CN102066444A - 胶束装配体 - Google Patents
胶束装配体 Download PDFInfo
- Publication number
- CN102066444A CN102066444A CN2009801234403A CN200980123440A CN102066444A CN 102066444 A CN102066444 A CN 102066444A CN 2009801234403 A CN2009801234403 A CN 2009801234403A CN 200980123440 A CN200980123440 A CN 200980123440A CN 102066444 A CN102066444 A CN 102066444A
- Authority
- CN
- China
- Prior art keywords
- micellic assembly
- block
- micellic
- chargeable
- species
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Obesity (AREA)
- Nanotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5291408P | 2008-05-13 | 2008-05-13 | |
| US5290808P | 2008-05-13 | 2008-05-13 | |
| US61/052,908 | 2008-05-13 | ||
| US61/052,914 | 2008-05-13 | ||
| US9129408P | 2008-08-22 | 2008-08-22 | |
| US61/091,294 | 2008-08-22 | ||
| US11204808P | 2008-11-06 | 2008-11-06 | |
| US61/112,048 | 2008-11-06 | ||
| US14077408P | 2008-12-24 | 2008-12-24 | |
| US61/140,774 | 2008-12-24 | ||
| US17136909P | 2009-04-21 | 2009-04-21 | |
| US61/171,369 | 2009-04-21 | ||
| PCT/US2009/043849 WO2009140429A2 (en) | 2008-05-13 | 2009-05-13 | Micellic assemblies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102066444A true CN102066444A (zh) | 2011-05-18 |
Family
ID=41319324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801234403A Pending CN102066444A (zh) | 2008-05-13 | 2009-05-13 | 胶束装配体 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9339558B2 (https=) |
| EP (1) | EP2285853B1 (https=) |
| JP (2) | JP5755563B2 (https=) |
| KR (1) | KR101764427B1 (https=) |
| CN (1) | CN102066444A (https=) |
| AU (1) | AU2009246329B8 (https=) |
| BR (1) | BRPI0911989A2 (https=) |
| CA (1) | CA2724014C (https=) |
| ES (1) | ES2404136T3 (https=) |
| IL (1) | IL209239A0 (https=) |
| MX (1) | MX2010012239A (https=) |
| WO (1) | WO2009140429A2 (https=) |
| ZA (1) | ZA201008730B (https=) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107530436A (zh) * | 2015-01-21 | 2018-01-02 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
| CN108392471A (zh) * | 2018-03-01 | 2018-08-14 | 苏州大学张家港工业技术研究院 | 基于末端含硫辛酰基星型聚合物的纳米药物 |
| CN110730656A (zh) * | 2017-06-02 | 2020-01-24 | 特一华制药株式会社 | 水难溶性成分增溶胶束及含有该胶束的液体制剂 |
| CN112279983A (zh) * | 2020-10-30 | 2021-01-29 | 金陵科技学院 | 一种电荷翻转两亲嵌段共聚物、制备方法、前体聚合物、纳米胶束和应用 |
| CN114555654A (zh) * | 2019-09-13 | 2022-05-27 | 波音公司 | 抗微生物纳米蠕虫 |
| CN115803353A (zh) * | 2020-04-30 | 2023-03-14 | 陶氏环球技术有限责任公司 | 通过raft聚合制备烯烃-丙烯酸酯嵌段共聚物的方法 |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
| US8034396B2 (en) | 2008-04-01 | 2011-10-11 | Tyco Healthcare Group Lp | Bioadhesive composition formed using click chemistry |
| KR101764427B1 (ko) | 2008-05-13 | 2017-08-02 | 유니버시티 오브 워싱톤 | 미셀성 어셈블리 |
| WO2009140421A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| CN103342789B (zh) * | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| EP2364330B1 (en) * | 2008-11-06 | 2015-03-25 | University Of Washington | Multiblock copolymers |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| US9593169B2 (en) | 2008-12-08 | 2017-03-14 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
| US8535477B2 (en) | 2009-02-21 | 2013-09-17 | Sofradim Production | Medical devices incorporating functional adhesives |
| US8877170B2 (en) | 2009-02-21 | 2014-11-04 | Sofradim Production | Medical device with inflammatory response-reducing coating |
