CN101375855A - Compound niacin norfloxacin injection and preparation method - Google Patents

Abstract

The invention discloses a compound norfloxacin nicotinate injection which is applicable to the treatment of bacterial gastrointestinal infection of pigs, cattle, sheep and horses, and a preparation method thereof. The compound norfloxacin nicotinate injection is composed of 80-150 parts of norfloxacin nicotinate, 20-80 parts of apramycin sulfate and 5-30 parts of scopolamine hydrobromide. The preparation method is as follows: the components are weighted according to the weight, 300 parts of water for injection are taken, and the norfloxacin nicotinate, the scopolamine hydrobromide and the apramycin sulfate are sequentially added for stirring and dissolution; the mixture is maintained for 15 -20min, the pH value is regulated to 5.0-7.0, and the water for injection is added till 1000 parts after the clarification of liquid medicine for the preparation. The compound preparation is effective and has high efficiency for bacterial diarrhoea of pigs, cattle, sheep and horses, and the compound preparation can treat both manifestation and root cause of disease and alleviate the body stress reaction of affected animals.

Description

Compound niacin norfloxacin injection and preparation method

Technical field

The present invention relates to the medicaments injection field, particularly relate to a kind of compound niacin norfloxacin injection and preparation method that is applicable to treatment pig, cattle, sheep, the bacillary gastrointestinal infection of horse.

Background technology

Bacillary dysentery is the disease that pig, cattle, sheep, horse very easily infect, and can cause pig, cattle, sheep, horse dehydration, physical weakness, undergrowth even cause death.

The main malignant bacteria of primary disease has Salmonella, Listeria monocytogenes etc., in the ordinary course of things, these antibacterials are in and have the property of residing permanently in the carcass, under normal operation, these antibacterials are not pathogenic, but under the situation that environment changes or the resistance of domestic animal descends, these antibacterials might become pathogenic bacterium and cause animal infection, cause serious diarrhoea.In these years streptomycin, quinolinones etc. is listed in the choice drug of treatment pig, cattle, sheep, the bacillary dysentery infection of horse all over the world, because a kind of antibiotic of prolonged and repeated use or antimicrobial drug, make pathogenic microorganism produce very strong Drug resistance to medicine, reduced curative effect, drug residue exceeds standard.

Summary of the invention

The objective of the invention is in order to enlarge the antibacterial range of medicine, alleviate the discomfort that pig, cattle, sheep, the bacillary dysentery of horse cause, provide a kind of dual anti-pathogenic microorganism compound niacin norfloxacin injection.

Second purpose of the present invention provides a kind of preparation method of compound niacin norfloxacin injection.

The 3rd purpose of the present invention provides the application of a kind of compound niacin norfloxacin injection aspect treatment pig, cattle, sheep, the bacillary gastrointestinal infection of horse.

Technical scheme of the present invention is summarized as follows:

Compound niacin norfloxacin injection is become by following components in weight portion array: norfloxacin nicotinate 80-150 part, 20-80 parts of AI3-29795,5-30 parts of scopolamine hydrobromides.

Wherein preferred proportioning is: 90 parts of norfloxacin nicotinate, 10 parts of scopolamine hydrobromides, 20-80 parts of AI3-29795.

Wherein most preferred proportioning is: 90 parts of norfloxacin nicotinate, 10 parts of scopolamine hydrobromides, 25 parts of AI3-29795.

With a kind of compound niacin norfloxacin injection of method for preparing in the application aspect treatment pig, cattle, sheep, the bacillary gastrointestinal tract of horse.

Advantage of the present invention is: adopt compound preparation, effectively also efficient to pig, cattle, sheep, the bacillary dysentery of horse, treating both the principal and secondary aspects of a disease, alleviate to suffer from poultry health stress, experiment showed, uniting use and can making the curative effect enhancing of norfloxacin nicotinate and scopolamine hydrobromide and AI3-29795, clinical practice is extensive, can be widely used in pig, cattle, sheep, the bacillary gastrointestinal tract of horse, improve the survival rate of pig, cattle, sheep, horse, increase the body weight of pig, cattle, sheep, horse.

The specific embodiment

The present invention is further illustrated below in conjunction with specific embodiment in the following table, and wherein every part is 500g.

	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5
						Norfloxacin nicotinate	90 parts	80 parts	100 parts	120 parts	150 parts
AI3-29795	25 parts	20 parts	40 parts	50 parts	80 parts
						Scopolamine hydrobromide	10 parts	5 parts	10 parts	7 parts	30 parts

With embodiment 1 compound niacin norfloxacin injection in detail preparation method is described in detail below:

(1) 90 parts of norfloxacin nicotinate, 25 parts of AI3-29795,10 parts of scopolamine hydrobromides;

(2) get 300 parts of waters for injection, add norfloxacin nicotinate, scopolamine hydrobromide, AI3-29795 stirring and dissolving successively.

(3) keep 15-20min, regulate pH value to 5.0～7.0, treat to add behind medicinal liquid clear and bright injection water to 1000 part, promptly make a kind of compound niacin norfloxacin injection.

Clinical trial:

Only 100 of the ill pigs of picked at random are equally divided into four groups according to the close situation of body condition.

Numbering

Group

Mortality rate %

Inefficiency %

Effective percentage %

Cure rate %

Symptom pig's head number is arranged during end

The relative weight gain rate %

A	Do not treat (matched group)	80	—	—	—	—	—
								B	The ZHUSHEYONG LIUSUAN LIANMEISU treatment	2	4.6	82.1	80.0	4	73.2
C	The enrofloxacin injection treatment	2	2.0	80.0	79.4	2	71.5
								D	The compound niacin norfloxacin injection treatment	0	1.2	98.3	89.9	1	80.0

This result of the test is analyzed by statistics, and compound niacin norfloxacin sodium injection treatment group, enrofloxacin injection treatment group and matched group difference is (P＜0.01) extremely significantly, norfloxacin nicotinate treatment group and matched group significant difference (P＜0.05).

Claims (4)

1. a compound niacin norfloxacin injection is characterized in that, is become by following components in weight portion array: norfloxacin nicotinate 80-150 part, 20-80 parts of AI3-29795,5-30 parts of scopolamine hydrobromides.

2. compound niacin norfloxacin injection according to claim 1 is characterized in that, 90 parts of described norfloxacin nicotinate, 10 parts of scopolamine hydrobromides.

3. compound niacin norfloxacin injection according to claim 1 and 2 is characterized in that, 25 parts of described AI3-29795.

4. the preparation method of a compound niacin norfloxacin injection is characterized in that comprising the steps:

(1) takes by weighing norfloxacin nicotinate 80-150 part, 20-80 parts of AI3-29795,5-30 parts of scopolamine hydrobromides by weight;

(2) get 300 parts of waters for injection, add norfloxacin nicotinate, scopolamine hydrobromide, AI3-29795 stirring and dissolving successively;

(3) keep 15-20min, regulate pH value to 5.0～7.0, treat to add behind medicinal liquid clear and bright injection water to 1000 part, promptly make a kind of compound niacin norfloxacin injection.