CN101983055A - 以咪达那新为有效成分的口腔内速崩片的制造方法 - Google Patents
以咪达那新为有效成分的口腔内速崩片的制造方法 Download PDFInfo
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- CN101983055A CN101983055A CN200980111934XA CN200980111934A CN101983055A CN 101983055 A CN101983055 A CN 101983055A CN 200980111934X A CN200980111934X A CN 200980111934XA CN 200980111934 A CN200980111934 A CN 200980111934A CN 101983055 A CN101983055 A CN 101983055A
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- miaow
- naxin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
样品 | 平均含量% | 标准偏差(σ) | 判定值(%) |
实施例1 | 104.7 | 1.7 | 8.4 |
实施例2 | 103.6 | 0.9 | 5.6 |
实施例3 | 104.0 | 0.8 | 5.8 |
实施例4 | 102.7 | 1.2 | 5.3 |
实施例5 | 104.6 | 1.4 | 7.7 |
实施例6 | 104.3 | 1.2 | 6.9 |
Claims (2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2008-020183 | 2008-01-31 | ||
JP2008020183 | 2008-01-31 | ||
PCT/JP2009/051651 WO2009096559A1 (ja) | 2008-01-31 | 2009-01-30 | イミダフェナシンを有効成分とする口腔内速崩錠の製造方法 |
Publications (2)
Publication Number | Publication Date |
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CN101983055A true CN101983055A (zh) | 2011-03-02 |
CN101983055B CN101983055B (zh) | 2013-05-08 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN200980111934XA Active CN101983055B (zh) | 2008-01-31 | 2009-01-30 | 以咪达那新为有效成分的口腔内速崩片的制造方法 |
Country Status (10)
Country | Link |
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US (1) | US8722133B2 (zh) |
EP (1) | EP2246051B1 (zh) |
JP (1) | JP4656672B2 (zh) |
KR (1) | KR101528953B1 (zh) |
CN (1) | CN101983055B (zh) |
CA (1) | CA2713677A1 (zh) |
DK (1) | DK2246051T3 (zh) |
ES (1) | ES2444718T3 (zh) |
PT (1) | PT2246051E (zh) |
WO (1) | WO2009096559A1 (zh) |
Cited By (3)
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CN103063795A (zh) * | 2012-12-27 | 2013-04-24 | 南京艾德凯腾生物医药有限责任公司 | 咪达那新的含量测定及有关物质检测方法 |
CN104614468A (zh) * | 2015-03-02 | 2015-05-13 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法分离咪达那新及其有关物质的方法 |
CN110068623A (zh) * | 2019-04-08 | 2019-07-30 | 南京海纳医药科技股份有限公司 | 一种咪达那新中有关物质的检测方法 |
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KR101528954B1 (ko) * | 2008-01-31 | 2015-06-15 | 교린 세이야꾸 가부시키 가이샤 | 이미다페나신 함유 구강 내 속붕괴성 정제 |
WO2012154778A1 (en) * | 2011-05-10 | 2012-11-15 | Theravida, Inc. | Combinations of imidafenacin and salivary stimulants for the treatment of overactive bladder |
JP6186139B2 (ja) * | 2013-03-08 | 2017-08-23 | 杏林製薬株式会社 | 口腔内速崩壊性錠剤 |
WO2017110965A1 (ja) | 2015-12-25 | 2017-06-29 | 杏林製薬株式会社 | バソプレシン様作用増強剤 |
JP6212588B2 (ja) * | 2016-03-24 | 2017-10-11 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
JP6303045B1 (ja) * | 2017-03-30 | 2018-03-28 | 杏林製薬株式会社 | 攪拌造粒法を用いたイミダフェナシンを含有する製剤の製造方法 |
JP6423034B2 (ja) * | 2017-03-30 | 2018-11-14 | 杏林製薬株式会社 | イミダフェナシン含有錠剤 |
JP6435363B2 (ja) * | 2017-03-30 | 2018-12-05 | 杏林製薬株式会社 | 湿式造粒法によるイミダフェナシンを含有する造粒物の製造方法 |
JP6303044B1 (ja) * | 2017-03-30 | 2018-03-28 | 杏林製薬株式会社 | 押出し造粒法を用いたイミダフェナシンを含有する製剤の製造方法 |
JP6423035B2 (ja) * | 2017-03-30 | 2018-11-14 | 杏林製薬株式会社 | イミダフェナシン含有造粒物のコーティング顆粒 |
JP6435362B2 (ja) * | 2017-03-30 | 2018-12-05 | 杏林製薬株式会社 | 保存安定性に優れたイミダフェナシンを含有する製剤 |
JP2018203789A (ja) * | 2018-10-09 | 2018-12-27 | 杏林製薬株式会社 | 製造工程分解物の少ないイミダフェナシンを含有する造粒物 |
JP2019019148A (ja) * | 2018-11-12 | 2019-02-07 | 杏林製薬株式会社 | 保存安定性に優れたイミダフェナシンを含有する製剤 |
CN110554104B (zh) * | 2019-07-26 | 2022-05-13 | 南京海纳医药科技股份有限公司 | 一种hplc-ms/ms联用检测人血浆中咪达那新的方法 |
WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