| US8663689B2 (en) | 2009-02-21 | 2014-03-04 | Sofradim Production | Functionalized adhesive medical gel |
| US8512728B2 (en) | 2009-02-21 | 2013-08-20 | Sofradim Production | Method of forming a medical device on biological tissue |
| US8968733B2 (en) | 2009-02-21 | 2015-03-03 | Sofradim Production | Functionalized surgical adhesives |
| US8426214B2 (en) | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
| US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
| WO2011060281A1 (en) * | 2009-11-13 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Hydrophobic block conjugated therapeutic agents |
| WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| CA2804263A1 (en) | 2010-06-29 | 2012-01-12 | Tyco Healthcare Group Lp | Microwave-powered reactor and method for in situ forming implants |
| EP2588153A2 (en) | 2010-07-01 | 2013-05-08 | Sofradim Production | Medical device with predefined activated cellular integration |
| EP3345944B1 (en) | 2010-09-22 | 2020-03-18 | The Board of Regents of the University of Texas System | Novel block copolymer and micelle compositions and methods of use thereof |
| CA2859127C (en) * | 2011-12-15 | 2017-04-25 | Bioneer Corporation | Novel oligonucleotide conjugates and use thereof |
| JP6195848B2 (ja) * | 2012-01-27 | 2017-09-13 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアThe Regents Of The University Of California | 糖ポリマーを用いた生体分子の安定化 |
| US9808480B2 (en) | 2012-04-27 | 2017-11-07 | Nanocarrier Co., Ltd. | Unit structure-type pharmaceutical composition for nucleic acid delivery |
| WO2014015367A1 (en) * | 2012-07-23 | 2014-01-30 | The University Of Queensland | Polymers for sirna delivery |
| US10046086B2 (en) | 2012-09-21 | 2018-08-14 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| WO2014047524A1 (en) | 2012-09-21 | 2014-03-27 | Vanderbilt University | Poly(thioketal-urethane) scaffolds and methods of use |
| US10172956B2 (en) * | 2012-10-26 | 2019-01-08 | Vanderbilt University | Polymeric nanoparticles |
| CN105142620B (zh) | 2013-02-25 | 2018-09-28 | 罗切斯特大学 | 用于受控释放抗生物膜剂的纳米颗粒 |
| CN103319661B (zh) * | 2013-05-24 | 2015-05-20 | 天津大学 | 琼脂糖基硫代甜菜碱丙烯酸酯接枝聚合物及其制备方法 |
| US9775928B2 (en) | 2013-06-18 | 2017-10-03 | Covidien Lp | Adhesive barbed filament |
| EP3027221A1 (en) | 2013-07-30 | 2016-06-08 | PhaseRx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
| ES2777302T3 (es) * | 2014-03-27 | 2020-08-04 | Sika Tech Ag | Copolímero de bloque |
| US10695288B2 (en) | 2014-11-19 | 2020-06-30 | Vanderbilt University | Reactive oxygen species (ROS)-responsive compositions and methods thereof |
| US20210330599A1 (en) | 2016-08-01 | 2021-10-28 | University Of Rochester | Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use |
| JP7387429B2 (ja) * | 2016-08-26 | 2023-11-28 | キレーション パートナーズ インコーポレイテッド | 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法 |
| KR102350647B1 (ko) | 2016-09-02 | 2022-01-14 | 다이서나 파마수이티컬, 인크. | 4'-포스페이트 유사체 및 이를 포함하는 올리고뉴클레오타이드 |
| WO2018067648A1 (en) * | 2016-10-04 | 2018-04-12 | Cornell University | Lubricating block copolymers and their use as biomimetic boundary lubricants |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| EP3533524A4 (en) * | 2016-10-28 | 2020-07-15 | Oji Holdings Corporation | PATTERN FORMING METHOD, BASE AGENT AND LAMINATE |
| WO2018126084A1 (en) | 2016-12-30 | 2018-07-05 | Phaserx, Inc. | Branched peg molecules and related compositions and methods |
