CN102414314A - 用于生产丙酮的细胞和方法 - Google Patents

用于生产丙酮的细胞和方法 Download PDF

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Publication number
CN102414314A
CN102414314A CN2010800177745A CN201080017774A CN102414314A CN 102414314 A CN102414314 A CN 102414314A CN 2010800177745 A CN2010800177745 A CN 2010800177745A CN 201080017774 A CN201080017774 A CN 201080017774A CN 102414314 A CN102414314 A CN 102414314A
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China
Prior art keywords
acetone
enzyme
clostridium
cell
coa
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Pending
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CN2010800177745A
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English (en)
Chinese (zh)
Inventor
U.贝克
G.格伦德
M.奥尔舍尔
K.多德雷尔
G.勒登
G.布兰
P.迪雷
S.图姆
H.J巴尔
R-J.菲舍尔
A.梅伊
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Evonik Operations GmbH
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Evonik Degussa GmbH
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Publication of CN102414314A publication Critical patent/CN102414314A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C12P7/30—Acetone-containing products produced from substrate containing inorganic compounds other than water
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2010800177745A 2009-04-23 2010-02-23 用于生产丙酮的细胞和方法 Pending CN102414314A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009002583A DE102009002583A1 (de) 2009-04-23 2009-04-23 Zellen und Verfahren zur Herstellung von Aceton
DE102009002583.9 2009-04-23
PCT/EP2010/052244 WO2010121849A1 (de) 2009-04-23 2010-02-23 Zellen und verfahren zur herstellung von aceton

Publications (1)

Publication Number Publication Date
CN102414314A true CN102414314A (zh) 2012-04-11

Family

ID=42103849

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800177745A Pending CN102414314A (zh) 2009-04-23 2010-02-23 用于生产丙酮的细胞和方法

Country Status (9)

Country Link
US (1) US9453210B2 (https=)
EP (1) EP2421960B1 (https=)
JP (1) JP5805073B2 (https=)
CN (1) CN102414314A (https=)
AU (1) AU2010241185B2 (https=)
BR (1) BRPI1013430A2 (https=)
DE (1) DE102009002583A1 (https=)
ES (1) ES2639224T3 (https=)
WO (1) WO2010121849A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105821084A (zh) * 2015-01-28 2016-08-03 赢创德固赛有限公司 生产醇的好氧方法
CN107404882A (zh) * 2015-02-27 2017-11-28 白狗实验室有限公司 用于生产丙酮、异丙醇、丁酸、其他生物产品及其混合物的混合营养发酵方法
CN112608935A (zh) * 2020-12-18 2021-04-06 北京化工大学 一种改造乙酸梭菌代谢途径产丙酮的方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5397136B2 (ja) * 2009-09-30 2014-01-22 住友電気工業株式会社 Ｉｉｉ族窒化物半導体レーザ素子、及びｉｉｉ族窒化物半導体レーザ素子を作製する方法
DE102010062587A1 (de) 2010-12-08 2012-06-14 Evonik Degussa Gmbh Verfahren zur Herstellung von Isophoron
BR112013021524A2 (pt) * 2011-02-25 2017-06-13 Lanzatech New Zealand Ltd micro-organismos recombinantes e usos dos mesmos
US9365868B2 (en) 2011-02-25 2016-06-14 Lanzatech New Zealand Limited Fermentation process for producing isopropanol using a recombinant microorganism
US9410130B2 (en) 2011-02-25 2016-08-09 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
DE102011075777A1 (de) 2011-05-13 2012-11-15 Evonik Degussa Gmbh Verfahren zur Herstellung von Isophoron in Gegenwart mindestens eines Entschäumers in der Abwasserkolonne im Aufarbeitungsteil
DE102011077705A1 (de) * 2011-06-17 2012-12-20 Evonik Degussa Gmbh Mikrobielles Verfahren zur Herstellung niedermolekularer, organischer Verbindungen umfassend die Produktabsorption durch Isophoron
JP6512825B2 (ja) 2012-01-31 2019-05-15 ランザテク・ニュージーランド・リミテッド 組換え微生物およびその使用方法
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
MY183766A (en) * 2013-03-15 2021-03-12 Lanzatech New Zealand Ltd A system and method for controlling metabolite production in a microbial fermentation
KR101750293B1 (ko) * 2015-03-04 2017-06-26 한국과학기술연구원 이산화탄소로부터의 아세톤 생성능을 갖는 형질전환된 시네코코커스 일롱게투스 균주
EP3348646A1 (de) 2017-01-17 2018-07-18 Evonik Degussa GmbH Mikrobielles verfahren zur herstellung von aceton, isopropanol, butanol und/oder ethanol umfassend die produktabsorption durch wasser
BR112022014752A2 (pt) * 2020-01-29 2022-10-11 Jupeng Bio Hk Ltd Processo para controlar proporções de ácidos orgânicos em processo de bioconversão de dióxido de carbono
KR20260010725A (ko) * 2023-05-11 2026-01-21 에보니크 오퍼레이션즈 게엠베하 아세톤의 생명공학적 생산

