CN101952319B - 抗-间皮素抗体及其用途 - Google Patents

抗-间皮素抗体及其用途 Download PDF

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Publication number
CN101952319B
CN101952319B CN200880125390.8A CN200880125390A CN101952319B CN 101952319 B CN101952319 B CN 101952319B CN 200880125390 A CN200880125390 A CN 200880125390A CN 101952319 B CN101952319 B CN 101952319B
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China
Prior art keywords
seq
antibody
mesothelin
antibodies
dna
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Expired - Fee Related
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CN200880125390.8A
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English (en)
Chinese (zh)
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CN101952319A (zh
Inventor
A·卡纳特
D·莱特
D·施奈德
R·帕里
N·萨托扎瓦
T·R·海特纳汉森
S·斯泰德尔
U·舒伯特
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
Bayer Schering Pharma AG
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Priority to CN201410396441.8A priority Critical patent/CN104151429B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200880125390.8A 2007-11-26 2008-11-19 抗-间皮素抗体及其用途 Expired - Fee Related CN101952319B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410396441.8A CN104151429B (zh) 2007-11-26 2008-11-19 抗-间皮素抗体及其用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US437807P 2007-11-26 2007-11-26
US61/004378 2007-11-26
US61/004,378 2007-11-26
PCT/EP2008/009756 WO2009068204A1 (en) 2007-11-26 2008-11-19 Anti-mesothelin antibodies and uses therefor

Related Child Applications (1)

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CN201410396441.8A Division CN104151429B (zh) 2007-11-26 2008-11-19 抗-间皮素抗体及其用途

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CN101952319A CN101952319A (zh) 2011-01-19
CN101952319B true CN101952319B (zh) 2015-04-15

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US (3) US9023351B2 (https=)
EP (3) EP3103814A1 (https=)
JP (3) JP5608091B2 (https=)
KR (1) KR101559599B1 (https=)
CN (2) CN101952319B (https=)
AU (1) AU2008329221B2 (https=)
BR (1) BRPI0819909B8 (https=)
CA (1) CA2706529C (https=)
CO (1) CO6280409A2 (https=)
CR (1) CR11456A (https=)
CU (1) CU23833A3 (https=)
CY (1) CY1117437T1 (https=)
DK (1) DK2215121T3 (https=)
DO (1) DOP2010000150A (https=)
EC (1) ECSP10010191A (https=)
ES (1) ES2569513T3 (https=)
GT (1) GT201000148A (https=)
HN (1) HN2010001062A (https=)
HR (1) HRP20160485T1 (https=)
HU (1) HUE027358T2 (https=)
IL (1) IL205681A0 (https=)
MA (1) MA31862B1 (https=)
MX (1) MX2010005603A (https=)
MY (1) MY157164A (https=)
NZ (1) NZ585551A (https=)
PL (1) PL2215121T3 (https=)
SI (1) SI2215121T1 (https=)
TN (1) TN2010000234A1 (https=)
UA (1) UA106036C2 (https=)
WO (1) WO2009068204A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108350084A (zh) * 2015-09-24 2018-07-31 牧岩生命科学研究所 新的间皮素抗体和包含其的组合物

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