CN102313982B - 显微镜及区域确定方法 - Google Patents

显微镜及区域确定方法 Download PDF

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Publication number
CN102313982B
CN102313982B CN201110174640.0A CN201110174640A CN102313982B CN 102313982 B CN102313982 B CN 102313982B CN 201110174640 A CN201110174640 A CN 201110174640A CN 102313982 B CN102313982 B CN 102313982B
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image
dark field
specimen
area
unit
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CN102313982A (zh
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松延刚
山腰隆道
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Sony Corp
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Sony Corp
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/04Measuring microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • G02B21/08Condensers
    • G02B21/12Condensers affording bright-field illumination
    • G02B21/125Condensers affording bright-field illumination affording both dark- and bright-field illumination
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365Control or image processing arrangements for digital or video microscopes
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/24Base structure
    • G02B21/26Stages; Adjusting means therefor
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/20Image preprocessing
    • G06V10/24Aligning, centring, orientation detection or correction of the image
    • G06V10/245Aligning, centring, orientation detection or correction of the image by locating a pattern; Special marks for positioning

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Microscoopes, Condenser (AREA)
  • Studio Devices (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
CN201110174640.0A 2010-07-02 2011-06-24 显微镜及区域确定方法 Active CN102313982B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010152367A JP5703609B2 (ja) 2010-07-02 2010-07-02 顕微鏡及び領域判定方法
JP2010-152367 2010-07-02

Publications (2)

Publication Number Publication Date
CN102313982A CN102313982A (zh) 2012-01-11
CN102313982B true CN102313982B (zh) 2017-05-24

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Family Applications (1)

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CN201110174640.0A Active CN102313982B (zh) 2010-07-02 2011-06-24 显微镜及区域确定方法

Country Status (5)

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US (1) US9013570B2 (enExample)
EP (1) EP2402813B1 (enExample)
JP (1) JP5703609B2 (enExample)
KR (1) KR20120003376A (enExample)
CN (1) CN102313982B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012101377B4 (de) * 2012-02-21 2017-02-09 Leica Biosystems Nussloch Gmbh Verfahren bei der Vorbereitung von Proben zum Mikroskopieren und Vorrichtung zum Überprüfen der Eindeckqualität von Proben
TWI595428B (zh) * 2012-05-29 2017-08-11 財團法人工業技術研究院 特徵點匹配方法
JP6019798B2 (ja) * 2012-06-22 2016-11-02 ソニー株式会社 情報処理装置、情報処理システム及び情報処理方法
WO2014006964A1 (ja) * 2012-07-04 2014-01-09 ソニー株式会社 情報処理装置、情報処理方法、プログラム及び顕微鏡システム
CA2878957A1 (en) 2012-07-25 2014-01-30 Theranos, Inc. Image analysis and measurement of biological samples
US9513224B2 (en) * 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
JP6245177B2 (ja) * 2012-10-15 2017-12-13 ソニー株式会社 画像取得装置およびスライド傾き測定方法
CA2905564A1 (en) * 2013-03-15 2014-09-18 Richard Harry Turner A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids
JP6120675B2 (ja) * 2013-05-23 2017-04-26 オリンパス株式会社 顕微鏡システム、画像生成方法及びプログラム
US9562860B1 (en) 2013-06-19 2017-02-07 Theranos, Inc. Methods and devices for sample analysis
KR101463005B1 (ko) * 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
JP6315655B2 (ja) * 2013-11-19 2018-04-25 浜松ホトニクス株式会社 細胞画像処理方法、細胞画像処理装置及び細胞画像処理プログラム
JP2016052116A (ja) * 2014-08-28 2016-04-11 パナソニックIpマネジメント株式会社 画像処理装置、画像処理方法およびコンピュータプログラム
US9645379B2 (en) * 2014-12-29 2017-05-09 Novartis Ag Magnification in ophthalmic procedures and associated devices, systems, and methods
CN113514945B (zh) * 2015-03-13 2024-04-09 格尼亚Ip控股私人有限公司 用于显微技术的方法与装置
US10510143B1 (en) * 2015-09-21 2019-12-17 Ares Trading S.A. Systems and methods for generating a mask for automated assessment of embryo quality
US10551608B2 (en) * 2016-03-24 2020-02-04 Molecular Devices, Llc Imaging system with ancillary image detector for sample location
CN109073517A (zh) 2016-04-27 2018-12-21 文塔纳医疗系统公司 用于实时体积控制的系统和方法
CN110383038B (zh) * 2016-10-21 2022-09-23 第一前沿有限公司 用于对空气样本进行自动分析的系统和方法
DE102016122528A1 (de) 2016-11-22 2018-05-24 Carl Zeiss Microscopy Gmbh Verfahren zum Steuern oder Regeln einer Mikroskopbeleuchtung
US10663711B2 (en) 2017-01-04 2020-05-26 Corista, LLC Virtual slide stage (VSS) method for viewing whole slide images
CN106973258B (zh) * 2017-02-08 2020-05-22 上海交通大学 病理切片信息快速获取装置
JP7009619B2 (ja) * 2017-09-29 2022-01-25 ライカ バイオシステムズ イメージング インコーポレイテッド 2回通過式マクロ画像
JP7195269B2 (ja) * 2017-11-22 2022-12-23 富士フイルム株式会社 観察装置、観察装置の作動方法、及び観察制御プログラム
JP7458328B2 (ja) 2018-05-21 2024-03-29 コリスタ・エルエルシー マルチ分解能登録を介したマルチサンプル全体スライド画像処理
DE102019113540A1 (de) * 2019-05-21 2020-11-26 Carl Zeiss Microscopy Gmbh Lichtmikroskop mit automatischer Fokussierung
EP3839596B1 (de) * 2019-12-20 2023-08-23 Euroimmun Medizinische Labordiagnostika AG Vorrichtung und verfahren zur identifikation von deckglasbereichen eines objektträgers
FR3109159B1 (fr) * 2020-04-09 2023-06-23 Interscience Procédé de traitement d’images appliqué aux compteurs de colonies en microbiologie
CN112363309B (zh) * 2020-11-13 2023-02-17 杭州医派智能科技有限公司 一种用于显微镜下病理图像的自动寻焦方法和系统
EP4080265B1 (en) * 2021-04-20 2025-02-12 Leica Instruments (Singapore) Pte Ltd Microscope system and corresponding method
US11425313B1 (en) 2021-11-29 2022-08-23 Unity Technologies Sf Increasing dynamic range of a virtual production display
CN115265408A (zh) * 2022-07-29 2022-11-01 深圳市中图仪器股份有限公司 闪测仪及其操作方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1208486A (zh) * 1995-12-19 1999-02-17 神经医药体系股份有限公司 边界绘制系统和方法
US7250963B2 (en) * 2001-12-19 2007-07-31 Olympus Corporation Microscopic image capture apparatus
EP2053535A2 (en) * 2007-10-22 2009-04-29 Applied Imaging Corporation Automated detection of cell colonies and coverslip detection using hough transforms