| EP3677268A4 (en) | 2017-08-31 | 2021-04-21 | The University Of Tokyo | UNIFORM POLYIONAL COMPLEX LOADED WITH NUCLEIC ACID |
| KR20210120988A (ko) * | 2018-11-02 | 2021-10-07 | 제네반트 사이언시즈 게엠베하 | 치료 방법 |
| CN109528648A (zh) * | 2018-12-11 | 2019-03-29 | 中国药科大学 | 肿瘤基质微酸环境响应的两亲性高分子前药胶束及其制备方法和应用 |
| WO2020205473A1 (en) | 2019-03-29 | 2020-10-08 | Decerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of kras associated diseases or disorders |
| WO2020226960A1 (en) | 2019-05-03 | 2020-11-12 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| US20220226239A1 (en) * | 2019-06-04 | 2022-07-21 | Aravasc Inc. | Polymeric micelle complexes, formulations, and uses thereof |
| JP2021046542A (ja) * | 2019-09-10 | 2021-03-25 | 独立行政法人国立高等専門学校機構 | 両親媒性ブロック共重合体 |
| BR112022013821A2 (pt) | 2020-01-15 | 2022-09-13 | Dicerna Pharmaceuticals Inc | Ácidos nucleicos de 4?-o-metileno fosfonato e seus análogos |
| US11786464B2 (en) | 2020-04-24 | 2023-10-17 | The Board Of Regents Of The University Of Texas System | PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins |
| WO2022010764A1 (en) * | 2020-07-06 | 2022-01-13 | Vivtex Corporation | Mucopenetrating formulations |
| IL300283A (en) | 2020-08-04 | 2023-04-01 | Dicerna Pharmaceuticals Inc | Systemic administration of oligonucleotides |
| CN116887866A (zh) | 2020-12-03 | 2023-10-13 | 巴特尔纪念研究院 | 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法 |
| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| WO2025038596A1 (en) * | 2023-08-15 | 2025-02-20 | University Of Washington | De novo genetically-encodable polypeptides for extracellular protein degradation, and fusion proteins thereof |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4877603A (en) | 1987-12-18 | 1989-10-31 | The Procter & Gamble Company | Oral compositions |
| US5219945A (en) * | 1992-02-20 | 1993-06-15 | E. I. Du Pont De Nemours And Company | ABC triblock methacrylate polymers |
| US6359054B1 (en) | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
| WO1997049387A1 (en) * | 1996-06-27 | 1997-12-31 | G.D. Searle And Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| FR2767829B1 (fr) | 1997-09-01 | 1999-12-03 | Georges Sturtz | Composes phosphonates ou gem-bisphosphonates acryliques ou methacryliques |
| US6210717B1 (en) | 1997-12-12 | 2001-04-03 | Samyang Corporation | Biodegradable mixed polymeric micelles for gene delivery |
| US6410057B1 (en) | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| ATE443528T1 (de) | 1998-01-05 | 2009-10-15 | Univ Washington | Erhöhter transport unter benutzung membranzerstörender stoffe |
| DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
| US6306994B1 (en) | 1999-05-14 | 2001-10-23 | E. I. Du Pont De Nemours And Company | Inks with enhanced substrate binding characteristics |
| US8137695B2 (en) | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| US7098032B2 (en) | 2001-01-02 | 2006-08-29 | Mirus Bio Corporation | Compositions and methods for drug delivery using pH sensitive molecules |
| US6916488B1 (en) * | 1999-11-05 | 2005-07-12 | Biocure, Inc. | Amphiphilic polymeric vesicles |
| US7033607B2 (en) | 1999-12-31 | 2006-04-25 | Mirus Bio Corporation | pH-titratable polyampholytes for delivering polyions to a cell |
| US7737108B1 (en) | 2000-01-07 | 2010-06-15 | University Of Washington | Enhanced transport using membrane disruptive agents |
