CN102246039A - 胰岛素测定法 - Google Patents

胰岛素测定法 Download PDF

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Publication number
CN102246039A
CN102246039A CN2010800035212A CN201080003521A CN102246039A CN 102246039 A CN102246039 A CN 102246039A CN 2010800035212 A CN2010800035212 A CN 2010800035212A CN 201080003521 A CN201080003521 A CN 201080003521A CN 102246039 A CN102246039 A CN 102246039A
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CN
China
Prior art keywords
insulin
antibody
monoclonal antibody
monoclonal
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800035212A
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English (en)
Chinese (zh)
Inventor
近藤纯一
清水知
山本光章
中村靖
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Sekisui Medical Co Ltd
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Sekisui Medical Co Ltd
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Filing date
Publication date
Application filed by Sekisui Medical Co Ltd filed Critical Sekisui Medical Co Ltd
Publication of CN102246039A publication Critical patent/CN102246039A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04—Sandwich assay format
    • G01N2470/06—Second binding partner specifically binding complex of analyte with first binding partner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2010800035212A 2009-07-21 2010-07-21 胰岛素测定法 Pending CN102246039A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009170292 2009-07-21
JP2009-170292 2009-07-21
PCT/JP2010/062261 WO2011010673A1 (ja) 2009-07-21 2010-07-21 インスリン測定方法

Publications (1)

Publication Number Publication Date
CN102246039A true CN102246039A (zh) 2011-11-16

Family

ID=43499145

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800035212A Pending CN102246039A (zh) 2009-07-21 2010-07-21 胰岛素测定法

Country Status (11)

Country Link
US (1) US9476891B2 (https=)
EP (1) EP2458378B1 (https=)
JP (2) JP4782249B2 (https=)
KR (1) KR101366353B1 (https=)
CN (1) CN102246039A (https=)
AU (1) AU2010274320B2 (https=)
BR (1) BRPI1005176B1 (https=)
CA (1) CA2739310C (https=)
MX (1) MX2011003927A (https=)
MY (1) MY151976A (https=)
WO (1) WO2011010673A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104995517A (zh) * 2012-08-17 2015-10-21 莫佛塞斯公司 复合物特异性抗体和抗体片段及其用途
CN105358976A (zh) * 2013-03-29 2016-02-24 积水医疗株式会社 胰岛素测定法
CN105866420A (zh) * 2015-01-22 2016-08-17 艾托金生物医药（苏州）有限公司 一种检测免疫原的方法和装置
CN106918708A (zh) * 2015-12-28 2017-07-04 北京九强生物技术股份有限公司 一种用于检测胰岛素的竞争法胶乳增强免疫透射比浊试剂盒
CN111690064A (zh) * 2020-06-24 2020-09-22 合肥天麦生物科技发展有限公司 一种胰岛素原前体蛋白的检测方法及其ppi单克隆抗体的制备方法
CN116449031A (zh) * 2016-07-29 2023-07-18 Diazyme 研究室有限公司 用于测定维生素d的方法和成分

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2853103C (en) * 2011-10-21 2020-01-07 Decimadx, Llc Point-of-care immunoassay for quantitative small analyte detection
JP6182027B2 (ja) * 2013-09-10 2017-08-16 デンカ生研株式会社 Ｂ型インフルエンザウイルスの測定方法
JP6862845B2 (ja) * 2016-01-22 2021-04-21 日立化成ダイアグノスティックス・システムズ株式会社 可溶性インターロイキン−２受容体の測定方法及び測定用試薬
JP7421711B2 (ja) * 2018-10-09 2024-01-25 積水メディカル株式会社 ロイシンリッチα２グリコプロテインの免疫測定方法及び測定試薬
CN114195892B (zh) * 2020-09-18 2024-08-13 苏州鲲鹏生物技术有限公司 一种人胰岛素单链前体残留检测控制方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514505A (en) * 1982-05-21 1985-04-30 The Trustees Of Columbia University In The City Of New York Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
JPS61283868A (ja) * 1985-06-10 1986-12-13 Teijin Ltd ヒト・プロテインｃの測定方法
EP0314338A1 (en) * 1987-10-12 1989-05-03 Tosoh Corporation Method for measuring human insulin
JPH05297000A (ja) * 1992-04-17 1993-11-12 S R L:Kk インスリン抗体の測定方法
US5561049A (en) * 1994-09-21 1996-10-01 Behringwerke Ag Method for detecting antibodies
US5583003A (en) * 1989-09-25 1996-12-10 Agen Limited Agglutination assay
US6103536A (en) * 1997-05-02 2000-08-15 Silver Lake Research Corporation Internally referenced competitive assays
US6177281B1 (en) * 1993-06-02 2001-01-23 Teikoku Hormone Mfg. Co., Ltd. Simple immunochemical semi-quantitative assay method and apparatus
JP2007171213A (ja) * 2007-02-19 2007-07-05 Hamamatsu Photonics Kk 蛍光免疫測定方法
CN101087877A (zh) * 2004-12-28 2007-12-12 第一化学药品株式会社 抗人可溶性血纤蛋白单克隆抗体及使用该抗体的免疫学测定方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3636724A1 (de) * 1986-10-29 1988-06-23 Joern Dr Med Kekow Enzymimmunoassay (elisa) zur insulinbestimmung im mikrotiterplattensystem
JPH01148962A (ja) 1987-12-07 1989-06-12 Tosoh Corp インスリン免疫測定法
DE3806430A1 (de) * 1988-02-29 1989-09-07 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines proteins nach dem prinzip des fluoreszenz-polarisations-immunoassays
JPH03118472A (ja) 1989-09-29 1991-05-21 Sekisui Chem Co Ltd インスリン定量方法及び定量試薬
CA2072758A1 (en) * 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
ATE465409T1 (de) * 2001-07-02 2010-05-15 Sekisui Medical Co Ltd Latex-trägerpartikel für ein testreagenz, und testreagenz
FI20022048A0 (fi) 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
JP5115852B2 (ja) 2008-04-28 2013-01-09 国立大学法人電気通信大学 コグニティブ無線通信システム、通信方法、および通信機器
EP2322562B1 (en) * 2008-09-05 2016-03-30 Sekisui Medical Co., Ltd. Monoclonal antibody, and immunoassay using same

