CN101015560A - Compound suladime sulfadiazine sodium injection and its preparation - Google Patents
Compound suladime sulfadiazine sodium injection and its preparation Download PDFInfo
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- CN101015560A CN101015560A CN 200710056802 CN200710056802A CN101015560A CN 101015560 A CN101015560 A CN 101015560A CN 200710056802 CN200710056802 CN 200710056802 CN 200710056802 A CN200710056802 A CN 200710056802A CN 101015560 A CN101015560 A CN 101015560A
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Abstract
The invention discloses an injection of compound m-sulfanilamide-methyl-pyrimidine sodium and its preparation method. the injection is prepared form m-sulfanilamide-methyl-pyrimidine sodium 50-20, naproxen 0.5-4, ofloxacin 1-8, and TMP 1-3 by dissolving m-sulfanilamide-methyl-pyrimidine sodium and ofloxacin in water in turn with opptionally booster solvent, stirring, dissolving TMP, naproxen in solvent respectively, merging the solutions, mixing uniformly, adjusting ph value, adding active carbon, stirring for adsorption for 15-20min, and adding water for injection to 1000 to obtain the final product. The injection can be used for treating general infection of livestock with rational formula and good therapeutic effect.
Description
Technical field
The present invention relates to the medicaments injection field, particularly relate to a kind of injection of compound m-sulfanilamide-methyl-pyrimidine and preparation method thereof.
Background technology
Mixed cell for domestic animal infects, and the single antipyretic-antalgic anti-inflammatory agent of the prolonged and repeated use in various places makes pathogenic microorganism produce Drug resistance to medicine, and reduced curative effect.
Summary of the invention
The objective of the invention is in order to enlarge the antibacterial range of medicine, provide a kind of avoiding to use a kind of antibacterials repeatedly, and make injection of compound m-sulfanilamide-methyl-pyrimidine that pathogenic microorganism develops immunity to drugs and preparation method thereof.
Injection of compound m-sulfanilamide-methyl-pyrimidine of the present invention, be by following component by described content proportioning: Solumedine 5-20 part, naproxen 0.5-4 part, ofloxacin 1-8 part, trimethoprim (TMP) 1-3 part, propylene glycol 30-65 part, sodium thiosulfate 0.05-0.3 part, dimethyl formamide 5-20 part.
The most preferred proportioning of the present invention is: 10 parts of Solumedines, 1 part of naproxen, 5 parts of ofloxacins, 2 parts of trimethoprims (TMP), 45 parts of propylene glycol, 0.2 part in sodium thiosulfate, 10 parts of dimethyl formamides.
A kind of preparation method of injection of compound m-sulfanilamide-methyl-pyrimidine is made of following steps:
(1) takes by weighing Solumedine 5-20 part, naproxen 0.5-4 part, ofloxacin 1-8 part, TMP1-3 part by weight;
(2) described Solumedine, ofloxacin are added in 25 parts of waters for injection successively, be stirred to the clear and bright solution " 1 " that gets;
(3) add 1-3 part TMP stirring and dissolving after getting 30-65 part propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 5 parts of water for injection dissolving antioxidant sodium thiosulfate 0.05-0.3 parts in addition, get solution " 3 ";
(5) get dimethyl formamide 5-20 part adding naproxen stirring and dissolving and get solution " 4 ";
(6) mixed solution " 1 ", " 2 ", " 3 ", " 4 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% active carbon stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
Advantage of the present invention is: adopts compound preparation, increases antimicrobial spectrum, reduce Drug resistance, and the systemic infection that can treat domestic animal, and can see through blood brain barrier, the treatment brain infection.Experimental results show that, use the uniting of Solumedine and naproxen, ofloxacin and assistant can make curative effect of medication strengthen several times with TMP, clinical practice is extensive, has overcome single time spent drug resistance of being produced of antibacterial, the mixed cell that can be widely used in domestic animal infects, and increases the body weight of domestic animal relatively.
