CN102203067A - Hedgehog通路调节剂 - Google Patents
Hedgehog通路调节剂 Download PDFInfo
- Publication number
- CN102203067A CN102203067A CN200980141972XA CN200980141972A CN102203067A CN 102203067 A CN102203067 A CN 102203067A CN 200980141972X A CN200980141972X A CN 200980141972XA CN 200980141972 A CN200980141972 A CN 200980141972A CN 102203067 A CN102203067 A CN 102203067A
- Authority
- CN
- China
- Prior art keywords
- bases
- tetrahydroisoquinoline
- phenyl
- amino
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *c1nccc(C2)c1CCN2I Chemical compound *c1nccc(C2)c1CCN2I 0.000 description 1
- OCLBQOVXDRFJSI-UHFFFAOYSA-N Brc1nccc2c1CCN(Cc1ccccc1)C2 Chemical compound Brc1nccc2c1CCN(Cc1ccccc1)C2 OCLBQOVXDRFJSI-UHFFFAOYSA-N 0.000 description 1
- VKGMIJLSCRAPLV-TVRCVXMWSA-O C[C@H](C(C1)c2cc(cccc3)c3cn2)C1Nc1nccc(C2)c1CCN2S(C)(=O)=[OH+] Chemical compound C[C@H](C(C1)c2cc(cccc3)c3cn2)C1Nc1nccc(C2)c1CCN2S(C)(=O)=[OH+] VKGMIJLSCRAPLV-TVRCVXMWSA-O 0.000 description 1
- SJOVBIPUGSKPRX-UHFFFAOYSA-N Cc(c(-c1cc(cccc2)c2cn1)c1)ccc1Nc1nccc2c1CCN(Cc1ccccc1)C2 Chemical compound Cc(c(-c1cc(cccc2)c2cn1)c1)ccc1Nc1nccc2c1CCN(Cc1ccccc1)C2 SJOVBIPUGSKPRX-UHFFFAOYSA-N 0.000 description 1
- CKFRKNGGESTGQK-UHFFFAOYSA-N Cc(c(C1NC=C(CCC=C2)C2=C1)c1)ccc1N Chemical compound Cc(c(C1NC=C(CCC=C2)C2=C1)c1)ccc1N CKFRKNGGESTGQK-UHFFFAOYSA-N 0.000 description 1
- BVUNDCISIIJBSR-UHFFFAOYSA-N Cc(ccc(Nc1nccc2c1CCNC2)c1)c1-c1cc(cccc2)c2cn1 Chemical compound Cc(ccc(Nc1nccc2c1CCNC2)c1)c1-c1cc(cccc2)c2cn1 BVUNDCISIIJBSR-UHFFFAOYSA-N 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N O=C(c1c2cccc1)NC2=O Chemical compound O=C(c1c2cccc1)NC2=O XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- RGSOMLGEDNNJIO-UHFFFAOYSA-N O=C1NC=CC2=C1CCN(Cc1ccccc1)C2 Chemical compound O=C1NC=CC2=C1CCN(Cc1ccccc1)C2 RGSOMLGEDNNJIO-UHFFFAOYSA-N 0.000 description 1
- STRGFZIRUNEHOR-IBGZPJMESA-N OC[C@H](CN(CCc1c2cccc1Nc(cc1)cc(-c3ncc(-c4ccccc4)[nH]3)c1Cl)C2=O)O Chemical compound OC[C@H](CN(CCc1c2cccc1Nc(cc1)cc(-c3ncc(-c4ccccc4)[nH]3)c1Cl)C2=O)O STRGFZIRUNEHOR-IBGZPJMESA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Description
Claims (31)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9149608P | 2008-08-25 | 2008-08-25 | |
US61/091,496 | 2008-08-25 | ||
PCT/US2009/054802 WO2010027746A2 (en) | 2008-08-25 | 2009-08-24 | Hedgehog pathway modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102203067A true CN102203067A (zh) | 2011-09-28 |
CN102203067B CN102203067B (zh) | 2014-01-15 |
Family
ID=41728033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980141972.XA Expired - Fee Related CN102203067B (zh) | 2008-08-25 | 2009-08-24 | Hedgehog通路调节剂 |
Country Status (12)
Country | Link |
---|---|
US (2) | US8507491B2 (zh) |
EP (1) | EP2328871B1 (zh) |
JP (1) | JP5555236B2 (zh) |
KR (1) | KR101354763B1 (zh) |
CN (1) | CN102203067B (zh) |
AU (1) | AU2009288399B2 (zh) |
BR (1) | BRPI0917936A2 (zh) |
CA (1) | CA2733533C (zh) |
EA (1) | EA018721B1 (zh) |
