CN101969953B - 用于治疗bh4反应性疾病的喋呤类似物 - Google Patents

用于治疗bh4反应性疾病的喋呤类似物 Download PDF

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CN101969953B
CN101969953B CN2008801242617A CN200880124261A CN101969953B CN 101969953 B CN101969953 B CN 101969953B CN 2008801242617 A CN2008801242617 A CN 2008801242617A CN 200880124261 A CN200880124261 A CN 200880124261A CN 101969953 B CN101969953 B CN 101969953B
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disease
acid
alkenylene
compound
alkylene
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CN101969953A (zh
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E·D·卡基斯
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Biomarin Pharmaceutical Inc
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN2008801242617A 2008-01-03 2008-07-07 用于治疗bh4反应性疾病的喋呤类似物 Expired - Fee Related CN101969953B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1873508P 2008-01-03 2008-01-03
US61/018,735 2008-01-03
US1975308P 2008-01-08 2008-01-08
US61/019,753 2008-01-08
PCT/US2008/069319 WO2009088530A1 (en) 2008-01-03 2008-07-07 Pterin analog for treating bh4 responsive condition

Publications (2)

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CN101969953A CN101969953A (zh) 2011-02-09
CN101969953B true CN101969953B (zh) 2013-01-09

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US (2) US7601717B2 (https=)
EP (1) EP2224927B1 (https=)
JP (1) JP2011508775A (https=)
CN (1) CN101969953B (https=)
AU (1) AU2008347005B2 (https=)
BR (1) BRPI0821970A2 (https=)
CA (1) CA2711160A1 (https=)
ES (1) ES2524026T3 (https=)
MX (1) MX2010006025A (https=)
RU (1) RU2470642C2 (https=)
WO (1) WO2009088530A1 (https=)

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WO2012058598A1 (en) * 2010-10-29 2012-05-03 The Trustees Of Columbia University In The City Of New York Methods of preventing and treating hyperlipidemia or atherosclerosis
CN103988080B (zh) * 2011-10-11 2016-06-08 加利福尼亚大学董事会 用于腹主动脉瘤的生物标记物
SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
MX2015002252A (es) 2012-08-21 2015-07-21 Sage Therapeutics Inc Metodos para tratar epilepsia o estado de epilepsia.
WO2014077715A1 (en) 2012-11-14 2014-05-22 BIAL - PORTELA & Cª, S.A. 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
NZ732812A (en) * 2014-12-30 2019-01-25 Dow Agrosciences Llc Use of picolinamides and other compounds as fungicides
HK1258616A1 (zh) 2016-03-08 2019-11-15 Sage Therapeutics, Inc. 神经活性类固醇、组合物、及其用途
CN110769855A (zh) * 2017-04-21 2020-02-07 史蒂文·霍夫曼 用于治疗视网膜病变的组合物和方法
WO2019067782A1 (en) * 2017-09-28 2019-04-04 University Of Massachusetts COMBINED TREATMENT OF NEUROPSYCHIATRIC DISORDERS
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
JP7553906B2 (ja) * 2018-11-01 2024-09-19 宏 一瀬 Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
CN112394178B (zh) * 2020-11-16 2022-08-05 首都医科大学附属北京朝阳医院 莫西沙星相关肝损伤的生物标志物、试剂盒及应用

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EP2224927B1 (en) 2014-08-20
MX2010006025A (es) 2010-06-30
EP2224927A1 (en) 2010-09-08
BRPI0821970A2 (pt) 2015-06-23
AU2008347005A1 (en) 2009-07-16
RU2010132278A (ru) 2012-02-10
US20090176790A1 (en) 2009-07-09
WO2009088530A1 (en) 2009-07-16
US20100093742A1 (en) 2010-04-15
CA2711160A1 (en) 2009-07-16
CN101969953A (zh) 2011-02-09
ES2524026T3 (es) 2014-12-03
AU2008347005B2 (en) 2013-10-03
US7601717B2 (en) 2009-10-13
US8324210B2 (en) 2012-12-04
JP2011508775A (ja) 2011-03-17
RU2470642C2 (ru) 2012-12-27

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