Extensively distribute at whole body after the intravenous injection of Solumedine injection, enterobacteriaceae lactobacteriaceae, Diplococcus gonorrhoeae, Neisseria meningitidis, hemophilus influenza, toxoplasma, streptococcus etc. such as non-product enzyme staphylococcus aureus, micrococcus scarlatinae, streptococcus pneumoniae, escherichia coli, Klebsiella, Salmonella, Shigella are had very strong antibacterial action.Ofloxacin is the third generation fluoroquinolones of animal specific, and broad-spectrum bactericidal action is arranged, and is all effective to the antibacterial of resting stage and trophophase, and multiple gram negative bacilli and coccus are had good antibacterial action, obvious to the mycoplasma effect.Naproxen does not have the antipyretic-antalgic anti-inflammatory agent of toleration for efficient, low toxicity, life-time service.Above-mentioned three kinds of compatibility of drugss are learnt from other's strong points to offset one's weaknesses, and heighten the effect of a treatment after being equipped with TMP, imitate medicine during existing active remedy has again, meet the Therapeutic Principle of clinical disease.Experimental results show that, uniting use and helping with TMP of Solumedine and naproxen, ofloxacin can make curative effect of medication strengthen several times, clinical practice is extensive, the drug resistance that antibacterial is produced when having overcome a kind of antipyretic-antalgic anti-inflammatory agent of single usefulness or drug resistance, reduced the dependency of body to medicine, the mixed cell that can be widely used in domestic animal infects, and increases the body weight of domestic animal relatively.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1 (every part is 500g):
Injection of compound m-sulfanilamide-methyl-pyrimidine: 10 parts of Solumedines, 0.5 part of naproxen, 4 parts of ofloxacins, TMP2 part, 50 parts of propylene glycol, 0.2 part in 10 parts of sodium thiosulfate of dimethyl formamide.
Injection of compound m-sulfanilamide-methyl-pyrimidine is to make with following method:
(1) takes by weighing 10 parts of Solumedines, 10 parts of naproxens, 4 parts of ofloxacins by weight;
(2) described Solumedine, ofloxacin are added in 25 parts of waters for injection successively, be stirred to the clear and bright solution " 1 " that gets;
(3) add 2 parts of TMP stirring and dissolving after getting 50 parts of propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 0.2 part in 5 parts of water for injection dissolving antioxidant sodium thiosulfate in addition, get solution " 3 ";
(5) get dimethyl formamide 5-20 part adding naproxen 5-20 part stirring and dissolving and get solution " 4 ";
(6) mixed solution " 1 ", " 2 ", " 3 " " 4 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% active carbon stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
Embodiment 2 (every part is 1500g):
Injection of compound m-sulfanilamide-methyl-pyrimidine: 10 parts of Solumedines, 1 part of naproxen, 5 parts of ofloxacins, TMP1 part, 45 parts of propylene glycol, 0.2 part in sodium thiosulfate, 15 parts of dimethyl formamides.
Injection of compound m-sulfanilamide-methyl-pyrimidine is to make with following method:
(1) 10 parts of Solumedines, 1 part of naproxen, 5 parts of ofloxacins, TMP1 part, 45 parts of propylene glycol, 0.2 part in sodium thiosulfate;
(2) described Solumedine, ofloxacin are added in 25 parts of waters for injection successively, be stirred to the clear and bright solution " 1 " that gets;
(3) add 1 part of TMP stirring and dissolving after getting 45 parts of propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 0.2 part in 5 parts of water for injection dissolving antioxidant sodium thiosulfate in addition, get solution " 3 ";
(5) get 1 part of stirring and dissolving of dimethyl formamide 15 parts of addings naproxen and get solution " 4 ";
(6) mixed solution " 1 ", " 2 ", " 3 " " 4 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% active carbon stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
Embodiment 3 (every part is 2500g):
Injection of compound m-sulfanilamide-methyl-pyrimidine: 5 parts of Solumedines, 5 parts of naproxens, 1 part of ofloxacin, TMP2 part, 30 parts of propylene glycol, 0.2 part in sodium thiosulfate, 5 parts of dimethyl formamides.
Injection of compound m-sulfanilamide-methyl-pyrimidine is to make with following method:
(1) 5 parts of Solumedines, 5 parts of naproxens, 1 part of ofloxacin, TMP2 part, 30 parts of propylene glycol, 0.2 part in sodium thiosulfate;
(2) described Solumedine, naproxen, ofloxacin are added in 25 parts of waters for injection successively, be stirred to the clear and bright solution " 1 " that gets;
(3) add 2 parts of TMP stirring and dissolving after getting 30 parts of propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 0.2 part in 5 parts of water for injection dissolving antioxidant sodium thiosulfate in addition, get solution " 3 ";
(5) get 5 parts of stirring and dissolving of dimethyl formamide 5 parts of addings naproxen and get solution " 4 ";
(6) mixed solution " 1 ", " 2 ", " 3 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
Embodiment 4 (every part is 1500g)
Injection of compound m-sulfanilamide-methyl-pyrimidine: 10 parts of Solumedines, 0.5 part of naproxen, 5 parts of ofloxacins, TMP2 part, 30 parts of propylene glycol, 0.2 part in sodium thiosulfate, 15 parts of dimethyl formamides.
