods 0.000 claims description 18
- 238000012856 packing Methods 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 11
- 239000011265 semifinished product Substances 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 208000015181 infectious disease Diseases 0.000 abstract description 10
- 230000000845 anti-microbial effect Effects 0.000 abstract description 5
- 210000002345 respiratory system Anatomy 0.000 abstract description 5
- 238000001228 spectrum Methods 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000004615 ingredient Substances 0.000 abstract description 4
- 208000003322 Coinfection Diseases 0.000 abstract description 2
- 206010028470 Mycoplasma infections Diseases 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 33
- 239000003814 drug Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 238000005303 weighing Methods 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 238000011835 investigation Methods 0.000 description 6
- 244000144977 poultry Species 0.000 description 6
- 239000000273 veterinary drug Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- 241000204031 Mycoplasma Species 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229930194936 Tylosin Natural products 0.000 description 3
- 239000004182 Tylosin Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229960004059 tylosin Drugs 0.000 description 3
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 3
- 235000019375 tylosin Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000204003 Mycoplasmatales Species 0.000 description 2
- 241000606856 Pasteurella multocida Species 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 206010062255 Soft tissue infection Diseases 0.000 description 2
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 229940051027 pasteurella multocida Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 208000013223 septicemia Diseases 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 208000014085 Chronic respiratory disease Diseases 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 208000001572 Mycoplasma Pneumonia Diseases 0.000 description 1
- 201000008235 Mycoplasma pneumoniae pneumonia Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210277080 CN102784158B (en) | 2012-08-06 | 2012-08-06 | Preparation method of compound synergy tylosin tartrate for veterinary injection |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210277080 CN102784158B (en) | 2012-08-06 | 2012-08-06 | Preparation method of compound synergy tylosin tartrate for veterinary injection |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2013103647339A Division CN103432151A (en) | 2012-08-06 | 2012-08-06 | Preparation method for compound synergistic tylosin tartrate |
CN2013103634983A Division CN103405465A (en) | 2012-08-06 | 2012-08-06 | Preparation method of medicine for treating respiratory system infection of livestock and poultry |
CN2013103634358A Division CN103405463A (en) | 2012-08-06 | 2012-08-06 | Preparation method of synergistic tylosin tartrate soluble powder compound medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102784158A true CN102784158A (en) | 2012-11-21 |
CN102784158B CN102784158B (en) | 2013-08-21 |
Family
ID=47149879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201210277080 Expired - Fee Related CN102784158B (en) | 2012-08-06 | 2012-08-06 | Preparation method of compound synergy tylosin tartrate for veterinary injection |
Country Status (1)
Country | Link |
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CN (1) | CN102784158B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4368195A1 (en) * | 2022-11-14 | 2024-05-15 | European Molecular Biology Laboratory | Novel combinations of antibiotics and non-antibiotic drugs effective in vivo against gram-positive bacteria, in particular methicillin-resistant s. aureus (mrsa) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1843329A (en) * | 2006-05-17 | 2006-10-11 | 天津生机集团有限公司 | Compound amikacin sulfate injection for animal and its preparation method |
CN101468032A (en) * | 2007-12-26 | 2009-07-01 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating respiratory illness of livestock and poultry |
CN101822688A (en) * | 2010-05-19 | 2010-09-08 | 陈建波 | Compound tylosin injection for animals and preparation method thereof |
-
2012
- 2012-08-06 CN CN 201210277080 patent/CN102784158B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1843329A (en) * | 2006-05-17 | 2006-10-11 | 天津生机集团有限公司 | Compound amikacin sulfate injection for animal and its preparation method |
CN101468032A (en) * | 2007-12-26 | 2009-07-01 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating respiratory illness of livestock and poultry |
CN101822688A (en) * | 2010-05-19 | 2010-09-08 | 陈建波 | Compound tylosin injection for animals and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4368195A1 (en) * | 2022-11-14 | 2024-05-15 | European Molecular Biology Laboratory | Novel combinations of antibiotics and non-antibiotic drugs effective in vivo against gram-positive bacteria, in particular methicillin-resistant s. aureus (mrsa) |
Also Published As
Publication number | Publication date |
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CN102784158B (en) | 2013-08-21 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20121121 Assignee: Sichuan Lanme Biological Pharmaceutical Co., Ltd. Assignor: Sichuan Deruntong Biotechnology Co., Ltd. Contract record no.: 2013510000094 Denomination of invention: Preparation method of compound synergy tylosin tartrate for veterinary injection Granted publication date: 20130821 License type: Exclusive License Record date: 20130922 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
PP01 | Preservation of patent right |
Effective date of registration: 20170223 Granted publication date: 20130821 |
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PP01 | Preservation of patent right | ||
PD01 | Discharge of preservation of patent |
Date of cancellation: 20170823 Granted publication date: 20130821 |
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PD01 | Discharge of preservation of patent | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130821 Termination date: 20180806 |
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CF01 | Termination of patent right due to non-payment of annual fee |