ECSP10010191A - Anticuerpos antimesotelina y usos de los mismos - Google Patents
Anticuerpos antimesotelina y usos de los mismosInfo
- Publication number
- ECSP10010191A ECSP10010191A EC2010010191A ECSP10010191A ECSP10010191A EC SP10010191 A ECSP10010191 A EC SP10010191A EC 2010010191 A EC2010010191 A EC 2010010191A EC SP10010191 A ECSP10010191 A EC SP10010191A EC SP10010191 A ECSP10010191 A EC SP10010191A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- antigen
- binding regions
- antimesotheline
- mesothelin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona regiones de unión a antígeno y anticuerpos recombinantes y fragmentos funcionales que contienen dichas regiones de unión a antígeno que son específicas del polipéptido mesotelina de 40 kDa unido a la membrana, que esta sobreexpresado en varios tumores, tales como tumores pancreáticos y ováricos, mesotelioma y células de cáncer de pulmón. En consecuencia, estos anticuerpos se pueden usar para tratar éstos y otros trastornos y afecciones. Los anticuerpos de la invención también se pueden usar en el campo del diagnóstico, así como para investigaciones adicionales del papel de la mesotelina en la progresión de los trastornos asociados con cáncer. La invención también proporciona secuencias de ácido nucleico que codifican los anticuerpos anteriores, vectores que contienen las mismas, composiciones farmacéuticas y kit con instrucciones de uso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US437807P | 2007-11-26 | 2007-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP10010191A true ECSP10010191A (es) | 2010-07-30 |
Family
ID=40351874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2010010191A ECSP10010191A (es) | 2007-11-26 | 2010-05-21 | Anticuerpos antimesotelina y usos de los mismos |
Country Status (31)
Country | Link |
---|---|
US (3) | US9023351B2 (es) |
EP (3) | EP3103814A1 (es) |
JP (3) | JP5608091B2 (es) |
KR (1) | KR101559599B1 (es) |
CN (2) | CN104151429B (es) |
AU (1) | AU2008329221B2 (es) |
BR (1) | BRPI0819909B8 (es) |
CA (1) | CA2706529C (es) |
CO (1) | CO6280409A2 (es) |
CR (1) | CR11456A (es) |
CU (1) | CU23833A3 (es) |
CY (1) | CY1117437T1 (es) |
DK (1) | DK2215121T3 (es) |
DO (1) | DOP2010000150A (es) |
EC (1) | ECSP10010191A (es) |
ES (1) | ES2569513T3 (es) |
GT (1) | GT201000148A (es) |
HK (2) | HK1148541A1 (es) |
HN (1) | HN2010001062A (es) |
HR (1) | HRP20160485T1 (es) |
HU (1) | HUE027358T2 (es) |
IL (1) | IL205681A0 (es) |
MA (1) | MA31862B1 (es) |
MX (1) | MX2010005603A (es) |
MY (1) | MY157164A (es) |
NZ (1) | NZ585551A (es) |
PL (1) | PL2215121T3 (es) |
SI (1) | SI2215121T1 (es) |
TN (1) | TN2010000234A1 (es) |
UA (1) | UA106036C2 (es) |
WO (1) | WO2009068204A1 (es) |
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PL2195017T3 (pl) * | 2007-10-01 | 2015-03-31 | Bristol Myers Squibb Co | Ludzkie antyciała, które wiążą mezotelinę i ich zastosowania |
US9023351B2 (en) * | 2007-11-26 | 2015-05-05 | Bayer Intellectual Property Gmbh | Anti-mesothelin antibodies and uses thereof |
UY32560A (es) * | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
AU2011349443B2 (en) * | 2010-12-20 | 2015-12-24 | Genentech, Inc. | Anti-mesothelin antibodies and immunoconjugates |
EP3138581B1 (en) | 2011-03-17 | 2019-01-02 | The University of Birmingham | Re-directed immunotherapy |
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
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WO2014004549A2 (en) * | 2012-06-27 | 2014-01-03 | Amgen Inc. | Anti-mesothelin binding proteins |
CA2885761C (en) * | 2012-09-27 | 2021-09-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin antibodies and methods for eliciting potent antitumor activity |
CN103819559B (zh) * | 2013-12-10 | 2016-02-24 | 中国科学院武汉病毒研究所 | 一种抗间皮素纳米抗体及其编码基因和该纳米抗体的用途 |
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US20090047211A1 (en) * | 2005-05-12 | 2009-02-19 | The Govt. Of The U.S. As Represented By The Sec. Of The Dept. Of Health And Human Services | Anti-mesothelin antibodies useful for immunological assays |
PT3620171T (pt) | 2005-05-18 | 2022-06-30 | Morphosys Ag | Anticorpos anti-gm-csf e suas utilizações |
AU2006252733A1 (en) | 2005-06-02 | 2006-12-07 | Astrazeneca Ab | Antibodies directed to CD20 and uses thereof |
PL2195017T3 (pl) * | 2007-10-01 | 2015-03-31 | Bristol Myers Squibb Co | Ludzkie antyciała, które wiążą mezotelinę i ich zastosowania |
US9023351B2 (en) * | 2007-11-26 | 2015-05-05 | Bayer Intellectual Property Gmbh | Anti-mesothelin antibodies and uses thereof |
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2008
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