CN102351722B - 一种左卡尼汀化合物及其组合物 - Google Patents
一种左卡尼汀化合物及其组合物 Download PDFInfo
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- CN102351722B CN102351722B CN201110228887A CN201110228887A CN102351722B CN 102351722 B CN102351722 B CN 102351722B CN 201110228887 A CN201110228887 A CN 201110228887A CN 201110228887 A CN201110228887 A CN 201110228887A CN 102351722 B CN102351722 B CN 102351722B
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- levocarnitine
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- acetone
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- 229960001518 levocarnitine Drugs 0.000 claims description 156
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 99
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 82
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 46
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- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 24
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 5
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- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
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- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
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Images
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Abstract
Description
1个月 | 2个月 | 3个月 | 6个月 | 12个月 | |
1 | 99.66% | 99.66% | 99.64% | 99.62% | 99.41% |
2 | 99.20% | 99.19% | 99.16% | 99.13% | 98.90% |
3 | 99.65% | 99.64% | 99.58% | 99.27% | 98.44% |
4 | 99.66% | 99.63% | 99.57% | 99.24% | 97.43% |
5 | 99.64% | 99.62% | 99.52% | 99.20% | 98.38% |
3个月 | 6个月 | 9个月 | 12个月 | 18个月 | |
1 | 99.66% | 99.66% | 99.66% | 99.65% | 99.63% |
2 | 99.20% | 99.20% | 99.20% | 99.18% | 99.15% |
3 | 99.65% | 99.65% | 99.64% | 99.60% | 99.28% |
4 | 99.66% | 99.66% | 99.64% | 99.59% | 99.21% |
5 | 99.64% | 99.64% | 99.62% | 99.55% | 99.15% |
Claims (15)
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CN114249665B (zh) * | 2021-12-07 | 2024-01-23 | 安徽普利药业有限公司 | 一种左卡尼汀原料药制备方法 |
CN114376228A (zh) * | 2021-12-24 | 2022-04-22 | 北京康比特体育科技股份有限公司 | 一种生酮饮食的饮料配方及其制备方法 |
CN117368378B (zh) * | 2023-12-01 | 2024-03-19 | 山东齐都药业有限公司 | 左卡尼汀口服溶液中辅料含量的检测方法 |
Citations (3)
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CN101723843A (zh) * | 2008-10-13 | 2010-06-09 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种制备高纯度左旋卡尼汀的方法 |
CN101875616A (zh) * | 2010-06-12 | 2010-11-03 | 胡建荣 | 一种左卡尼汀化合物及其新制法 |
CN102020575A (zh) * | 2010-12-09 | 2011-04-20 | 浙江工业大学 | 一种左旋肉碱的合成方法 |
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2011
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101723843A (zh) * | 2008-10-13 | 2010-06-09 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种制备高纯度左旋卡尼汀的方法 |
CN101875616A (zh) * | 2010-06-12 | 2010-11-03 | 胡建荣 | 一种左卡尼汀化合物及其新制法 |
CN102020575A (zh) * | 2010-12-09 | 2011-04-20 | 浙江工业大学 | 一种左旋肉碱的合成方法 |
Non-Patent Citations (1)
Title |
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