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3037983C2 (de) * 1980-10-08 1983-03-31 Fa. Carl Zeiss, 7920 Heidenheim Verfahren und Vorrichtung zur lichtinduzierten rastermikroskopischen Darstellung von Probenparametern in ihrer räumlichen Verteilung
DE3540916A1 (de) * 1985-11-19 1987-05-21 Zeiss Carl Fa Verfahren und vorrichtung zur raster-lichtmikroskopischen darstellung von objekten im dunkelfeld
JP3075315B2 (ja) * 1992-02-06 2000-08-14 オリンパス光学工業株式会社 顕微鏡システム
US5638459A (en) * 1994-09-20 1997-06-10 Neopath, Inc. Method and apparatus for detecting a microscope slide coverslip
US6272235B1 (en) 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6404906B2 (en) 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6031930A (en) 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
JP3865013B2 (ja) 1997-10-24 2007-01-10 株式会社ニコン 顕微鏡及び顕微鏡遠隔操作システム
DE10016838B4 (de) * 2000-04-05 2006-10-19 Jan-Gerd Dipl.-Ing. Frerichs In-situ Mikroskopvorrichtung für Reaktoren
US6711283B1 (en) * 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner
JP2003246176A (ja) 2002-02-25 2003-09-02 Kaneko Ichiro 折り曲げ型紙挟み具
US7541048B2 (en) * 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
US20060050376A1 (en) * 2004-09-02 2006-03-09 Houston Edward S Robotic microscopy apparatus for high throughput observation of multicellular organisms
FI20055007A0 (fi) * 2005-01-05 2005-01-05 Wallac Oy Menetelmä näytteen analysoimiseksi
US20080219890A1 (en) * 2005-08-04 2008-09-11 Helicos Biosciences Corporation Sample loading and recovery
JP4890096B2 (ja) * 2006-05-19 2012-03-07 浜松ホトニクス株式会社 画像取得装置、画像取得方法、及び画像取得プログラム
WO2008118886A1 (en) * 2007-03-23 2008-10-02 Bioimagene, Inc. Digital microscope slide scanning system and methods
US7782452B2 (en) * 2007-08-31 2010-08-24 Kla-Tencor Technologies Corp. Systems and method for simultaneously inspecting a specimen with two distinct channels
JP4979777B2 (ja) 2010-01-18 2012-07-18 オリンパス株式会社 顕微鏡画像処理装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1208486A (zh) * 1995-12-19 1999-02-17 神经医药体系股份有限公司 边界绘制系统和方法
US7250963B2 (en) * 2001-12-19 2007-07-31 Olympus Corporation Microscopic image capture apparatus
EP2053535A2 (en) * 2007-10-22 2009-04-29 Applied Imaging Corporation Automated detection of cell colonies and coverslip detection using hough transforms

Also Published As

Publication number Publication date
CN102313982A (zh) 2012-01-11
JP2012014078A (ja) 2012-01-19
EP2402813A2 (en) 2012-01-04
US9013570B2 (en) 2015-04-21
EP2402813A3 (en) 2012-03-07
KR20120003376A (ko) 2012-01-10
JP5703609B2 (ja) 2015-04-22
US20120002034A1 (en) 2012-01-05
EP2402813B1 (en) 2016-03-30

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