CN101537176B - Application of staphylococcus lysozyme compound in preparing medicament improving animal health condition - Google Patents
Application of staphylococcus lysozyme compound in preparing medicament improving animal health condition Download PDFInfo
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- CN101537176B CN101537176B CN200810060812XA CN200810060812A CN101537176B CN 101537176 B CN101537176 B CN 101537176B CN 200810060812X A CN200810060812X A CN 200810060812XA CN 200810060812 A CN200810060812 A CN 200810060812A CN 101537176 B CN101537176 B CN 101537176B
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Abstract
The invention relates to application of a staphylococcus lysozyme compound in preparing a medicament capable of improving the animal health condition. The technical proposal is as follows: the staphylococcus lysozyme compound comprises the following components in portion by weight: 50 to 70 portions of staphylococcus lysozyme compound agent, 10 to 20 portions of lysozyme, 5 to 15 portions of Amino, 0.1 to 0.2 portion of potassium phosphate, 5 to 20 portions of rare earth feed additive, and 0.5 to 2 portions of feeding stuff antistaling agent; the rare earth feed additive can be an SOA vitality element; and the staphylococcus lysozyme compound agent comprises the following components in portion by weight: 0.1 to 20 portions of staphylococcus lysozyme, 50 to 85 portions of lysozyme, 1 to 20 portions of feeding stuff disinfectant and 0.1 to 20 portions of feeding stuff antistaling agent. In addition, any combination of three components including Ruiteqi, immunoglobulin for swine and leukocyte interferon for swine in portion by weight is also added into the compound, wherein the combination comprises 0.001 to 0.01 portion of Ruiteqi, 0.001 to 0.005 portion of immunoglobulin for swine and 0.001 to 0.005 portion of leukocyte interferon for swine.
Description
Technical field
The present invention relates to the application of a kind of biological compound formulation aspect animal health, especially relate to a kind of staphylococcus lysozyme compound and improve the application in the animal health condition medicine in preparation.
Background technology
Bacterial resistance has become the severe problem that global the world of medicine faces.Livestock breeding industry also faces same problem aspect the Animal diseases preventing and treating.Chinese patent 00116397.3 provides a kind of staphylococcus lysozyme compound formulation can crack drug-resistance of bacteria; This product and technology are since coming out; Be used as human shell disinfectant always; The inventor has studied the application of staphylococcus lysozyme compound formulation aspect the herding health care, laboratory result be this staphylococcus lysozyme compound formulation to the bacteriostatic diameter of porcine contagious pleuropneumonia Actinobacillus only 9mm, to the bacteriostatic diameter 14mm of staphylococcus aureus,, to the bacteriostatic diameter of escherichia coli EC-130 also 9mm only; All be lower than lysozyme, its effect is unsatisfactory.
Summary of the invention
The present invention mainly provides a kind of animal health medicine that can kill drug tolerant bacteria.
Above-mentioned technical problem of the present invention mainly is able to solve through following technical proposals: when staphylococcus lysozyme compound improves the application in the animal health condition medicine in preparation; Its prescription is by weight: composite dose 50～70 of staphylococcus lysozyme, lysozyme 10～20, A Meinuo 5～15, potassium phosphate 0.1～0.2, rare-earth forage additive 5～20, feedstuff antistaling agent 0.5～2; Said rare-earth forage additive is that the SOA vigor is plain, and composite dose of said staphylococcus lysozyme is made up of following component by weight: staphylococcus lysozyme 0.1～20, lysozyme 50～85, feedstuff antibacterial 1～20, feedstuff antistaling agent 0.1～20.
As preferably; Staphylococcus lysozyme compound can also add Rui Teqi in parts by weight, the pig combination in any with immunoglobulin, three kinds of components of leukocyte interferon of pig in application process, special strange 0.001～0.01 part of its China and Sweden, pig are with 0.001～0.005 part of immunoglobulin, 0.001～0.005 part of leukocyte interferon of pig.
As preferably, the optional sodium benzoate of said feedstuff antibacterial.