Injection of compound m-sulfanilamide-methyl-pyrimidine is to make with following method:
(1) 5 parts of Solumedines, 0.5 part of naproxen, 5 parts of ofloxacins, TMP2 part, 50 parts of propylene glycol, 0.2 part in sodium thiosulfate;
(2) described Solumedine, ofloxacin are added successively in 25 parts of waters for injection, if insoluble ethanolamine a little is stirred to the clear and bright solution " 1 " that gets;
(3) add 2 parts of TMP stirring and dissolving after getting 30 parts of propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 0.2 part in 5 parts of water for injection dissolving antioxidant sodium thiosulfate in addition, get solution " 3 ";
(5) get 0.5 part of stirring and dissolving of dimethyl formamide 15 parts of addings naproxen and get solution " 4 "
(6) mixed solution " 1 ", " 2 ", " 3 " " 4 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% active carbon stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
Clinical trial:
Only 100 of the ill pigs of picked at random are equally divided into four groups according to the close situation of body condition.
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | The symptom pig's head is arranged during end | The relative weight gain |
| A | Do not treat (matched group) | 80 | - | - | - | - | - |
| B | The ofloxacin treatment | 2 | 4.6 | 82.1 | 80.0 | 4 | 73.2 |
| C | Sulfadimidine sodium is controlled | 2 | 2.0 | 80.0 | 79.4 | 2 | 71.5 |
| D | Methoxy is phonetic between compound sulfonamide | 0 | 1.2 | 98.3 | 89.9 | 1 | 80.0 |
This result of the test is analyzed by statistics, and composite sulfamonomethoxine sodium injection treatment group, ofloxacin treatment group and matched group difference is (P＜0.01) extremely significantly, sulfamonomethoxine sodium treatment group and matched group significant difference (P＜0.05).
Claims (3)
1. injection of compound m-sulfanilamide-methyl-pyrimidine, it is characterized in that, constitute by described proportioning: Solumedine 5-20 part, naproxen 0.5-4 part, ofloxacin 1-8 part, trimethoprim 1-3 part, propylene glycol 30-65 part, sodium thiosulfate 0.05-0.3 part, dimethyl formamide 5-20 part by following component.
2. injection of compound m-sulfanilamide-methyl-pyrimidine according to claim 1, it is characterized in that, constitute by described proportioning: 10 parts of Solumedines, 1 part of naproxen, 5 parts of ofloxacins, 2 parts of trimethoprims, 45 parts of propylene glycol, 0.2 part in sodium thiosulfate, 10 parts of dimethyl formamides by following component.
3. an injection of compound m-sulfanilamide-methyl-pyrimidine preparation method is characterized in that, is made of following step:
(1) takes by weighing Solumedine 5-20 part, naproxen 0.5-4 part, ofloxacin 1-8 part, TMP1-3 part, propylene glycol 30-65 part, sodium thiosulfate 0.05-0.3 part, dimethyl formamide 5-20 part;
(2) described Solumedine, ofloxacin are added successively be stirred to clear and bright solution " 1 " in 25 parts of waters for injection;
(3) add above-mentioned trimethoprim stirring and dissolving after getting above-mentioned propylene glycol and being heated to 80-90 degree centigrade, solution " 2 ";
(4) get 5 parts of water for injection dissolving antioxidant sodium thiosulfate parts in addition, get solution " 3 ";
(5) get described dimethyl formamide adding naproxen 5-20 part stirring and dissolving and get solution " 4 "
(6) mixed solution " 1 ", " 2 ", " 3 ", " 4 " stir, and regulate pH to 10.3-10.7 with ethanolamine;
(7) in solution, add 0.1% active carbon stirring and adsorbing 15-20min, add injection water to 1000 part, promptly make a kind of injection of compound m-sulfanilamide-methyl-pyrimidine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710056802 CN101015560A (en) | 2007-02-13 | 2007-02-13 | Compound suladime sulfadiazine sodium injection and its preparation |
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| CN 200710056802 CN101015560A (en) | 2007-02-13 | 2007-02-13 | Compound suladime sulfadiazine sodium injection and its preparation |
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| CN 200710056802 Pending CN101015560A (en) | 2007-02-13 | 2007-02-13 | Compound suladime sulfadiazine sodium injection and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102188436A (en) * | 2011-03-28 | 2011-09-21 | 郑州百瑞动物药业有限公司 | Injection for treating porcine mixed infection |
-
2007
- 2007-02-13 CN CN 200710056802 patent/CN101015560A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN101954084B (en) * | 2010-09-06 | 2015-06-17 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN102188436A (en) * | 2011-03-28 | 2011-09-21 | 郑州百瑞动物药业有限公司 | Injection for treating porcine mixed infection |
| CN102188436B (en) * | 2011-03-28 | 2012-07-11 | 郑州百瑞动物药业有限公司 | Injection for treating porcine mixed infection |
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Open date: 20070815 |