US5958453A (en) * | 1996-10-31 | 1999-09-28 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility |
TWI271198B (en) * | 1999-02-15 | 2007-01-21 | Dainippon Sumitomo Pharma Co | Tables disintegrating rapidly in the oral cavity |
US20030026835A1 (en) * | 1999-02-15 | 2003-02-06 | Sumitomo Pharmaceuticals Company Limited | Tablets disintegrating rapidly in the oral cavity |
ATE316375T1 (de) | 1999-11-11 | 2006-02-15 | Kyorin Seiyaku Kk | Orale feste zusammensetzung |
US8449911B2 (en) * | 2003-03-12 | 2013-05-28 | Takeda Pharmaceutical Company Limited | Drug composition having active ingredient adhered at high concentration to spherical core |
JP5062871B2 (ja) * | 2003-05-13 | 2012-10-31 | 東和薬品株式会社 | 苦味を低減した口腔内崩壊錠剤 |
EP1640021A4 (en) * | 2003-06-30 | 2008-01-23 | Takeda Pharmaceutical | PREVENTIVE / MEDICAMENT FOR URINARY DISTURBANCE |
CA2532714C (en) | 2003-08-04 | 2010-11-16 | Kyorin Pharmaceutical Co., Ltd. | Oral sustained-release tablet comprising 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide |
WO2005011683A1 (ja) | 2003-08-04 | 2005-02-10 | Kyorin Pharmaceutical Co., Ltd. | 経皮吸収型製剤 |
US9050249B2 (en) | 2004-04-30 | 2015-06-09 | Astellas Pharma Inc. | Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition |
WO2006080481A1 (ja) | 2005-01-31 | 2006-08-03 | Kyorin Pharmaceutical Co., Ltd. | マルチプルユニット型経口徐放性製剤及びその製造方法 |
EP1844773A4 (en) | 2005-02-03 | 2010-04-28 | Kyorin Seiyaku Kk | PREPARATION FOR PERCUTANEOUS ABSORPTION |
-
2009
- 2009-01-30 CA CA2713677A patent/CA2713677A1/en not_active Abandoned
- 2009-01-30 CN CN200980111934XA patent/CN101983055B/zh active Active
- 2009-01-30 KR KR1020107019209A patent/KR101528953B1/ko active IP Right Grant
- 2009-01-30 WO PCT/JP2009/051651 patent/WO2009096559A1/ja active Application Filing
- 2009-01-30 ES ES09705447.2T patent/ES2444718T3/es active Active
- 2009-01-30 US US12/865,632 patent/US8722133B2/en not_active Expired - Fee Related
- 2009-01-30 JP JP2009551623A patent/JP4656672B2/ja active Active
- 2009-01-30 DK DK09705447.2T patent/DK2246051T3/da active
- 2009-01-30 EP EP09705447.2A patent/EP2246051B1/en active Active
- 2009-01-30 PT PT97054472T patent/PT2246051E/pt unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103063795A (zh) * | 2012-12-27 | 2013-04-24 | 南京艾德凯腾生物医药有限责任公司 | 咪达那新的含量测定及有关物质检测方法 |
CN103063795B (zh) * | 2012-12-27 | 2015-01-07 | 南京艾德凯腾生物医药有限责任公司 | 咪达那新的含量测定及有关物质检测方法 |
CN104614468A (zh) * | 2015-03-02 | 2015-05-13 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法分离咪达那新及其有关物质的方法 |
CN104614468B (zh) * | 2015-03-02 | 2020-11-03 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法分离咪达那新及其有关物质的方法 |
CN110068623A (zh) * | 2019-04-08 | 2019-07-30 | 南京海纳医药科技股份有限公司 | 一种咪达那新中有关物质的检测方法 |
Also Published As
Publication number | Publication date |
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PT2246051E (pt) | 2014-01-07 |
EP2246051A1 (en) | 2010-11-03 |
JP4656672B2 (ja) | 2011-03-23 |
EP2246051A4 (en) | 2013-03-06 |
DK2246051T3 (da) | 2014-01-13 |
KR101528953B1 (ko) | 2015-06-15 |
CN101983055B (zh) | 2013-05-08 |
US8722133B2 (en) | 2014-05-13 |
KR20100126335A (ko) | 2010-12-01 |
ES2444718T3 (es) | 2014-02-26 |
WO2009096559A1 (ja) | 2009-08-06 |
JPWO2009096559A1 (ja) | 2011-05-26 |
US20100323090A1 (en) | 2010-12-23 |
EP2246051B1 (en) | 2013-12-11 |
CA2713677A1 (en) | 2009-08-06 |
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