Because the bigger pathogenic bacterium of harm all belong to gram negative bacteria in the commonly encountered diseases of livestock breeding industry, this is the difference of herding health care and body-care, and staphylococcus lysozyme is comparatively responsive to gram negative bacteria; Therefore; Need to improve the ratio of staphylococcus lysozyme, leukocyte increasing interferon in addition, binding lysozyme, A Meinuo, potassium phosphate, SOA vigor are plain; Harmoniously, realize the purpose prevent and cure diseases.
The mechanism of action of staphylococcus lysozyme compound is to destroy the RF of bacteria cell wall Peptidoglycan rapidly; Dual breaking cellular wall antibacterial; Gram-positive bacteria and gram-negative bacteria all there are killing action, especially can kill the on-the-spot escherichia coli that developed immunity to drugs, be difficult for producing endurance strain; Its bactericidal mechanism is different fully with antibiotic, the antibiotic application of alternative part and whole body.Therefore, after staphylococcus lysozyme and lysozyme were composite, fungicidal spectrum was wider; Sterilizing ability is stronger, owing to be the breaking cellular wall antibacterial, the antibacterial instantaneous death, not through the metabolism link, so antibiotic-free drug resistance problem; Zinciferous protease can promote wound healing, and stability is better, and (reduce the antibiotic medication, shorten treatment time, reduce and infect complication) reduces the financial burden.
A Meinuo can be alleviated the functional additive that stress and improve resistance, and main function is changeed crowd, transport stress for reducing, and makeup energy activates metabolism.But anion cation balance in the cation in the potassium phosphate supplemental blood, balance animal body.Antistaling agent can prolong the holding time of composite dose of feedstuff or staphylococcus lysozyme; Antibacterial can prevent that feedstuff is mouldy.
SOA vigor element is the rare earth-chitosamine chelate; It is not single inorganic rare earth chemical compound, but the organic chelated salt of Rare Earth Lanthanum cerium more is prone to digested and assimilated; Biological activity than the rare earth compound that does not carry out chelation treatment is much higher, as the better effects if of feed additive.Because chitosan with Rare Earth Lanthanum cerium chelating; It is a kind of natural organic high-molecular polysaccharide; Its special biochemical function comes from amino in the molecular structure, and (NH2) active group, this aminopolysaccharide have the staphylococcus killed, escherichia coli, small intestinal and tie the excellent properties of toadstool in scorching yersinia, Salmonella typhimurium and these 5 kinds of common food of Liszt's single pole hypertrophy bacterium.The SQA chelating salt is participated in physiology process in the organism, and its mechanism of action is similar to biocatalyzer, can activate polycalcium accent protease activities in the animal body, improves the vigor of enzyme.CS-La and CS-Ce after assimilating, by the animal body internal memory enzymolysis such as chitinase or lysozyme or be hydrolyzed into glucosamine and La (III) and Ce (III) ion.Glucosamine is the interior a large amount of a kind of compositions that exist of organism just, have the panimmunity regulating action, can promote zooprophylazis or overcome pathogenic microorganism or the ability of the adverse effect of its toxin.And La (III) has stronger activation to the brain metalloproteases, and Ce (III) then has differential stimulus somatotroph and the effect of secreting growth hormone.Thereby the acceleration bodies intracellular metabolic is improved food conversion ratio, and transfers biological intravital potential, thereby promotes growth, and the enhance immunity resistant effect, but is not that type of clenobuterol hydrochloride (clenbuterol hydrochloride) adrenal gland medicine hormonal action.
Therefore, the present invention has reasonable recipe, simple and convenient preparation, and bactericidal property strong (especially for drug tolerant bacteria), antibiotic-free can shorten treatment time, reduce characteristics such as infecting complication.
The specific embodiment
Through embodiment, do further bright specifically below to technical scheme of the present invention.
