DE102009002583A1 - Zellen und Verfahren zur Herstellung von Aceton - Google Patents
Zellen und Verfahren zur Herstellung von Aceton Download PDFInfo
- Publication number
- DE102009002583A1 DE102009002583A1 DE102009002583A DE102009002583A DE102009002583A1 DE 102009002583 A1 DE102009002583 A1 DE 102009002583A1 DE 102009002583 A DE102009002583 A DE 102009002583A DE 102009002583 A DE102009002583 A DE 102009002583A DE 102009002583 A1 DE102009002583 A1 DE 102009002583A1
- Authority
- DE
- Germany
- Prior art keywords
- acetone
- enzyme
- cell
- acetogenic
- clostridium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title claims abstract description 198
- 238000000034 method Methods 0.000 title claims abstract description 37
- 230000008569 process Effects 0.000 title claims description 19
- 238000004519 manufacturing process Methods 0.000 title abstract description 22
- 102000004190 Enzymes Human genes 0.000 claims description 34
- 108090000790 Enzymes Proteins 0.000 claims description 34
- 230000000789 acetogenic effect Effects 0.000 claims description 27
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- 241000193401 Clostridium acetobutylicum Species 0.000 claims description 19
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims description 15
- 235000015097 nutrients Nutrition 0.000 claims description 12
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 11
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 10
- 241001656810 Clostridium aceticum Species 0.000 claims description 9
- 239000001569 carbon dioxide Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 241000186566 Clostridium ljungdahlii Species 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 7
- 108091022873 acetoacetate decarboxylase Proteins 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims description 6
- 108030002956 Butyrate-acetoacetate CoA-transferases Proteins 0.000 claims description 5
- 241001611022 Clostridium carboxidivorans Species 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 4
- 241001468163 Acetobacterium woodii Species 0.000 claims description 3
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims description 3
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 3
- 102000008172 Palmitoyl-CoA Hydrolase Human genes 0.000 claims description 3
- 108010035473 Palmitoyl-CoA Hydrolase Proteins 0.000 claims description 3
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims description 3
- 241001112780 Acetoanaerobium Species 0.000 claims description 2
- 241001464894 Blautia producta Species 0.000 claims description 2
- 241000186398 Eubacterium limosum Species 0.000 claims description 2
- 241000193459 Moorella thermoacetica Species 0.000 claims description 2
- 241000204649 Thermoanaerobacter kivui Species 0.000 claims description 2
- 229940100228 acetyl coenzyme a Drugs 0.000 claims description 2
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 claims 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 claims 1
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- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 33
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 10
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
- C12P7/30—Acetone-containing products produced from substrate containing inorganic compounds other than water
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009002583A DE102009002583A1 (de) | 2009-04-23 | 2009-04-23 | Zellen und Verfahren zur Herstellung von Aceton |
| JP2012506411A JP5805073B2 (ja) | 2009-04-23 | 2010-02-23 | アセトン生成細胞およびアセトンを生成する方法 |
| CN2010800177745A CN102414314A (zh) | 2009-04-23 | 2010-02-23 | 用于生产丙酮的细胞和方法 |
| PCT/EP2010/052244 WO2010121849A1 (de) | 2009-04-23 | 2010-02-23 | Zellen und verfahren zur herstellung von aceton |
| US13/260,012 US9453210B2 (en) | 2009-04-23 | 2010-02-23 | Cells and method for producing acetone |
| AU2010241185A AU2010241185B2 (en) | 2009-04-23 | 2010-02-23 | Cells and method for producing acetone |
| EP10704577.5A EP2421960B1 (de) | 2009-04-23 | 2010-02-23 | Zellen und verfahren zur herstellung von aceton |
| BRPI1013430-1A BRPI1013430A2 (pt) | 2009-04-23 | 2010-02-23 | Células acetogênicas, acetona e método para a fabricação da mesma |
| ES10704577.5T ES2639224T3 (es) | 2009-04-23 | 2010-02-23 | Células y procedimiento para la producción de acetona |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| DE102009002583A DE102009002583A1 (de) | 2009-04-23 | 2009-04-23 | Zellen und Verfahren zur Herstellung von Aceton |
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| DE102009002583A1 true DE102009002583A1 (de) | 2010-10-28 |
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| DE102009002583A Withdrawn DE102009002583A1 (de) | 2009-04-23 | 2009-04-23 | Zellen und Verfahren zur Herstellung von Aceton |
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|---|---|
| US (1) | US9453210B2 (https=) |
| EP (1) | EP2421960B1 (https=) |
| JP (1) | JP5805073B2 (https=) |
| CN (1) | CN102414314A (https=) |
| AU (1) | AU2010241185B2 (https=) |
