CN102319426B - 一种去除调节性t细胞的特异性肿瘤疫苗的制备方法 - Google Patents
一种去除调节性t细胞的特异性肿瘤疫苗的制备方法 Download PDFInfo
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CN102657853A (zh) * | 2012-04-27 | 2012-09-12 | 蔡建辉 | 初始t细胞来源的肿瘤特异性杀伤细胞的制备及其应用 |
CN103589685B (zh) * | 2013-11-26 | 2015-09-30 | 复旦大学 | 一种dc细胞的快速制备方法 |
CN105838674A (zh) * | 2016-05-30 | 2016-08-10 | 上海市血液中心 | 一种免疫抑制剂诱导调节性cd8+t细胞体外扩增的方法 |
CN106119198A (zh) * | 2016-06-24 | 2016-11-16 | 安徽未名细胞治疗有限公司 | 一种高效获取dc细胞的方法 |
CN109609450A (zh) * | 2019-01-14 | 2019-04-12 | 温州医科大学附属第医院 | 一种减少调节性t细胞比例的培养方法 |
CN113151166A (zh) * | 2021-01-26 | 2021-07-23 | 广州润生细胞医药科技有限责任公司 | 一种个体化肿瘤新生抗原特异性cd8细胞的获取方法及应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101724010A (zh) * | 2008-10-21 | 2010-06-09 | 江苏省中医院 | 一种肿瘤组织全抗原的制备方法和用途 |
CN102091327A (zh) * | 2010-12-27 | 2011-06-15 | 蔡建辉 | 一种负载自体肿瘤相关全抗原的树突状细胞疫苗的制备方法 |
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CN101724010A (zh) * | 2008-10-21 | 2010-06-09 | 江苏省中医院 | 一种肿瘤组织全抗原的制备方法和用途 |
CN102091327A (zh) * | 2010-12-27 | 2011-06-15 | 蔡建辉 | 一种负载自体肿瘤相关全抗原的树突状细胞疫苗的制备方法 |
Non-Patent Citations (4)
Title |
---|
Carsten T. Viehl et al.Depletion of CD4+CD25+ Regulatory T Cells Promotes a Tumor-Specific Immune Response in Pancreas Cancer–Bearing Mice.《Annals of Surgical Oncology》.2006,全文. |
Depletion of CD4+CD25+ Regulatory T Cells Promotes a Tumor-Specific Immune Response in Pancreas Cancer–Bearing Mice;Carsten T. Viehl et al;《Annals of Surgical Oncology》;20061231;全文 * |
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells;Jens Dannull et al;《The Journal of Clinical Investigation》;20051231;全文 * |
Jens Dannull et al.Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.《The Journal of Clinical Investigation》.2005,全文. |
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