CN102088962B - 用于皮质类固醇口服给药的组合物 - Google Patents

用于皮质类固醇口服给药的组合物 Download PDF

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Publication number
CN102088962B
CN102088962B CN2009801272725A CN200980127272A CN102088962B CN 102088962 B CN102088962 B CN 102088962B CN 2009801272725 A CN2009801272725 A CN 2009801272725A CN 200980127272 A CN200980127272 A CN 200980127272A CN 102088962 B CN102088962 B CN 102088962B
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CN
China
Prior art keywords
release component
drug
sustained release
composition according
acid
Prior art date
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Active
Application number
CN2009801272725A
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English (en)
Chinese (zh)
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CN102088962A (zh
Inventor
皮特·沃茨
A·M·迪俄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Famanik Co
Kalititas Treatment Co
Xiehe Qilin Service Co ltd
Kyowa Kirin Services Ltd
Original Assignee
Archimedes Development Ltd
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Application filed by Archimedes Development Ltd filed Critical Archimedes Development Ltd
Publication of CN102088962A publication Critical patent/CN102088962A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801272725A 2008-05-12 2009-05-07 用于皮质类固醇口服给药的组合物 Active CN102088962B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0808537.5 2008-05-12
GBGB0808537.5A GB0808537D0 (en) 2008-05-12 2008-05-12 Compositions
PCT/GB2009/001150 WO2009138716A1 (en) 2008-05-12 2009-05-07 Compositions for the oral delivery of corticosteroids

Publications (2)

Publication Number Publication Date
CN102088962A CN102088962A (zh) 2011-06-08
CN102088962B true CN102088962B (zh) 2013-07-31

Family

ID=39571149

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801272725A Active CN102088962B (zh) 2008-05-12 2009-05-07 用于皮质类固醇口服给药的组合物

Country Status (9)

Country Link
US (1) US8491932B2 (enExample)
EP (1) EP2278958B1 (enExample)
JP (1) JP5608641B2 (enExample)
CN (1) CN102088962B (enExample)
DK (1) DK2278958T3 (enExample)
ES (1) ES2452265T3 (enExample)
GB (1) GB0808537D0 (enExample)
PL (1) PL2278958T3 (enExample)
WO (1) WO2009138716A1 (enExample)

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RU2419443C1 (ru) * 2009-12-08 2011-05-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" Способ лечения больных язвенным колитом
DK2659881T3 (en) 2012-04-30 2018-02-05 Tillotts Pharma Ag Delayed release drug formulation
WO2015062640A1 (en) 2013-10-29 2015-05-07 Tillotts Pharma Ag A delayed release drug formulation
CN104257669A (zh) * 2014-09-25 2015-01-07 合肥平光制药有限公司 一种用于向肠道递送水杨酸类药物的口服给药组合物
JP2018530535A (ja) * 2015-09-11 2018-10-18 サン・ファーマシューティカル・インダストリーズ・リミテッド ブデゾニドの経口医薬剤形
EP3257501A1 (en) * 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
WO2018111329A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-1 inhibitors at the site of gastrointestinal tract disease
CA3046023A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
EP3641734A4 (en) 2017-06-23 2021-03-17 Sun Pharma Advanced Research Company Limited ANTI-ABUSE ORAL SOLID DOSAGE FORM
EP3613414A1 (de) 2018-08-24 2020-02-26 Dr. Falk Pharma Gmbh Pellets mit mehrschichtiger struktur zur verzögerten freisetzung des wirkstoffs im distalen kolon
CN110200947A (zh) * 2019-06-27 2019-09-06 深圳市泛谷药业股份有限公司 一种安非他酮肠溶缓释微丸胶囊及其制备方法
CN112999229B (zh) * 2019-12-19 2023-01-24 江苏恒瑞医药股份有限公司 一种包含布地奈德的口服药物组合物
WO2022222972A1 (zh) 2021-04-20 2022-10-27 江苏恒瑞医药股份有限公司 用于药物特定递送的胶囊及其制备方法
WO2022222971A1 (zh) * 2021-04-20 2022-10-27 江苏恒瑞医药股份有限公司 一种口服肠溶皮质类固醇的药物组合物
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
US20250352556A1 (en) 2022-07-15 2025-11-20 Synthon B.V. Budesonide two layers capsule formulation

Citations (1)

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Publication number Priority date Publication date Assignee Title
US5914122A (en) * 1994-12-27 1999-06-22 Dr. Falk Pharma Gmbh Stable budesonide solutions, method of preparing them and use of these solutions as enema preparations and pharmaceutical foams

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US4502888A (en) * 1982-12-13 1985-03-05 The Dow Chemical Company Aqueous dispersions of plasticized polymer particles
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5142906A (en) * 1990-07-09 1992-09-01 Westinghouse Electric Corp. Apparatus for measuring valve stem loads in a motor operated valve assembly
DE69425453T2 (de) * 1993-04-23 2001-04-12 Novartis Ag, Basel Wirkstoffabgabevorrichtung mit gesteuerter Freigabe
DE4332394A1 (de) * 1993-09-23 1995-03-30 Falk Pharma Gmbh Budesonid-Pellets mit kontrolliertem Freigabeprofil und Verfahren zu ihrer Herstellung
GB9412394D0 (en) 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
JP3185206B2 (ja) * 1995-07-20 2001-07-09 田辺製薬株式会社 消化管下部放出型被覆カプセル製剤
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JP2003201256A (ja) * 2001-12-28 2003-07-18 Hisamitsu Pharmaceut Co Inc 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤
DE10214002A1 (de) 2002-03-27 2003-10-09 Roehm Gmbh Pharmazeutische Formulierung für den Wirkstoff Budesonid
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US5914122A (en) * 1994-12-27 1999-06-22 Dr. Falk Pharma Gmbh Stable budesonide solutions, method of preparing them and use of these solutions as enema preparations and pharmaceutical foams

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
唐星.乙基纤维素.《口服缓控释制剂》.人民卫生出版社,2007,(第1版), *

Also Published As

Publication number Publication date
EP2278958B1 (en) 2014-01-01
WO2009138716A1 (en) 2009-11-19
GB0808537D0 (en) 2008-06-18
US8491932B2 (en) 2013-07-23
JP2011519967A (ja) 2011-07-14
ES2452265T3 (es) 2014-03-31
CN102088962A (zh) 2011-06-08
US20110104269A1 (en) 2011-05-05
EP2278958A1 (en) 2011-02-02
HK1158510A1 (en) 2012-07-20
DK2278958T3 (da) 2014-01-20
JP5608641B2 (ja) 2014-10-15
PL2278958T3 (pl) 2014-05-30

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Address after: London

Patentee after: Xiehe Qilin Service Co.,Ltd.

Patentee after: Kalititas Treatment Co.

Address before: Nottingham, England

Patentee before: ARCHIMEDES DEVELOPMENT LTD.

Patentee before: Famanik Co.

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Effective date of registration: 20231115

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