| BR (1) | BRPI1013430A2 (https=) |
| DE (1) | DE102009002583A1 (https=) |
| ES (1) | ES2639224T3 (https=) |
| WO (1) | WO2010121849A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5397136B2 (ja) * | 2009-09-30 | 2014-01-22 | 住友電気工業株式会社 | Ｉｉｉ族窒化物半導体レーザ素子、及びｉｉｉ族窒化物半導体レーザ素子を作製する方法 |
| DE102010062587A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron |
| BR112013021524A2 (pt) * | 2011-02-25 | 2017-06-13 | Lanzatech New Zealand Ltd | micro-organismos recombinantes e usos dos mesmos |
| US9365868B2 (en) | 2011-02-25 | 2016-06-14 | Lanzatech New Zealand Limited | Fermentation process for producing isopropanol using a recombinant microorganism |
| US9410130B2 (en) | 2011-02-25 | 2016-08-09 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| DE102011075777A1 (de) | 2011-05-13 | 2012-11-15 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron in Gegenwart mindestens eines Entschäumers in der Abwasserkolonne im Aufarbeitungsteil |
| DE102011077705A1 (de) * | 2011-06-17 | 2012-12-20 | Evonik Degussa Gmbh | Mikrobielles Verfahren zur Herstellung niedermolekularer, organischer Verbindungen umfassend die Produktabsorption durch Isophoron |
| JP6512825B2 (ja) | 2012-01-31 | 2019-05-15 | ランザテク・ニュージーランド・リミテッド | 組換え微生物およびその使用方法 |
| MY183766A (en) * | 2013-03-15 | 2021-03-12 | Lanzatech New Zealand Ltd | A system and method for controlling metabolite production in a microbial fermentation |
| EP3050966A1 (en) * | 2015-01-28 | 2016-08-03 | Evonik Degussa GmbH | An aerobic method of producing alcohols |
| CN107404882A (zh) * | 2015-02-27 | 2017-11-28 | 白狗实验室有限公司 | 用于生产丙酮、异丙醇、丁酸、其他生物产品及其混合物的混合营养发酵方法 |
| KR101750293B1 (ko) * | 2015-03-04 | 2017-06-26 | 한국과학기술연구원 | 이산화탄소로부터의 아세톤 생성능을 갖는 형질전환된 시네코코커스 일롱게투스 균주 |
| EP3348646A1 (de) | 2017-01-17 | 2018-07-18 | Evonik Degussa GmbH | Mikrobielles verfahren zur herstellung von aceton, isopropanol, butanol und/oder ethanol umfassend die produktabsorption durch wasser |
| BR112022014752A2 (pt) * | 2020-01-29 | 2022-10-11 | Jupeng Bio Hk Ltd | Processo para controlar proporções de ácidos orgânicos em processo de bioconversão de dióxido de carbono |
| CN112608935A (zh) * | 2020-12-18 | 2021-04-06 | 北京化工大学 | 一种改造乙酸梭菌代谢途径产丙酮的方法 |
| KR20260010725A (ko) * | 2023-05-11 | 2026-01-21 | 에보니크 오퍼레이션즈 게엠베하 | 아세톤의 생명공학적 생산 |
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| GB1009370A (en) | 1962-12-18 | 1965-11-10 | Ajinomoto I I | A process for the production of 1-glutamic acid by fermentation |
| WO1998000558A1 (en) | 1994-11-30 | 1998-01-08 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases |
| WO2000068407A1 (en) | 1999-05-07 | 2000-11-16 | Bioengineering Resources, Inc. | Clostridium strains which produce ethanol from substrate-containing gases |
| WO2002008438A2 (en) | 2000-07-25 | 2002-01-31 | Bioengineering Resources, Inc. | Methods for increasing the production of ethanol from microbial fermentation |
| US20070275447A1 (en) | 2006-05-25 | 2007-11-29 | Lewis Randy S | Indirect or direct fermentation of biomass to fuel alcohol |
| US20080057554A1 (en) | 2006-08-31 | 2008-03-06 | Huhnke Raymond L | Isolation and characterization of novel clostridial species |
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| EP2182051A4 (en) * | 2007-08-29 | 2010-12-29 | Res Inst Innovative Tech Earth | FOR THE MANUFACTURE OF ISOPROPANOL SUITABLE TRANSFORMERS |
| EP2198039A4 (en) * | 2007-10-12 | 2012-05-09 | Univ California | MODIFIED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| DE102007052463A1 (de) * | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
| DE102010062587A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron |
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- 2010-02-23 EP EP10704577.5A patent/EP2421960B1/de active Active
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| WO1998000558A1 (en) | 1994-11-30 | 1998-01-08 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases |
| WO2000068407A1 (en) | 1999-05-07 | 2000-11-16 | Bioengineering Resources, Inc. | Clostridium strains which produce ethanol from substrate-containing gases |
| WO2002008438A2 (en) | 2000-07-25 | 2002-01-31 | Bioengineering Resources, Inc. | Methods for increasing the production of ethanol from microbial fermentation |
| US20070275447A1 (en) | 2006-05-25 | 2007-11-29 | Lewis Randy S | Indirect or direct fermentation of biomass to fuel alcohol |
| US20080057554A1 (en) | 2006-08-31 | 2008-03-06 | Huhnke Raymond L | Isolation and characterization of novel clostridial species |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2639224T3 (es) | 2017-10-25 |
| JP2012524529A (ja) | 2012-10-18 |
| EP2421960B1 (de) | 2017-07-19 |
| CN102414314A (zh) | 2012-04-11 |
| US20120101304A1 (en) | 2012-04-26 |
| EP2421960A1 (de) | 2012-02-29 |
| AU2010241185A1 (en) | 2011-10-27 |
| US9453210B2 (en) | 2016-09-27 |
| BRPI1013430A2 (pt) | 2015-09-01 |
| WO2010121849A1 (de) | 2010-10-28 |
| JP5805073B2 (ja) | 2015-11-04 |
| AU2010241185B2 (en) | 2016-03-10 |
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