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514505A (en) * 1982-05-21 1985-04-30 The Trustees Of Columbia University In The City Of New York Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
JPS61283868A (ja) * 1985-06-10 1986-12-13 Teijin Ltd ヒト・プロテインｃの測定方法
EP0314338A1 (en) * 1987-10-12 1989-05-03 Tosoh Corporation Method for measuring human insulin
US5583003A (en) * 1989-09-25 1996-12-10 Agen Limited Agglutination assay
JPH05297000A (ja) * 1992-04-17 1993-11-12 S R L:Kk インスリン抗体の測定方法
US6177281B1 (en) * 1993-06-02 2001-01-23 Teikoku Hormone Mfg. Co., Ltd. Simple immunochemical semi-quantitative assay method and apparatus
US5561049A (en) * 1994-09-21 1996-10-01 Behringwerke Ag Method for detecting antibodies
US6103536A (en) * 1997-05-02 2000-08-15 Silver Lake Research Corporation Internally referenced competitive assays
CN101087877A (zh) * 2004-12-28 2007-12-12 第一化学药品株式会社 抗人可溶性血纤蛋白单克隆抗体及使用该抗体的免疫学测定方法
JP2007171213A (ja) * 2007-02-19 2007-07-05 Hamamatsu Photonics Kk 蛍光免疫測定方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
EDWIN F. ULLMAN: "Anti-immune complex antibodies enhance affinity and specificity of primary antibodies", 《PROC. NATL. ACAD. SCI. USA》, vol. 90, 28 February 1993 (1993-02-28), pages 1184 - 1189, XP002974350, DOI: doi:10.1073/pnas.90.4.1184 *
FRANZ X. HEINZ，ET AL: "Antibody-induced conformational changes result in enhanced avidity of antibodies to different antigenic sites on the tick-borne encephalitis virus glycoprotein", 《VIROLOGY》, vol. 133, no. 1, 31 December 1984 (1984-12-31), pages 25 - 34 *
HARRY TOWBIN,ET AL: "Neoepitope immunoassay-an assay for human interleukin 1 beta based on an antibody induced conformational change", 《JOURNAL OF IMMUNOASSAY》, vol. 17, no. 4, 31 December 1996 (1996-12-31), XP001070211 *
TORBJöRN LINDSTRöM, MD，ET AL: "Use of a Novel Double-Antibody Technique to Describe the Pharmacokinetics of Rapid-Acting Insulin Analogs", 《DIABETES CARE》, vol. 25, no. 6, 30 June 2002 (2002-06-30), XP009169183 *
付光宇: "人胰岛素化学发光检测方法的建立及临床应用", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》, no. 04, 30 April 2004 (2004-04-30), pages 059 - 413 *
贾娟娟等: "人胰岛素酶联免疫分析法的建立", 《同位素》, vol. 20, no. 01, 28 February 2007 (2007-02-28), pages 24 - 28 *
黎明等: "人血清真胰岛素酶联免疫法的建立及初步应用", 《中华内分泌代谢杂志》, vol. 13, no. 04, 31 December 1997 (1997-12-31), pages 214 - 217 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104995517A (zh) * 2012-08-17 2015-10-21 莫佛塞斯公司 复合物特异性抗体和抗体片段及其用途
CN105358976A (zh) * 2013-03-29 2016-02-24 积水医疗株式会社 胰岛素测定法
CN105358976B (zh) * 2013-03-29 2018-11-06 积水医疗株式会社 胰岛素测定法
CN105866420A (zh) * 2015-01-22 2016-08-17 艾托金生物医药（苏州）有限公司 一种检测免疫原的方法和装置
CN106918708A (zh) * 2015-12-28 2017-07-04 北京九强生物技术股份有限公司 一种用于检测胰岛素的竞争法胶乳增强免疫透射比浊试剂盒
CN116449031A (zh) * 2016-07-29 2023-07-18 Diazyme 研究室有限公司 用于测定维生素d的方法和成分
CN111690064A (zh) * 2020-06-24 2020-09-22 合肥天麦生物科技发展有限公司 一种胰岛素原前体蛋白的检测方法及其ppi单克隆抗体的制备方法

Also Published As

Publication number Publication date
EP2458378A4 (en) 2013-01-02
MX2011003927A (es) 2011-07-20
JPWO2011010673A1 (ja) 2013-01-07
EP2458378A1 (en) 2012-05-30
JP4782249B2 (ja) 2011-09-28
WO2011010673A1 (ja) 2011-01-27
CA2739310A1 (en) 2011-01-27
US20110195438A1 (en) 2011-08-11
JP2011237442A (ja) 2011-11-24
EP2458378B1 (en) 2017-12-06
KR20110095349A (ko) 2011-08-24
AU2010274320A1 (en) 2011-01-27
AU2010274320B2 (en) 2013-08-01
BRPI1005176B1 (pt) 2021-06-08
KR101366353B1 (ko) 2014-02-21
JP5661572B2 (ja) 2015-01-28
MY151976A (en) 2014-07-31
US9476891B2 (en) 2016-10-25
CA2739310C (en) 2014-07-08
BRPI1005176A2 (pt) 2016-12-06

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