| US20030134420A1 (en) | 2000-02-18 | 2003-07-17 | Lollo Charles Peter | Methods and compositions for gene delivery |
| EP1286643A2 (en) | 2000-05-17 | 2003-03-05 | Labopharm Inc. | Drug containing polymeric micelles |
| SE517421C2 (sv) | 2000-10-06 | 2002-06-04 | Bioglan Ab | Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav |
| WO2003087188A1 (en) | 2001-04-26 | 2003-10-23 | Nanosphere, Inc. | Oligonucleotide-modified romp polymers and co-polymers |
| US7094810B2 (en) | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
| US6939564B2 (en) | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| US6780428B2 (en) | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
| KR100566911B1 (ko) * | 2001-06-25 | 2006-04-03 | 주식회사 삼양사 | 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체 |
| US6906128B2 (en) * | 2001-12-12 | 2005-06-14 | Rhodia Chimie | Method for depositing a polymer onto a surface by applying a composition onto said surface |
| US20030191081A1 (en) | 2001-12-28 | 2003-10-09 | Pierre Lemieux | Pharmaceutical compositions and methods of use thereof comprising polyanionic polymers and amphiphilic block copolymers to improve gene expression |
| JP3936966B2 (ja) * | 2002-02-28 | 2007-06-27 | サンノプコ株式会社 | 顔料塗被紙用塗料用コバインダーおよび顔料塗被紙 |
| US20050220880A1 (en) | 2002-03-07 | 2005-10-06 | Lewis Andrew L | Drug carriers comprising amphiphilic block copolymers |
| US7229973B2 (en) | 2002-05-19 | 2007-06-12 | You Han Bae | pH-sensitive polymeric micelles for drug delivery |
| EP1400555A1 (en) | 2002-09-17 | 2004-03-24 | Kawamura Institute Of Chemical Research | Water-soluble block copolymer and production method therefor |
| JP2006505686A (ja) * | 2002-11-07 | 2006-02-16 | ロディア・シミ | 両性又は双極性イオン性部分を含む制御された構造のコポリマー |
| AU2003293082A1 (en) | 2002-11-27 | 2004-06-23 | Tufts University | Antioxidant-functionalized polymers |
| ATE461961T1 (de) | 2002-12-30 | 2010-04-15 | Nektar Therapeutics | Mehrarmige polypeptid-poly(ethylenglykol)- blockcopolymere als arzneistoffzufuhrvehikel |
| US7871818B2 (en) | 2003-01-31 | 2011-01-18 | Roche Madison Inc. | Membrane active polymers |
| US7217776B1 (en) | 2003-02-14 | 2007-05-15 | Iowa State University Research Foundation | pH-sensitive methacrylic copolymer gels and the production thereof |
| US20040162235A1 (en) | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| JP4535229B2 (ja) | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
| EP1660548B1 (en) * | 2003-09-03 | 2008-08-27 | Rhodia Inc. | New copolymer having a controlled structure, and use thereof |
| US7632905B2 (en) | 2004-04-09 | 2009-12-15 | L'oreal S.A. | Block copolymer, composition comprising it and cosmetic treatment process |
| US20080274454A1 (en) | 2004-04-07 | 2008-11-06 | Mirkin Chad A | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles |
| US8821859B2 (en) | 2004-05-19 | 2014-09-02 | Agency For Science, Technology And Research | Methods and articles for the delivery of therapeutic agents |
| GB0418123D0 (en) * | 2004-08-13 | 2004-09-15 | Asahi Chemical Ind | Polymers useful as medical materials |
| US20060134221A1 (en) | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
| US20060165810A1 (en) | 2004-12-28 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Controlled release from block co-polymer worm micelles |
| US20060171980A1 (en) | 2005-02-01 | 2006-08-03 | Helmus Michael N | Implantable or insertable medical devices having optimal surface energy |
