CN102209713B - 作为5-羟色胺-6配体的1-(芳磺酰基)-4-(哌嗪-1-基)-1h-苯并咪唑 - Google Patents

作为5-羟色胺-6配体的1-(芳磺酰基)-4-(哌嗪-1-基)-1h-苯并咪唑 Download PDF

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Publication number
CN102209713B
CN102209713B CN200980144578.1A CN200980144578A CN102209713B CN 102209713 B CN102209713 B CN 102209713B CN 200980144578 A CN200980144578 A CN 200980144578A CN 102209713 B CN102209713 B CN 102209713B
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benzimidazole
alkyl
sulfonyl
compound
piperazin
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Chinese (zh)
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CN102209713A (zh
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S·N·海达尔
P·M·安德烈
H·云
A·J·罗比乔德
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Wyeth LLC
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Wyeth LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/22—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms directly attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980144578.1A 2008-11-11 2009-11-10 作为5-羟色胺-6配体的1-(芳磺酰基)-4-(哌嗪-1-基)-1h-苯并咪唑 Expired - Fee Related CN102209713B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11329608P 2008-11-11 2008-11-11
US61/113,296 2008-11-11
PCT/US2009/063816 WO2010056644A1 (en) 2008-11-11 2009-11-10 1- (ARYLSULFONYL) -4- (PI PERAZIN-I -YL) -IH-BENZ IMIDAZOLES AS δ-HYDROXYTRYPTAMINE- 6 LIGANDS

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CN102209713A CN102209713A (zh) 2011-10-05
CN102209713B true CN102209713B (zh) 2014-07-02

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US (1) US8063053B2 (https=)
EP (1) EP2285784B1 (https=)
JP (1) JP5087171B2 (https=)
KR (1) KR101323417B1 (https=)
CN (1) CN102209713B (https=)
AP (1) AP2814A (https=)
AR (1) AR074325A1 (https=)
AU (1) AU2009314221B2 (https=)
BR (1) BRPI0920682A2 (https=)
CA (1) CA2740262C (https=)
CL (1) CL2011001050A1 (https=)
CO (1) CO6440548A2 (https=)
CR (1) CR20110247A (https=)
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CY (1) CY1113025T1 (https=)
DK (1) DK2285784T3 (https=)
DO (1) DOP2011000130A (https=)
EA (1) EA018369B1 (https=)
EC (1) ECSP11011045A (https=)
ES (1) ES2389694T3 (https=)
GE (1) GEP20135805B (https=)
HR (1) HRP20120561T1 (https=)
IL (1) IL212213A0 (https=)
MA (1) MA32788B1 (https=)
ME (1) ME01129B (https=)
MX (1) MX2011004996A (https=)
MY (1) MY156324A (https=)
NI (1) NI201100093A (https=)
NZ (1) NZ592563A (https=)
PE (1) PE20120026A1 (https=)
PL (1) PL2285784T3 (https=)
PT (1) PT2285784E (https=)
RS (1) RS52381B (https=)
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SI (1) SI2285784T1 (https=)
SV (1) SV2011003902A (https=)
TN (1) TN2011000203A1 (https=)
TW (1) TWI481605B (https=)
UA (1) UA100192C2 (https=)
WO (1) WO2010056644A1 (https=)
ZA (1) ZA201103283B (https=)

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CA2580857A1 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP5080256B2 (ja) * 2004-09-20 2012-11-21 ゼノン・ファーマシューティカルズ・インコーポレイテッド 二環式複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）のインヒビターとしてのそれらの使用
AU2005286648A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051091A1 (es) * 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CN104557726B (zh) * 2013-10-19 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
EP3166924B1 (en) 2014-07-08 2019-02-20 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
WO2017052394A1 (en) 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
EP3530651A1 (en) * 2018-02-21 2019-08-28 Adamed sp. z o.o. Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists
US12398097B2 (en) 2019-07-29 2025-08-26 Vanderbilt University WDR5-MYC inhibitors
MX2022012828A (es) * 2020-04-22 2023-01-04 Recurium Ip Holdings Llc Preparación de un degradador selectivo de receptores de estrógeno.

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CN1714077A (zh) * 2000-10-20 2005-12-28 比奥维特罗姆股份公司 2－、3－、4－或5－取代的n1－(苯磺酰基)吲哚及其治疗用途

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CN1484638A (zh) * 2000-11-02 2004-03-24 作为5-羟色胺-6配体的1-芳基-或1-烷基磺酰基-杂环基吲哚
CN1694866A (zh) * 2001-06-15 2005-11-09 弗·哈夫曼-拉罗切有限公司 具有5－ht6受体亲和力的4－哌嗪基吲哚衍生物

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JP2012508275A (ja) 2012-04-05
HRP20120561T1 (hr) 2012-07-31
SI2285784T1 (sl) 2012-08-31
SA109300673B1 (ar) 2013-05-25
EA018369B1 (ru) 2013-07-30
PL2285784T3 (pl) 2012-12-31
BRPI0920682A2 (pt) 2016-09-27
ES2389694T3 (es) 2012-10-30
AR074325A1 (es) 2011-01-05
AU2009314221A1 (en) 2010-05-20
DK2285784T3 (da) 2012-07-23
CL2011001050A1 (es) 2011-08-19
DOP2011000130A (es) 2017-04-30
UA100192C2 (en) 2012-11-26
AP2814A (en) 2013-12-31
HK1158647A1 (en) 2012-07-20
CU20110101A7 (es) 2012-01-31
ECSP11011045A (es) 2011-06-30
AU2009314221B2 (en) 2012-08-30
GEP20135805B (en) 2013-04-10
EA201100696A1 (ru) 2011-10-31
CY1113025T1 (el) 2016-04-13
JP5087171B2 (ja) 2012-11-28
PT2285784E (pt) 2012-09-19
WO2010056644A8 (en) 2010-11-18
CO6440548A2 (es) 2012-05-15
RS52381B (sr) 2012-12-31
NZ592563A (en) 2012-10-26
MA32788B1 (fr) 2011-11-01
CU24020B1 (es) 2014-07-30
ME01129B (me) 2013-03-20
AP2011005664A0 (en) 2011-04-30
EP2285784A1 (en) 2011-02-23
US20100120779A1 (en) 2010-05-13
MY156324A (en) 2016-02-15
CR20110247A (es) 2011-06-24
SV2011003902A (es) 2011-07-05
MX2011004996A (es) 2011-05-25
US8063053B2 (en) 2011-11-22
NI201100093A (es) 2011-10-31
TN2011000203A1 (fr) 2012-12-17
IL212213A0 (en) 2011-06-30
TW201022247A (en) 2010-06-16
CA2740262A1 (en) 2010-05-20
TWI481605B (zh) 2015-04-21
ZA201103283B (en) 2012-01-25
PE20120026A1 (es) 2012-02-12
WO2010056644A1 (en) 2010-05-20
CA2740262C (en) 2013-05-28
KR20110075013A (ko) 2011-07-05
KR101323417B1 (ko) 2013-10-29
EP2285784B1 (en) 2012-07-04
CN102209713A (zh) 2011-10-05

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