ES (1) | ES2797955T3 (zh) |
MX (1) | MX2011002060A (zh) |
WO (1) | WO2010027746A2 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102731373A (zh) * | 2012-07-19 | 2012-10-17 | 南京药石药物研发有限公司 | 抗肿瘤药物gdc-0449中间体的制备方法 |
CN103864770A (zh) * | 2012-12-10 | 2014-06-18 | 江苏先声药业有限公司 | 作为Hedgehog信号传导的嘧啶胺类和吡啶胺类抑制剂 |
WO2015144001A1 (zh) * | 2014-03-24 | 2015-10-01 | 南京明德新药研发股份有限公司 | 作为smo抑制剂的喹啉衍生物 |
CN108431001A (zh) * | 2015-11-27 | 2018-08-21 | 大鹏药品工业株式会社 | 稠环嘧啶化合物或其盐 |
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HUE030052T4 (en) | 2007-06-29 | 2017-06-28 | Pfizer | Benzimidazole derivatives |
AU2010258800B2 (en) | 2009-06-09 | 2013-10-10 | Nantbio, Inc. | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
WO2011027249A2 (en) * | 2009-09-01 | 2011-03-10 | Pfizer Inc. | Benzimidazole derivatives |
US20120184529A1 (en) * | 2011-01-14 | 2012-07-19 | Demario Mark D | Combination therapy |
JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
CN103910672B (zh) * | 2013-01-08 | 2016-10-05 | 连云港润众制药有限公司 | Vismodegib的制备方法 |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
WO2014143659A1 (en) | 2013-03-15 | 2014-09-18 | Araxes Pharma Llc | Irreversible covalent inhibitors of the gtpase k-ras g12c |
US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US9186361B2 (en) | 2013-03-15 | 2015-11-17 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Kras g12c之抑制劑 |
US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
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CN102731373A (zh) * | 2012-07-19 | 2012-10-17 | 南京药石药物研发有限公司 | 抗肿瘤药物gdc-0449中间体的制备方法 |
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CN103864770A (zh) * | 2012-12-10 | 2014-06-18 | 江苏先声药业有限公司 | 作为Hedgehog信号传导的嘧啶胺类和吡啶胺类抑制剂 |
CN103864770B (zh) * | 2012-12-10 | 2019-06-11 | 江苏先声药业有限公司 | 作为Hedgehog信号传导的嘧啶胺类和吡啶胺类抑制剂 |
WO2015144001A1 (zh) * | 2014-03-24 | 2015-10-01 | 南京明德新药研发股份有限公司 | 作为smo抑制剂的喹啉衍生物 |
US9938292B2 (en) | 2014-03-24 | 2018-04-10 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | Quinoline derivatives as SMO inhibitors |
CN108431001A (zh) * | 2015-11-27 | 2018-08-21 | 大鹏药品工业株式会社 | 稠环嘧啶化合物或其盐 |
CN108431001B (zh) * | 2015-11-27 | 2021-09-17 | 大鹏药品工业株式会社 | 稠环嘧啶化合物或其盐 |
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CN102203067B (zh) | 2014-01-15 |
EP2328871B1 (en) | 2020-04-01 |
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WO2010027746A2 (en) | 2010-03-11 |
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US9216964B2 (en) | 2015-12-22 |
EP2328871A2 (en) | 2011-06-08 |
AU2009288399B2 (en) | 2013-03-07 |
KR101354763B1 (ko) | 2014-01-22 |
EA201100378A1 (ru) | 2011-10-31 |
BRPI0917936A2 (pt) | 2017-07-11 |
JP2012500853A (ja) | 2012-01-12 |
MX2011002060A (es) | 2011-04-05 |
US20130296333A1 (en) | 2013-11-07 |
US8507491B2 (en) | 2013-08-13 |
JP5555236B2 (ja) | 2014-07-23 |
CA2733533A1 (en) | 2010-03-11 |
EA018721B1 (ru) | 2013-10-30 |
AU2009288399A1 (en) | 2010-03-11 |
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