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301993A (https=) 1962-12-18
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
NZ515009A (en) 1999-05-07 2003-04-29 Emmaus Foundation Inc Clostridium strains which produce ethanol from substrate-containing gases
DK1303629T3 (da) 2000-07-25 2006-10-30 Emmaus Foundation Inc Fremgangsmåde til forögelse af ethanolproduktion fra mikrobiel fermetering
US20070275447A1 (en) 2006-05-25 2007-11-29 Lewis Randy S Indirect or direct fermentation of biomass to fuel alcohol
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
EP2182051A4 (en) * 2007-08-29 2010-12-29 Res Inst Innovative Tech Earth FOR THE MANUFACTURE OF ISOPROPANOL SUITABLE TRANSFORMERS
EP2198039A4 (en) * 2007-10-12 2012-05-09 Univ California MODIFIED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
DE102007052463A1 (de) * 2007-11-02 2009-05-07 Evonik Degussa Gmbh Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges
DE102010062587A1 (de) 2010-12-08 2012-06-14 Evonik Degussa Gmbh Verfahren zur Herstellung von Isophoron

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BYUNG HONG KIM ET AL: "Control of Carbon and Electron Flow in Clostridium acetobutylicum Fermentations: Utilization of Carbon Monoxide to Inhibit Hydrogen Production and to Enhance Butanol Yields.", 《APPL.ENVIRON.MICROBIOL.》 *
LEE D. MERMELSTEIN ET AL: "MetaboIic Engineering of Clostridium acetobutylicum ATCC 824 for Increased Solvent Production by Enhancement of Acetone Formation Enzyme Activities Using a Synthetic Acetone Operon.", 《BIOTECHNOLOGY AND BIOENGINEERING》 *
LOURDES L. BERMEJO等: "Expression of Clostridium acetobutylicum ATCC 824 Genes in Escherichia coli for Acetone Production and Acetate Detoxification", 《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》 *
MOLLAH A H ET AL: "The influence of hydeogen carbon dioxide and dilution reta on the continuous fermentation of acetone butanol", 《APPLIED MICROBIOLOGY AND BIOTECHNOLOGY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105821084A (zh) * 2015-01-28 2016-08-03 赢创德固赛有限公司 生产醇的好氧方法
CN105821084B (zh) * 2015-01-28 2021-02-26 赢创运营有限公司 生产醇的好氧方法
CN107404882A (zh) * 2015-02-27 2017-11-28 白狗实验室有限公司 用于生产丙酮、异丙醇、丁酸、其他生物产品及其混合物的混合营养发酵方法
CN112608935A (zh) * 2020-12-18 2021-04-06 北京化工大学 一种改造乙酸梭菌代谢途径产丙酮的方法

Also Published As

Publication number Publication date
ES2639224T3 (es) 2017-10-25
JP2012524529A (ja) 2012-10-18
EP2421960B1 (de) 2017-07-19
US20120101304A1 (en) 2012-04-26
DE102009002583A1 (de) 2010-10-28
EP2421960A1 (de) 2012-02-29
AU2010241185A1 (en) 2011-10-27
US9453210B2 (en) 2016-09-27
BRPI1013430A2 (pt) 2015-09-01
WO2010121849A1 (de) 2010-10-28
JP5805073B2 (ja) 2015-11-04
AU2010241185B2 (en) 2016-03-10

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