CN102156088B - 粒子分析仪及粒子拍摄方法 - Google Patents

粒子分析仪及粒子拍摄方法 Download PDF

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Publication number
CN102156088B
CN102156088B CN201010565424.4A CN201010565424A CN102156088B CN 102156088 B CN102156088 B CN 102156088B CN 201010565424 A CN201010565424 A CN 201010565424A CN 102156088 B CN102156088 B CN 102156088B
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light
light source
particles
optical system
particle
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Expired - Fee Related
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CN201010565424.4A
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Chinese (zh)
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CN102156088A (zh
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小篠正继
小林宽征
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Sysmex Corp
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Sysmex Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession

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  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Computer Vision & Pattern Recognition (AREA)
CN201010565424.4A 2009-11-30 2010-11-30 粒子分析仪及粒子拍摄方法 Expired - Fee Related CN102156088B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009272974 2009-11-30
JP2009-272974 2009-11-30
JP2010-198593 2010-09-06
JP2010198593A JP5537347B2 (ja) 2009-11-30 2010-09-06 粒子分析装置

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CN102156088A CN102156088A (zh) 2011-08-17
CN102156088B true CN102156088B (zh) 2014-03-12

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US (1) US8772738B2 (enExample)
EP (1) EP2327977A3 (enExample)
JP (1) JP5537347B2 (enExample)
CN (1) CN102156088B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012177367A2 (en) * 2011-06-24 2012-12-27 Becton, Dickinson And Company Absorbance spectrum scanning flow cytometry
JP6014590B2 (ja) 2011-06-27 2016-10-25 シスメックス株式会社 細胞分析装置および細胞分析方法
TWI708052B (zh) 2011-08-29 2020-10-21 美商安美基公司 用於非破壞性檢測-流體中未溶解粒子之方法及裝置
EP2786117B1 (en) * 2011-12-01 2022-12-21 Particle Measuring Systems, Inc. Detection scheme for particle size and concentration measurement
JP5876359B2 (ja) 2012-03-30 2016-03-02 シスメックス株式会社 癌化情報提供方法および癌化情報提供装置
JP5959988B2 (ja) * 2012-08-16 2016-08-02 シスメックス株式会社 癌化情報取得装置、細胞分析装置、および細胞採取適否判定装置、ならびに、癌化情報取得方法および細胞採取適否判定方法。
US9140648B2 (en) 2013-03-12 2015-09-22 Ecolab Usa Inc. Fluorometer with multiple detection channels
US9591268B2 (en) * 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
EP3127084B1 (en) * 2014-04-03 2020-07-15 Koninklijke Philips N.V. Examining device for processing and analyzing an image
DE102014007355B3 (de) * 2014-05-19 2015-08-20 Particle Metrix Gmbh Verfahren der Partikel Tracking Aalyse mit Hilfe von Streulicht (PTA) und eine Vorrichtung zur Erfassung und Charakterisierung von Partikeln in Flüssigkeiten aller Art in der Größenordnung von Nanometern
JP6313123B2 (ja) * 2014-05-28 2018-04-18 東京エレクトロン株式会社 測定装置及び測定方法
JP6328493B2 (ja) * 2014-05-28 2018-05-23 東京エレクトロン株式会社 測定装置及び測定方法