| EP1863859A4 (en) | 2005-03-31 | 2009-04-22 | Ap Pharma Inc | PEG-POLYACETAL AND PEG-POLYACETAL-POE-PFROPOPOPOLYMERS AND PHARMACEUTICAL COMPOSITIONS |
| EP1868664A2 (en) | 2005-04-15 | 2007-12-26 | Interface Biologics Inc. | Methods and compositions for the delivery of biologically active agents |
| US9139850B2 (en) | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
| EP1891141B1 (en) | 2005-05-31 | 2016-11-16 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| WO2007109584A1 (en) | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| CN101501108A (zh) * | 2006-07-05 | 2009-08-05 | 新加坡科技研究局 | 用于药物递送的胶束 |
| JP2008050506A (ja) * | 2006-08-25 | 2008-03-06 | Canon Inc | 組成物 |
| WO2008085556A2 (en) | 2006-09-12 | 2008-07-17 | University Of South Florida | Surfactant-free nanoparticles for drug delivery |
| US20080081075A1 (en) | 2006-10-02 | 2008-04-03 | National Tsing Hua University | Multifunctional mixed micelle of graft and block copolymers and preparation thereof |
| GB0624729D0 (en) * | 2006-12-12 | 2007-01-17 | Univ Leeds | Reversible micelles and applications for their use |
| WO2008071009A1 (en) | 2006-12-15 | 2008-06-19 | The Governors Of The University Of Alberta | Novel ligand guided block copolymers for targeted drug delivery |
| WO2008088658A2 (en) | 2007-01-17 | 2008-07-24 | Immunomedics, Inc. | Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites |
| US20080311045A1 (en) | 2007-06-06 | 2008-12-18 | Biovaluation & Analysis, Inc. | Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
| WO2008148174A1 (en) | 2007-06-08 | 2008-12-11 | Queensland University Of Technology | Wound repair composition and method |
| WO2008153940A1 (en) | 2007-06-11 | 2008-12-18 | Biocure, Inc. | Vesicles for active macromolecule delivery |
| JP2010532786A (ja) | 2007-07-06 | 2010-10-14 | ノースイースタン ユニバーシティ | Rna薬剤の両親媒性接合を含む混合ミセルおよびその使用 |
| US20090036625A1 (en) | 2007-08-01 | 2009-02-05 | Chung Yuan Christian University | Amphiphilic Polymer, Method for Forming the Same and Application thereof |
| EP2025348A1 (en) | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| US20110142951A1 (en) | 2008-05-13 | 2011-06-16 | University Of Washington | Micelles for intracellular delivery of therapeutic agents |
| KR101764427B1 (ko) | 2008-05-13 | 2017-08-02 | 유니버시티 오브 워싱톤 | 미셀성 어셈블리 |
| WO2009140421A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| US20110129921A1 (en) | 2008-05-13 | 2011-06-02 | University Of Washington | Targeted polymer bioconjugates |
| CN103342789B (zh) | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| ES2366758T3 (es) | 2008-10-22 | 2011-10-25 | Clariant Finance (Bvi) Limited | Compuestos de fosfonato olefínicamente insaturados, polímeros fabricados a partir de ellos, y su uso. |
| EP2364330B1 (en) | 2008-11-06 | 2015-03-25 | University Of Washington | Multiblock copolymers |
| US20110281934A1 (en) | 2008-11-06 | 2011-11-17 | Phaserx, Inc. | Micelles of hydrophilically shielded membrane-destabilizing copolymers |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| US20100150952A1 (en) | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
| US9593169B2 (en) | 2008-12-08 | 2017-03-14 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
-
2009
- 2009-05-13 KR KR1020107027809A patent/KR101764427B1/ko not_active Expired - Fee Related
- 2009-05-13 BR BRPI0911989A patent/BRPI0911989A2/pt not_active IP Right Cessation
