CN102125551B - 胃容纳障碍治疗剂 - Google Patents

胃容纳障碍治疗剂 Download PDF

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Publication number
CN102125551B
CN102125551B CN201010611741.5A CN201010611741A CN102125551B CN 102125551 B CN102125551 B CN 102125551B CN 201010611741 A CN201010611741 A CN 201010611741A CN 102125551 B CN102125551 B CN 102125551B
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CN
China
Prior art keywords
gastric
compound
group
therapeutic agent
stomach
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN201010611741.5A
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English (en)
Chinese (zh)
Other versions
CN102125551A (zh
Inventor
松永勇吾
上木茂
东野雷太
河内雅直
加藤博树
小林四郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28786350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102125551(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Publication of CN102125551A publication Critical patent/CN102125551A/zh
Application granted granted Critical
Publication of CN102125551B publication Critical patent/CN102125551B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201010611741.5A 2002-04-08 2003-04-08 胃容纳障碍治疗剂 Expired - Lifetime CN102125551B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002-104894 2002-04-08
JP2002104894 2002-04-08
CNA038079755A CN1646123A (zh) 2002-04-08 2003-04-08 胃食物容纳障碍治疗剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA038079755A Division CN1646123A (zh) 2002-04-08 2003-04-08 胃食物容纳障碍治疗剂

Publications (2)

Publication Number Publication Date
CN102125551A CN102125551A (zh) 2011-07-20
CN102125551B true CN102125551B (zh) 2015-07-22

Family

ID=28786350

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201010611741.5A Expired - Lifetime CN102125551B (zh) 2002-04-08 2003-04-08 胃容纳障碍治疗剂
CNA038079755A Pending CN1646123A (zh) 2002-04-08 2003-04-08 胃食物容纳障碍治疗剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA038079755A Pending CN1646123A (zh) 2002-04-08 2003-04-08 胃食物容纳障碍治疗剂

Country Status (14)

Country Link
US (4) US20050176788A1 (https=)
EP (2) EP2301540A1 (https=)
JP (2) JP5281226B2 (https=)
KR (4) KR20110010837A (https=)
CN (2) CN102125551B (https=)
AT (1) ATE522214T1 (https=)
AU (1) AU2003236326B2 (https=)
CA (1) CA2481916C (https=)
CY (1) CY1112057T1 (https=)
DK (1) DK1493441T3 (https=)
ES (1) ES2368732T3 (https=)
PT (1) PT1493441E (https=)
SI (1) SI1493441T1 (https=)
WO (1) WO2003084537A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447612A (zh) * 2013-09-16 2015-03-25 天津市汉康医药生物技术有限公司 阿考替胺水合物晶型及其制备方法和用途
CN103980226A (zh) * 2014-05-10 2014-08-13 杭州新博思生物医药有限公司 盐酸阿考替胺水合物晶型及其制备方法
CN105315225A (zh) * 2014-07-07 2016-02-10 中美华世通生物医药科技（武汉）有限公司 阿考替胺的酸加成盐及其制备方法
CN104045606B (zh) * 2014-07-11 2015-09-30 杭州新博思生物医药有限公司 一锅法制备阿考替胺盐酸盐的方法
CN109988121B (zh) * 2019-04-28 2023-01-03 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
KR20240083168A (ko) 2021-07-14 2024-06-11 블루프린트 메디신즈 코포레이션 Map4k1 저해제로서의 헤테로사이클 화합물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1184471A (zh) * 1995-05-18 1998-06-10 泽里新药工业株式会社 氨基噻唑衍生物、含有它们的药物及制备该化合物的中间体
CN1261357A (zh) * 1997-06-24 2000-07-26 泽里新药工业株式会社 用于制备2－羟基苯甲酰胺衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10212271A (ja) * 1997-01-31 1998-08-11 Zeria Pharmaceut Co Ltd Ｎ−置換ベンゾイルアミン誘導体、それを含有する医薬及び該化合物の製造中間体
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
KR20010080025A (ko) * 1998-11-23 2001-08-22 디르크 반테 소화불량 치료용 의약의 제조를 위한 프루칼로프라이드의용도
EA004645B1 (ru) * 1999-06-02 2004-06-24 Янссен Фармацевтика Н.В. Аминоалкилзамещенные производные бензопирана
DE60025261T2 (de) * 1999-11-23 2006-08-24 Janssen Pharmaceutica N.V. Verwendung von 5ht3 antagonisten zur fundusentspannung
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
WO2002020010A1 (en) * 2000-09-08 2002-03-14 Zeria Pharmaceutical Co., Ltd. Pharmaceutical compositions containing aminothiazole derivatives for the treatment of colonic motor dysfunctions
US6986882B2 (en) * 2002-01-17 2006-01-17 Astrazeneca Ab Therapy for functional dyspepsia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1184471A (zh) * 1995-05-18 1998-06-10 泽里新药工业株式会社 氨基噻唑衍生物、含有它们的药物及制备该化合物的中间体
CN1261357A (zh) * 1997-06-24 2000-07-26 泽里新药工业株式会社 用于制备2－羟基苯甲酰胺衍生物的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Hiromitsu Morita.《Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach》.《JAPANESE JOURNAL OF PHARMACOLOGY》.2002,第89卷(第4期),356-365. *
MASAYUKI OGISHIMA.《Z-338 facilitates acetylcholine release from enteric neurons due to blockade of muscarinic autoreceptors in guinea pig stomach》.《OURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》.2000,第294卷(第1期),33-37. *
Yumik Kanemoto.《An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338》.《BRITISH JOURNAL OF PHARMACOLOGY》.2002,第135卷(第6期),1403-1414. *

Also Published As

Publication number Publication date
EP2301540A1 (en) 2011-03-30
AU2003236326A1 (en) 2003-10-20
JP2011068692A (ja) 2011-04-07
KR20130101162A (ko) 2013-09-12
JP5281226B2 (ja) 2013-09-04
DK1493441T3 (da) 2011-10-17
US20090156652A1 (en) 2009-06-18
US20150141475A1 (en) 2015-05-21
SI1493441T1 (sl) 2011-12-30
EP1493441A1 (en) 2005-01-05
JP5360075B2 (ja) 2013-12-04
ATE522214T1 (de) 2011-09-15
US20050176788A1 (en) 2005-08-11
PT1493441E (pt) 2011-09-28
AU2003236326B2 (en) 2008-02-28
US20200375954A1 (en) 2020-12-03
KR101423284B1 (ko) 2014-07-24
WO2003084537A1 (en) 2003-10-16
ES2368732T3 (es) 2011-11-21
EP1493441A4 (en) 2007-10-17
CN102125551A (zh) 2011-07-20
CA2481916C (en) 2013-02-26
KR20120037035A (ko) 2012-04-18
JPWO2003084537A1 (ja) 2005-08-11
CA2481916A1 (en) 2003-10-16
KR20110010837A (ko) 2011-02-07
EP1493441B1 (en) 2011-08-31
CN1646123A (zh) 2005-07-27
KR20050002925A (ko) 2005-01-10
CY1112057T1 (el) 2015-11-04

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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CX01 Expiry of patent term

Granted publication date: 20150722