FR3022998B1 (fr) * 2014-06-30 2016-07-15 Alain Rousseau Techniques & Innovations Arteion Systeme et ensemble de cytometrie en flux, dispositif d’analyse comprenant un tel ensemble de cytometrie et ensemble comprenant un tel systeme de cytometrie
US9261459B1 (en) * 2014-08-12 2016-02-16 Ecolab Usa Inc. Handheld fluorometer
JP6238856B2 (ja) * 2014-08-25 2017-11-29 シスメックス株式会社 尿中異型細胞の分析方法、尿分析装置および体液中異型細胞の分析方法
WO2016127364A1 (zh) 2015-02-12 2016-08-18 深圳迈瑞生物医疗电子股份有限公司 细胞分析仪、粒子分类方法及装置
JP6438319B2 (ja) * 2015-02-18 2018-12-12 アズビル株式会社 粒子検出装置
JP6557022B2 (ja) * 2015-02-18 2019-08-07 アズビル株式会社 粒子検出装置
EP4538996A3 (en) * 2015-03-31 2025-07-23 Sysmex Corporation Urine analysis system, image capturing apparatus, cell image capturing apparatus, urine analysis method, management apparatus, and information processing apparatus
USD793473S1 (en) 2015-12-18 2017-08-01 Abbott Laboratories Print tape cartridge
USD799055S1 (en) 2015-12-18 2017-10-03 Abbott Laboratories Smear tape cartridge
USD811616S1 (en) 2015-12-18 2018-02-27 Abbott Laboratories Tube rack
USD799057S1 (en) 2015-12-18 2017-10-03 Abbott Laboratories Slide rack
USD812244S1 (en) 2015-12-18 2018-03-06 Abbott Laboratories Tube rack
USD802787S1 (en) 2015-12-18 2017-11-14 Abbott Laboratories Slide carrier
USD782064S1 (en) 2015-12-18 2017-03-21 Abbott Laboratories Tube rack
USD782695S1 (en) 2015-12-18 2017-03-28 Abbott Laboratories Slide carrier
CN109154551B (zh) * 2015-12-30 2021-05-14 生物辐射实验室股份有限公司 用于颗粒测定的检测和信号处理系统
JP6286455B2 (ja) * 2016-01-20 2018-02-28 シスメックス株式会社 細胞分析方法、癌化情報提供方法、細胞分析装置および癌化情報提供装置
KR101766838B1 (ko) * 2016-01-26 2017-08-23 윈포시스(주) 입자 분석 장치
USD799058S1 (en) 2016-02-18 2017-10-03 Abbott Laboratories Slide caddy
US10607316B2 (en) * 2016-07-22 2020-03-31 Panasonic Intellectual Property Management Co., Ltd. Image generating apparatus and image generating method
DE102016013236B4 (de) * 2016-11-07 2020-07-16 Particle Metrix Gmbh Vorrichtung und Verfahren zum Messen der Konzentration, der Größe und des Zetapotentials von Nanopartikeln in Flüssigkeiten im Streulichtmodus und im Fluoreszenzmodus
US10088660B2 (en) 2017-02-10 2018-10-02 Amgen Inc. Imaging system for counting and sizing particles in fluid-filled vessels
CN110945403A (zh) 2017-07-26 2020-03-31 浜松光子学株式会社 试样观察装置和试样观察方法
JP7326256B2 (ja) 2017-10-26 2023-08-15 パーティクル・メージャーリング・システムズ・インコーポレーテッド 粒子計測システム及び方法
KR102333898B1 (ko) * 2019-04-09 2021-12-01 가부시끼가이샤 히다치 세이사꾸쇼 입자 사이즈 측정 장치 및 측정 방법
JP7504912B2 (ja) 2019-04-25 2024-06-24 パーティクル・メージャーリング・システムズ・インコーポレーテッド 軸上粒子検出及び／又は差分検出のための粒子検出システム及び方法
JP2021056125A (ja) 2019-09-30 2021-04-08 ソニー株式会社 生体粒子分析装置及び微小粒子分析装置
WO2021102256A1 (en) 2019-11-22 2021-05-27 Particle Measuring Systems, Inc. Advanced systems and methods for interferometric particle detection and detection of particles having small size dimensions
US11885743B2 (en) * 2020-07-22 2024-01-30 Agar Corporation, Inc. Fluorescence and scatter and absorption spectroscopic apparatus with a sapphire tube and method for analyzing inline low level hydrocarbon in a flow medium
LU102108B1 (de) * 2020-10-06 2022-04-06 Cytena Gmbh Verfahren zum automatischen Untersuchen einer flüssigen Probe