- 2009-05-13 US US12/992,525 patent/US9339558B2/en active Active
- 2009-05-13 MX MX2010012239A patent/MX2010012239A/es active IP Right Grant
- 2009-05-13 ES ES09747512T patent/ES2404136T3/es active Active
- 2009-05-13 EP EP09747512A patent/EP2285853B1/en not_active Not-in-force
- 2009-05-13 CN CN2009801234403A patent/CN102066444A/zh active Pending
- 2009-05-13 JP JP2011509671A patent/JP5755563B2/ja not_active Expired - Fee Related
- 2009-05-13 CA CA2724014A patent/CA2724014C/en active Active
- 2009-05-13 AU AU2009246329A patent/AU2009246329B8/en not_active Ceased
- 2009-05-13 WO PCT/US2009/043849 patent/WO2009140429A2/en not_active Ceased
-
2010
- 2010-11-10 IL IL209239A patent/IL209239A0/en unknown
- 2010-12-03 ZA ZA2010/08730A patent/ZA201008730B/en unknown
-
2015
- 2015-05-27 JP JP2015107802A patent/JP2015221898A/ja active Pending
-
2016
- 2016-03-02 US US15/059,026 patent/US9662403B2/en active Active
-
2017
- 2017-04-27 US US15/499,683 patent/US10420790B2/en active Active
-
2019
- 2019-09-23 US US16/579,662 patent/US11707483B2/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107530436A (zh) * | 2015-01-21 | 2018-01-02 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
| CN110730656A (zh) * | 2017-06-02 | 2020-01-24 | 特一华制药株式会社 | 水难溶性成分增溶胶束及含有该胶束的液体制剂 |
| CN110730656B (zh) * | 2017-06-02 | 2022-09-16 | 特一华制药株式会社 | 水难溶性成分增溶胶束及含有该胶束的液体制剂 |
| CN108392471A (zh) * | 2018-03-01 | 2018-08-14 | 苏州大学张家港工业技术研究院 | 基于末端含硫辛酰基星型聚合物的纳米药物 |
| CN114555654A (zh) * | 2019-09-13 | 2022-05-27 | 波音公司 | 抗微生物纳米蠕虫 |
| CN114555654B (zh) * | 2019-09-13 | 2024-03-15 | 波音公司 | 抗微生物纳米蠕虫 |
| CN115803353A (zh) * | 2020-04-30 | 2023-03-14 | 陶氏环球技术有限责任公司 | 通过raft聚合制备烯烃-丙烯酸酯嵌段共聚物的方法 |
| CN112279983A (zh) * | 2020-10-30 | 2021-01-29 | 金陵科技学院 | 一种电荷翻转两亲嵌段共聚物、制备方法、前体聚合物、纳米胶束和应用 |
| CN112279983B (zh) * | 2020-10-30 | 2022-12-20 | 金陵科技学院 | 一种电荷翻转两亲嵌段共聚物、制备方法、前体聚合物、纳米胶束和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009140429A2 (en) | 2009-11-19 |
| US9339558B2 (en) | 2016-05-17 |
| JP2015221898A (ja) | 2015-12-10 |
| KR20110020803A (ko) | 2011-03-03 |
| CA2724014A1 (en) | 2009-11-19 |
| US10420790B2 (en) | 2019-09-24 |
| US20110123636A1 (en) | 2011-05-26 |
| US20170239360A1 (en) | 2017-08-24 |
| US20160250338A1 (en) | 2016-09-01 |
| IL209239A0 (en) | 2011-01-31 |
| US9662403B2 (en) | 2017-05-30 |
| BRPI0911989A2 (pt) | 2015-10-20 |
| ZA201008730B (en) | 2012-05-30 |
| US20200147121A1 (en) | 2020-05-14 |
| EP2285853B1 (en) | 2013-02-27 |
| AU2009246329A1 (en) | 2009-11-19 |
| AU2009246329A8 (en) | 2011-01-20 |
| CA2724014C (en) | 2016-09-13 |
| JP2011522070A (ja) | 2011-07-28 |
| AU2009246329B2 (en) | 2013-11-07 |
| WO2009140429A3 (en) | 2010-02-25 |
| KR101764427B1 (ko) | 2017-08-02 |
| US11707483B2 (en) | 2023-07-25 |
| EP2285853A2 (en) | 2011-02-23 |
| EP2285853A4 (en) | 2011-10-26 |
| AU2009246329B8 (en) | 2013-12-05 |
| JP5755563B2 (ja) | 2015-07-29 |
| ES2404136T3 (es) | 2013-05-24 |
| MX2010012239A (es) | 2011-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11707483B2 (en) | Micellic assemblies | |
| US9006193B2 (en) | Polymeric carrier | |
| EP2364330B1 (en) | Multiblock copolymers | |
| US9415113B2 (en) | Targeting monomers and polymers having targeting blocks | |
| CN102076328A (zh) | 用于胞内递送治疗剂的胶束 | |
| US20130017167A1 (en) | Hydrophobic block conjugated therapeutic agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110518 |