Embodiment 1: when staphylococcus lysozyme compound improves the application in the animal health condition medicine in preparation; Its prescription is by weight: composite dose 50 of staphylococcus lysozyme, lysozyme 20, A Meinuo 10, potassium phosphate 0.1, SOA vigor are plain 5, feedstuff antistaling agent 0.5, Rui Te are strange 0.001, pig immune globulin 0.005, leukocyte interferon of pig 0.001, and composite dose of said staphylococcus lysozyme is made up of following component by weight: staphylococcus lysozyme 2, lysozyme 55, sodium benzoate 10, feedstuff antistaling agent 0.2.
Embodiment 2: when staphylococcus lysozyme compound improves the application in the animal health condition medicine in preparation; Its prescription is by weight: composite dose 60 of staphylococcus lysozyme, lysozyme 12, A Meinuo 8, potassium phosphate 0.1, SOA vigor are plain 10, feedstuff antistaling agent 0.8, Rui Te are strange 0.005, pig is with immunoglobulin 0.001, and composite dose of said staphylococcus lysozyme is made up of following component by weight: staphylococcus lysozyme 0.1～20, lysozyme 50～85, sodium benzoate 12, feedstuff antistaling agent 0.5.
At last, should be pointed out that above embodiment only is the more representational example of the present invention.Obviously, technical scheme of the present invention is not limited to the foregoing description, and many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (3)
1. a staphylococcus lysozyme compound preparation improves the application of animal health condition medicine in the animal husbandry in preparation; It is characterized in that its prescription is made up of following component by weight: composite dose 50～70 of staphylococcus lysozyme, lysozyme 10～20, A Meinuo 5～15, potassium phosphate 0.1～0.2, rare-earth forage additive 5～20, feedstuff antistaling agent 0.5～2; Said rare-earth forage additive is that the SQA vigor is plain, and composite dose of said staphylococcus lysozyme is made up of following component by weight: staphylococcus lysozyme 0.1～20, lysozyme 50～85, feedstuff antibacterial 1～20, feedstuff antistaling agent 0.1～20.
2. a kind of staphylococcus lysozyme compound preparation according to claim 1 improves the application of animal health condition medicine in the animal husbandry in preparation; It is characterized in that said staphylococcus lysozyme compound can also add Rui Teqi in parts by weight, the pig combination in any with immunoglobulin, three kinds of components of leukocyte interferon of pig in application process, special strange 0.001～0.01 part of its China and Sweden, pig are with 0.001～0.005 part of immunoglobulin, 0.001～0.005 part of leukocyte interferon of pig.
3. a kind of staphylococcus lysozyme compound preparation according to claim 1 and 2 improves the application of animal health condition medicine in the animal husbandry in preparation, it is characterized in that said feedstuff antibacterial is a sodium benzoate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810060812XA CN101537176B (en) | 2008-03-21 | 2008-03-21 | Application of staphylococcus lysozyme compound in preparing medicament improving animal health condition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810060812XA CN101537176B (en) | 2008-03-21 | 2008-03-21 | Application of staphylococcus lysozyme compound in preparing medicament improving animal health condition |
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| Publication Number | Publication Date |
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| CN101537176A CN101537176A (en) | 2009-09-23 |
| CN101537176B true CN101537176B (en) | 2012-02-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810060812XA Expired - Fee Related CN101537176B (en) | 2008-03-21 | 2008-03-21 | Application of staphylococcus lysozyme compound in preparing medicament improving animal health condition |
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Families Citing this family (1)
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| CN115462454A (en) * | 2022-09-24 | 2022-12-13 | 昆山博青生物科技有限公司 | Quick-acting antidiarrheal nutritional paste for pets and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327741A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Compound lysostaphin enzyme disinfectant |
| CN1367018A (en) * | 2002-01-28 | 2002-09-04 | 上海高科生物工程有限公司 | Compound preparation of staphylococcolysis enzyme and its preparation method and application |
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2008
- 2008-03-21 CN CN200810060812XA patent/CN101537176B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327741A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Compound lysostaphin enzyme disinfectant |
| CN1367018A (en) * | 2002-01-28 | 2002-09-04 | 上海高科生物工程有限公司 | Compound preparation of staphylococcolysis enzyme and its preparation method and application |
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| CN101537176A (en) | 2009-09-23 |
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Granted publication date: 20120229 Termination date: 20140321 |