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578395A (en) * 1994-03-08 1996-11-26 Sanyo Electric Co., Ltd. Lithium secondary battery
CN101118208A (zh) * 2006-07-31 2008-02-06 希森美康株式会社 粒子分析装置用光学系统及用此光学系统的粒子分析装置
CN101236150A (zh) * 2007-02-02 2008-08-06 深圳迈瑞生物医疗电子股份有限公司 用于基于流式细胞术的仪器的光电传感器及其照射单元

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6375640A (ja) * 1986-09-19 1988-04-06 Shimadzu Corp 血球計数装置
JP3049254B2 (ja) * 1990-02-08 2000-06-05 シスメックス株式会社 ２種類の光源を備えた光学式粒子分析装置
JPH0734012B2 (ja) * 1991-02-27 1995-04-12 東亜医用電子株式会社 フローイメージサイトメータ
US5548395A (en) 1991-09-20 1996-08-20 Toa Medical Electronics Co., Ltd. Particle analyzer
US5422712A (en) * 1992-04-01 1995-06-06 Toa Medical Electronics Co., Ltd. Apparatus for measuring fluorescent spectra of particles in a flow
JP3260469B2 (ja) * 1992-04-01 2002-02-25 シスメックス株式会社 粒子分析装置
JP3375203B2 (ja) * 1994-08-08 2003-02-10 シスメックス株式会社 細胞分析装置
JP3127111B2 (ja) * 1996-02-22 2001-01-22 株式会社日立製作所 フロー式粒子画像解析方法および装置
JP3640461B2 (ja) * 1996-04-03 2005-04-20 シスメックス株式会社 粒子分析装置
JPH1073528A (ja) * 1996-08-30 1998-03-17 Toa Medical Electronics Co Ltd 撮像機能付きフローサイトメータ
US6133995A (en) 1997-05-09 2000-10-17 Sysmex Corporation Particle measuring apparatus
JP4215397B2 (ja) * 1998-05-14 2009-01-28 ルミネックス コーポレイション 多重分析物診断システム
US8005314B2 (en) * 2005-12-09 2011-08-23 Amnis Corporation Extended depth of field imaging for high speed object analysis
US20020018211A1 (en) * 2000-06-07 2002-02-14 Megerle Clifford A. System and method to detect the presence of a target organism within an air sample using flow cytometry
JP4763159B2 (ja) * 2001-06-15 2011-08-31 シスメックス株式会社 フローサイトメータ
JP4659252B2 (ja) * 2001-03-29 2011-03-30 シスメックス株式会社 フローサイトメータ
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
WO2006103920A1 (ja) * 2005-03-29 2006-10-05 Sysmex Corporation 癌・異型細胞および凝集粒子を弁別する方法および細胞分析装置
JP2007304044A (ja) * 2006-05-15 2007-11-22 Sysmex Corp 粒子画像分析装置
JP2007304059A (ja) * 2006-05-15 2007-11-22 Sysmex Corp 粒子画像分析装置
JP2009244253A (ja) * 2008-03-10 2009-10-22 Sysmex Corp 粒子分析装置、粒子分析方法およびコンピュータプログラム

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578395A (en) * 1994-03-08 1996-11-26 Sanyo Electric Co., Ltd. Lithium secondary battery
CN101118208A (zh) * 2006-07-31 2008-02-06 希森美康株式会社 粒子分析装置用光学系统及用此光学系统的粒子分析装置
CN101236150A (zh) * 2007-02-02 2008-08-06 深圳迈瑞生物医疗电子股份有限公司 用于基于流式细胞术的仪器的光电传感器及其照射单元

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US20110127444A1 (en) 2011-06-02
EP2327977A2 (en) 2011-06-01
JP2011133460A (ja) 2011-07-07
US8772738B2 (en) 2014-07-08
JP5537347B2 (ja) 2014-07-02
CN102156088A (zh) 2011-08-17
EP2327977A3 (en) 2017-08-23

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